Toward Parathyroid Hormone Minimization: Conformational Studies of Cyclic PTH(1-14) Analogues

Biochemistry

Volumn 43, Issue 3, 2004, Pages 690-699

  Tsomaia, Natia ^a   Pellegrini, Maria ^a,d   Hyde, Kimberly ^a   Gardella, Thomas J ^c   Mierke, Dale F ^a,b  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; CHEMICAL MODIFICATION; COMPUTER SIMULATION; CONFORMATIONS; HORMONES; MOLECULAR DYNAMICS; SUBSTITUTION REACTIONS;

HELICAL STRUCTURES;

BIOCHEMISTRY;

AMINO ACID; LACTAM; PARATHYROID HORMONE; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE[1-14]; PARATHYROID HORMONE[1-34]; PEPTIDE HORMONE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; MOLECULAR DYNAMICS; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; SIMULATION;

AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; HUMANS; LACTAMS; LIGANDS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECEPTORS, PARATHYROID HORMONE; SIGNAL TRANSDUCTION; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 1642535625     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035703i     Document Type: Article

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