TLR2 ligation induces the production of IL-23/IL-17 via IL-6, STAT3 and NF-kB pathway in patients with primary Sjogren's syndrome

Arthritis Research and Therapy

Volumn 14, Issue 2, 2012, Pages

  Kwok, Seung Ki ^a   Cho, Mi La ^b   Her, Yang Mi ^b   Oh, Hye Joa ^b   Park, Mi Kyung ^b   Lee, Seon Yeong ^b   Woo, Yun J ^b   Ju, Ji H ^a   Park, Kyung Su ^a   Kim, Ho Youn ^a   Park, Sung Hwan ^a  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; STAT3 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; IL6 PROTEIN, HUMAN; LIGAND; STAT3 PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SALIVARY GLAND; SALIVARY GLAND BIOPSY; SJOEGREN SYNDROME; TH17 CELL; BIOSYNTHESIS; CELL CULTURE; IMMUNOLOGY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FEMALE; HUMANS; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKIN-6; LIGANDS; MALE; NF-KAPPA B; SALIVARY GLANDS; SIGNAL TRANSDUCTION; SJOGREN'S SYNDROME; STAT3 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 2;

EID: 84862784072     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3780     Document Type: Article

References (43)

1. Fox RI. Sjogren's syndrome. Lancet 2005, 366:321-331. 10.1016/S0140-6736(05)66990-5, 16039337.
2. Fox RI. Epidemiology, pathogenesis, animal models, and treatment of Sjogren's syndrome. Curr Opin Rheumatol 1994, 6:501-508. 10.1097/00002281-199409000-00008, 7993708.
3. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004, 4:499-511. 10.1038/nri1391, 15229469.
4. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801. 10.1016/j.cell.2006.02.015, 16497588.
5. Kawai T, Akira S. TLR signaling. Semin Immunol 2007, 19:24-32. 10.1016/j.smim.2006.12.004, 17275323.
6. Li M, Zhou Y, Feng G, Su SB. The critical role of Toll-like receptor signaling pathways in the induction and progression of autoimmune diseases. Curr Mol Med 2009, 9:365-374. 10.2174/156652409787847137, 19355917.
7. Brentano F, Kyburz D, Schorr O, Gay R, Gay S. The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol 2005, 233:90-96. 10.1016/j.cellimm.2005.04.018, 15963480.
8. Chang JH, McCluskey PJ, Wakefield D. Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease. Br J Ophthalmol 2006, 90:103-108. 10.1136/bjo.2005.072686, 1856909, 16361678.
9. Huang QQ, Pope RM. The role of toll-like receptors in rheumatoid arthritis. Curr Rheumatol Rep 2009, 11:357-364. 10.1007/s11926-009-0051-z, 2913446, 19772831.
10. Kanczkowski W, Ziegler CG, Zacharowski K, Bornstein SR. Toll-like receptors in endocrine disease and diabetes. Neuroimmunomodulation 2008, 15:54-60.
11. Pisetsky DS. The role of innate immunity in the induction of autoimmunity. Autoimmun Rev 2008, 8:69-72. 10.1016/j.autrev.2008.07.028, 18708168.
12. Smith KD. Toll-like receptors in kidney disease. Curr Opin Nephrol Hypertens 2009, 18:189-196. 10.1097/MNH.0b013e32832a1d5f, 2896868, 19352178.
13. Kawakami A, Nakashima K, Tamai M, Nakamura H, Iwanaga N, Fujikawa K, Aramaki T, Arima K, Iwamoto N, Ichinose K, Kamachi M, Ida H, Origuchi T, Eguchi K. Toll-like receptor in salivary glands from patients with Sjogren's syndrome: functional analysis by human salivary gland cell line. J Rheumatol 2007, 34:1019-1026.
14. Spachidou MP, Bourazopoulou E, Maratheftis CI, Kapsogeorgou EK, Moutsopoulos HM, Tzioufas AG, Manoussakis MN. Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjogren's syndrome. Clin Exp Immunol 2007, 147:497-503. 10.1111/j.1365-2249.2006.03311.x, 1810489, 17302899.
15. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986, 136:2348-2357.
16. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005, 6:1123-1132. 10.1038/ni1254, 16200070.
17. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6:1133-1141. 10.1038/ni1261, 1618871, 16200068.
18. Dong C. Differentiation and function of pro-inflammatory Th17 cells. Microbes Infect 2009, 11:584-588. 10.1016/j.micinf.2009.04.001, 2698049, 19371793.
19. Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th17 cells in human disease. Immunol Rev 2008, 223:87-113. 10.1111/j.1600-065X.2008.00628.x, 3299089, 18613831.
20. Dong C. IL-23/IL-17 biology and therapeutic considerations. J Immunotoxicol 2008, 5:43-46. 10.1080/15476910801897953, 18382857.
