Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity

EMBO Journal

Volumn 30, Issue 7, 2011, Pages 1389-1401

  Fujita, Yuki ^a,b   Endo, Shota ^c   Takai, Toshiyuki ^c   Yamashita, Toshihide ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

axon regeneration; myelin; paired immunoglobulin like receptor B (PIR B); Src homology 2 containing protein tyrosine phosphatase (SHP); tropomyosin receptor kinase (Trk)

Indexed keywords

MEMBRANE PROTEIN; MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN; PAIRED IMMUNOGLOBULIN LIKE RECEPTOR B; PHOSPHOTRANSFERASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; RECEPTOR; SMALL INTERFERING RNA; TROPOMYOSIN RECEPTOR KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC ASSOCIATION; MOUSE; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; OPTIC NERVE INJURY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION;

ANIMALS; AXONS; CELLS, CULTURED; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MYELIN SHEATH; NERVE REGENERATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

MUS;

EID: 79953789490     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.55     Document Type: Article

References (23)

1. Atwal JK, Pinkston-Gosse J, Syken J, Stawicki S, Wu Y, Shatz C, Tessier-Lavigne M (2008) PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science 322: 967-970
2. Bibel M, Hoppe E, Barde YA (1999) Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. EMBO J 18: 616-622 (Pubitemid 29057246)
3. Endo S, Sakamoto Y, Kobayashi E, Nakamura A, Takai T (2008) Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells. Proc Natl Acad Sci USA 105: 14515-14520
4. Hata K, Fujitani M, Yasuda Y, Doya H, Saito T, Yamagishi S, Mueller BK, Yamashita T (2006) RGMa inhibition promotes axonal growth and recovery after spinal cord injury J Cell Biol 173: 47-58
5. Hata K, Kaibuchi K, Inagaki S, Yamashita T (2009) Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J Cell Biol 184: 737-750
6. Kaplan DR, Miller FD (2000) Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 10: 381-391 (Pubitemid 30389307)
7. Lee JK, Geoffroy CG, Chan AF, Tolentino KE, Crawford MJ, Leal MA, Kang B, Zheng B (2010) Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron 66: 663-670
8. Lee KF, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV, Jaenisch R (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69: 737-749
9. Marsh HN, Dubreuil CI, Quevedo C, Lee A, Majdan M, Walsh GS, Hausdorff S, Said FA, Zoueva O, Kozlowski M, Siminovitch K, Neel BG, Miller FD, Kaplan DR (2003) SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. J Cell Biol 163: 999-1010 (Pubitemid 37541876)
10. Nakamura Y, Fujita Y, Ueno M, Takai T, Yamashita T (2011) Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury. J Biol Chem 286: 1876-1883; PMID: 21087927
11. Patapoutian A, Reichardt LF (2001) Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 11: 272-280 (Pubitemid 32524091)
12. Rusanescu G, Yang W, Bai A, Neel BG, Feig LA (2005) Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity. EMBO J 24: 305-314 (Pubitemid 40216135)
13. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285: 1569-1572 (Pubitemid 29420581)
14. Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z (2009) SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron 64: 617-623
15. Syken J, Grandpre T, Kanold PO, Shatz CJ (2006) PirB restricts ocular-dominance plasticity in visual cortex. Science 313: 1795-1800 (Pubitemid 44454157)
16. Takai T (2005) Paired immunoglobulin-like receptors and their MHC class I recognition. Immunology 115: 433-440 (Pubitemid 41032431)
17. Tonks NK, Neel BG (2001) Combinatorial control of the specificity of protein tyrosine phosphatases. Curr Opin Cell Biol 13: 182-195 (Pubitemid 32209219)
18. Ujike A, Takeda K, Nakamura A, Ebihara S, Akiyama K, Takai T (2002) Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(?/\) mice. Nat Immunol 3: 542-548 (Pubitemid 34662306)
19. Wang KC, Kim JA, Sivasankaran R, Segal R, He Z (2002) P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 420: 74-78 (Pubitemid 35291442)
20. Yamashita T, Higuchi H, Tohyama M (2002) The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J Cell Biol 157: 565-570 (Pubitemid 34839785)
21. Yano H, Lee FS, Kong H, Chuang J, Arevalo J, Perez P, Sung C, Chao MV (2001) Association of Trk neurotrophin receptors with com-ponents of the cytoplasmic dynein motor. J Neurosci 21: RC125
22. Yiu G, He Z (2006) Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 7: 617-627 (Pubitemid 44106744)
23. Zheng B, Atwal J, Ho C, Case L, He XL, Garcia KC, Steward O, Tessier-Lavigne M (2005) Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticosp-inal tract regeneration in vivo. Proc Natl Acad Sci USA 102: 1205-1210 (Pubitemid 40170750)