The Nogo-66 receptor family in the intact and diseased CNS

Cell and Tissue Research

Volumn 349, Issue 1, 2012, Pages 105-117

  Borrie, Sarah C ^a   Baeumer, Bastian E ^a   Bandtlow, Christine E ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Activity dependent plasticity; Alzheimer's disease; Nogo receptor; Regeneration and sprouting; Stem cells

Indexed keywords

BETA SECRETASE; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NOGO 66 RECEPTOR; NOGO 66 RECEPTOR 1; NOGO 66 RECEPTOR 2; NOGO 66 RECEPTOR 3; PROTEIN NOGO A; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BINDING AFFINITY; BINDING SITE; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROVASCULAR DISEASE; COMPLEX FORMATION; GENE OVEREXPRESSION; HUMAN; INTRACELLULAR SIGNALING; LIGAND BINDING; NERVE CELL DIFFERENTIATION; NERVE CELL INHIBITION; NERVE CELL PLASTICITY; NERVE FIBER REGENERATION; NERVE SPROUTING; NEUROMODULATION; NOGO 66 RECEPTOR 1 GENE; NOGO 66 RECEPTOR 2 GENE; NOGO 66 RECEPTOR 3 GENE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR GENE; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SPINAL CORD INJURY;

ANIMALS; AXONS; CENTRAL NERVOUS SYSTEM; HUMANS; MULTIGENE FAMILY; NEURONAL PLASTICITY; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 84862759653     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-012-1332-9     Document Type: Review

References (114)

1. Atalay B, Bavbek M, Cekinmez M, Ozen O, Nacar A, Karabay G, Gulsen S (2007) Antibodies neutralizing Nogo-A increase pancadherin expression and motor recovery following spinal cord injury in rats. Spinal Cord 45:780-786 (Pubitemid 350224262)
2. Atwal JK, Pinkston-Gosse J, Syken J, Stawicki S, Wu Y, Shatz C, Tessier-Lavigne M (2008) PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science 322:967-970
3. Bandtlow CE, Schmidt MF, Hassinger TD, Schwab ME, Kater SB (1993) Role of intracellular calcium in NI-35-evoked collapse of neuronal growth cones. Science 259:80-83 (Pubitemid 23036090)
4. Barrette B, Vallieres N, Dube M, Lacroix S (2007) Expression profile of receptors for myelin-associated inhibitors of axonal regeneration in the intact and injured mouse central nervous system. Mol Cell Neurosci 34:519-538 (Pubitemid 46483077)
5. Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB (2003) Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J 22:3291-3302 (Pubitemid 36834859)
6. Bauer S, Kerr BJ, Patterson PH (2007) The neuropoietic cytokine family in development, plasticity, disease and injury. Nat Rev Neurosci 8:221-232 (Pubitemid 46294661)
7. Budel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S, Lauren J, Park JH, McGee AW, Liao J, Stillman A, Kim JE, Yang BZ, SodiS, Gelernter J, Zhao H, Hisama F, Arnsten AF, Strittmatter SM (2008) Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci 28:13161-13172
8. Cancro MP (2004) The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation. Immunol Rev 202:237-249
9. Cao QL, Zhang YP, Howard RM, Walters WM, Tsoulfas P, Whittemore SR (2001) Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage. Exp Neurol 167:48-58 (Pubitemid 32066408)
10. Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M (2008) Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat. Neurorehabil Neural Repair 22:262-278 (Pubitemid 351561674)
11. Carim-Todd L, Escarceller M, Estivill X, Sumoy L (2003) LRRN6A/ LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Eur J Neurosci 18:3167-3182 (Pubitemid 38031043)
12. Crawley JN (2007) What's wrong with my mouse?: behavioral phenotyping of transgenic and knockout mice, 2nd edn. Wiley-Interscience, Hoboken
13. Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, Buxbaum J, Haroutunian V (2003) White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry 60:443-456 (Pubitemid 36539053)
