메뉴 건너뛰기




Volumn 248, Issue 1-2, 2012, Pages 23-31

Transcriptomics: mRNA and alternative splicing

Author keywords

Alternative splicing; Bioinformatics; Microarrays; Multiple sclerosis; Next generation sequencing; Transcriptomics

Indexed keywords

MESSENGER RNA; TRANSCRIPTOME;

EID: 84862594116     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.04.008     Document Type: Article
Times cited : (44)

References (72)
  • 1
    • 1442304886 scopus 로고    scopus 로고
    • Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity
    • Achiron Anat, et al. Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity. Ann. Neurol. 2004, 55(3):410-417.
    • (2004) Ann. Neurol. , vol.55 , Issue.3 , pp. 410-417
    • Achiron, A.1
  • 2
    • 34648835408 scopus 로고    scopus 로고
    • Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse
    • Achiron Anat, et al. Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Ann. N. Y. Acad. Sci. 2007, 1107:155-167.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1107 , pp. 155-167
    • Achiron, A.1
  • 3
    • 74049156448 scopus 로고    scopus 로고
    • Molecular profiling of glatiramer acetate early treatment effects in multiple sclerosis
    • Achiron Anat, Feldman A., Gurevich Michael Molecular profiling of glatiramer acetate early treatment effects in multiple sclerosis. Dis. Markers 2009, 27(2):63-73.
    • (2009) Dis. Markers , vol.27 , Issue.2 , pp. 63-73
    • Achiron, A.1    Feldman, A.2    Gurevich, M.3
  • 4
    • 29244448340 scopus 로고    scopus 로고
    • Microarray data analysis: from disarray to consolidation and consensus
    • Allison D.B., et al. Microarray data analysis: from disarray to consolidation and consensus. Nat. Rev. Genet. 2006, 7(1):55-65.
    • (2006) Nat. Rev. Genet. , vol.7 , Issue.1 , pp. 55-65
    • Allison, D.B.1
  • 5
    • 42449106065 scopus 로고    scopus 로고
    • Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission
    • Arthur Ariel T., et al. Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Med. Genet. 2008, 9(1):17.
    • (2008) BMC Med. Genet. , vol.9 , Issue.1 , pp. 17
    • Arthur, A.T.1
  • 7
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • Black D.L. Mechanisms of alternative pre-messenger RNA splicing. Annu. Rev. Biochem. 2003, 72:291-336.
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 291-336
    • Black, D.L.1
  • 8
    • 10744231299 scopus 로고    scopus 로고
    • Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease
    • Bomprezzi R., et al. Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum. Mol. Genet. 2003, 12(17):2191-2199.
    • (2003) Hum. Mol. Genet. , vol.12 , Issue.17 , pp. 2191-2199
    • Bomprezzi, R.1
  • 9
    • 26044433609 scopus 로고    scopus 로고
    • Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis
    • Booth D.R., et al. Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. J. Mol. Med. 2005, 83(10):822-830.
    • (2005) J. Mol. Med. , vol.83 , Issue.10 , pp. 822-830
    • Booth, D.R.1
  • 10
    • 79955760409 scopus 로고    scopus 로고
    • An empirical assessment of validation practices for molecular classifiers
    • Castaldi P.J., Dahabreh I.J., Ioannidis J.P.A. An empirical assessment of validation practices for molecular classifiers. Brief. Bioinform. 2011, 12(3):189-202.
    • (2011) Brief. Bioinform. , vol.12 , Issue.3 , pp. 189-202
    • Castaldi, P.J.1    Dahabreh, I.J.2    Ioannidis, J.P.A.3
  • 11
    • 34347248415 scopus 로고    scopus 로고
    • Genomics in multiple sclerosis-current state and future directions
    • Comabella Manuel, Martin Roland Genomics in multiple sclerosis-current state and future directions. J. Neuroimmunol. 2007, 187(1-2):1-8.
    • (2007) J. Neuroimmunol. , vol.187 , Issue.1-2 , pp. 1-8
    • Comabella, M.1    Martin, R.2
  • 12
    • 72649106903 scopus 로고    scopus 로고
    • A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis
    • Comabella M., et al. A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis. Brain: J. Neurol. 2009, 132(Pt 12):3353-3365.
