siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat

Journal of Controlled Release

Volumn 161, Issue 1, 2012, Pages 132-141

  Al Soraj, M ^a   He, L ^a   Peynshaert, K ^a   Cousaert, J ^a   Vercauteren, D ^b   Braeckmans, K ^b,c   De Smedt, S C ^b   Jones, A T ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b GHENT UNIVERSITY   (Belgium)

^c Centre for Nano and Biophotonics   (Belgium)

Author keywords

Cell penetrating peptides; Dextran; Endocytosis; Epidermal growth factor; Macropinocytosis; Pak 1

Indexed keywords

CELL-PENETRATING PEPTIDE; ENDOCYTOSIS; EPIDERMAL GROWTH FACTORS; MACROPINOCYTOSIS; PAK-1;

CELL CULTURE; CELL MEMBRANES; DEXTRAN; DRUG DELIVERY; MOLECULAR BIOLOGY; PROBES;

PEPTIDES;

CAVEOLIN 1; CELL PENETRATING PEPTIDE; CLATHRIN HEAVY CHAIN; CYTOCHALASIN D; DEXTRAN; DRUG CARRIER; DYNAMIN II; FLOTILLIN 1; HIV TAT; JASPAMIDE; OCTAARGININE; P21 ACTIVATED KINASE 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ARTICLE; CARCINOMA CELL; CELL DISRUPTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENDOSOME; EPITHELIUM CELL; HUMAN; HUMAN CELL; INTERNALIZATION; INTRACELLULAR SIGNALING; MOLECULAR PROBE; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STABILITY; RNA SEQUENCE;

ACTIN CYTOSKELETON; AMINO ACID SEQUENCE; CAVEOLIN 1; CELL LINE, TUMOR; CELL-PENETRATING PEPTIDES; DEXTRANS; ENDOCYTOSIS; EPIDERMAL GROWTH FACTOR; GENE PRODUCTS, TAT; HELA CELLS; HIV; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; P21-ACTIVATED KINASES; PINOCYTOSIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84862618219     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.03.015     Document Type: Article

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