Inhibitor potencies and substrate preference for endothelin-converting enzyme-1 are dramatically affected by pH

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Fahnoe, D C ^a   Knapp, J ^a   Johnson, G D ^a   Ahn, K ^a  

^a PFIZER INC   (United States)

Author keywords

Endothelin (ET); Endothelin converting enzyme 1 (ECE 1); pH optimum; pH dependence

Indexed keywords

CGS 31447; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME INHIBITOR; PD 069185; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HYDROLYSIS; NONHUMAN; PH; PRIORITY JOURNAL;

EID: 0033766102     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00026     Document Type: Article

References (18)

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