Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Kotelevets, Nataliya ^a   Fabbro, Doriano ^b   Huwiler, Andrea ^a,c   Zangemeister Wittke, Uwe ^a,d  

^a UNIVERSITY OF BERN   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 1; PACLITAXEL; PROTEIN KINASE C; SHORT HAIRPIN RNA; SPHINGOSINE; SPHINGOSINE KINASE 1;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; COLON CARCINOMA; COLONY FORMATION; CONTROLLED STUDY; CYTOKINESIS; DNA CONTENT; DOWN REGULATION; ENDOREDUPLICATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LUNG CARCINOMA; MITOSIS INDEX; MITOSIS INHIBITION; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN TARGETING;

APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; CHROMATOGRAPHY, LIQUID; CYTOKINESIS; ENZYME INHIBITORS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INDOLES; LYSOPHOSPHOLIPIDS; MITOSIS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN KINASE C; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPHINGOSINE; TUMOR CELLS, CULTURED;

EID: 84862649942     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039209     Document Type: Article

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