Immunization with a DNA vaccine cocktail induces a Th1 response and protects mice against Mycobacterium avium subsp. paratuberculosis challenge

Vaccine

Volumn 26, Issue 34, 2008, Pages 4329-4337

  Park, Sung Un ^a   Kathaperumal, Kumanan ^a   McDonough, Sean ^a   Akey, Bruce ^a   Huntley, John ^b   Bannantine, John P ^c   Chang, Yung Fu ^a  

^a Department of Obstetrics Gynecology   (United States)

^b New York State Department of Agriculture and Markets   (United States)

^c NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

35 kDa; 85 antigen complex; DNA vaccine; Mycobacterium avium subsp. paratuberculosis; SOD

Indexed keywords

CYTOKINE; DNA VACCINE; DNA VACCINE PVR1020; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; RECOMBINANT ANTIGEN; RECOMBINANT DNA COCKTAIL; RECOMBINANT MAP ANTIGEN; RECOMBINANT PROTEIN 85A; RECOMBINANT PROTEIN 85B; RECOMBINANT PROTEIN 85C; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ACID FAST BACTERIUM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GRANULOMA; HEPATITIS; HISTOPATHOLOGY; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; MOUSE; MYCOBACTERIUM AVIUM; MYCOBACTERIUM AVIUM PARATUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPLEEN; TH1 CELL; VACCINATION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; COLONY COUNT, MICROBIAL; FEMALE; IMMUNIZATION, SECONDARY; INJECTIONS, INTRAMUSCULAR; INTERFERON TYPE II; LIVER; MICE; MICE, INBRED C57BL; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; PARATUBERCULOSIS; SPLEEN; TH1 CELLS; TUBERCULOSIS VACCINES; VACCINES, DNA;

EID: 47649114038     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.06.016     Document Type: Article

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