메뉴 건너뛰기




Volumn 73, Issue 8, 2005, Pages 5074-5085

In vitro cellular immune responses to recombinant antigens of Mycobacterium avium subsp. paratuberculosis

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3D RECEPTOR; COMPLEMENTARY DNA; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; MYCOBACTERIUM ANTIGEN; RECOMBINANT ANTIGEN; RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 23344446665     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.8.5074-5085.2005     Document Type: Article
Times cited : (44)

References (56)
  • 1
    • 0030254341 scopus 로고    scopus 로고
    • Polymerase chain reaction analysis of TNF-alpha and IL-6 mRNA levels in whole blood from cattle naturally or experimentally infected with Mycobacterium paratuberculosis
    • Adams, J. L., M. T. Collins, and C. J. Czuprynski. 1996. Polymerase chain reaction analysis of TNF-alpha and IL-6 mRNA levels in whole blood from cattle naturally or experimentally infected with Mycobacterium paratuberculosis. Can. J. Vet. Res. 60:257-262.
    • (1996) Can. J. Vet. Res. , vol.60 , pp. 257-262
    • Adams, J.L.1    Collins, M.T.2    Czuprynski, C.J.3
  • 2
    • 0041923953 scopus 로고    scopus 로고
    • The Mycobacterium avium subsp. paratuberculosis 35 kDa protein plays a role in invasion of bovine epithelial cells
    • Bannantine, J. P., J. F. Huntley, E. Miltner, J. R. Stabel, and L. E. Bermudez. 2003. The Mycobacterium avium subsp. paratuberculosis 35 kDa protein plays a role in invasion of bovine epithelial cells. Microbiology 149:2061-2069.
    • (2003) Microbiology , vol.149 , pp. 2061-2069
    • Bannantine, J.P.1    Huntley, J.F.2    Miltner, E.3    Stabel, J.R.4    Bermudez, L.E.5
  • 6
    • 0033136317 scopus 로고    scopus 로고
    • Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis
    • Caruso, A. M., N. Serbina, E. Klein, K. Triebold, B. R. Bloom, and J. L. Flynn. 1999. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis. J. Immunol. 162:5407-5416.
    • (1999) J. Immunol. , vol.162 , pp. 5407-5416
    • Caruso, A.M.1    Serbina, N.2    Klein, E.3    Triebold, K.4    Bloom, B.R.5    Flynn, J.L.6
  • 8
    • 0027034919 scopus 로고
    • The cellular immunology of bovine paratuberculosis: The predominant response is mediated by cytotoxic gamma/delta T lymphocytes which prevent CD4+ activity
    • Chiodini, R. J., and W. C. Davis. 1992. The cellular immunology of bovine paratuberculosis: the predominant response is mediated by cytotoxic gamma/delta T lymphocytes which prevent CD4+ activity. Microb. Pathog. 13:447-463.
    • (1992) Microb. Pathog. , vol.13 , pp. 447-463
    • Chiodini, R.J.1    Davis, W.C.2
  • 10
    • 0032167527 scopus 로고    scopus 로고
    • Molecular cloning and immunologic reactivity of a novel low molecular mass antigen of Mycobacterium tuberculosis
    • Coler, R. N., Y. A. Skeiky, T. Vedvick, T. Bement, P. Ovendale, A. Campos-Neto, M. R. Alderson, and S. G. Reed. 1998. Molecular cloning and immunologic reactivity of a novel low molecular mass antigen of Mycobacterium tuberculosis. J. Immunol. 161:2356-2364.
    • (1998) J. Immunol. , vol.161 , pp. 2356-2364
    • Coler, R.N.1    Skeiky, Y.A.2    Vedvick, T.3    Bement, T.4    Ovendale, P.5    Campos-Neto, A.6    Alderson, M.R.7    Reed, S.G.8
  • 12
    • 0032036493 scopus 로고    scopus 로고
    • Vaccination with plasmid DNA encoding mycobacterial antigen 85A stimulates a CD4+ and CD8+ T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection
    • Denis, O., A. Tanghe, K. Palfliet, F. Jurion, T.-P. van den Berg, A. Vanonckelen, J. Ooms, E. Saman, J. B. Ulmer, J. Content, and K. Huygen. 1998. Vaccination with plasmid DNA encoding mycobacterial antigen 85A stimulates a CD4+ and CD8+ T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection. Infect. Immun. 66: 1527-1533.
