Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells

Cancer Letters

Volumn 107, Issue 1, 1996, Pages 83-89

  Qiao, Liang ^a   Koutsos, Markos ^a   Tsai, Li Lan ^b   Kozoni, Vassiliki ^a,b   Guzman, Jeanette ^a   Shiff, Steven J ^a,b   Rigas, Basil ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Apoptosis; Cell proliferation; HT 29; Staurosporine

Indexed keywords

ANTINEOPLASTIC AGENT; CELL DNA; PROTEIN KINASE C INHIBITOR; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL STRUCTURE; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0030272773     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04346-7     Document Type: Article

References (23)

1. [1] Boring, C.C., Squires, T.S., Tong, T. and Montgomery, S. (1994) Cancer statistics 1994, Chem. Abstr., 44, 7-26.
2. [2] Hass, R., Pfannkuche, H., Kharbanda, S., Gunji, H., Meyer, G., Hartman, A., Hidaka, A., Resch, K., Kufe, D. and Goppet-Strube, M. (1991) Protein Kinase C activation and proto oncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells, Cell Growth Differ., 2, 541-548.
3. [3] Nishizuka, Y. (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation, Nature (London), 334, 661-665.
4. [4] Craven, P.A. and DeRubertis, D. (1988) Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids, Gastroenterology, 95, 676-685.
5. [5] Rahmsdorf, H.J. and Herrilich, P. (1990) Regulation of gene expression by tumor promoters, Pharmacol. Ther., 48, 157-188.
6. [6] Davis, P.D., Hill, C.H., Keech, E., Lawton, G., Nixon, J.S. and Sedgwick, A.D. (1989) Potent selective inhibitors of protein kinase C, FEBS Lett., 259, 61-63.
7. [7] Bruno, S., Ardelt, B., Skierski, J.S., Traganos, F. and Darzynkiewicz, Z. (1992) Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes, Cancer Res., 51, 470-473.
8. 2 synchrony in cultured rodent and human diploid fibroblasts, Proc. Natl. Acad. Sci. USA, 87, 5104-5108.
9. 1 phase of nontransformed mammalian cells are absent in transformed cells, Proc. Natl. Acad. Sci. USA, 89, 8626-8630.
10. [10] Lin, Y., Chest, F.J. and Gabrielion, E.W. (1992) Reversible G1 arrest of a human epithelial cell line by staurosporine, J. Cell Physiol., 152, 646-653.
11. 1 phase of the cell cycle, Proc. Natl. Acad. Sci. USA, 88, 7580-7584.
12. 2 phase (Abstract), Cell Prolif., 26, 394.
13. [13] Schwartz, G.K., Redwood, S.M., Ohhuma, T., Holland, J.K., Droller, M.J. and Liu, B.C.-S. (1990) Inhibition of invasion of invasive human bladder carcinoma cells by protein kinase C inhibitor staurosporine, J. Natl. Cancer Inst., 82, 1753-1756.
14. [14] Kerr, J.F.R., Wyllie, A.H. and Currie, A.R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging applications in tissue kinetics, Br. J. Cancer, 26, 293-297.
15. [15] Duvall, E. and Wyllie, A.H. (1986) Death and the cell, Immunol. Today, 7, 115-118.
16. [16] Wyllie, A.H. (1981) Cell death: a new classification separating apoptosis from necrosis. In: Cell Death in Biology and Pathology, pp. 9-34. Editors: I.D. Bowen and R.A. Lockshin. Chapman and Hall, London.
17. [17] Darzynkiewicz, Z. (1990) Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange, Methods Cell Biol., 33, 285-298.
18. [18] Cohen, J.J.(1993) Apoptosis. Immunol. Today, 14, 126-130.
19. 2 block caused by staurosporine, a potent inhibitor of protein kinases, Exp. Cell. Res., 192, 122-127.
20. [20] Falcieri, E., Martelli, A.M., Bareggi, R., Cataldi, A. and Cocco, L. (1993) The protein kinase C inhibitor staurosporine induces morphological changes typical of apoptosis in MOLT-4 cells without concomitant DNA fragmentation, Biochem. Biophys. Res. Commun., 193, 19-25.
21. [21] Bertrand, R., Solary, E., O'Connor, P., Kohn, K.W. and Pommier, Y. (1994) Induction of a common pathway of apoptosis by staurosporine, Exp. Cell. Res., 211, 314-321.
22. [22] Craven, P.A., Pfanstiel, J. and DeRubertis, F.R. (1987) Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile salts, J. Clin. Invest., 79, 532-541.
23. [23] Javis, W.D., Turner, A.J., Povirk, L.F., Traylor, R.S. and Grant, S. (1994) Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C, Cancer Res., 54, 1707-1714.