A sensitive and rapid liquid chromatography tandem mass spectrometry method for quantitative determination of 7-ethyl-10-hydroxycamptothecin (SN-38) in human plasma containing liposome-based SN-38 (LE-SN38)

Biomedical Chromatography

Volumn 17, Issue 8, 2003, Pages 493-499

  Khan, Sumsullah ^a   Ahmad, Ateeq ^a   Ahmad, Imran ^a  

^a NeoPharm Inc   (United States)

Author keywords

Camptothecin; Electrospray ionization; Irinotecan; Liposome; Multiple reactions monitoring

Indexed keywords

ACETIC ACID; ACETONITRILE; DRUG DELIVERY; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; PLASMA (HUMAN); POSITIVE IONS;

ACTIVE METABOLITES; CAMPTOTHECINS; HUMAN PLASMAS; HYDROXYCAMPTOTHECIN; INTERNAL STANDARDS; IRINOTECAN; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MULTIPLE REACTION MONITORING; QUANTITATIVE DETERMINATIONS;

ELECTROSPRAY IONIZATION;

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ACETIC ACID; ACETONITRILE; CAMPTOTHECIN; CATION; LIPOSOME;

ACCURACY; ARTICLE; CANCER CHEMOTHERAPY; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG STRUCTURE; ELECTROSPRAY; ELUTION; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; PRECIPITATION; PROTEIN DENATURATION; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; STANDARD; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 0346258150     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.257     Document Type: Article

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