메뉴 건너뛰기




Volumn 56, Issue 7, 2012, Pages 3785-3796

Potent synergistic effect of doxycycline with fluconazole against Candida albicans is mediated by interference with iron homeostasis

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; DOXYCYCLINE; FLUCONAZOLE; FUNGAL PROTEIN; IRON;

EID: 84862576549     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.06017-11     Document Type: Article
Times cited : (89)

References (62)
  • 1
    • 22744455661 scopus 로고    scopus 로고
    • An update on antifungal targets and mechanisms of resistance in Candida albicans
    • Akins RA. 2005. An update on antifungal targets and mechanisms of resistance in Candida albicans. Med. Mycol. 43:285-318.
    • (2005) Med. Mycol. , vol.43 , pp. 285-318
    • Akins, R.A.1
  • 2
    • 57149114313 scopus 로고    scopus 로고
    • The hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin
    • doi:10.1371/journal.ppat.1000217
    • Almeida RS, et al. 2008. The hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLoS Pathog. 4:e1000217. doi:10.1371/journal.ppat.1000217.
    • (2008) PLoS Pathog. , vol.4
    • Almeida, R.S.1
  • 3
    • 0034666186 scopus 로고    scopus 로고
    • Evaluation of the CaMAL2 promoter for regulated expression of genes in Candida albicans
    • Backen AC, et al. 2000. Evaluation of the CaMAL2 promoter for regulated expression of genes in Candida albicans. Yeast 16:1121-1129.
    • (2000) Yeast , vol.16 , pp. 1121-1129
    • Backen, A.C.1
  • 4
    • 33744504444 scopus 로고    scopus 로고
    • Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1
    • Balashov SV, Park S, Perlin DS. 2006. Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1. Antimicrob. Agents Chemother. 50:2058-2063.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 2058-2063
    • Balashov, S.V.1    Park, S.2    Perlin, D.S.3
  • 5
    • 1842577512 scopus 로고    scopus 로고
    • GFP as a quantitative reporter of gene regulation in Candida albicans
    • Barelle CJ, et al. 2004. GFP as a quantitative reporter of gene regulation in Candida albicans. Yeast 21:333-340.
    • (2004) Yeast , vol.21 , pp. 333-340
    • Barelle, C.J.1
  • 6
    • 0036895608 scopus 로고    scopus 로고
    • Candida albicans: A molecular revolution built on lessons from budding yeast
    • Berman J, Sudbery PE. 2002. Candida albicans: a molecular revolution built on lessons from budding yeast. Nat. Rev. Genet. 3:918-930.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 918-930
    • Berman, J.1    Sudbery, P.E.2
  • 7
    • 77955617560 scopus 로고    scopus 로고
    • A human-curated annotation of the Candida albicans genome
    • Braun BR, et al. 2005. A human-curated annotation of the Candida albicans genome. PLoS Genet. 1:36-57.
    • (2005) PLoS Genet. , vol.1 , pp. 36-57
    • Braun, B.R.1
  • 8
    • 0037347350 scopus 로고    scopus 로고
    • Minimum fungicidal concentrations of amphotericin B for bloodstream Candida species
    • Canton E, et al. 2003. Minimum fungicidal concentrations of amphotericin B for bloodstream Candida species. Diagn. Microbiol. Infect. Dis. 45:203-206.
    • (2003) Diagn. Microbiol. Infect. Dis. , vol.45 , pp. 203-206
    • Canton, E.1
  • 9
    • 0034973583 scopus 로고    scopus 로고
    • Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance
    • Chopra I, Roberts M. 2001. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol. Mol. Biol. Rev. 65:232-260.
    • (2001) Microbiol. Mol. Biol. Rev. , vol.65 , pp. 232-260
    • Chopra, I.1    Roberts, M.2
  • 10
    • 62949225044 scopus 로고    scopus 로고
    • Clinical and Laboratory Standards Institute. Approved standard M27-A3, 3rd ed. Clinical and Laboratory Standards Institute, Wayne, PA
    • Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard M27-A3, 3rd ed. Clinical and Laboratory Standards Institute, Wayne, PA.
