Cutting edge: Rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B

Journal of Immunology

Volumn 183, Issue 1, 2009, Pages 37-40

  Regner, Matthias ^a   Pavlinovic, Lisa ^a   Koskinen, Aulikki ^a   Young, Nicolie ^a   Trapani, Joseph A ^b   Müllbacher, Arno ^a  

^a Biology and Environment   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME A; GRANZYME B; GRANZYME; GZMB PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; FEMALE; IMMUNE ADHERENCE; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; VIRUS; WILD TYPE; ANIMAL; C57BL MOUSE; CELL DEATH; ECTROMELIA VIRUS; ENZYMOLOGY; GENETICS; IMMUNOLOGY; INFLUENZA VIRUS A; MOUSE MUTANT; ORTHOMYXOVIRUS INFECTION; PATHOLOGY; PHYSIOLOGY; RODENT DISEASE; TIME; VIROLOGY;

ANIMALS; CELL DEATH; CYTOTOXICITY, IMMUNOLOGIC; ECTROMELIA VIRUS; ECTROMELIA, INFECTIOUS; GRANZYMES; INFLUENZA A VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE INFECTIONS; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS;

EID: 68949090398     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900466     Document Type: Article

References (32)

1. Kägi, D., B. Ledermann, K. Burki, R. M. Zinkernagel, and H. Hengartner. 1996. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14: 207-232. (Pubitemid 26130183)
2. Grossman, W. J., P. A. Revell, Z. H. Lu, H. Johnson, A. J. Bredemeyer, and T. J. Ley. 2003. The orphan granzymes of humans and mice. Curr. Opin. Immunol. 15: 544-552.
3. Revell, P. A., W. J. Grossman, D. A. Thomas, X. Cao, R. Behl, J. A. Ratner, Z. H. Lu, and T. J. Ley. 2005. Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J. Immunol. 174: 2124-2131.
4. Pardo, J., R. Wallich, P. Martin, C. Urban, A. Rongvaux, R. A. Flavell, A.Müllbacher, C. Borner, and M. M. Simon. 2008. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 15: 567-579.
5. Shresta, S., T. A. Graubert, D. A. Thomas, S. Z. Raptis, and T. J. Ley. 1999. Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity 10: 595-605.
6. Simon, M. M., M. Hausmann, T. Tran, K. Ebnet, J. Tschopp, R. ThaHla, and A.Müllbacher. 1997. In vitro- and ex vivo-derived cytolytic leukocytes from granzyme AxB double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells. J. Exp. Med. 186: 1781-1786.
7. Pardo, J., S. Balkow, A. Anel, and M. M. Simon. 2002. The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells. Eur. J. Immunol. 32: 1980-1985.
8. Pardo, J., A. Bosque, R. Brehm, R. Wallich, J. Naval, A. Müllbacher, A. Anel, and M. M. Simon. 2004. Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. J. Cell Biol. 167: 457-468.
9. Waterhouse, N. J., V. R. Sutton, K. A. Sedelies, A. Ciccone, M. Jenkins, S. J. Turner, P. I. Bird, and J. A. Trapani. 2006. Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforindependent lysis. J. Cell Biol. 173: 133-144.
10. Chowdhury, D., and J. Lieberman. 2008. Death by a thousand cuts: granzyme pathways of programmed cell death. Annu. Rev. Immunol. 26: 389-420.
11. + cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice. J. Virol. 74: 1029-1032.
12. Fehniger, T. A., S. F. Cai, X. Cao, A. J. Bredemeyer, R. M. Presti, A. R. French, and T. J. Ley. 2007. Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity 26: 798-811.
13. Riera, L., M. Gariglio, G. Valente, A. Mullbacher, C. Museteanu, S. Landolfo, and M. M. Simon. 2000. Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection. Eur. J. Immunol. 30: 1350-1355.