    • (2009) Brain: J. Neurol. , vol.132 , Issue.PART 12 , pp. 3353-3365
    • Comabella, M.1
  • 13
    • 50149102578 scopus 로고    scopus 로고
    • Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event
    • Corvol J.-C., Pelletier D., Henry R.G., et al. Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(33):11839-11844.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , Issue.33 , pp. 11839-11844
    • Corvol, J.-C.1    Pelletier, D.2    Henry, R.G.3
  • 14
    • 77957372656 scopus 로고    scopus 로고
    • Differential gene expression and translational approaches to identify biomarkers of interferon beta activity in multiple sclerosis
    • Croze E. Differential gene expression and translational approaches to identify biomarkers of interferon beta activity in multiple sclerosis. J. Interferon Cytokine Res.: Off. J. Int. Soc. Interferon Cytokine Res. 2010, 30(10):743-749.
    • (2010) J. Interferon Cytokine Res.: Off. J. Int. Soc. Interferon Cytokine Res. , vol.30 , Issue.10 , pp. 743-749
    • Croze, E.1
  • 15
    • 33747822629 scopus 로고    scopus 로고
    • The affymetrix GeneChip platform: an overview
    • Dalma-Weiszhausz D.D., et al. The affymetrix GeneChip platform: an overview. Methods Enzymol. 2006, 410:3-28.
    • (2006) Methods Enzymol. , vol.410 , pp. 3-28
    • Dalma-Weiszhausz, D.D.1
  • 16
    • 0043203327 scopus 로고    scopus 로고
    • Multiple hypothesis testing in microarray experiments
    • Dudoit S., Shaffer J.P., Boldrick J.C. Multiple hypothesis testing in microarray experiments. Statistical Science 2003, 18:71-103.
    • (2003) Statistical Science , vol.18 , pp. 71-103
    • Dudoit, S.1    Shaffer, J.P.2    Boldrick, J.C.3
  • 18
    • 33846978784 scopus 로고    scopus 로고
    • Critical Review of Published Microarray Studies for Cancer Outcome and Guidelines on Statistical Analysis and Reporting
    • Dupuy A., Simon R.M. Critical Review of Published Microarray Studies for Cancer Outcome and Guidelines on Statistical Analysis and Reporting. JNCI J. Natl. Cancer Inst. 2007, 99(2):147.
    • (2007) JNCI J. Natl. Cancer Inst. , vol.99 , Issue.2 , pp. 147
    • Dupuy, A.1    Simon, R.M.2
  • 19
    • 7444260846 scopus 로고    scopus 로고
    • The ENCODE (ENCyclopedia Of DNA Elements) Project
    • Encode P.C. The ENCODE (ENCyclopedia Of DNA Elements) Project. Science 2004, 306(5696):636-640.
    • (2004) Science , vol.306 , Issue.5696 , pp. 636-640
    • Encode, P.C.1
  • 20
    • 34250330777 scopus 로고    scopus 로고
    • What is a gene, post-ENCODE? History and updated definition
    • Gerstein M.B., et al. What is a gene, post-ENCODE? History and updated definition. Genome Res. 2007, 17(6):669-681.
    • (2007) Genome Res. , vol.17 , Issue.6 , pp. 669-681
    • Gerstein, M.B.1
  • 21
    • 77952966689 scopus 로고    scopus 로고
    • Prediction of cancer outcome using DNA microarray technology: past, present and future
    • Gevaert O., De Moor B. Prediction of cancer outcome using DNA microarray technology: past, present and future. Expert Opin. Med. Diagn. 2009, 3:157-165.
    • (2009) Expert Opin. Med. Diagn. , vol.3 , pp. 157-165
    • Gevaert, O.1    De Moor, B.2
  • 22
    • 77949639406 scopus 로고    scopus 로고
    • Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS
    • Goertsches Robert H., et al. Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS. Pharmacogenomics 2010, 11(2):147-161.
    • (2010) Pharmacogenomics , vol.11 , Issue.2 , pp. 147-161
    • Goertsches, R.H.1
  • 23
    • 0242667881 scopus 로고    scopus 로고
    • Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult
    • Graumann U., et al. Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult. Brain Pathol. 2003, 13(4):554-573.
    • (2003) Brain Pathol. , vol.13 , Issue.4 , pp. 554-573
    • Graumann, U.1
  • 25
    • 84859006684 scopus 로고    scopus 로고
    • Network analysis of transcriptional regulation in response to intramuscular interferon-β-1a multiple sclerosis treatment
    • Available at: [Accessed January 24, 2012]
    • Hecker M., et al. Network analysis of transcriptional regulation in response to intramuscular interferon-β-1a multiple sclerosis treatment. Pharmacogenomics J. 2010, Available at: http://www.ncbi.nlm.nih.gov/pubmed/20956993 [Accessed January 24, 2012].