    • (2008) Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts
  • 11
    • 35348903338 scopus 로고    scopus 로고
    • Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates
    • Coste A, et al. 2007. Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates. Eukaryot. Cell 6:1889-1904.
    • (2007) Eukaryot. Cell , vol.6 , pp. 1889-1904
    • Coste, A.1
  • 12
    • 37549014195 scopus 로고    scopus 로고
    • Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51
    • Craven RJ, Mallory JC, Hand RA. 2007. Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51. J. Biol. Chem. 282:36543-36551.
    • (2007) J. Biol. Chem. , vol.282 , pp. 36543-36551
    • Craven, R.J.1    Mallory, J.C.2    Hand, R.A.3
  • 13
    • 0037083792 scopus 로고    scopus 로고
    • Calcineurin is essential for survival during membrane stress in Candida albicans
    • Cruz MC, et al. 2002. Calcineurin is essential for survival during membrane stress in Candida albicans. EMBO J. 21:546-559.
    • (2002) EMBO J. , vol.21 , pp. 546-559
    • Cruz, M.C.1
  • 14
    • 3042771191 scopus 로고    scopus 로고
    • Shuttle vectors for Candida albicans: Control of plasmid copy number and elevated expression of cloned genes
    • Du W, Coaker M, Sobel JD, Akins RA. 2004. Shuttle vectors for Candida albicans: control of plasmid copy number and elevated expression of cloned genes. Curr. Genet. 45:390-398.
    • (2004) Curr. Genet. , vol.45 , pp. 390-398
    • Du, W.1    Coaker, M.2    Sobel, J.D.3    Akins, R.A.4
  • 15
    • 70350463600 scopus 로고    scopus 로고
    • A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections
    • Enjalbert B, et al. 2009. A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections. Infect. Immun. 77:4847-4858.
    • (2009) Infect. Immun. , vol.77 , pp. 4847-4858
    • Enjalbert, B.1
  • 16
    • 20344370498 scopus 로고    scopus 로고
    • Susceptibility testing methods of antifungal agents
    • Ernst EJ. 2005. Susceptibility testing methods of antifungal agents. Methods Mol. Med. 118:3-12.
    • (2005) Methods Mol. Med. , vol.118 , pp. 312
    • Ernst, E.J.1
  • 17
    • 0027192868 scopus 로고
    • Isogenic strain construction and gene mapping in Candida albicans
    • Fonzi WA, Irwin MY. 1983. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
    • (1983) Genetics , vol.134 , pp. 717-728
    • Fonzi, W.A.1    Irwin, M.Y.2
  • 18
    • 0024266139 scopus 로고
    • New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
    • Gietz RD, Sugino A. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534.
    • (1988) Gene , vol.74 , pp. 527-534
    • Gietz, R.D.1    Sugino, A.2
  • 19
    • 0021742042 scopus 로고
    • Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
    • Gillum AM, Tsay EY, Kirsch DR. 1984. Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol. Gen. Genet. 198:179-182.
    • (1984) Mol. Gen. Genet. , vol.198 , pp. 179-182
    • Gillum, A.M.1    Tsay, E.Y.2    Kirsch, D.R.3
  • 20
    • 0033996306 scopus 로고    scopus 로고
    • Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics
    • Grenier D, Huot MP, Mayrand D. 2000. Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics. Antimicrob. Agents Chemother. 44:763-766.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 763-766
    • Grenier, D.1    Huot, M.P.2    Mayrand, D.3
  • 21
    • 79251631666 scopus 로고    scopus 로고
    • Tetracycline compounds with non-antimicrobial organ protective properties: Possible mechanisms of action
    • Griffin MO, Ceballos G, Villarreal FJ. 2011. Tetracycline compounds with non-antimicrobial organ protective properties: possible mechanisms of action. Pharmacol. Res. 63:102-107.
