Immunogenicity and protective efficacy of the Mycobacterium avium subsp. paratuberculosis attenuated mutants against challenge in a mouse model

Vaccine

Volumn 30, Issue 19, 2012, Pages 3015-3025

  Chen, Jenn Wei ^a   Faisal, Syed M ^a   Chandra, Subhash ^a   McDonough, Sean P ^a   Moreira, Maria A S ^a   Scaria, Joy ^a   Chang, Chao Fu ^b   Bannantine, John P ^c   Akey, Bruce ^a   Chang, Yung Fu ^a  

^a College of Veterinary Medicine Cornell University ^*  (United States)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

Johne's disease; LeuD, mpt64; Mutant; Mycobacterium avium subsp. paratuberculosis; SecA2

Indexed keywords

GAMMA INTERFERON; LEUD PROTEIN; MPT64 PROTEIN; MYCOBACTERIUM VACCINE; SECA2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BACTERIAL CLEARANCE; BACTERIAL LOAD; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; INFLAMMATION; LIVER; MOUSE; MUTANT; MYCOBACTERIUM PARATUBERCULOSIS; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PARATUBERCULOSIS; PATHOGENICITY; PRIORITY JOURNAL; PROVOCATION TEST; SPLEEN; VACCINATION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL LOAD; BACTERIAL PROTEINS; BACTERIAL VACCINES; CELL LINE; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENE DELETION; HYDRO-LYASES; LIVER; MACROPHAGES; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; PARATUBERCULOSIS; SPLEEN; VACCINES, ATTENUATED; VIRULENCE; VIRULENCE FACTORS;

EID: 84862785802     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.11.029     Document Type: Article

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