14. Delekate A, Zagrebelsky M, Kramer S, Schwab ME, Korte M (2011) NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale. Proc Natl Acad Sci USA 108:2569-2574
15. Dergham P, Ellezam B, Essagian C, Avedissian H, Lubell WD, McKerracher L (2002) Rho signaling pathway targeted to promote spinal cord repair. J Neurosci 22:6570-6577 (Pubitemid 35386413)
16. Domeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang K, Nikulina E, Kimura N, Cai H, Deng K, Gao Y, He Z, Filbin M (2002) Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 35:283-290 (Pubitemid 34876731)
17. Dupuis L, Gonzalez de Aguilar JL, diScala F, Rene F, de Tapia M, Pradat PF, Lacomblez L, Seihlan D, Prinjha R,Walsh FS,Meininger V, Loeffler JP (2002) Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis. Neurobiol Dis 10:358-365 (Pubitemid 35217587)
18. Dupuis L, Pehar M, Cassina P, Rene F, Castellanos R, Rouaux C, Gandelman M, Dimou L, Schwab ME, Loeffler JP, Barbeito L, Gonzalez de Aguilar JL (2008) Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proc Natl Acad Sci USA 105:740-745 (Pubitemid 351171778)
19. Ferraro GB, Morrison CJ, Overall CM, Strittmatter SM, Fournier AE (2011) Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage. J Biol Chem 286:31418-31424
20. Fournier AE, GrandPre T, Strittmatter SM (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409:341-346 (Pubitemid 32151238)
21. Fournier AE, Gould GC, Liu BP, Strittmatter SM (2002) Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. J Neurosci 22:8876-8883 (Pubitemid 35379057)
22. Fujita Y, Endo S, Takai T, Yamashita T (2011) Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. EMBO J 30:1389-1401
23. Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (2006) Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science 313:1792-1795 (Pubitemid 44454156)
24. Funahashi S, Hasegawa T, Nagano A, Sato K (2008) Differential expression patterns of messenger RNAs encoding Nogo receptors and their ligands in the rat central nervous system. J Comp Neurol 506:141-160 (Pubitemid 350293495)
25. Gao Y, Wang B, Xiao Z, Chen B, Han J, Wang X, Zhang J, Gao S, Zhao Y, Dai J (2010) Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells. Stem Cells Dev 19:53-60
26. Gossrau G, Thiele J, Konang R, Schmandt T, Brustle O (2007) Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells. Stem Cells 25:939-949 (Pubitemid 46572591)
27. GrandPre T, Li S, Strittmatter SM (2002) Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417:547-551 (Pubitemid 34595921)
28. Hånell A, Clausen F, Björk M, Jansson K, Philipson O, Nilsson LN, Hillered L, Weinreb PH, Lee D, McIntosh TK, Gimbel DA, Strittmatter SM, Marklund N (2010) Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice. J Neurotrauma 27:1297-1309
29. Harrington AW, Li QM, Tep C, Park JB, He Z, Yoon SO (2008) The role of Kalirin9 in p75/nogo receptor-mediated RhoA activation in cerebellar granule neurons. J Biol Chem 283:24690-24697
30. Hasegawa Y, Fujitani M, Hata K, Tohyama M, Yamagishi S, Yamashita T (2004) Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G. J Neurosci 24:6826-6832 (Pubitemid 38993905)
31. He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R (2004) Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nat Med 10:959-965 (Pubitemid 39273737)
32. Hooper NM, Karran EH, Turner AJ (1997) Membrane protein secretases. Biochem J 321:265-279 (Pubitemid 27056469)
33. Hsieh SH, Ferraro GB, Fournier AE (2006) Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase. J Neurosci 26:1006-1015 (Pubitemid 43237092)
