Identification of two mutations (F758W and F758Y) in the N-methyl-D-aspartate receptor glycine-binding site that selectively prevent competitive inhibition by xenon without affecting glycine binding

Anesthesiology

Volumn 117, Issue 1, 2012, Pages 38-47

  Armstrong, Scott P ^a   Banks, Paul J ^a   McKitrick, Thomas J W ^a   Geldart, Catharine H ^a   Edge, Christopher J ^a   Babla, Rohan ^a   Simillis, Constantinos ^a   Franks, Nicholas P ^a   Dickinson, Robert ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPROPANE; GLYCINE; ISOFLURANE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITROUS OXIDE; PHENYLALANINE; SEVOFLURANE; TRYPTOPHAN; TYROSINE; XENON;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NEUROPROTECTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

ANESTHETICS, INHALATION; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; GLYCINE; HEK293 CELLS; HUMANS; ISOFLURANE; METHYL ETHERS; MUTATION; NEUROPROTECTIVE AGENTS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; XENON;

EID: 84862760628     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31825ada2e     Document Type: Article

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