Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission

Science

Volumn 313, Issue 5794, 2006, Pages 1792-1795

  Fukata, Yuko ^a   Adesnik, Hillel ^b   Iwanaga, Tsuyoshi ^a   Bredt, David S ^c   Nicoll, Roger A ^b   Fukata, Masaki ^a,d  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BRAIN; DISEASES; NEUROLOGY; PROTEINS; SCAFFOLDS;

AUDITORY FEATURES (ADPEAF); PARTIAL EPILEPSY; POSTSYNAPTIC DENSITY; SYNAPTIC TRANSMISSION;

BIOELECTRIC POTENTIALS;

CYTOSKELETON PROTEIN; GENE PRODUCT; ION CHANNEL; MEMBRANE PROTEIN; PROTEIN ADAM22; PROTEIN LGI1; STARGAZIN; UNCLASSIFIED DRUG;

BRAIN; MUTATION; PROTEIN;

ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT PARTIAL EPILEPSY WITH AUDITORY FEATURE; BRAIN SLICE; CONTROLLED STUDY; EPILEPSY; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; SEIZURE; SYNAPTIC TRANSMISSION;

ADAM PROTEINS; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CALCIUM CHANNELS; CELL LINE; CEREBELLAR CORTEX; CEREBRAL CORTEX; EPILEPSIES, PARTIAL; HIPPOCAMPUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; MICE; N-METHYLASPARTATE; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RATS; RECEPTORS, AMPA; RECOMBINANT FUSION PROTEINS; SYNAPSES; SYNAPTIC TRANSMISSION; TRANSFECTION;

EID: 33749038646     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1129947     Document Type: Article

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26. We thank J. Trinidad and A. Watanabe for technical guidance on mass spectral analysis; A. Kato for suggestion on AP staining; T. Tabira, K. Takahashi, and T. Imai for sharing equipment; and Kazusa DNA Research Institute for giving (m)KIAA cDNA clones. Y.F. is supported by grants from the Human Frontier Science Program (HFSP) and the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) (18700376). H.A. is supported by a Howard Hughes predoctoral fellowship. R.A.N. is a member of the Keck Center for Integrate Neurascience and the Silvio Conte Center for Neuroscience Research. M.F. is supported by grants from HFSP, MEXT (18022054, 18057032, and 18687008), National Institute of Biomedical Innovation (05-27), Ministry of Health, Labor, and Welfare (17C-2) and Astellas, Mochida, Sagawa, and Japan Health Foundations.