34. Hsu R, Woodroffe A, Lai WS, Cook MN, Mukai J, Dunning JP, Swanson DJ, Roos JL, Abecasis GR, Karayiorgou M, Gogos JA (2007) Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches. PLoS One 2:e1234
35. Jiang W, Xia F, Han J, Wang J (2009) Patterns of Nogo-A, NgR, and RhoA expression in the brain tissues of rats with focal cerebral infarction. Transl Res 154:40-48
36. Jitoku D, Hattori E, Iwayama Y, Yamada K, Toyota T, Kikuchi M, Maekawa M, Nishikawa T, Yoshikawa T (2011) Association study of Nogo-related genes with schizophrenia in a Japanese case-control sample. Am J Med Genet B Neuropsychiatr Genet 156:581-592
37. Jokic N, de Aguilar JL Gonzalez, Pradat PF, Dupuis L, Echaniz-Laguna A, Muller A, Dubourg O, Seilhean D, Hauw JJ, Loeffler JP, Meininger V (2005) Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity. Ann Neurol 57:553-556 (Pubitemid 40471166)
38. Jokic N, de Aguilar JL Gonzalez, Dimou L, Lin S, Fergani A, Ruegg MA, Schwab ME, Dupuis L, Loeffler JP (2006) The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. EMBO Rep 7:1162-1167 (Pubitemid 44660574)
39. Josephson A, Trifunovski A, Scheele C, Widenfalk J, Wahlestedt C, Brene S, Olson L, Spenger C (2003) Activity-induced and developmental downregulation of the Nogo receptor. Cell Tissue Res 311:333-342 (Pubitemid 36459672)
40. Karlen A, Karlsson TE, Mattsson A, Lundstromer K, Codeluppi S, Pham TM, Backman CM, Ogren SO, Aberg E, Hoffman AF, Sherling MA, Lupica CR, Hoffer BJ, Spenger C, Josephson A, Brene S, Olson L (2009) Nogo receptor 1 regulates formation of lasting memories. Proc Natl Acad Sci USA 106:20476-20481
41. Kim JE, Liu BP, Park JH, Strittmatter SM (2004) Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron 44:439-451 (Pubitemid 39423346)
42. Krumbholz M, Theil D, Derfuss T, Rosenwald A, Schrader F, Monoranu CM, Kalled SL, Hess DM, Serafini B,Aloisi F,Wekerle H, Hohlfeld R,Meinl E (2005) BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 201:195-200 (Pubitemid 40189428)
43. Lauren J, Airaksinen MS, Saarma M, Timmusk T (2003) Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. Mol Cell Neurosci 24:581-594 (Pubitemid 37506003)
44. Lauren J, Hu F, Chin J, Liao J, Airaksinen MS, Strittmatter SM (2007) Characterization of myelin ligand complexes with neuronal Nogo-66 receptor family members. J Biol Chem 282:5715-5725 (Pubitemid 47093783)
45. Lazar NL, Singh S, Paton T, Clapcote SJ, Gondo Y, Fukumura R, Roder JC, Cain DP (2011) Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice. Behav Brain Res 224:73-79
46. Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y, Yeh HH, Shrager P, Giger RJ (2008) Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. J Neurosci 28:2753-2765 (Pubitemid 351398865)
47. Lee JK, Kim JE, Sivula M, Strittmatter SM (2004) Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci 24:6209-6217 (Pubitemid 38891112)
48. Lehmann M, Fournier A, Selles-Navarro I, Dergham P, Sebok A, Leclerc N, Tigyi G, McKerracher L (1999) Inactivation of Rho signaling pathway promotes CNS axon regeneration. J Neurosci 19:7537-7547 (Pubitemid 29404610)
49. Li Q, Sudhof TC (2004) Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J Biol Chem 279:10542-10550 (Pubitemid 38372665)
50. Li S, Strittmatter SM (2003) Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J Neurosci 23:4219-4227 (Pubitemid 36958442)
51. Li S, Kim JE, Budel S, Hampton TG, Strittmatter SM (2005) Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury. Mol Cell Neurosci 29:26-39 (Pubitemid 40613057)
52. Li S, Overman JJ, Katsman D, Kozlov SV, Donnelly CJ, Twiss JL, Giger RJ, Coppola G, Geschwind DH, Carmichael ST (2010) An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke. Nat Neurosci 13:1496-1504
