Design, conformational studies and analysis of structure-function relationships of PTH (1-11) analogues: The essential role of Val in position 2

Amino Acids

Volumn 43, Issue 1, 2012, Pages 207-218

  Caporale, A ^a   Gesiot, L ^b   Sturlese, M ^b   Wittelsberger, A ^c   Mammi, S ^b   Peggion, E ^b  

^a CA' FOSCARI UNIVERSITY OF VENICE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

MeVal; Conformational analogues; NMR analysis; Pharmacophoric model; PTH; Structure activity analysis

Indexed keywords

GLYCINE DERIVATIVE; N ISOPROPYLGLYCINE; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE[1-11] DERIVATIVE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BIOLOGICAL ACTIVITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG DESIGN; EMBRYO; HUMAN; HUMAN CELL; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PHARMACOPHORIC MODEL; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CELL LINE; HEK293 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, PARATHYROID HORMONE, TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP; VALINE;

EID: 84862770811     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-1065-1     Document Type: Article

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