Sequence and promoter regulation of the PCK1 gene encoding phosphoenolpyruvate carboxykinase of the fungal pathogen Candida albicans

Gene

Volumn 192, Issue 2, 1997, Pages 235-240

  Leuker, Christoph E ^a   Sonneborn, Anja ^a   Delbrück, Sebastian ^a   Ernst, Joachim F ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Candida albicans; PCK1; PEP carboxykinase; Regulation; Transcription

Indexed keywords

CARBON; FUNGAL DNA; GLUCOSE; PHOSPHOPYRUVATE CARBOXYLASE;

ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE FUSION; GENE ISOLATION; GENE REPRESSION; GENETIC TRANSCRIPTION; GLUCONEOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CANDIDA ALBICANS; CULTURE MEDIA; DOWN-REGULATION; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; MOLECULAR SEQUENCE DATA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROMOTER REGIONS (GENETICS); SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0030970379     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(97)00069-3     Document Type: Article

References (26)

1. Bennetzen, J.L., Hall, B.D., 1982. Codon selection in yeast. J. Biol. Chem. 257, 3026-3031.
2. Brown Jr., D.H., Slobodkin, I.V., Kumamoto, C.A., 1996. Stable transformation and regulated expression of an inducible reporter construct in Candida albicans using restriction enzyme-mediated integration. Mol. Gen. Genet. 251, 75-80.
3. Burlini, N., Morandi, S., Tortora, P., Guerritore, A., 1989. Studies on the degradation mechanism of phosphoeno/pyruvate carboxykinase from the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta 1014, 153-161.
4. Cannon, R.D., Jenkinson, H.F., Shepherd, M.G., 1992. Cloning and expression of Candida albicans ADE2 and proteinase genes on a replicative plasmid in C. albicans and in Saccharomyces cerevisiae. Mol. Gen. Genet. 235, 453-457.
5. Christianson, T.W., Sikorski, R.S., Dante, M., Shero, J.H., Hieter, P., 1992. Multifunctional yeast high-copy-number shuttle vectors. Gene 110, 119-122.
6. Delbrück, S., Ernst, J.F., 1993. Morphogenesis-independent regulation of actin transcript levels in the pathogenic yeast Candida albicans. Mol. Microbiol. 10, 859-866.
7. Encinas, M.V., Rojas, M.C., Goldie, H., Cardemil, E., 1993. Comparative steady-state fluorescence studies of cytosolic rat liver (GTP), Saccharomyces cerevisiae (ATP) and Escherichia coli (ATP) phosphoeno/pyruvate carboxykinase. Biochim. Biophys. Acta 1162, 195-202.
8. Finnegan, P.M., Burnell, J.N., 1995. Isolation and sequence analysis of cDNAs encoding phosphoeno/pyruvate carboxykinase from the PCK-type C4 grass Urochloa panicoides. Plant Mol. Biol. 27, 365-376.
9. Fonzi, W.A., Irwin, M.Y., 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134, 717-728.
10. Jones, E.W., 1990. Vacuolar proteases in yeast Saccharomyces cerevisiae. Meth. Enzymol. 185, 372-386.
11. Kelly, R., Miller, S.M., Kurtz, M.B., 1988. One-step gene disruption by cotransformation to isolate double auxotrophs in Candida albicans. Mol. Gen. Genet. 214, 24-31.
12. Krautwurst, H., Encinas, M.V., Marcus, F., Latshaw, S.P., Kemp, R.G., Frey, P.A., Cardemil, E., 1995. Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase: revised amino acid sequence, site-directed mutagenesis, and microenvironmental characteristics of cysteines 365 and 458. Biochemistry 34, 6382-6388.
13. Leuker, C. E., Hahn, A.-M., Ernst, J.F., 1992. b-Galactosidase of Kluyveromyces lactis (Lac4p) as reporter of gene expression in Candida albicans and C. tropicalis. Mol. Gen. Genet. 235, 235-241.
14. Scherer, S., Magee, P.T., 1990. Genetics of Candida albicans. Microbiol. Rev. 54, 226-241.
15. Medina, V., Pontarolla, R., Glaeske, D., label, H., Goldie, H., 1990. Sequence of the pckA gene of Escherichia coli K12: relevance to genetic and allosteric regulation and homology of E. coli phosphoenolpyruvate carboxykinase with the enzymes from Trypanosoma brucei and Saccharomyces cerevisiae. J. Bacteriol. 172, 7151-7156.
16. Mercado, J.J., Smith, R., Sagliocco, F.A., Brown, A.J.P., Gancedo, J.M., 1994. The levels of yeast gluconeogenetic mRNAs respond to environmental factors. Eur. J. Biochem. 224, 473-481.
17. Odds, F.C., Candida and Candidosis, Baillière Tindall, London, 1988.
18. Proft, M., Grzesitza, D., Entian, K.-D., 1995. Identification and characterization of regulatory elements in the phosphoeno/pyruvate carboxykinase gene PCK1 of Saccharomyces cerevisiae. Mol. Gen. Genet. 246, 367-373.
19. Sanglard, D., Ischer, F., Monod, M., Bille, J., 1996. Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob. Agents Chemother. 40, 2300-2306.
20. Schöler, A., Schüller, H.-J., 1994. A carbon source-responsive promoter element necessary for activation of the isocitrate lyase gene ICL1 is common to genes of the gluconeogenetic pathway in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 14, 3613-3622.
21. Saez-Vasquez, J., Raynal, M., Delseny, M., 1995. A rapeseed cold-inducible transcript encodes a phosphoeno/pyruvate carboxykinase. Plant Physiol. 109, 611-618.
22. Sambrook, J., Fritsch, E.R., Maniatis, T., Molecular Cloning. A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
23. Sherman, F., Fink, G., Hicks, J., Methods in Yeast Genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1986.
24. Srikantha, T., Klapach, A., Lorenz, W.W., Tsai, L.K., Laughlin, L.A., Gorman, J.A., Soll, D.R., 1996. The sea pansy Renilla reniformis luciferase serves as a sensitive bioluminescent reporter for differential gene expression in Candida albicans. J. Bacteriol. 178, 121-129.
25. Stucka, R., Valdés-Hevia, M.D., Gancedo, C., Schwarzlose, C., Feldmann, H., 1988. Nucleotide sequence of the phosphoeno/pyruvate carboxykinase gene from Saccharomyces cerevisiae. Nucleic Acids Res. 16, 10926.
26. Viera, J., Messing, J., 1991. New pUC-derived cloning vectors with different selectable markers and DNA replication origins. Gene 100, 189-194.