    • (2011) Pharmacol. Res. , vol.63 , pp. 102-107
    • Griffin, M.O.1    Ceballos, G.2    Villarreal, F.J.3
  • 22
    • 0035839062 scopus 로고    scopus 로고
    • Molecular evidence for the early colonization of land by fungi and plants
    • Heckman DS, et al. 2001. Molecular evidence for the early colonization of land by fungi and plants. Science 293:1129-1133.
    • (2001) Science , vol.293 , pp. 1129-1133
    • Heckman, D.S.1
  • 24
    • 0027739728 scopus 로고
    • Molecular genetic analysis of azole antifungal mode of action
    • Kelly SL, Arnoldi A, Kelly DE. 1993. Molecular genetic analysis of azole antifungal mode of action. Biochem. Soc. Trans. 21:1034-1038.
    • (1993) Biochem. Soc. Trans. , vol.21 , pp. 1034-1038
    • Kelly, S.L.1    Arnoldi, A.2    Kelly, D.E.3
  • 25
    • 0032748417 scopus 로고    scopus 로고
    • Overexpression of Erg11p by the regulatable GAL1 promoter confers fluconazole resistance in Saccharomyces cerevisiae
    • Kontoyiannis DP, Sagar N, Hirschi KD. 1999. Overexpression of Erg11p by the regulatable GAL1 promoter confers fluconazole resistance in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 43:2798-2800.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 2798-2800
    • Kontoyiannis, D.P.1    Sagar, N.2    Hirschi, K.D.3
  • 26
    • 4444300862 scopus 로고    scopus 로고
    • Regulatory networks affected by iron availability in Candida albicans
    • Lan CY, et al. 2004. Regulatory networks affected by iron availability in Candida albicans. Mol. Microbiol. 53:1451-1469.
    • (2004) Mol. Microbiol. , vol.53 , pp. 1451-1469
    • Lan, C.Y.1
  • 27
    • 63849233258 scopus 로고    scopus 로고
    • The changing face of epidemiology of invasive fungal disease in Europe
    • Lass-Florl C. 2009. The changing face of epidemiology of invasive fungal disease in Europe. Mycoses 52:197-205.
    • (2009) Mycoses , vol.52 , pp. 197-205
    • Lass-Florl, C.1
  • 28
    • 33645755409 scopus 로고    scopus 로고
    • Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole
    • Lepak A, et al. 2006. Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole. Antimicrob. Agents Chemother. 50:1311-1319.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 1311-1319
    • Lepak, A.1
  • 29
    • 0030970379 scopus 로고    scopus 로고
    • Sequence and promoter regulation of the PCK1 gene encoding phosphoenolpyruvate carboxykinase of the fungal pathogen Candida albicans
    • Leuker CE, Sonneborn A, Delbruck S, Ernst JF. 1997. Sequence and promoter regulation of the PCK1 gene encoding phosphoenolpyruvate carboxykinase of the fungal pathogen Candida albicans. Gene 192:235-240.
    • (1997) Gene , vol.192 , pp. 235-240
    • Leuker, C.E.1    Sonneborn, A.2    Delbruck, S.3    Ernst, J.F.4
  • 30
    • 67650433788 scopus 로고    scopus 로고
    • Overview of the changing epidemiology of candidemia
    • Lewis RE. 2009. Overview of the changing epidemiology of candidemia. Curr. Med. Res. Opin. 25:1732-1740.
    • (2009) Curr. Med. Res. Opin. , vol.25 , pp. 1732-1740
    • Lewis, R.E.1
  • 31
    • 77950180902 scopus 로고    scopus 로고
    • Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection
    • MacCallum DM, et al. 2010. Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. Antimicrob. Agents Chemother. 54:1476-1483.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1476-1483
    • MacCallum, D.M.1
  • 32
    • 0032216576 scopus 로고    scopus 로고
    • Synergic effects of tacrolimus and azole antifungal agents against azole-resistant Candida albicans strains
    • Maesaki S, et al. 1998. Synergic effects of tacrolimus and azole antifungal agents against azole-resistant Candida albicans strains. J. Antimicrob. Chemother. 42:747-753.