    • (1998) Infect. Immun. , vol.66 , pp. 1527-1533
    • Denis, O.1    Tanghe, A.2    Palfliet, K.3    Jurion, F.4    Van Den Berg, T.-P.5    Vanonckelen, A.6    Ooms, J.7    Saman, E.8    Ulmer, J.B.9    Content, J.10    Huygen, K.11
  • 14
    • 0033834025 scopus 로고    scopus 로고
    • CD4+ T cells contain Mycobacterium tuberculosis infection in the absence of CD8+ T cells in mice vaccinated with DNA encoding Ag85A
    • D'Souza, S., O. Denis, T. Scorza, F. Nzabintwali, H. Verschueren, and K. Huygen. 2000. CD4+ T cells contain Mycobacterium tuberculosis infection in the absence of CD8+ T cells in mice vaccinated with DNA encoding Ag85A. Eur. J. Immunol. 30:2455-2459.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 2455-2459
    • D'Souza, S.1    Denis, O.2    Scorza, T.3    Nzabintwali, F.4    Verschueren, H.5    Huygen, K.6
  • 15
    • 0347269081 scopus 로고    scopus 로고
    • Immunology of tuberculosis and implications in vaccine development
    • Flynn, J. L. 2004. Immunology of tuberculosis and implications in vaccine development. Tuberculosis 84:93-101.
    • (2004) Tuberculosis , vol.84 , pp. 93-101
    • Flynn, J.L.1
  • 16
    • 0035064072 scopus 로고    scopus 로고
    • Immunology of tuberculosis
    • Flynn, J. L., and J. Chan. 2001. Immunology of tuberculosis. Annu. Rev. Immunol. 19:93-129.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 93-129
    • Flynn, J.L.1    Chan, J.2
  • 17
    • 0027360333 scopus 로고
    • An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
    • Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-2254.
    • (1993) J. Exp. Med. , vol.178 , pp. 2249-2254
    • Flynn, J.L.1    Chan, J.2    Triebold, K.J.3    Dalton, D.K.4    Stewart, T.A.5    Bloom, B.R.6
  • 18
    • 0034541180 scopus 로고    scopus 로고
    • Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A*0201-restricted CD8(+) T cells in HLA-transgenic mice and humans
    • Geluk, A., K. E. van Meijgaarden, K. L. Franken, J. W. Drijfhout, S. D'Souza, A. Necker, K. Huygen, and T. H. Ottenhoff. 2000. Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A*0201-restricted CD8(+) T cells in HLA-transgenic mice and humans. J. Immunol. 165:6463-6471.
    • (2000) J. Immunol. , vol.165 , pp. 6463-6471
    • Geluk, A.1    Van Meijgaarden, K.E.2    Franken, K.L.3    Drijfhout, J.W.4    D'Souza, S.5    Necker, A.6    Huygen, K.7    Ottenhoff, T.H.8
  • 19
    • 0034932360 scopus 로고    scopus 로고
    • Mycobacterium avium subsp. paratuberculosis in veterinary medicine
    • Harris, N. B., and R. G. Barletta. 2001. Mycobacterium avium subsp. paratuberculosis in veterinary medicine. Clin. Microbiol. Rev. 14:489-512.
    • (2001) Clin. Microbiol. Rev. , vol.14 , pp. 489-512
    • Harris, N.B.1    Barletta, R.G.2
  • 20
    • 0030056239 scopus 로고    scopus 로고
    • Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis
    • Harth, G., B.-Y. Lee, J. Wang, D. L. Clemens, and M. A. Horwitz. 1996. Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis. Infect. Immun. 64:3038-3047.
    • (1996) Infect. Immun. , vol.64 , pp. 3038-3047
    • Harth, G.1    Lee, B.-Y.2    Wang, J.3    Clemens, D.L.4    Horwitz, M.A.5
  • 23
    • 0033063963 scopus 로고    scopus 로고
    • Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis
    • Kamath, A. T., C. G. Feng, M. Macdonald, H. Briscoe, and W. J. Britton. 1999. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect. Immun. 67:1702-1707.
    • (1999) Infect. Immun. , vol.67 , pp. 1702-1707
    • Kamath, A.T.1    Feng, C.G.2    Macdonald, M.3    Briscoe, H.4    Britton, W.J.5
  • 26
    • 0027018406 scopus 로고
    • Paratuberculosis vaccine in a large dairy herd
    • Kormendy, B. 1992. Paratuberculosis vaccine in a large dairy herd. Acta Vet. Hung. 40:171-184.
    • (1992) Acta Vet. Hung. , vol.40 , pp. 171-184
    • Kormendy, B.1
  • 27
    • 0016651734 scopus 로고
    • Age of cattle as related to resistance to infection with Mycobacterium paratuberculosis
    • Larsen, A. B., R. S. Merkal, and R. C. Cutlip. 1975. Age of cattle as related to resistance to infection with Mycobacterium paratuberculosis. Am. J. Vet. Res. 36:255-257.
