High-performance liquid chromatographic assay with fluorescence detection for the simultaneous measurement of carboxylate and lactone forms of irinotecan and three metabolites in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 788, Issue 1, 2003, Pages 65-74

  Owens, Thandranese S ^a   Dodds, Helen ^a   Fricke, Katrin ^a   Hanna, Suzan K ^a   Crews, Kristine R ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Irinotecan; SN 38

Indexed keywords

FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRECIPITATION (CHEMICAL); PROTEINS;

HUMAN PLASMA;

METABOLITES;

ACETONITRILE; AMMONIUM ACETATE; APC; CARBOXYLIC ACID; DNA TOPOISOMERASE; ENZYME INHIBITOR; GLUCURONIDE; IRINOTECAN; LACTONE; PHOSPHATE; PLASMA PROTEIN; TETRABUTYLAMMONIUM PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; DRUG BLOOD LEVEL; ENZYME ASSAY; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MEASUREMENT; METABOLITE; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CALIBRATION; CAMPTOTHECIN; CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LACTONES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

EID: 0037420729     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)01016-4     Document Type: Article

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