    • (1998) J. Antimicrob. Chemother. , vol.42 , pp. 747-753
    • Maesaki, S.1
  • 33
    • 14044252188 scopus 로고    scopus 로고
    • Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae
    • Mallory JC, et al. 2005. Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae. Mol. Cell. Biol. 25:1669-1679.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 1669-1679
    • Mallory, J.C.1
  • 34
    • 0033836026 scopus 로고    scopus 로고
    • Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans
    • Marchetti O, et al. 2000. Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans . Antimicrob. Agents Chemother. 44:2373-2381.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2373-2381
    • Marchetti, O.1
  • 35
    • 0030761555 scopus 로고    scopus 로고
    • Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation
    • Marr KA, White TC, van Burik JA, Bowden RA. 1997. Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation. Clin. Infect. Dis. 25:908-910.
    • (1997) Clin. Infect. Dis. , vol.25 , pp. 908-910
    • Marr, K.A.1    White, T.C.2    Van Burik, J.A.3    Bowden, R.A.4
  • 36
    • 0032145257 scopus 로고    scopus 로고
    • Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids: Expression vectors with bi-directional promoters for use in Saccharomyces cerevisiae
    • Miller CA, Martinat MA, Hyman LE. 1998. Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids: expression vectors with bi-directional promoters for use in Saccharomyces cerevisiae. Nucleic Acids Res. 26:3577-3583.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 3577-3583
    • Miller, C.A.1    Martinat, M.A.2    Hyman, L.E.3
  • 37
    • 0037130284 scopus 로고    scopus 로고
    • The genetic basis of fluconazole resistance development in Candida albicans
    • Morschhauser J. 2002. The genetic basis of fluconazole resistance development in Candida albicans. Biochim. Biophys. Acta 1587:240-248.
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 240-248
    • Morschhauser, J.1
  • 38
    • 0034653201 scopus 로고    scopus 로고
    • CIp10, an efficient and convenient integrating vector for Candida albicans
    • Murad AM, et al. 2000. CIp10, an efficient and convenient integrating vector for Candida albicans. Yeast 16:325-327.
    • (2000) Yeast , vol.16 , pp. 325-327
    • Murad, A.M.1
  • 39
    • 0034351185 scopus 로고    scopus 로고
    • Tetracycline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicans
    • Nakayama H, et al. 2000. Tetracycline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicans. Infect. Immun. 68:6712-6719.
    • (2000) Infect. Immun. , vol.68 , pp. 6712-6719
    • Nakayama, H.1
  • 40
    • 0032198174 scopus 로고    scopus 로고
    • Chemical and biological dynamics of tetracyclines
    • Nelson ML. 1998. Chemical and biological dynamics of tetracyclines. Adv. Dent. Res. 12:5-11.
    • (1998) Adv. Dent. Res. , vol.12 , pp. 5-11
    • Nelson, M.L.1
  • 41
    • 44449137688 scopus 로고    scopus 로고
    • Genetics of Candida albicans, a diploid human fungal pathogen
    • Noble SM, Johnson AD. 2007. Genetics of Candida albicans, a diploid human fungal pathogen. Annu. Rev. Genet. 41:193-211.
    • (2007) Annu. Rev. Genet. , vol.41 , pp. 193-211
    • Noble, S.M.1    Johnson, A.D.2
  • 42
    • 0038601510 scopus 로고    scopus 로고
    • Synergy, antagonism, and what the chequerboard puts between them
    • Odds FC. 2003. Synergy, antagonism, and what the chequerboard puts between them. J. Antimicrob. Chemother. 52:1.
