Extracellular HMGB1 released by NMDA treatment confers neuronal apoptosis via RAGE-p38 MAPK/ERK signaling pathway

Neurotoxicity Research

Volumn 20, Issue 2, 2011, Pages 159-169

  Kim, Seung Woo ^a   Lim, Chae Moon ^a   Kim, Jung Bin ^a   Shin, Joo Hyun ^a   Lee, Sanghyun ^b   Lee, Minhyung ^b   Lee, Ja Kyeong ^a  

^a Inha University School of Medicine   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Apoptosis; HMGB1; NMDA conditioned media; Primary cortical culture; RAGE

Indexed keywords

CASPASE 3; HIGH MOBILITY GROUP B1 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; EXCITOTOXICITY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CASPASE 3; CELL SURVIVAL; CEREBRAL CORTEX; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY AMINO ACID AGONISTS; EXTRACELLULAR FLUID; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HMGB1 PROTEIN; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; MICE; N-METHYLASPARTATE; NEUROGLIA; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPYRUVATE HYDRATASE; RECEPTORS, IMMUNOLOGIC; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; ZINC;

EID: 80052615268     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-010-9231-x     Document Type: Article

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