    • (2010) Pharmacogenomics J.
    • Hecker, M.1
  • 26
    • 3042513728 scopus 로고    scopus 로고
    • Gene expression profiling of relevant biomarkers for treatment evaluation in multiple sclerosis
    • Hong J., et al. Gene expression profiling of relevant biomarkers for treatment evaluation in multiple sclerosis. J. Neuroimmunol. 2004, 152(1-2):126-139.
    • (2004) J. Neuroimmunol. , vol.152 , Issue.1-2 , pp. 126-139
    • Hong, J.1
  • 27
    • 70249146903 scopus 로고    scopus 로고
    • Advantages of next-generation sequencing versus the microarray in epigenetic research
    • Hurd P.J., Nelson C.J. Advantages of next-generation sequencing versus the microarray in epigenetic research. Brief. Funct. Genomic. Proteomic. 2009, 8(3):174-183.
    • (2009) Brief. Funct. Genomic. Proteomic. , vol.8 , Issue.3 , pp. 174-183
    • Hurd, P.J.1    Nelson, C.J.2
  • 28
    • 1842687455 scopus 로고    scopus 로고
    • Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells
    • Iglesias A.H., Camelo S., Hwang D., Villanueva R., Stephanopoulos G., Dangond F. Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells. J. Neuroimmunol. 2004, 150:163-177.
    • (2004) J. Neuroimmunol. , vol.150 , pp. 163-177
    • Iglesias, A.H.1    Camelo, S.2    Hwang, D.3    Villanueva, R.4    Stephanopoulos, G.5    Dangond, F.6
  • 29
    • 27744569254 scopus 로고    scopus 로고
    • Frequency of blood CX3CR1-positive natural killer cells correlates with disease activity in multiple sclerosis patients
    • Infante-Duarte C., et al. Frequency of blood CX3CR1-positive natural killer cells correlates with disease activity in multiple sclerosis patients. FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol. 2005, 19(13):1902-1904.
    • (2005) FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol. , vol.19 , Issue.13 , pp. 1902-1904
    • Infante-Duarte, C.1
  • 30
    • 27744476769 scopus 로고    scopus 로고
    • Exploiting genotypic differences to identify genes important for EAE development
    • Jelinsky S.A., et al. Exploiting genotypic differences to identify genes important for EAE development. J. Neurol. Sci. 2005, 239(1):81-93.
    • (2005) J. Neurol. Sci. , vol.239 , Issue.1 , pp. 81-93
    • Jelinsky, S.A.1
  • 31
    • 15444364657 scopus 로고    scopus 로고
    • On the utility of pooling biological samples in microarray experiments
    • Kendziorski C., et al. On the utility of pooling biological samples in microarray experiments. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(12):4252-4257.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , Issue.12 , pp. 4252-4257
    • Kendziorski, C.1
  • 32
    • 0000884487 scopus 로고    scopus 로고
    • Experimental design for gene expression microarrays
    • (Jun)
    • Kerr M.K., Churchill G.A. Experimental design for gene expression microarrays. Biostatistics 2001, 2(2):183-201. (Jun).
    • (2001) Biostatistics , vol.2 , Issue.2 , pp. 183-201
    • Kerr, M.K.1    Churchill, G.A.2
  • 33
    • 0038546727 scopus 로고    scopus 로고
    • Microarray analysis identifies interferon beta-regulated genes in multiple sclerosis
    • Koike F., et al. Microarray analysis identifies interferon beta-regulated genes in multiple sclerosis. J. Neuroimmunol. 2003, 139(1-2):109-118.
    • (2003) J. Neuroimmunol. , vol.139 , Issue.1-2 , pp. 109-118
    • Koike, F.1
  • 34
    • 84873062128 scopus 로고    scopus 로고
    • ASBMB 38 (3) (December). Available at:
    • Kolle Gabriel Microarrays and alternative splicing ASBMB 38 (3) (December). Available at:. http://www.asbmb.org.au/magazine/2007-December_Issue38-3/Technical%20Feature%202%20-%20Kolle.pdf.
    • Microarrays and alternative splicing
    • Kolle, G.1
  • 35
    • 54049124109 scopus 로고    scopus 로고
    • The death of microarrays?
    • Ledford H. The death of microarrays?. Nature 2008, 455(7215):847.