    • (2003) J. Antimicrob. Chemother. , vol.52 , pp. 1
    • Odds, F.C.1
  • 43
    • 84907125780 scopus 로고
    • Improved method for estimation of azole antifungal inhibitory concentrations against Candida species, based on azole/antibiotic interactions
    • Odds FC, Abbott AB, Pye G, Troke PF. 1986. Improved method for estimation of azole antifungal inhibitory concentrations against Candida species, based on azole/antibiotic interactions. J. Med. Vet. Mycol. 24:305-311.
    • (1986) J. Med. Vet. Mycol. , vol.24 , pp. 305-311
    • Odds, F.C.1    Abbott, A.B.2    Pye, G.3    Troke, P.F.4
  • 44
    • 42949138135 scopus 로고    scopus 로고
    • Tetracycline alters drug susceptibility in Candida albicans and other pathogenic fungi
    • Oliver BG, et al. 2008. Tetracycline alters drug susceptibility in Candida albicans and other pathogenic fungi. Microbiology 154:960-970.
    • (2008) Microbiology , vol.154 , pp. 960-970
    • Oliver, B.G.1
  • 45
    • 77956343542 scopus 로고    scopus 로고
    • An insight into the antifungal pipeline: Selected new molecules and beyond
    • Ostrosky-Zeichner L, et al. 2010. An insight into the antifungal pipeline: selected new molecules and beyond. Nat. Rev. Drug Discov. 9:719-727.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 719-727
    • Ostrosky-Zeichner, L.1
  • 46
    • 23844485512 scopus 로고    scopus 로고
    • Tetracycline-inducible gene expression and gene deletion in Candida albicans
    • Park YN, Morschhauser J. 2005. Tetracycline-inducible gene expression and gene deletion in Candida albicans. Eukaryot. Cell 4:1328-1342.
    • (2005) Eukaryot. Cell , vol.4 , pp. 1328-1342
    • Park, Y.N.1    Morschhauser, J.2
  • 47
    • 0034812585 scopus 로고    scopus 로고
    • Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients
    • Perea S, et al. 2001. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 45:2676-2684.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2676-2684
    • Perea, S.1
  • 48
    • 33846466508 scopus 로고    scopus 로고
    • Epidemiology of invasive candidiasis: A persistent public health problem
    • Pfaller MA, Diekema DJ. 2007. Epidemiology of invasive candidiasis: a persistent public health problem. Clin. Microbiol. Rev. 20:133-163.
    • (2007) Clin. Microbiol. Rev. , vol.20 , pp. 133-163
    • Pfaller, M.A.1    Diekema, D.J.2
  • 49
    • 0031876866 scopus 로고    scopus 로고
    • Evaluation of the Etest method for determining fluconazole susceptibilities of 402 clinical yeast isolates by using three different agar media
    • Pfaller MA, Messer SA, Karlsson A, Bolmstrom A. 1998. Evaluation of the Etest method for determining fluconazole susceptibilities of 402 clinical yeast isolates by using three different agar media. J. Clin. Microbiol. 36:2586-2589.
    • (1998) J. Clin. Microbiol. , vol.36 , pp. 2586-2589
    • Pfaller, M.A.1    Messer, S.A.2    Karlsson, A.3    Bolmstrom, A.4
  • 50
    • 2042454166 scopus 로고    scopus 로고
    • Determination of fungicidal activities against yeasts and molds: Lessons learned from bactericidal testing and the need for standardization
    • Pfaller MA, Sheehan DJ, Rex JH. 2004. Determination of fungicidal activities against yeasts and molds: lessons learned from bactericidal testing and the need for standardization. Clin. Microbiol. Rev. 17:268-280.
    • (2004) Clin. Microbiol. Rev. , vol.17 , pp. 268-280
    • Pfaller, M.A.1    Sheehan, D.J.2    Rex, J.H.3
  • 51
    • 33750601648 scopus 로고    scopus 로고
    • Unexpected link between iron and drug resistance of Candida spp.: Iron depletion enhances membrane fluidity and drug diffusion, leading to drug-susceptible cells
    • Prasad T, Chandra A, Mukhopadhyay CK, Prasad R. 2006. Unexpected link between iron and drug resistance of Candida spp.: iron depletion enhances membrane fluidity and drug diffusion, leading to drug-susceptible cells. Antimicrob. Agents Chemother. 50:3597-3606.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3597-3606
    • Prasad, T.1    Chandra, A.2    Mukhopadhyay, C.K.3    Prasad, R.4
  • 52
    • 0034640466 scopus 로고    scopus 로고
    • A high-affinity iron permease essential for Candida albicans virulence
    • Ramanan N, Wang Y. 2000. A high-affinity iron permease essential for Candida albicans virulence. Science 288:1062-1064.
