Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection

Critical Care

Volumn 14, Issue 4, 2010, Pages

  Dickinson, Robert ^a   Franks, Nicholas P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGON; HELIUM; INERT GAS; KRYPTON; NEON; NITROGEN; XENON; ANESTHETIC AGENT; NEUROPROTECTIVE AGENT;

ANESTHESIA; DRUG MECHANISM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; CHEMICALLY INDUCED DISORDER; HYPOTHERMIA;

ANESTHETICS; ANIMALS; HELIUM; HUMANS; HYPOTHERMIA; NEUROPROTECTIVE AGENTS; NOBLE GASES; XENON;

EID: 79952116272     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc9051     Document Type: Review

References (109)

1. Lockwood GG, Franks NP, Downie NA, Taylor KM, Maze M. Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study. Anesthesiology 2006, 104:458-465. 10.1097/00000542-200603000-00012, 16508392.
2. Wappler F, Rossaint R, Baumert J, Scholz J, Tonner PH, van Aken H, Berendes E, Klein J, Gommers D, Hammerle A, Franke A, Hofmann T, Schulte Esch J. Multicenter randomized comparison of xenon and isoflurane on left ventricular function in patients undergoing elective surgery. Anesthesiology 2007, 106:463-471. 10.1097/00000542-200703000-00010, 17325504.
3. Goto T, Hanne P, Ishiguro Y, Ichinose F, Niimi Y, Morita S. Cardiovascular effects of xenon and nitrous oxide in patients during fentanyl-midazolam anaesthesia. Anaesthesia 2004, 59:1178-1183. 10.1111/j.1365-2044.2004.03900.x, 15549976.
4. Goto T, Nakata Y, Ishiguro Y, Niimi Y, Suwa K, Morita S. Minimum alveolar concentration-awake of xenon alone and in combination with isoflurane or sevofl-urane. Anesthesiology 2000, 93:1188-1193. 10.1097/00000542-200011000-00009, 11046204.
5. Homi HM, Yokoo N, Ma D, Warner DS, Franks NP, Maze M, Grocott HP. The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology 2003, 99:876-881. 10.1097/00000542-200310000-00020, 14508320.
6. Wilhelm S, Ma D, Maze M, Franks NP. Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology 2002, 96:1485-1491. 10.1097/00000542-200206000-00031, 12170064.
7. Banks P, Franks NP, Dickinson R. Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia. Anesthesiology 2010, 112:614-622. 10.1097/ALN.0b013e3181cea398, 20124979.
8. Huhn R, Heinen A, Weber NC, Hieber S, Hollmann MW, Schlack W, Preckel B. Helium-induced late preconditioning in the rat heart in vivo. Br J Anaesth 2009, 102:614-619. 10.1093/bja/aep042, 19297370.
9. Huhn R, Heinen A, Weber NC, Kerindongo RP, Oei GT, Hollmann MW, Schlack W, Preckel B. Helium-induced early preconditioning and postconditioning are abolished in obese Zucker rats in vivo. J Pharmacol Exp Ther 2009, 329:600-607. 10.1124/jpet.108.149971, 19244549.
10. Heinen A, Huhn R, Smeele KM, Zuurbier CJ, Schlack W, Preckel B, Weber NC, Hollmann MW. Helium-induced preconditioning in young and old rat heart: impact of mitochondrial Ca2+-sensitive potassium channel activation. Anesthesiology 2008, 109:830-836. 10.1097/ALN.0b013e3181895aa0, 18946295.
11. Pan Y, Zhang H, VanDeripe DR, Cruz-Flores S, Panneton WM. Heliox and oxygen reduce infarct volume in a rat model of focal ischemia. Exp Neurol 2007, 205:587-590. 10.1016/j.expneurol.2007.03.023, 17467695.