21. Iwakura Y, Nakae S, Saijo S, Ishigame H. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev 2008, 226:57-79. 10.1111/j.1600-065X.2008.00699.x, 19161416.
22. Katsifis GE, Rekka S, Moutsopoulos NM, Pillemer S, Wahl SM. Systemic and local interleukin-17 and linked cytokines associated with Sjogren's syndrome immunopathogenesis. Am J Pathol 2009, 175:1167-1177. 10.2353/ajpath.2009.090319, 2731135, 19700754.
23. Nguyen CQ, Hu MH, Li Y, Stewart C, Peck AB. Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjogren's syndrome: findings in humans and mice. Arthritis Rheum 2008, 58:734-743. 10.1002/art.23214, 2850059, 18311793.
24. Sakai A, Sugawara Y, Kuroishi T, Sasano T, Sugawara S. Identification of IL-18 and Th17 cells in salivary glands of patients with Sjogren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J Immunol 2008, 181:2898-2906.
25. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002, 61:554-558. 10.1136/ard.61.6.554, 1754137, 12006334.
26. Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjogren's disease. J Clin Pathol 1968, 21:656-660. 10.1136/jcp.21.5.656, 473887, 5697370.
27. Kishimoto T. Interleukin-6: from basic science to medicine--40 years in immunology. Annu Rev Immunol 2005, 23:1-21. 10.1146/annurev.immunol.23.021704.115806, 15771564.
28. Skopouli FN, Fox PC, Galanopoulou V, Atkinson JC, Jaffe ES, Moutsopoulos HM. T cell subpopulations in the labial minor salivary gland histopathologic lesion of Sjogren's syndrome. J Rheumatol 1991, 18:210-214.
29. Katsifis GE, Moutsopoulos NM, Wahl SM. T lymphocytes in Sjogren's syndrome: contributors to and regulators of pathophysiology. Clin Rev Allergy Immunol 2007, 32:252-264. 10.1007/s12016-007-8011-8, 17992592.
30. Nickoloff BJ, Qin JZ, Nestle FO. Immunopathogenesis of psoriasis. Clin Rev Allergy Immunol 2007, 33:45-56. 10.1007/s12016-007-0039-2, 18094946.
31. Di Cesare A, Di Meglio P, Nestle FO. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 2009, 129:1339-1350. 10.1038/jid.2009.59, 19322214.
32. Gaffen SL. The role of interleukin-17 in the pathogenesis of rheumatoid arthritis. Curr Rheumatol Rep 2009, 11:365-370. 10.1007/s11926-009-0052-y, 2811488, 19772832.
33. Peck A, Mellins ED. Breaking old paradigms: Th17 cells in autoimmune arthritis. Clin Immunol 2009, 132:295-304. 10.1016/j.clim.2009.03.522, 2720426, 19403336.
34. McFarland HF, Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol 2007, 8:913-919. 10.1038/ni1507, 17712344.
35. Liu ZJ, Yadav PK, Su JL, Wang JS, Fei K. Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease. World J Gastroenterol 2009, 15:5784-5788. 10.3748/wjg.15.5784, 2791270, 19998498.
36. Wang YH, Liu YJ. The IL-17 cytokine family and their role in allergic inflammation. Curr Opin Immunol 2008, 20:697-702. 10.1016/j.coi.2008.09.004, 18832032.
37. Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M. TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur J Immunol 2009, 39:1221-1230. 10.1002/eji.200838742, 19350551.
38. Yu CF, Peng WM, Oldenburg J, Hoch J, Bieber T, Limmer A, Hartmann G, Barchet W, Eis-Hubinger AM, Novak N. Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation. J Immunol 2010, 184:1159-1167. 10.4049/jimmunol.0901706, 20026744.
39. Loures FV, Pina A, Felonato M, Calich VL. TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection. J Immunol 2009, 183:1279-1290. 10.4049/jimmunol.0801599, 19553529.
40. Moutsopoulos HM. Sjogren's syndrome: autoimmune epithelitis. Clin Immunol Immunopathol 1994, 72:162-165. 10.1006/clin.1994.1123, 8050187.
41. Mitsias DI, Kapsogeorgou EK, Moutsopoulos HM. Sjogren's syndrome: why autoimmune epithelitis?. Oral Dis 2006, 12:523-532. 10.1111/j.1601-0825.2006.01292.x, 17054763.
42. Polihronis M, Tapinos NI, Theocharis SE, Economou A, Kittas C, Moutsopoulos HM. Modes of epithelial cell death and repair in Sjogren's syndrome (SS). Clin Exp Immunol 1998, 114:485-490. 10.1046/j.1365-2249.1998.00705.x, 1905140, 9844061.
43. Reksten TR, Jonsson MV, Szyszko EA, Brun JG, Jonsson R, Brokstad KA. Cytokine and autoantibody profiling related to histopathological features in primary Sjogren's syndrome. Rheumatology (Oxford) 2009, 48:1102-1106.