    • (1975) Am. J. Vet. Res. , vol.36 , pp. 255-257
    • Larsen, A.B.1    Merkal, R.S.2    Cutlip, R.C.3
  • 28
    • 0017862901 scopus 로고
    • Experimental vaccination of cattle against paratuberculosis (Johne's disease) with killed bacterial vaccines: A controlled field study
    • Larsen, A. B., A. I. Moyle, and E. M. Himes. 1978. Experimental vaccination of cattle against paratuberculosis (Johne's disease) with killed bacterial vaccines: a controlled field study. Am. J. Vet. Res. 39:65-69.
    • (1978) Am. J. Vet. Res. , vol.39 , pp. 65-69
    • Larsen, A.B.1    Moyle, A.I.2    Himes, E.M.3
  • 29
    • 0032725461 scopus 로고    scopus 로고
    • Purification and immunoreactivity of three components from the 30/32-kilodalton antigen 85 complex in Mycobacterium tuberculosis
    • Lim, J.-H., J.-K. Park, E.-K. Jo, C.-H. Song, D. Min, Y.-J. Song, and H.-J. Kim. 1999. Purification and immunoreactivity of three components from the 30/32-kilodalton antigen 85 complex in Mycobacterium tuberculosis. Infect. Immun. 67:6187-6190.
    • (1999) Infect. Immun. , vol.67 , pp. 6187-6190
    • Lim, J.-H.1    Park, J.-K.2    Jo, E.-K.3    Song, C.-H.4    Min, D.5    Song, Y.-J.6    Kim, H.-J.7
  • 31
    • 0031593686 scopus 로고    scopus 로고
    • The gammadelta T-cell bridge: Linking innate and acquired immunity
    • Mak, T. W., and D. A. Ferrick. 1998. The gammadelta T-cell bridge: linking innate and acquired immunity. Nat. Med. 4:764-765.
    • (1998) Nat. Med. , vol.4 , pp. 764-765
    • Mak, T.W.1    Ferrick, D.A.2
  • 32
    • 7044270950 scopus 로고    scopus 로고
    • Application of mycobacterial proteomics to vaccine design: Improved protection by Mycobacterium bovis BCG prime-Rv3407 DNA boost vaccination against tuberculosis
    • Mollenkopf, H. J., L. Grode, J. Mattow, M. Stein, P. Mann, B. Knapp, J. Ulmer, and S. H. Kaufmann. 2004. Application of mycobacterial proteomics to vaccine design: improved protection by Mycobacterium bovis BCG prime-Rv3407 DNA boost vaccination against tuberculosis. Infect. Immun. 72: 6471-6479.
    • (2004) Infect. Immun. , vol.72 , pp. 6471-6479
    • Mollenkopf, H.J.1    Grode, L.2    Mattow, J.3    Stein, M.4    Mann, P.5    Knapp, B.6    Ulmer, J.7    Kaufmann, S.H.8
  • 33
    • 0035898950 scopus 로고    scopus 로고
    • Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA
    • Mollenkopf, H. J., D. Groine-Triebkorn, P. Andersen, J. Hess, and S. H. Kaufmann. 2001. Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA. Vaccine 19:4028-4035.
    • (2001) Vaccine , vol.19 , pp. 4028-4035
    • Mollenkopf, H.J.1    Groine-Triebkorn, D.2    Andersen, P.3    Hess, J.4    Kaufmann, S.H.5
  • 36
    • 0032724567 scopus 로고    scopus 로고
    • The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice
    • Naito, M., M. Matsuoka, N. Ohara, H. Nomaguchi, and T. Yamada. 1999. The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice. Vaccine 18:795-798.
    • (1999) Vaccine , vol.18 , pp. 795-798
    • Naito, M.1    Matsuoka, M.2    Ohara, N.3    Nomaguchi, H.4    Yamada, T.5
  • 38
    • 9244251567 scopus 로고    scopus 로고
    • The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis
    • Parra, M., T. Pickett, G. Delogu, V. Dheenadhayalan, A. S. Debrie, C. Locht, and M. J. Brennan. 2004. The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis. Infect. Immun. 72:6799-6805.