12. David HN, Haelewyn B, Chazalviel L, Lecocq M, Degoulet M, Risso JJ, Abraini JH. Post-ischemic helium provides neuroprotection in rats subjected to middle cerebral artery occlusion-induced ischemia by producing hypothermia. J Cereb Blood Flow Metab 2009, 29:1159-1165. 10.1038/jcbfm.2009.40, 19384333.
13. Pagel PS, Krolikowski JG, Shim YH, Venkatapuram S, Kersten JR, Weihrauch D, Warltier DC, Pratt PF. Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo. Anesth Analg 2007, 105:562-569. 10.1213/01.ane.0000278083.31991.36, 17717207.
14. Yarin YM, Amarjargal N, Fuchs J, Haupt H, Mazurek B, Morozova SV, Gross J. Argon protects hypoxia-, cisplatin- and gentamycin-exposed hair cells in the newborn rat's organ of Corti. Hear Res 2005, 201:1-9. 10.1016/j.heares.2004.09.015, 15721555.
15. Jawad N, Rizvi M, Gu J, Adeyi O, Tao G, Maze M, Ma D. Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury. Neurosci Lett 2009, 460:232-236. 10.1016/j.neulet.2009.05.069, 19500647.
16. Behnke A, Thomson R, Motley E. The psychologic effects from breathing air at 4 atmospheres pressure. Am J Physiol 1935, 112:554-558.
17. Behnke A, Yarbrough O. Respiratory resistance, oil-water solubility and mental effects of argon compared with helium and nitrogen. Am J Physiol 1939, 126:409-415.
18. Bennett PB, Rostain JC. Inert gas narcosis. Bennett and Elliot's Physiology and Medicine of Diving 2003, 300-322. Edinburgh: Saunders, Brubakk AO, Neuman TS.
19. Rostain JC, Balon N. Recent neurochemical basis of inert gas narcosis and pressure effects. Undersea Hyperb Med 2006, 33:197-204.
20. Behnke A, Yarbrough O. Physiologic studies of helium. US Navy Med Bull 1938,
21. Lawrence JH, Loomis WF, Tobias CA, Turpin FH. Preliminary observations on the narcotic effect of xenon with a review of values for solubilities of gases in water and oils. J Physiol 1946, 105(3):197-204. 1393631, 16991720.
22. Miller KW, Paton WD, Smith EB, Smith RA. Physicochemical approaches to the mode of action of general anesthetics. Anesthesiology 1972, 36:339-351. 10.1097/00000542-197204000-00008, 5020643.
23. Gray A, Read S, McGale P, Darby S. Lung cancer deaths from indoor radon and the cost effectiveness and potential of policies to reduce them. BMJ 2009, 338:a3110. 2769068, 19129153, 10.1136/bmj.a3110.
24. Miller KW, Paton WD, Streett WB, Smith EB. Animals at very high pressures of helium and neon. Science 1967, 157:97-98. 10.1126/science.157.3784.97, 6026676.
25. Koblin DD, Fang Z, Eger EL, Laster MJ, Gong D, Ionescu P, Halsey MJ, Trudell JR. Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: helium and neon as nonimmobilizers (nonanesthetics). Anesth Analg 1998, 87:419-424. 10.1097/00000539-199808000-00035, 9706943.
26. Lever MJ, Miller KW, Paton WDM, Streett WB, Smith EB. Effects of hydrostatic pressure on mammals. Proceedings of the IVth Symposium on Underwater Physiology 1971, 101-108. New York: Academic Press, Lambertsen CJ.
27. Halsey MJ. Effects of high pressure on the central nervous system. Physiol Rev 1982, 62(4 Pt 1):1341-1377.
28. Franks NP, Dickinson R, de Sousa SLM, Hall AC, Lieb ER. How does xenon produce anaesthesia?. Nature 1998, 396:324. 10.1038/24525, 9845069.
29. de Sousa SLM, Dickinson R, Lieb WR, Franks NP. Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon. Anesthesiology 2000, 92:1055-1066. 10.1097/00000542-200004000-00024, 10754626.