    • (2008) Nature , vol.455 , Issue.7215 , pp. 847
    • Ledford, H.1
  • 36
    • 0034730124 scopus 로고    scopus 로고
    • Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridizations
    • Lee M.-L.T., et al. Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridizations. Proc. Natl. Acad. Sci. 2000, 97(18):9834-9839.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , Issue.18 , pp. 9834-9839
    • Lee, M.-L.T.1
  • 37
    • 10444280144 scopus 로고    scopus 로고
    • An extensive comparison of recent classification tools applied to microarray data
    • Lee J., et al. An extensive comparison of recent classification tools applied to microarray data. Comput. Stat. Data Anal. 2005, 48:869-885.
    • (2005) Comput. Stat. Data Anal. , vol.48 , pp. 869-885
    • Lee, J.1
  • 38
    • 33845437985 scopus 로고    scopus 로고
    • Transcriptional profiling of multiple sclerosis: towards improved diagnosis and treatment
    • Lindberg R.L., Kappos L. Transcriptional profiling of multiple sclerosis: towards improved diagnosis and treatment. Expert Rev. Mol. Diagn. 2006, 6(6):843-855.
    • (2006) Expert Rev. Mol. Diagn. , vol.6 , Issue.6 , pp. 843-855
    • Lindberg, R.L.1    Kappos, L.2
  • 39
    • 3042653294 scopus 로고    scopus 로고
    • Multiple sclerosis as a generalized CNS disease-comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS
    • Lindberg R.L.P., De Groot C.J.A., et al. Multiple sclerosis as a generalized CNS disease-comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS. J. Neuroimmunol. 2004, 152(1-2):154-167.
    • (2004) J. Neuroimmunol. , vol.152 , Issue.1-2 , pp. 154-167
    • Lindberg, R.L.P.1    De Groot, C.J.A.2
  • 40
    • 39849089879 scopus 로고    scopus 로고
    • Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients
    • Lindberg R.L.P., et al. Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients. J. Neuroimmunol. 2008, 194(1-2):153-164.
    • (2008) J. Neuroimmunol. , vol.194 , Issue.1-2 , pp. 153-164
    • Lindberg, R.L.P.1
  • 42
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C., Hermans G., et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002, 8(5):500-508.
    • (2002) Nat. Med. , vol.8 , Issue.5 , pp. 500-508
    • Lock, C.1    Hermans, G.2
  • 43
    • 4644343950 scopus 로고    scopus 로고
    • Autoimmunity gene expression portrait: specific signature that intersects or differentiates between multiple sclerosis and systemic lupus erythematosus
    • Mandel M., et al. Autoimmunity gene expression portrait: specific signature that intersects or differentiates between multiple sclerosis and systemic lupus erythematosus. Clin. Exp. Immunol. 2004, 138(1):164-170.
    • (2004) Clin. Exp. Immunol. , vol.138 , Issue.1 , pp. 164-170
    • Mandel, M.1
  • 45
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies - the next generation
    • Metzker M.L. Sequencing technologies - the next generation. Nat. Rev. Genet. 2010, 11(1):31-46.
    • (2010) Nat. Rev. Genet. , vol.11 , Issue.1 , pp. 31-46
    • Metzker, M.L.1
  • 46
    • 70350783877 scopus 로고    scopus 로고
    • Current and future applications of transcriptomics for discovery in CNS disease and injury
    • Munro K.M., Perreau V.M. Current and future applications of transcriptomics for discovery in CNS disease and injury. Neurosignals 2009, 17(4):311-327.
    • (2009) Neurosignals , vol.17 , Issue.4 , pp. 311-327
    • Munro, K.M.1    Perreau, V.M.2
  • 47
    • 0242432319 scopus 로고    scopus 로고
    • CDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity
    • Mycko M.P., Papoian R., et al. cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity. Brain: J. Neurol. 2003, 126(Pt 5):1048-1057.
    • (2003) Brain: J. Neurol. , vol.126 , Issue.PART 5 , pp. 1048-1057
    • Mycko, M.P.1    Papoian, R.2
  • 48
    • 2642539885 scopus 로고    scopus 로고
    • Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis
    • Mycko M.P., et al. Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis. Clin. Neurol. Neurosurg. 2004, 106(3):223-229.
    • (2004) Clin. Neurol. Neurosurg. , vol.106 , Issue.3 , pp. 223-229
    • Mycko, M.P.1
  • 49
    • 12244284624 scopus 로고    scopus 로고
    • DNA microarray experiments: biological and technological aspects
    • Nguyen D.V. DNA microarray experiments: biological and technological aspects. Biometrics 2002, 58:701-717.