    • (2004) Infect. Immun. , vol.72 , pp. 6799-6805
    • Parra, M.1    Pickett, T.2    Delogu, G.3    Dheenadhayalan, V.4    Debrie, A.S.5    Locht, C.6    Brennan, M.J.7
  • 39
    • 0024006174 scopus 로고
    • Accidental self-inoculation with Mycobacterium paratuberculosis bacterin (Johne's bacterin) by veterinarians in Wisconsin
    • Patterson, C. J., M. LaVenture, S. S. Hurley, and J. P. Davis. 1988. Accidental self-inoculation with Mycobacterium paratuberculosis bacterin (Johne's bacterin) by veterinarians in Wisconsin. J. Am. Vet. Med. Assoc. 192:1197-1199.
    • (1988) J. Am. Vet. Med. Assoc. , vol.192 , pp. 1197-1199
    • Patterson, C.J.1    Laventure, M.2    Hurley, S.S.3    Davis, J.P.4
  • 40
    • 0035339925 scopus 로고    scopus 로고
    • Antigen recognition and immunomodulation by gamma delta T cells in bovine tuberculosis
    • Rhodes, S. G., R. G. Hewinson, and H. M. Vordermeier. 2001. Antigen recognition and immunomodulation by gamma delta T cells in bovine tuberculosis. J. Immunol. 166:5604-5610.
    • (2001) J. Immunol. , vol.166 , pp. 5604-5610
    • Rhodes, S.G.1    Hewinson, R.G.2    Vordermeier, H.M.3
  • 41
    • 0034977007 scopus 로고    scopus 로고
    • + T cells participate in the memory immune response to Mycobacterium tuberculosis
    • + T cells participate in the memory immune response to Mycobacterium tuberculosis. Infect. Immun. 69:4320-4328.
    • (2001) Infect. Immun. , vol.69 , pp. 4320-4328
    • Serbina, N.V.1    Flynn, J.L.2
  • 42
    • 0032792687 scopus 로고    scopus 로고
    • + T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice
    • + T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice. Infect. Immun. 67:3980-3988.
    • (1999) Infect. Immun. , vol.67 , pp. 3980-3988
    • Serbina, N.V.1    Flynn, J.L.2
  • 43
    • 0034234609 scopus 로고    scopus 로고
    • CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perform in vivo and lyse infected macrophages
    • Serhina, N. V., C. C. Liu, C. A. Scanga, and J. L. Flynn. 2000. CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perform in vivo and lyse infected macrophages. J. Immunol. 165:353-363.
    • (2000) J. Immunol. , vol.165 , pp. 353-363
    • Serhina, N.V.1    Liu, C.C.2    Scanga, C.A.3    Flynn, J.L.4
  • 45
    • 3342911375 scopus 로고    scopus 로고
    • Comparative antibody response of five recombinant antigens in related to bacterial shedding levels and development of serological diagnosis based on 35 kDa antigen for Mycobacterium avium subsp. paratuberculosis
    • Shin, S. J., H. S. Yoo, S. P. McDonough, and Y. F. Chang. 2004. Comparative antibody response of five recombinant antigens in related to bacterial shedding levels and development of serological diagnosis based on 35 kDa antigen for Mycobacterium avium subsp. paratuberculosis. J. Vet. Sci. 5:111-117.
    • (2004) J. Vet. Sci. , vol.5 , pp. 111-117
    • Shin, S.J.1    Yoo, H.S.2    McDonough, S.P.3    Chang, Y.F.4
  • 46
    • 2942596008 scopus 로고    scopus 로고
    • Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein
    • Skeiky, Y. A., M. R. Alderson, P. J. Ovendale, J. A. Guderian, L. Brandt, D. C. Dillon, A. Campos-Neto, Y. Lobet, W. Dalemans, I. M. Orme, and S. G. Reed. 2004. Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein. J. Immunol. 172:7618-7628.
    • (2004) J. Immunol. , vol.172 , pp. 7618-7628
    • Skeiky, Y.A.1    Alderson, M.R.2    Ovendale, P.J.3    Guderian, J.A.4    Brandt, L.5    Dillon, D.C.6    Campos-Neto, A.7    Lobet, Y.8    Dalemans, W.9    Orme, I.M.10    Reed, S.G.11
  • 47
    • 0034671804 scopus 로고    scopus 로고
    • T cell expression cloning of a Mycobacterium tuberculosis gene encoding a protective antigen associated with the early control of infection
    • Skeiky, Y. A., P. J. Ovendale, S. Jen, M. R. Alderson, D. C. Dillon, S. Smith, C. B. Wilson, I. M. Orme, S. G. Reed, and A. Campos-Neto. 2000. T cell expression cloning of a Mycobacterium tuberculosis gene encoding a protective antigen associated with the early control of infection. J. Immunol. 165: 7140-7149.