30. White IL, Franks NP, Dickinson R. Effects of isoflurane and xenon on Ba2+- currents mediated by N-type calcium channels. Br J Anaesth 2005, 94:784-790. 10.1093/bja/aei126, 15778267.
31. Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP. Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Anesthesiology 2007, 107:756-767. 10.1097/01.anes.0000287061.77674.71, 18073551.
32. Furukawa H, Gouaux E. Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. EMBO J 2003, 22:2873-2885. 162155, 12805203, 10.1093/emboj/cdg303.
33. Colloc'h N, Sopkova-de Oliveira Santos J, Retailleau P, Vivares D, Bonnete F, Langlois d'Estainto B, Gallois B, Brisson A, Risso JJ, Lemaire M, Prange T, Abraini JH. Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action. Biophys J 2007, 92:217-224. 1697869, 17028130, 10.1529/biophysj.106.093807.
34. Haseneder R, Kratzer S, Kochs E, Mattusch C, Eder M, Rammes G. Xenon attenuates excitatory synaptic transmission in the rodent prefrontal cortex and spinal cord dorsal horn. Anesthesiology 2009, 111:1297-1307. 10.1097/ALN.0b013e3181c14c05, 19934875.
35. Yamakura T, Chavez-Noriega LE, Harris RA. Subunit-dependent inhibition of human neuronal nicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anesthetics ketamine and dizocilpine. Anesthesiology 2000, 92:1144-1153. 10.1097/00000542-200004000-00033, 10754635.
36. Yamakura T, Harris RA. Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology 2000, 93:1095-1101. 10.1097/00000542-200010000-00034, 11020766.
37. Tomlin SL, Jenkins A, Lieb WR, Franks NP. Stereoselective effects of etomidate optical isomers on γ-aminobutyric acid type A receptors and animals. Anesthesiology 1998, 88:708-717. 10.1097/00000542-199803000-00022, 9523815.
38. Hall AC, Lieb WR, Franks NP. Stereoselective and non-stereoselective actions of isofl urane on the GABAA receptor. Br J Pharmacol 1994, 112:906-910. 1910207, 7921619.
39. Jones MV, Harrison NL. Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons. J Neurophysiol 1993, 70:1339-1349.
40. Choi DW, Koh JY, Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J Neurosci 1988, 8:185-196.
41. Bullock R, Zauner A, Myseros JS, Marmarou A, Woodward JJ, Young HF. Evidence for prolonged release of excitatory amino acids in severe human head trauma. Relationship to clinical events. Ann N Y Acad Sci 1995, 765:290-297. 10.1111/j.1749-6632.1995.tb16586.x, 7486616.
42. Gruss M, Bushell TJ, Bright DP, Lieb WR, Mathie A, Franks NP. Two-pore-domainK+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Mol Pharmacol 2004, 65:443-452. 10.1124/mol.65.2.443, 14742687.
43. Patel AJ, Honore E, Lesage F, Fink M, Romey G, Luzdunski M. Inhalational anesthetics activate two-pore-domain background K+ channels. Nat Neurosci 1999, 2:422-426. 10.1038/8084, 10321245.
44. Heurteaux C, Guy N, Laigle C, Blondeau N, Duprat F, Mazzuca M, Lang-Lazdunski L, Widmann C, Zanzouri M, Romey G, Lazdunski M. TREK-1, a K+ channel involved in neuroprotection and general anesthesia. EMBO J 2004, 23:2684-2695. 449762, 15175651, 10.1038/sj.emboj.7600234.
45. Bantel C, Maze M, Trapp S. Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology 2009, 110:986-995. 10.1097/ALN.0b013e31819dadc7, 19352153, 2930813.
46. Ballanyi K. Protective role of neuronal KATP channels in brain hypoxia. J Exp Biol 2004, 207(Pt 18):3201-3212. 10.1242/jeb.01106, 15299041.
