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Volumn 877, Issue 27, 2009, Pages 3038-3044
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Quantitation of Irinotecan and its two major metabolites using a liquid chromatography-electrospray ionization tandem mass spectrometric
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Author keywords
Irinotecan; LC MS MS; Metabolites; Pharmacokinetics
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Indexed keywords
ANALYTES;
CAMPTOTHECINS;
CONCENTRATION OF;
CONCENTRATION RANGES;
ENZYMATIC METHODS;
GLUCURONIDASE;
GLUCURONIDES;
GRADIENT PROCEDURE;
HUMAN PLASMAS;
HYDROXYCAMPTOTHECIN;
INTERNAL STANDARDS;
IONIZATION SOURCES;
IRINOTECAN;
LC-MS-MS;
LOWER LIMIT OF QUANTIFICATIONS;
MOBILE PHASE;
MULTIPLE-REACTION MONITORING MODES;
PHASE II;
POSITIVE ELECTROSPRAY IONIZATION;
PROTEIN PRECIPITATION;
QUANTITIVE;
RELATIVE ERRORS;
RELATIVE STANDARD DEVIATIONS;
TANDEM MASS SPECTROMETRIC;
ACETONITRILE;
BIOMOLECULES;
BODY FLUIDS;
CHARGE TRAPPING;
CHROMATOGRAPHIC ANALYSIS;
CONCENTRATION (PROCESS);
ELECTROSPRAY IONIZATION;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
IONIZATION;
LIQUIDS;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
METABOLISM;
METABOLITES;
ORGANIC ACIDS;
PHARMACOKINETICS;
PLASMAS;
POSITIVE IONS;
STANDARDS;
DRUG PRODUCTS;
7 ETHYL 10 HYDROXYCAMPTOTHECIN;
7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE;
BETA GLUCURONIDASE;
CAMPTOTHECIN;
DRUG METABOLITE;
FORMIC ACID;
IRINOTECAN;
ARTICLE;
CHEMICAL STRUCTURE;
ELECTROSPRAY MASS SPECTROMETRY;
IONIZATION;
LIQUID CHROMATOGRAPHY;
PRIORITY JOURNAL;
ANTINEOPLASTIC AGENTS, PHYTOGENIC;
CAMPTOTHECIN;
CHROMATOGRAPHY, LIQUID;
GLUCURONATES;
GLUCURONIDASE;
HUMANS;
LINEAR MODELS;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
TANDEM MASS SPECTROMETRY;
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EID: 69749123035
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.07.025 Document Type: Article |
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Times cited : (22)
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References (15)
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