Simultaneous determination of the lactone and carboxylate forms of the camptothecin derivative CPT-11 and its metabolite SN-38 in plasma by high-performance liquid chromatography

Journal of Chromatography B: Biomedical Applications

Volumn 718, Issue 1, 1998, Pages 163-175

  Chollet, Daniel F ^a,b   Goumaz, Laurent ^a   Renard, Alain ^c   Montay, Guy ^c   Vernillet, Laurent ^c   Arnera, Valdo ^a   Mazzo, David J ^c  

^a Bioanalytical Division   (Switzerland)

^b COVANCE Ctrl Laboratory Services SA ^*  (Switzerland)

^c SANOFI   (France)

Author keywords

Camptothecin; CPT 11; Irinotecan; SN 38

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DRUG METABOLITE; IRINOTECAN;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG DETERMINATION; FEMALE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TECHNIQUE;

ANIMALS; CAMPTOTHECIN; CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FEMALE; LACTONES; LIGHT; MALE; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS;

EID: 0031722623     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(98)00270-9     Document Type: Article

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