47. Suzuki T, Ueta K, Sugimoto M, Uchida I, Mashimo T. Nitrous oxide and xenon inhibit the human (alpha 7)5 nicotinic acetylcholine receptor expressed in Xenopus oocyte. Anesth Analg 2003, 96:443-448. table of contents, 10.1097/00000539-200302000-00028, 12538194.
48. Bencherif M. Neuronal nicotinic receptors as novel targets for inflammation and neuroprotection: mechanistic considerations and clinical relevance. Acta Pharmacol Sin 2009, 30:702-714. 10.1038/aps.2009.37, 19498416.
49. Suzuki T, Koyama H, Sugimoto M, Uchida I, Mashimo T. The diverse actions of volatile and gaseous anesthetics on human-cloned 5-hydroxytryptamine3 receptors expressed in Xenopus oocytes. Anesthesiology 2002, 96:699-704. 10.1097/00000542-200203000-00028, 11873047.
50. Coburn M, Kunitz O, Apfel CC, Hein M, Fries M, Rossaint R. Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia. Br J Anaesth 2008, 100:787-791. 10.1093/bja/aen077, 18397921.
51. Cullen SC, Gross EG. The anesthetic properties of xenon in animals and human beings, with additional observations on krypton. Science 1951, 113:580-582. 10.1126/science.113.2942.580, 14834873.
52. Pittinger CB, Moyers J, Cullen SC, Featherstone RM, Gross EG. Clinicopathologic studies associated with xenon anesthesia. Anesthesiology 1953, 14:10-17. 10.1097/00000542-195301000-00002, 13017008.
53. Eger EI, Saidman LJ, Brandstater B. Minimum alveolar anesthetic concentration: a standard of anesthetic potency. Anesthesiology 1965, 26:756-763. 10.1097/00000542-196511000-00010, 5844267.
54. Cullen SC, Eger EI, Cullen BF, Gregory P. Observations on the anesthetic effect of the combination of xenon and halothane. Anesthesiology 1969, 31:305-309. 10.1097/00000542-196910000-00003, 5811596.
55. Nakata Y, Goto T, Ishiguro Y, Terui K, Kawakami H, Santo M, Niimi Y, Morita S. Minimum alveolar concentration (MAC) of xenon with sevoflurane in humans. Anesthesiology 2001, 94:611-614. 10.1097/00000542-200104000-00014, 11379681.
56. Eger EI, Laster MJ, Gregory GA, Katoh T, Sonner JM. Women appear to have the same minimum alveolar concentration as men: a retrospective study. Anesthesiology 2003, 99:1059-1061. 10.1097/00000542-200311000-00009, 14576539.
57. Boomsma F, Rupreht J, Man in "t Veld AJ, de Jong FH, Dzoljic M, Lachmann B. Haemodynamic and neurohumoral effects of xenon anaesthesia. A comparison with nitrous oxide. Anaesthesia 1990, 45:273-278. 10.1111/j.1365-2044.1990.tb14731.x, 2337209.
58. Lachmann B, Armbruster S, Schairer W, Landstra M, Trouwborst A, Van Daal GJ, Kusuma A, Erdmann W. Safety and efficacy of xenon in routine use as an inhalational anaesthetic. Lancet 1990, 335:1413-1415. 10.1016/0140-6736(90)91444-F, 1972207.
59. Nakata Y, Goto T, Saito H, Ishiguro Y, Terui K, Kawakami H, Tsuruta Y, Niimi Y, Morita S. Plasma concentration of fentanyl with xenon to block somatic and hemodynamic responses to surgical incision. Anesthesiology 2000, 92:1043-1048. 10.1097/00000542-200004000-00022, 10754624.
60. Petersen-Felix S, Luginbuhl M, Schnider TW, Curatolo M, Arendt-Nielsen L, Zbinden AM. Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain. Br J Anaesth 1998, 81:742-747.
61. Luttropp HH, Thomasson R, Dahm S, Persson J, Werner O. Clinical experience with minimal flow xenon anesthesia. Acta Anaesthesiol Scand 1994, 38:121-125. 10.1111/j.1399-6576.1994.tb03852.x, 7909641.