53. Li S, Liu BP, Budel S, Li M, Ji B, Walus L, Li W, Jirik A, Rabacchi S, Choi E, Worley D, Sah DW, Pepinsky B, Lee D, Relton J, Strittmatter SM (2004) Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. J Neurosci 24:10511-10520 (Pubitemid 39552636)
54. Li X, Fu QL, Jing XL, Liao XX, Zeng AH, Xiong Y (2009) Myelinassociated glycoprotein inhibits the neuronal differentiation of neural progenitors. Neuroreport 20:708-712
55. Liu BP, Fournier A, GrandPre T, Strittmatter SM (2002a) Myelinassociated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297:1190-1193 (Pubitemid 36193355)
56. Liu H, Abecasis GR, Heath SC, Knowles A, Demars S, Chen YJ, Roos JL, Rapoport JL, Gogos JA, Karayiorgou M (2002b) Genetic variation in the 22q11 locus and susceptibility to schizophrenia. Proc Natl Acad Sci USA 99:16859-16864 (Pubitemid 36034063)
57. Llorens F, Gil V, Iraola S, Carim-Todd L, Martí E, Estivill X, Soriano E, del Rio JA, Sumoy L (2008) Developmental analysis of Lingo- 1/Lern1 protein expression in the mouse brain: interaction of its intracellular domain with Myt1l. Dev Neurobiol 68:521-541 (Pubitemid 351328891)
58. Luo Y, Wu X, Liu S, Li K (2011) Reactivation of visual cortical plasticity by NEP1-40 from early monocular deprivation in adult rats. Neurosci Lett 494:196-201
59. Martin I, Andres CR, Védrine S, Tabagh R, Michelle C, Jourdan ML, Heuze-Vourc'h N, Corcia P, Duittoz A, Vourc'h P (2009) Effect of the oligodendrocyte myelin glycoprotein (OMgp) on the expansion and neuronal differentiation of rat neural stem cells. Brain Res 1284:22-30
60. Mathis C, Schröter A, Thallmair M, Schwab ME (2010) Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cereb Cortex 20:2380-2390
61. McDonald CL, Steinbach K, Kern F, Schweigreiter R, Martin R, Bandtlow CE, Reindl M (2011) Nogo receptor is involved in the adhesion of dendritic cells to myelin. J Neuroinflammation 8:113
62. McGee AW, Yang Y, Fischer QS, Daw NW, Strittmatter SM (2005) Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor. Science 309:2222-2226 (Pubitemid 41396073)
63. Meng J, Shi Y, Zhao X, Guo S,Wang H, Zheng Y, Tang R, Feng G, Gu N, Liu H, Zhu S, He L (2007) No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. J Neural Transm 114:249-254 (Pubitemid 46147163)
64. Metz CN, Brunner G, Choi-Muira NH, Nguyen H, Gabrilove J, Caras IW, Altszuler N, Rifkin DB, Wilson EL, Davitz MA (1994) Release of GPI-anchored membrane proteins by a cellassociated GPI-specific phospholipase D. EMBO J 13:1741-1751
65. Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowell T, Cate RL, McCoy JM, Pepinsky RB (2004) LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci 7:221-228 (Pubitemid 38280445)
66. Mingorance A, Fontana X, Sole M, Burgaya F, Urena JM, Teng FY, Tang BL, Hunt D, Anderson PN, Bethea JR, Schwab ME, Soriano E, del Rio JA (2004) Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions. Mol Cell Neurosci 26:34-49 (Pubitemid 38581021)
67. Montani L, Gerrits B, Gehrig P, Kempf A, Dimou L, Wollscheid B, Schwab ME (2009) Neuronal Nogo-A modulates growth cone motility via Rho-GTP/LIMK1/cofilin in the unlesioned adult nervous system. J Biol Chem 284:10793-10807
68. Nakamura Y, Fujita Y, Ueno M, Takai T, Yamashita T (2011) Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury. J Biol Chem 286:1876-1883
69. Nestler EJ, Hyman SE (2010) Animal models of neuropsychiatric disorders. Nat Neurosci 13:1161-1169
70. Niederost B, Oertle T, Fritsche J, McKinney RA, Bandtlow CE (2002) Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. J Neurosci 22:10368-10376 (Pubitemid 35416874)
71. Omoto S, Ueno M, Mochio S, Takai T, Yamashita T (2010) Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury. J Neurosci 30:13045-13052
72. Park JB, Yiu G, Kaneko S, Wang J, Chang J, He XL, Garcia KC, He Z (2005) A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron 45:345-351 (Pubitemid 40188202)