    • (2002) Biometrics , vol.58 , pp. 701-717
    • Nguyen, D.V.1
  • 50
    • 0035363488 scopus 로고    scopus 로고
    • In vivo gene expression revealed by cDNA arrays: the pattern in relapsing-remitting multiple sclerosis patients compared with normal subjects
    • Ramanathan M., et al. In vivo gene expression revealed by cDNA arrays: the pattern in relapsing-remitting multiple sclerosis patients compared with normal subjects. J. Neuroimmunol. 2001, 116(2):213-219.
    • (2001) J. Neuroimmunol. , vol.116 , Issue.2 , pp. 213-219
    • Ramanathan, M.1
  • 51
    • 79955943425 scopus 로고    scopus 로고
    • Excessive biologic response to IFNβ is associated with poor treatment response in patients with multiple sclerosis
    • Rudick R.A., et al. Excessive biologic response to IFNβ is associated with poor treatment response in patients with multiple sclerosis. PLoS One 2011, 6(5):e19262.
    • (2011) PLoS One , vol.6 , Issue.5
    • Rudick, R.A.1
  • 53
    • 79952049316 scopus 로고    scopus 로고
    • Bioinformatics approach to identifying molecular biomarkers and networks in multiple sclerosis
    • Satoh J. Bioinformatics approach to identifying molecular biomarkers and networks in multiple sclerosis. Clin. Exp. Neuroimmunol. 2010, 1(3):127-140.
    • (2010) Clin. Exp. Neuroimmunol. , vol.1 , Issue.3 , pp. 127-140
    • Satoh, J.1
  • 54
    • 20044383560 scopus 로고    scopus 로고
    • Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis
    • Satoh J.-ichi, et al. Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis. Neurobiol. Dis. 2005, 18(3):537-550.
    • (2005) Neurobiol. Dis. , vol.18 , Issue.3 , pp. 537-550
    • Satoh, J.-I.1
  • 55
    • 0028806048 scopus 로고
    • Quantitative monitoring of gene expression patterns with a complementary DNA microarray
    • Schena M., et al. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995, 270(5235):467-470.
    • (1995) Science , vol.270 , Issue.5235 , pp. 467-470
    • Schena, M.1
  • 56
    • 77649283873 scopus 로고    scopus 로고
    • Time course transcriptomics of IFNB1b drug therapy in multiple sclerosis
    • Serrano-Fernández P., et al. Time course transcriptomics of IFNB1b drug therapy in multiple sclerosis. Autoimmunity 2010, 43(2):172-178.
    • (2010) Autoimmunity , vol.43 , Issue.2 , pp. 172-178
    • Serrano-Fernández, P.1
  • 58
    • 34447106755 scopus 로고    scopus 로고
    • Alternative splicing in cancer: noise, functional, or systematic?
    • Skotheim R.I., Nees M. Alternative splicing in cancer: noise, functional, or systematic?. Int. J. Biochem. Cell Biol. 2007, 39(7-8):1432-1449.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , Issue.7-8 , pp. 1432-1449
    • Skotheim, R.I.1    Nees, M.2
  • 59
    • 34548011757 scopus 로고    scopus 로고
    • Interpretation of microarray data: trudging out of the abyss towards elucidation of biological significance
    • Smith G.W., Rosa G.J.M. Interpretation of microarray data: trudging out of the abyss towards elucidation of biological significance. J. Anim. Sci. 2007, 85(Suppl. 13):E20-E23.
    • (2007) J. Anim. Sci. , vol.85 , Issue.SUPPL. 13
    • Smith, G.W.1    Rosa, G.J.M.2
  • 60
    • 0038692013 scopus 로고    scopus 로고
    • Expression profiling identifies responder and non-responder phenotypes to interferon-beta in multiple sclerosis
    • Stürzebecher S., Wandinger K.P., et al. Expression profiling identifies responder and non-responder phenotypes to interferon-beta in multiple sclerosis. Brain: J. Neurol. 2003, 126(Pt 6):1419-1429.
    • (2003) Brain: J. Neurol. , vol.126 , Issue.PART 6 , pp. 1419-1429
    • Stürzebecher, S.1    Wandinger, K.P.2
  • 61
    • 79951676513 scopus 로고    scopus 로고
    • Prognosis prediction by microarray gene expression using support vector machine
    • Tago C., Okamoto M., Hanai T. Prognosis prediction by microarray gene expression using support vector machine. Genome Inform. 2003, 14:324-325.
