Single-chain variable fragment intrabody impairs LPS-induced inflammatory responses by interfering with the interaction between the WASP N-terminal domain and Btk in macrophages

Biochemical and Biophysical Research Communications

Volumn 423, Issue 1, 2012, Pages 164-169

  Sakuma, Chisato ^a,b   Sato, Mitsuru ^a   Takenouchi, Takato ^a   Chiba, Joe ^b   Kitani, Hiroshi ^a  

^a NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Bruton's tyrosine kinase; Intrabody; LPS signaling; Macrophage; Phosphorylation; Wiskott Aldrich syndrome protein

Indexed keywords

BRUTON TYROSINE KINASE; CD11B ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROTEIN SH3; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; GENETIC TRANSCRIPTION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; CELL LINE; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, TRANSGENIC; NF-KAPPA B; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; SINGLE-CHAIN ANTIBODIES; SRC HOMOLOGY DOMAINS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE; WISKOTT-ALDRICH SYNDROME PROTEIN;

MUS MUSCULUS;

EID: 84862686544     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.105     Document Type: Article

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