14. van Dommelen, S. L., N. Sumaria, R. D. Schreiber, A. A. Scalzo, M. J. Smyth, and M. A. Degli-Esposti. 2006. Perforin and granzymes have distinct roles in defensive immunity and immunopathology. Immunity 25: 835-848.
15. Müllbacher, A., P. Waring, R. Tha Hla, T. Tran, S. Chin, T. Stehle, C. Museteanu, and M. M. Simon. 1999. Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. USA 96: 13950-13955.
16. Müllbacher, A., K. Ebnet, R. V. Blanden, R. T. Hla, T. Stehle, C. Museteanu, and M. M. Simon. 1996. Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proc. Natl. Acad. Sci. USA 93: 5783-5787.
17. Metkar, S. S., C. Menaa, J. Pardo, B. Wang, R. Wallich, M. Freudenberg, S. Kim, S. M. Raja, L. Shi, M. M. Simon, and C. J. Froelich. 2008. Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity 29: 720-733.
18. Müllbacher, A., G. Ada, and R. Tha Hla. 1988. Gamma-irradiated influenza A virus can prime for a cross-reactive and cross-protective immune response against influenza A virus. Immunol. Cell Biol. 66: 153-157.
19. + T cell determinants to enable rational design and characterization of smallpox vaccines. J. Exp. Med. 201: 95-104.
20. + T cells in vivo. Eur. J. Immunol. 30: 1356-1363.
21. Barber, D. L., E. J. Wherry, and R. Ahmed. 2003. Cutting edge: rapid in vivo killing by memory CD8 T cells. J. Immunol. 171: 27-31.
22. Regoes, R. R., D. L. Barber, R. Ahmed, and R. Antia. 2007. Estimation of the rate of killing by cytotoxic T lymphocytes in vivo. Proc. Natl. Acad. Sci. USA 104: 1599-1603.
23. + T cells. J. Immunol. 171: 17-21.
24. Yates, A., F. Graw, D. L. Barber, R. Ahmed, R. R. Regoes, and R. Antia. 2007. Revisiting estimates of CTL killing rates in vivo. PLoS ONE 2: e1301.
25. Ganusov, V. V., and R. J. De Boer. 2008. Estimating in vivo death rates of targets due to CD8 T-cell-mediated killing. J. Virol. 82: 11749-11757.
26. Sutton, V. R., N. J. Waterhouse, K. A. Browne, K. Sedelies, A. Ciccone, D. Anthony, A. Koskinen, A. Müllbacher, and J. A. Trapani. 2007. Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis. J. Cell Biol. 176: 425-433.
27. Wonderlich, J., G. Shearer, A. Livingstone, and A. Brooks. 2006. Induction and measurement of cytotoxic T lymphocyte activity. In Current Protocols in Immunology, J. E. Coligan, B. E. Bierer, D. H. Margulies, E. M. Shevach, and W. Strober, eds. John Wiley & Sons, New York, pp. 3.11.1-3.11.23.
28. Pham, C. T., D. M. MacIvor, B. A. Hug, J. W. Heusel, and T. J. Ley. 1996. Longrange disruption of gene expression by a selectable marker cassette. Proc. Natl. Acad. Sci. USA 93: 13090-13095.
29. Simon, H. G., U. Fruth, M. D. Kramer, and M. M. Simon. 1987. A secretable serine proteinase with highly restricted specificity from cytolytic T lymphocytes inactivates retrovirus-associated reverse transcriptase. FEBS Lett. 223: 352-360.
30. Andrade, F., H. G. Bull, N. A. Thornberry, G. W. Ketner, L. A. Casciola-Rosen, and A. Rosen. 2001. Adenovirus L4 - 100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death. Immunity 14: 751-761.
31. Regner, M., and A. Müllbacher. 2004. Granzymes in cytolytic lymphocytes - to kill a killer? Immunol. Cell Biol. 82: 161-169.
32. Sower, L. E., G. R. Klimpel, W. Hanna, and C. J. Froelich. 1996. Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines. Cell. Immunol. 171: 159-163.