Elevated amyloid β production in senescent retinal pigment epithelium, a possible mechanism of subretinal deposition of amyloid β in age-related macular degeneration

Biochemical and Biophysical Research Communications

Volumn 423, Issue 1, 2012, Pages 73-78

  Wang, Jiying ^a   Ohno Matsui, Kyoko ^a   Morita, Ikuo ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Secretase; A ; AD; Age related macular degeneration; AMD; Amyloid ; Amyloid precursor protein; APP; BACE; NEP; Neprilysin; Retinal pigment epithelium; RPE

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE 1; BETA SECRETASE 2; GAMMA SECRETASE; MEMBRANE METALLOENDOPEPTIDASE; MESSENGER RNA;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL LYSATE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE INACTIVATION; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RETINA MACULA AGE RELATED DEGENERATION;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL AGING; CELL SEPARATION; MACULAR DEGENERATION; MICE; PROTEOLYSIS; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER; RNA, SMALL INTERFERING;

MUS;

EID: 84862652157     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.085     Document Type: Article

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