62. Goto T, Saito H, Nakata Y, Uezono S, Ichinose F, Morita S. Emergence times from xenon anaesthesia are independent of the duration of anaesthesia. Br J Anaesth 1997, 79:595-599.
63. Goto T, Suwa K, Uezono S, Ichinose F, Uchiyama M, Morita S. The blood-gas partition coefficient of xenon may be lower than generally accepted. Br J Anaesth 1998, 80:255-256.
64. Yentis SM, Hirsch NP, Smith GB. Anaesthesia and Intensive Care A-Z An Encyclopaedia of Priciples and Practice 2004, 271. Edinburgh: Elsevier.
65. Goto T. Is there a future for xenon anesthesia?. Can J Anaesth 2002, 49:335-338. 10.1007/BF03017319, 11927470.
66. Sanders RD, Weimann J, Maze M. Biologic effects of nitrous oxide: a mechanistic and toxicologic review. Anesthesiology 2008, 109:707-722. 10.1097/ALN.0b013e3181870a17, 18813051.
67. Baum VC. When nitrous oxide is no laughing matter: nitrous oxide and pediatric anesthesia. Paediatr Anaesth 2007, 17:824-830. 10.1111/j.1460-9592.2007.02264.x, 17683399.
68. Rossaint R, Reyle-Hahn M, Schulte Am Esch J, Scholz J, Scherpereel P, Vallet B, Giunta F, Del Turco M, Erdmann W, Tenbrinck R, Hammerle AF, Nagele P. Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery. Anesthesiology 2003, 98:6-13. 10.1097/00000542-200301000-00005, 12502972.
69. Coburn M, Kunitz O, Baumert JH, Hecker K, Haaf S, Zuhlsdorff A, Beeker T, Rossaint R. Randomized controlled trial of the haemodynamic and recovery effects of xenon or propofol anaesthesia. Br J Anaesth 2005, 94:198-202. 10.1093/bja/aei023, 15531620.
70. Bein B, Turowski P, Renner J, Hanss R, Steinfath M, Scholz J, Tonner PH. Comparison of xenon-based anaesthesia compared with total intravenous anaesthesia in high risk surgical patients. Anaesthesia 2005, 60:960-967. 10.1111/j.1365-2044.2005.04326.x, 16179039.
71. Baumert JH, Hein M, Hecker KE, Satlow S, Neef P, Rossaint R. Xenon or propofol anaesthesia for patients at cardiovascular risk in non-cardiac surgery. Br J Anaesth 2008, 100:605-611. 10.1093/bja/aen050, 18344556.
72. Olney JW. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 1969, 164:719-721. 10.1126/science.164.3880.719, 5778021.
73. Ma D, Wilhelm S, Maze M, Franks NP. Neuroprotective and neurotoxic properties of the "inert' gas, xenon. Br J Anaesth 2002, 89:739-746. 10.1093/bja/aef258, 12393773.
74. Nagata A, Nakao Si S, Nishizawa N, Masuzawa M, Inada T, Murao K, Miyamoto E, Shingu K. Xenon inhibits but N2O enhances ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices. Anesth Analg 2001, 92:362-368. 10.1097/00000539-200102000-00016, 11159233.
75. Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP. Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology 2003, 98:690-698. 10.1097/00000542-200303000-00017, 12606913.
76. Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol 2005, 58:182-193. 10.1002/ana.20547, 16049939.
77. Coburn M, Maze M, Franks NP. The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury. Crit Care Med 2008, 36:588-595. 10.1097/01.CCM.0B013E3181611F8A6, 18216607.
78. Fries M, Nolte KW, Coburn M, Rex S, Timper A, Kottmann K, Siepmann K, Hausler M, Weis J, Rossaint R. Xenon reduces neurohistopathological damage and improves the early neurological deficit after cardiac arrest in pigs. Crit Care Med 2008, 36:2420-2426. 10.1097/CCM.0b013e3181802874, 18664790.