    • (2000) J. Immunol. , vol.165 , pp. 7140-7149
    • Skeiky, Y.A.1    Ovendale, P.J.2    Jen, S.3    Alderson, M.R.4    Dillon, D.C.5    Smith, S.6    Wilson, C.B.7    Orme, I.M.8    Reed, S.G.9    Campos-Neto, A.10
  • 48
    • 0030178748 scopus 로고    scopus 로고
    • Production of gamma-interferon by peripheral blood mononuclear cells: An important diagnostic tool for detection of subclinical paratuberculosis
    • Stabel, J. R. 1996. Production of gamma-interferon by peripheral blood mononuclear cells: an important diagnostic tool for detection of subclinical paratuberculosis. J. Vet. Diagn. Investig. 8:345-350.
    • (1996) J. Vet. Diagn. Investig. , vol.8 , pp. 345-350
    • Stabel, J.R.1
  • 49
    • 0034695118 scopus 로고    scopus 로고
    • Transitions in immune responses to Mycobacterium paratuberculosis
    • Stabel, J. R. 2000. Transitions in immune responses to Mycobacterium paratuberculosis. Vet. Microbiol. 77:465-473.
    • (2000) Vet. Microbiol. , vol.77 , pp. 465-473
    • Stabel, J.R.1
  • 51
    • 0032113583 scopus 로고    scopus 로고
    • Interferon-gamma and interleukin 4 gene expression in cows infected with Mycobacterium paratuberculosis
    • Sweeney, R. W., D. E. Jones, P. Habecker, and P. Scott. 1998. Interferon-gamma and interleukin 4 gene expression in cows infected with Mycobacterium paratuberculosis. Am. J. Vet. Res. 59:842-847.
    • (1998) Am. J. Vet. Res. , vol.59 , pp. 842-847
    • Sweeney, R.W.1    Jones, D.E.2    Habecker, P.3    Scott, P.4
  • 52
    • 0026841179 scopus 로고
    • Mycobacterium paratuberculosis isolated from fetuses of infected cows not manifesting signs of the disease
    • Sweeney, R. W., R. H. Whitlock, and A. E. Rosenberger. 1992. Mycobacterium paratuberculosis isolated from fetuses of infected cows not manifesting signs of the disease. Am. J. Vet. Res. 53:477-480.
    • (1992) Am. J. Vet. Res. , vol.53 , pp. 477-480
    • Sweeney, R.W.1    Whitlock, R.H.2    Rosenberger, A.E.3
  • 53
    • 0034876286 scopus 로고    scopus 로고
    • Protective efficacy of a DNA vaccine encoding antigen 85A from Mycobacterium bovis BCG against Buruli ulcer
    • Tanghe, A., J. Content, J.-P. Van Vooren, F. Portaels, and K. Huygen. 2001. Protective efficacy of a DNA vaccine encoding antigen 85A from Mycobacterium bovis BCG against Buruli ulcer. Infect. Immun. 69:5403-5411.
    • (2001) Infect. Immun. , vol.69 , pp. 5403-5411
    • Tanghe, A.1    Content, J.2    Van Vooren, J.-P.3    Portaels, F.4    Huygen, K.5
  • 54
    • 0033917287 scopus 로고    scopus 로고
    • Tuberculosis DNA vaccine encoding Ag85A is immunogenic and protective when administered by intramuscular needle injection but not by epidermal gene gun bombardment
    • Tanghe, A., O. Denis, B. Lambrecht, V. Motte, T. van den Berg, and K. Huygen. 2000. Tuberculosis DNA vaccine encoding Ag85A is immunogenic and protective when administered by intramuscular needle injection but not by epidermal gene gun bombardment. Infect. Immun. 68:3854-3860.
    • (2000) Infect. Immun. , vol.68 , pp. 3854-3860
    • Tanghe, A.1    Denis, O.2    Lambrecht, B.3    Motte, V.4    Van Den Berg, T.5    Huygen, K.6
  • 56
    • 0034181856 scopus 로고    scopus 로고
    • Herd-level risk factors for infection with Mycobacterium paratuberculosis in US dairies and association between familiarity of the herd manager with the disease or prior diagnosis of the disease in that herd and use of preventive measures
    • Wells, S. J., and B. A. Wagner. 2000. Herd-level risk factors for infection with Mycobacterium paratuberculosis in US dairies and association between familiarity of the herd manager with the disease or prior diagnosis of the disease in that herd and use of preventive measures. J. Am. Vet. Med. Assoc. 216:1450-1457.
    • (2000) J. Am. Vet. Med. Assoc. , vol.216 , pp. 1450-1457
    • Wells, S.J.1    Wagner, B.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.