73. Park JH, Widi GA, Gimbel DA, Harel NY, Lee DH, Strittmatter SM (2006a) Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice. J Neurosci 26:13279-13286 (Pubitemid 46011638)
74. Park JH, Gimbel DA, GrandPre T, Lee JK, Kim JE, Li W, Lee DH, Strittmatter SM (2006b) Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci 26:1386-1395 (Pubitemid 43237009)
75. Pignot V, Hein AE, Barske C, Wiessner C, Walmsley AR, Kaupmann K, Mayeur H, Sommer B, Mir AK, Frentzel S (2003) Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J Neurochem 85:717-728 (Pubitemid 36531935)
76. Pool M, Niino M, Rambaldi I, Robson K, Bar-Or A, Fournier AE (2009) Myelin regulates immune cell adhesion and motility. Exp Neurol 217:371-377
77. Querfurth HW, LaFerla FM (2010) Alzheimer's disease. N Engl J Med 362:329-344
78. Raiker SJ, Lee H, Baldwin KT, Duan Y, Shrager P, Giger RJ (2010) Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. J Neurosci 30:12432-12445
79. Robak LA, Venkatesh K, Lee H, Raiker SJ, Duan Y, Lee-Osbourne J, Hofer T, Mage RG, Rader C, Giger RJ (2009) Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNIFc, a novel antagonist of CNS myelin inhibition. J Neurosci 29:5768-5783
80. Saha N, Kolev MV, Semavina M, Himanen J, Nikolov DB (2011) Ganglioside mediate the interaction between Nogo receptor 1 and LINGO-1. Biochem Biophys Res Commun 413:92-97
81. Semavina M, Saha N, Kolev MV, Goldgur Y, Giger RJ, Himanen JP, Nikolov DB (2011) Crystal structure of the Nogo-receptor-2. Protein Sci 20:684-689
82. Shao Z, Browning JL, Lee X, Scott ML, Shulga-Morskaya S, Allaire N, Thill G, Levesque M, Sah D, McCoy JM, Murray B, Jung V, Pepinsky RB, Mi S (2005) TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron 45:353-359 (Pubitemid 40188203)
83. Sinibaldi L, De Luca A, Bellacchio E, Conti E, Pasini A, Paloscia C, Spalletta G, Caltagirone C, Pizzuti A, Dallapiccola B (2004) Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. Hum Mutat 24:534-535
84. Sisodia SS, St George-Hyslop PH (2002) gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci 3:281-290 (Pubitemid 135706607)
85. Sivasankaran R, Pei J, Wang KC, Zhang YP, Shields CB, Xu XM, He Z (2004) PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat Neurosci 7:261-268 (Pubitemid 38280450)
86. Steward O, Sharp K, Yee KM, Hofstadter M (2008) A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice. Exp Neurol 209:446-468
87. Thomas R, Favell K, Morante-Redolat J, Pool M, Kent C, Wright M, Daignault K, Ferraro GB, Montcalm S, Durocher Y, Fournier A, Perez-Tur J, Barker PA (2010) LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition. J Neurosci 30:6607-6612
88. Vassar R, Kovacs DM, Yan R, Wong PC (2009) The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J Neurosci 29:12787-12794
89. Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, Newman BA, Mage R, Rader C, Giger RJ (2005) The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. J Neurosci 25:808-822 (Pubitemid 40170995)
90. Walmsley AR, Mir AK, Frentzel S (2005) Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases. Biochem Biophys Res Commun 327:112-116 (Pubitemid 40051359)
91. Walmsley AR, McCombie G, Neumann U, Marcellin D, Hillenbrand R, Mir AK, Frentzel S (2004) Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor. J Cell Sci 117:4591-4602 (Pubitemid 39368951)
92. Wang B, Xiao Z, Chen B, Han J, Gao Y, Zhang J, Zhao W, Wang X, Dai J (2008) Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway. PLoS One 3:e1856
93. Wang F, Zhu Y (2008) The interaction of Nogo-66 receptor with Nogop4 inhibits the neuronal differentiation of neural stem cells. Neuroscience 151:74-81
