Linear fidelity in quantification of anti-viral CD8+ T cells

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Flesch, Inge E A ^a   Hollett, Natasha A ^a   Wong, Yik Chun ^a   Tscharke, David C ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEGLUMINE IOCARMATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXICITY; DEGRANULATION; EPITOPE MAPPING; FEMALE; FLOW CYTOMETRY; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; IMMUNOGENICITY; IN VITRO STUDY; MOUSE; NONHUMAN; REPRODUCIBILITY; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; VACCINIA; VACCINIA VIRUS; VIRUS TITRATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES; FEMALE; INTERFERON-GAMMA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SIMPLEXVIRUS; VACCINIA VIRUS;

EID: 84862682075     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039533     Document Type: Article

References (40)

1. Doherty PC, Christensen JP, (2000) Accessing complexity: the dynamics of virus-specific T cell responses. Annu Rev Immunol 18: 561-592.
2. Zinkernagel RM, Doherty PC, (1979) MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol 27: 51-177.
3. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, et al. (1987) The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329: 512-518.
4. Yewdell JW, Haeryfar SM, (2005) Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design. Annu Rev Immunol 23: 651-682.
5. Brunner KT, Mauel J, Cerottini JC, Chapuis B, (1968) Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs. Immunology 14: 181-196.
6. Parish CR, Glidden MH, Quah BJ, Warren HS, (2009) Use of the intracellular fluorescent dye CFSE to monitor lymphocyte migration and proliferation. Current Protocols in Immunology Chapter 4: Unit 4.9.
7. Lyons AB, (2000) Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods 243: 147-154.
8. Altman JD, Moss PA, Goulder PJ, Barouch DH, McHeyzer-Williams MG, et al. (1996) Phenotypic analysis of antigen-specific T lymphocytes. Sci 274: 94-96.
9. Taguchi T, McGhee JR, Coffman RL, Beagley KW, Eldridge JH, et al. (1990) Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J Immunol Methods 128: 65-73.
10. Sander B, Andersson J, Andersson U, (1991) Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure. Immunol Rev 119: 65-93.
11. Jung T, Schauer U, Heusser C, Neumann C, Rieger C, (1993) Detection of intracellular cytokines by flow cytometry. J Immunol Methods 159: 197-207.
12. La Gruta NL, Turner SJ, Doherty PC, (2004) Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity. J Immunol 172: 5553-5560.
13. Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, et al. (2003) Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 281: 65-78.
14. Burkett MW, Shafer-Weaver KA, Strobl S, Baseler M, Malyguine A, (2005) A novel flow cytometric assay for evaluating cell-mediated cytotoxicity. J Immunother 28: 396-402.
15. Wolint P, Betts MR, Koup RA, Oxenius A, (2004) Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells. J Exp Med 199: 925-936.
16. Seder RA, Darrah PA, Roederer M, (2008) T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8: 247-258.
17. Klenerman P, Cerundolo V, Dunbar PR, (2002) Tracking T cells with tetramers: new tales from new tools. Nat Rev Immunol 2: 263-272.
18. Sun Y, Iglesias E, Samri A, Kamkamidze G, Decoville T, et al. (2003) A systematic comparison of methods to measure HIV-1 specific CD8 T cells. J Immunol Methods 272: 23-34.
19. Rubio-Godoy V, Dutoit V, Rimoldi D, Lienard D, Lejeune F, et al. (2001) Discrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life. Proc Natl Acad Sci U S A 98: 10302-10307.
20. Flynn KJ, Belz GT, Altman JD, Ahmed R, Woodland DL, et al. (1998) Virus-specific CD8+ T cells in primary and secondary influenza pneumonia. Immunity 8: 683-691.
21. Murali-Krishna K, Altman JD, Suresh M, Sourdive DJ, Zajac AJ, et al. (1998) Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8: 177-187.
22. Flesch IE, Woo WP, Wang Y, Panchanathan V, Wong YC, et al. (2010) Altered CD8+ T cell immunodominance after vaccinia virus infection and the naïve repertoire in inbred and F1 mice. J Immunol 184: 45-55.
23. Schneck JP, (2000) Monitoring antigen-specific T cells using MHC-Ig dimers. Immunol Invest 29: 163-169.
24. Wang Y, Flesch IEA, Tscharke DC, (2009) Vaccinia virus CD8+ T cell dominance hierarchies cannot be altered by prior immunization with individual peptides. J Virol 83: 9008-9012.
25. Yuen TJ, Flesch IEA, Hollett NA, Dobson BM, Russell TA, et al. (2010) Analysis of A47, an immunoprevalent protein of vaccinia virus, leads to a reevaluation of the total antiviral CD8+ T cell response. J Virol 84: 10220-10229.
26. Symons JA, Tscharke DC, Price N, Smith GL, (2002) A study of the vaccinia virus interferon-γ receptor and its contribution to virus virulence. J Gen Virol 83: 1953-1964.
27. Mackay LK, Wakim L, van Vliet CJ, Jones CM, Mueller SN, et al. (2012) Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol 188: 2173-2178.
28. Kastenmuller W, Gasteiger G, Gronau JH, Baier R, Ljapoci R, et al. (2007) Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination. J Exp Med 204: 2187-2198.
29. Valitutti S, Muller S, Dessing M, Lanzavecchia A, (1996) Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J Exp Med 183: 1917-1921.
30. Betts MR, Price DA, Brenchley JM, Lore K, Guenaga FJ, et al. (2004) The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration. J Immunol 172: 6407-6417.
31. Coles RM, Mueller SN, Heath WR, Carbone FR, Brooks AG, (2002) Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1. J Immunol 168: 834-838.
32. Byers AM, Kemball CC, Moser JM, Lukacher AE, (2003) Cutting edge: Rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells. J Immunol 171: 17-21.
33. Regner M, Pavlinovic L, Koskinen A, Young N, Trapani JA, et al. (2009) Cutting edge: Rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B. J Immunol 183: 37-40.
34. Tscharke DC, Karupiah G, Zhou J, Palmore T, Irvine KR, et al. (2005) Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J Exp Med 201: 95-104.
35. Moutaftsi M, Peters B, Pasquetto V, Tscharke DC, Sidney J, et al. (2006) A consensus epitope prediction approach identifies the breadth of murine TCD8+-cell responses to vaccinia virus. Nat Biotechnol 24: 817-819.
36. Bonneau RH, Salvucci LA, Johnson DC, Tevethia SS, (1993) Epitope specificity of H-2Kb-restricted, HSV-1-, and HSV-2-cross-reactive cytotoxic T lymphocyte clones. Virology 195: 62-70.
37. St. Leger AJ, Peters B, Sidney J, Sette A, Hendricks RL, (2011) Defining the Herpes Simplex Virus-Specific CD8+ T Cell Repertoire in C57BL/6 Mice. J Immunol 186: 3927-3933.
38. Rötzschke O, Falk K, Stevanovic S, Jung G, Walden P, et al. (1991) Exact prediction of a natural T cell epitope. EJI 21: 2891-2894.
39. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, et al. (1994) T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
40. Simmons A, Nash AA, (1984) Zosteriform spread of herpes simplex virus as a model of recrudescence and its use to investigate the role of immune cells in prevention of recurrent disease. J Virol 52: 816-821.