79. Thoresen M, Hobbs CE, Wood T, Chakkarapani E, Dingley J. Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia. J Cereb Blood Flow Metab 2009, 29:707-714. 10.1038/jcbfm.2008.163, 19142190.
80. Dingley J, Tooley J, Porter H, Thoresen M. Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxiaischemia. Stroke 2006, 37:501-506. 10.1161/01.STR.0000198867.31134.ac, 16373643.
81. Abraini JH, David HN, Lemaire M. Potentially neuroprotective and therapeutic properties of nitrous oxide and xenon. Ann N Y Acad Sci 2005, 1053:289-300. 10.1196/annals.1344.025, 16179534.
82. Ma D, Hossain M, Rajakumaraswamy N, Franks NP, Maze M. Combination of xenon and isoflurane produces a synergistic protective eff ect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model. Anesthesiology 2003, 99:748-751. 10.1097/00000542-200309000-00034, 12960563.
83. Dickinson R, Franks NP, Lieb WR. Thermodynamics of anesthetic/protein interactions. Temperature studies on firefly luciferase. Biophys J 1993, 64:1264-1271. 1262442, 8494981, 10.1016/S0006-3495(93)81491-7.
84. McKenzie JD, Calow P, Clyde J, Miles A, Dickinson R, Lieb WR, Franks NP. Effects of temperature on the anaesthetic potency of halothane, enflurane and ethanol in Daphnia magna (Cladocera: Crustacea). Comp Biochem Physiol C 1992, 101:15-19. 10.1016/0742-8413(92)90193-B, 1350959.
85. Dickinson R, Lieb WR, Franks NP. The effects of temperature on the interactions between volatile general anaesthetics and a neuronal nicotinic acetylcholine receptor. Br J Pharmacol 1995, 116:2949-2956. A published erratum appears in Br J Pharmacol 1996, 117:1369, 1909207, 8680729.
86. Ma D, Hossain M, Pettet GK, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M. Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. J Cereb Blood Flow Metab 2006, 26:199-208. 10.1038/sj.jcbfm.9600184, 16034370.
87. Hocker J, Stapelfeldt C, Leiendecker J, Meybohm P, Hanss R, Scholz J, Bein B. Postoperative neurocognitive dysfunction in elderly patients after xenon versus propofol anesthesia for major noncardiac surgery: a doubleblinded randomized controlled pilot study. Anesthesiology 2009, 110:1068-1076. 10.1097/ALN.0b013e31819dad92, 19352169.
88. Rasmussen LS, Schmehl W, Jakobsson J. Comparison of xenon with propofol for supplementary general anaesthesia for knee replacement: a randomized study. Br J Anaesth 2006, 97:154-159. 10.1093/bja/ael141, 16782975.
89. Coburn M, Baumert JH, Roertgen D, Thiel V, Fries M, Hein M, Kunitz O, Fimm B, Rossaint R. Emergence and early cognitive function in the elderly after xenon or desflurane anaesthesia: a double-blinded randomized controlled trial. Br J Anaesth 2007, 98:756-762. 10.1093/bja/aem103, 17485435.
90. Sta Maria N, Eckmann DM. Model predictions of gas embolism growth and reabsorption during xenon anesthesia. Anesthesiology 2003, 99:638-645. 10.1097/00000542-200309000-00019, 12960548.
91. Benavides R, Maze M, Franks NP. Expansion of gas bubbles by nitrous oxide and xenon. Anesthesiology 2006, 104:299-302. 10.1097/00000542-200602000-00015, 16436849.
92. Lockwood G. Expansion of air bubbles in aqueous solutions of nitrous oxide or xenon. Br J Anaesth 2002, 89:282-286. 10.1093/bja/aef183, 12378668.
93. Grocott HP, Sato Y, Homi HM, Smith BE. The influence of xenon, nitrous oxide and nitrogen on gas bubble expansion during cardiopulmonary bypass. Eur J Anaesthesiol 2005, 22:353-358. 10.1017/S0265021505000608, 15918383.