94. Wang F, Liang Z, Hou Q, Xing S, Ling L, He M, Pei Z, Zeng J (2007) Nogo-A is involved in secondary axonal degeneration of thalamus in hypertensive rats with focal cortical infarction. Neurosci Lett 417:255-260 (Pubitemid 46589790)
95. Wang KC, Kim JA, Sivasankaran R, Segal R, He Z (2002a) P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 420:74-78 (Pubitemid 35291442)
96. Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z (2002b) Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417:941-944 (Pubitemid 34716869)
97. Wang T, Wang J, Yin C, Liu R, Zhang JH, Qin X (2010) Downregulation of Nogo receptor promotes functional recovery by enhancing axonal connectivity after experimental stroke in rats. Brain Res 1360:147-158
98. Wang X, Chun SJ, Treloar H, Vartanian T, Greer CA, Strittmatter SM (2002c) Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J Neurosci 22:5505-5515 (Pubitemid 35386472)
99. Wen D, Wildes CP, Silvian L, Walus L, Mi S, Lee DH, Meier W, Pepinsky RB (2005) Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of Nogo-66 receptor. Biochemistry 44:16491-16501 (Pubitemid 41832032)
100. Wilhelm OG, Wilhelm S, Escott GM, Lutz V, Magdolen V, Schmitt M, Rifkin DB, Wilson EL, Graeff H, Brunner G (1999) Cellular glycosylphosphatidylinositol- specific phospholipase D regulates urokinase receptor shedding and cell surface expression. J Cell Physiol 180:225-235 (Pubitemid 29297199)
101. Williams G, Wood A, Williams EJ, Gao Y, Mercado ML, Katz A, Joseph-McCarthy D, Bates B, Ling HP, Aulabaugh A, Zaccardi J, Xie Y, Pangalos MN, Walsh FS, Doherty P (2008) Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem 283:16641-16652
102. Wong ST, Henley JR, Kanning KC, Huang KH, Bothwell M, Poo MM (2002) A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat Neurosci 5:1302-1308 (Pubitemid 35417765)
103. Worter V, Schweigreiter R, Kinzel B, Mueller M, Barske C, Bock G, Frentzel S, Bandtlow CE (2009) Inhibitory activity of myelinassociated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5. PLoS One 4:e5218
104. Xu CJ, Xu L, Huang LD, Li Y, Yu PP, Hang Q, Xu XM, Lu PH (2011) Combined NgR vaccination and neural stem cell transplantation promote functional recovery after spinal cord injury in adult rats. Neuropathol Appl Neurobiol 37:135-155
105. Yamashita T, Tohyama M (2003) The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci 6:461-467 (Pubitemid 36514693)
106. Yamashita T, Higuchi H, Tohyama M (2002) The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J Cell Biol 157:565-570 (Pubitemid 34839785)
107. Yang YS, Harel NY, Strittmatter SM (2009) Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. J Neurosci 29:13850-13859
108. Yong VW, Power C, Forsyth P, Edwards DR (2001) Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2:502-511 (Pubitemid 33676585)
109. Yoon K, Gaiano N (2005) Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat Neurosci 8:709-715 (Pubitemid 43085834)
110. Zagrebelsky M, Schweigreiter R, Bandtlow CE, Schwab ME, Korte M (2010) Nogo-A stabilizes the architecture of hippocampal neurons. J Neurosci 30:13220-13234
111. Zhang L, Zheng S, Wu H, Wu Y, Liu S, Fan M, Zhang J (2009a) Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. J Neurosci 29:6348-6352
112. Zhang Z, Xu X, Zhang Y, Zhou J, Yu Z, He C (2009b) LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension. J Biol Chem 284:15717-15728
113. Zheng B, Atwal J, Ho C, Case L, He XL, Garcia KC, Steward O, Tessier-Lavigne M (2005) Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci USA 102:1205-1210 (Pubitemid 40170750)
114. Zhou X, Hu X, He W, Tang X, Shi Q, Zhang Z, Yan R (2011) Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition. FASEB J 25:3146-3156