    • (2003) Genome Inform. , vol.14 , pp. 324-325
    • Tago, C.1    Okamoto, M.2    Hanai, T.3
  • 62
    • 0242643562 scopus 로고    scopus 로고
    • Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis
    • Tajouri L., et al. Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis. Brain Res. Mol. Brain Res. 2003, 119(2):170-183.
    • (2003) Brain Res. Mol. Brain Res. , vol.119 , Issue.2 , pp. 170-183
    • Tajouri, L.1
  • 63
    • 78650975552 scopus 로고    scopus 로고
    • Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects
    • Tian Y., et al. Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects. J. Neuroimmunol. 2011, 230(1-2):124-129.
    • (2011) J. Neuroimmunol. , vol.230 , Issue.1-2 , pp. 124-129
    • Tian, Y.1
  • 64
    • 0037076272 scopus 로고    scopus 로고
    • Diagnosis of multiple cancer types by shrunken centroids of gene expression
    • Tibshirani R., et al. Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc. Natl. Acad. Sci. 2002, 99(10):6567-6572.
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , Issue.10 , pp. 6567-6572
    • Tibshirani, R.1
  • 65
    • 33748295732 scopus 로고    scopus 로고
    • A subtype of multiple sclerosis defined by an activated immune defense program
    • van Baarsen L.G.M., et al. A subtype of multiple sclerosis defined by an activated immune defense program. Genes Immun. 2006, 7(6):522-531.
    • (2006) Genes Immun. , vol.7 , Issue.6 , pp. 522-531
    • van Baarsen, L.G.M.1
  • 66
    • 44849128066 scopus 로고    scopus 로고
    • Pharmacogenomics of interferon-beta therapy in multiple sclerosis: baseline IFN signature determines pharmacological differences between patients
    • van Baarsen Lisa G.M., et al. Pharmacogenomics of interferon-beta therapy in multiple sclerosis: baseline IFN signature determines pharmacological differences between patients. PLoS One 2008, 3(4):e1927.
    • (2008) PLoS One , vol.3 , Issue.4
    • van Baarsen, L.G.M.1
  • 67
    • 0034855936 scopus 로고    scopus 로고
    • Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes
    • Wandinger K.P., Stürzebecher C.S., et al. Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes. Ann. Neurol. 2001, 50(3):349-357.
    • (2001) Ann. Neurol. , vol.50 , Issue.3 , pp. 349-357
    • Wandinger, K.P.1    Stürzebecher, C.S.2
  • 68
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: a revolutionary tool for transcriptomics
    • Wang Z., Gerstein M., Snyder M. RNA-Seq: a revolutionary tool for transcriptomics. Nat. Rev. Genet. 2009, 10(1):57-63.
    • (2009) Nat. Rev. Genet. , vol.10 , Issue.1 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 69
    • 0042930859 scopus 로고    scopus 로고
    • Genomic effects of IFN-beta in multiple sclerosis patients
    • Weinstock-Guttman B., et al. Genomic effects of IFN-beta in multiple sclerosis patients. J. Immunol. 2003, 171(5):2694-2702.
    • (2003) J. Immunol. , vol.171 , Issue.5 , pp. 2694-2702
    • Weinstock-Guttman, B.1
  • 70
    • 0032882174 scopus 로고    scopus 로고
    • Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays
    • Whitney L.W., et al. Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann. Neurol. 1999, 46(3):425-428.
    • (1999) Ann. Neurol. , vol.46 , Issue.3 , pp. 425-428
    • Whitney, L.W.1
  • 71
    • 0035803832 scopus 로고    scopus 로고
    • Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions
    • Whitney L.W., Ludwin S.K., McFarland H.F., Biddison W.E. Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions. J. Neuroimmunol. 2001, 121:40-48.
    • (2001) J. Neuroimmunol. , vol.121 , pp. 40-48
    • Whitney, L.W.1    Ludwin, S.K.2    McFarland, H.F.3    Biddison, W.E.4
  • 72
    • 0035881251 scopus 로고    scopus 로고
    • Combinatorial peptide libraries and biometric score matrices permit the quantitative analysis of specific and degenerate interactions between clonotypic TCR and MHC peptide ligands
    • Zhao Y., Gran B., et al. Combinatorial peptide libraries and biometric score matrices permit the quantitative analysis of specific and degenerate interactions between clonotypic TCR and MHC peptide ligands. J. Immunol. 2001, 167(4):2130-2141.
    • (2001) J. Immunol. , vol.167 , Issue.4 , pp. 2130-2141
    • Zhao, Y.1    Gran, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.