94. Jungwirth B, Gordan ML, Blobner M, Schmehl W, Kochs EF, Mackensen GB. Xenon impairs neurocognitive and histologic outcome after cardiopulmonary bypass combined with cerebral air embolism in rats. Anesthesiology 2006, 104:770-776. 10.1097/00000542-200604000-00022, 16571973.
95. Jungwirth B, Kellermann K, Blobner M, Schmehl W, Kochs EF, Mackensen GB. Cerebral air emboli differentially alter outcome after cardiopulmonary bypass in rats compared with normal circulation. Anesthesiology 2007, 107:768-775. 10.1097/01.anes.0000287003.29685.c7, 18073552.
96. Martin JL, Ma D, Hossain M, Xu J, Sanders RD, Franks NP, Maze M. Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat. Br J Anaesth 2007, 98:236-240. 10.1093/bja/ael340, 17210733.
97. Barach AL. Use of helium as a new therapetic gas. Proc Soc Exp Biol Med 1934, 32:462-464.
98. Rodrigo CJ, Pollack CV, Rodrigo C, Rowe BH. Heliox for non-intubated acute asthma patients. Cochrane Database Syst Rev 2006, 4:CD002884.
99. Colebourn CL, Barber V, Young JD. Use of helium-oxygen mixture in adult patients presenting with exacerbations of asthma and chronic obstructive pulmonary disease: a systematic review. Anaesthesia 2007, 62:34-42. 10.1111/j.1365-2044.2006.04897.x, 17156225.
100. Miller KW, Wilson MW, Smith RA. Pressure resolves two sites of action of inert gases. Mol Pharmacol 1978, 14:950-959.
101. Miller KW, Wilson MW. The pressure reversal of a variety of anesthetic agents in mice. Anesthesiology 1978, 48:104-110. 10.1097/00000542-197802000-00005, 655442.
102. MacLellan CL, Clark DL, Silasi G, Colbourne F. Use of prolonged hypothermia to treat ischemic and hemorrhagic stroke. J Neurotrauma 2009, 26:313-323. 10.1089/neu.2008.0580, 19216634.
103. Dietrich WD, Atkins CM, Bramlett HM. Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia. J Neurotrauma 2009, 26:301-312. 2848835, 19245308, 10.1089/neu.2008.0806.
104. Pavlov BN, Grigoriev AI, Smolin VV, Komordin GM, Sokolov GM, Ramazanov RR, Spirkov PS, Soldatov PE, Vdovin AV, Buravkova LB, Diachenko AI, Ilyin VK. Investigations of Different Hyperoxic, Hypoxic and Normoxic Oxygen-Argon Gaseous Mixtures under Different Barometric Pressure and Respiration Periods, in High Pressure Biology and Medicine 1997, 133-142. University of Rochester Press, Bennet PB, Demchenko L, Marquis RE, Rochester MN.
105. Loetscher PD, Rossaint J, Rossaint R, Weis J, Fries M, Fahlenkamp A, Ryang YM, Grottke O, Coburn M. Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury. Crit Care 2009, 13:R206. 2811924, 20017934, 10.1186/cc8214.
106. Trudell JR, Koblin DD, Eger EI. A molecular description of how noble gases and nitrogen bind to a model site of anesthetic action. Anesth Analg 1998, 87:411-418. 10.1097/00000539-199808000-00034, 9706942.
107. Weast RC, Astle MJ, . (Eds) CRC Handbook of Chemistry & Physics 1980, Boca Raton, FL: CRC Press, 60, (Eds).
108. Selover TB, . (Ed) Thermophysical Properties of Neon, Argon, Krypton and Xenon 1988, Washington, DC: Hemisphere Publishing, (Ed).
109. Roth SH, Miller KW, . (Eds) Molecular and Cellular Mechanisms of Anesthetics 1986, London: Plenum, (Eds).