    • (2000) Science , vol.288 , pp. 1062-1064
    • Ramanan, N.1    Wang, Y.2
  • 53
    • 0033779701 scopus 로고    scopus 로고
    • Calcineurin: Form and function
    • Rusnak F, Mertz P. 2000. Calcineurin: form and function. Physiol. Rev. 80:1483-1521.
    • (2000) Physiol. Rev. , vol.80 , pp. 1483-1521
    • Rusnak, F.1    Mertz, P.2
  • 54
    • 0035031111 scopus 로고    scopus 로고
    • Excessive matrix metalloproteinase activity in diabetes: Inhibition by tetracycline analogues with zinc reactivity
    • Ryan ME, et al. 2001. Excessive matrix metalloproteinase activity in diabetes: inhibition by tetracycline analogues with zinc reactivity. Curr. Med. Chem. 8:305-316.
    • (2001) Curr. Med. Chem. , vol.8 , pp. 305-316
    • Ryan, M.E.1
  • 55
    • 0031938057 scopus 로고    scopus 로고
    • Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
    • Sanglard D, Ischer F, Koymans L, Bille J. 1998. Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents. Antimicrob. Agents Chemother. 42:241-253.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 241-253
    • Sanglard, D.1    Ischer, F.2    Koymans, L.3    Bille, J.4
  • 56
    • 0038016755 scopus 로고    scopus 로고
    • Calcineurin A of Candida albicans: Involvement in antifungal tolerance, cell morphogenesis and virulence
    • Sanglard D, et al. 2003. Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence. Mol. Microbiol. 48:959-976.
    • (2003) Mol. Microbiol. , vol.48 , pp. 959-976
    • Sanglard, D.1
  • 57
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
    • Sanglard D, et al. 1995. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39:2378-2386.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 2378-2386
    • Sanglard, D.1
  • 58
    • 41749113291 scopus 로고    scopus 로고
    • An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
    • Selmecki A, et al. 2008. An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1. Mol. Microbiol. 68:624-641.
    • (2008) Mol. Microbiol. , vol.68 , pp. 624-641
    • Selmecki, A.1
  • 59
    • 79958060479 scopus 로고    scopus 로고
    • Regulatory circuitry governing fungal development, drug resistance, and disease
    • Shapiro RS, Robbins N, Cowen LE. 2011. Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiol. Mol. Biol. Rev. 75:213-267.
    • (2011) Microbiol. Mol. Biol. Rev. , vol.75 , pp. 213-267
    • Shapiro, R.S.1    Robbins, N.2    Cowen, L.E.3
  • 60
    • 0036275447 scopus 로고    scopus 로고
    • Getting started with yeast
    • Sherman F. 2002. Getting started with yeast. Methods Enzymol. 350:3-41.
    • (2002) Methods Enzymol. , vol.350 , pp. 3-41
    • Sherman, F.1
  • 61
    • 0027195259 scopus 로고
    • A general suppressor of RNA polymerase I, II and III mutations in Saccharomyces cerevisiae
    • Stettler S, et al. 1993. A general suppressor of RNA polymerase I, II and III mutations in Saccharomyces cerevisiae. Mol. Gen. Genet. 239:169-176.
    • (1993) Mol. Gen. Genet. , vol.239 , pp. 169-176
    • Stettler, S.1
  • 62
    • 0030757227 scopus 로고    scopus 로고
    • Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    • White TC. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 41:1482-1487.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1482-1487
    • White, T.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.