Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 23068-23078

  Irving, Melita ^a,b   Zoete, Vincent ^b   Hebeisen, Michael ^c   Schmid, Daphné ^a   Baumgartner, Petra ^d   Guillaume, Philippe ^d   Romero, Pedro ^d   Speiser, Daniel ^d   Luescher, Immanuel ^d   Rufer, Nathalie ^a,b,c,d   Michielin, Olivier ^a,b,d  

^a Multidisciplinary Oncology Center (CePO)   (Switzerland)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE NUMBER; ACTIVITY LEVELS; ANTIGEN PRESENTING CELLS; BINDING PROPERTIES; CELL TRANSFER; CYTOKINES; DATA SUPPORT; DISSOCIATION CONSTANT; HIT RATE; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL AFFINITIES; RATIONAL DESIGN; T CELL ACTIVATION; T CELL RECEPTOR; T CELLS; T-CELL RECEPTORS; VACCINATION STRATEGY; WILD TYPES;

BINDING ENERGY; BIOACTIVITY; CELL MEMBRANES; DISSOCIATION; PEPTIDES;

CYTOLOGY;

CALCIUM ION; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; BIOLOGICAL ACTIVITY; CALCIUM TRANSPORT; CD8+ T LYMPHOCYTE; CELL LEVEL; CYTOKINE RELEASE; CYTOTOXICITY; DISSOCIATION CONSTANT; EMBRYO; HALF LIFE TIME; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR AFFINITY; RECEPTOR BINDING; T LYMPHOCYTE ACTIVATION; WILD TYPE;

ADAPTIVE IMMUNITY; APOPTOSIS; CALCIUM; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINES; CYTOKINES; HEK293 CELLS; HUMANS; IMMUNOTHERAPY, ACTIVE; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MODELS, IMMUNOLOGICAL; NEOPLASMS; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL;

EID: 84862636672     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.357673     Document Type: Article

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