Quantification of irinotecan, SN38, and SN38G in human and porcine plasma by ultra high-performance liquid chromatography-tandem mass spectrometry and its application to hepatic chemoembolization

Journal of Pharmaceutical and Biomedical Analysis

Volumn 62, Issue , 2012, Pages 140-148

  Chen, Xiaohong ^a   Peer, Cody J ^b   Alfaro, Raul ^c   Tian, Tian ^b   Spencer, Shawn D ^a   Figg, William D ^b  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Camptothecin; Irinotecan; Mass spectrometry; SN38; Ultra high performance liquid chromatography

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; CAMPTOTHECIN; IRINOTECAN; TOLBUTAMIDE;

ACCURACY; ARTICLE; CHEMOEMBOLIZATION; DRUG BLOOD LEVEL; FREEZE THAWING; HEPATIC CHEMOEMBOLIZATION; HUMAN; LIMIT OF QUANTITATION; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; ROOM TEMPERATURE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CALIBRATION; CAMPTOTHECIN; CHEMOEMBOLIZATION, THERAPEUTIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONIDES; HUMANS; LIVER; REFERENCE STANDARDS; SWINE; TANDEM MASS SPECTROMETRY;

EID: 84862779580     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.01.008     Document Type: Article

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