Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weights

Journal of Ethnopharmacology

Volumn 123, Issue 3, 2009, Pages 407-412

  Yang, Chih Min ^a   Zhou, Yu Jie ^a   Wang, Ran Juh ^b   Hu, Miao Lin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b FISHERIES RESEARCH INSTITUTE   (Taiwan)

Author keywords

Angiogenesis; Antrodia cinnamomea; Immunomodulation; Polysaccharides; Vascular endothelial growth factor

Indexed keywords

ANTRODIA CINNAMOMEA EXTRACT; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 8; MATRIGEL; POLYSACCHARIDE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HL 60; CHORIOALLANTOIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; LEUKEMIA CELL; MOLECULAR WEIGHT; MONONUCLEAR CELL; MUSHROOM; MYCELIUM; NEOVASCULARIZATION (PATHOLOGY); TAIWAN; UMBILICAL VEIN;

ANGIOGENESIS INHIBITORS; ANTRODIA; CELL LINE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOLOGIC FACTORS; INTERFERON-GAMMA; INTERLEUKIN-12; LEUKEMIA; MOLECULAR WEIGHT; MYCELIUM; NEOVASCULARIZATION, PATHOLOGIC; PLANT EXTRACTS; POLYSACCHARIDES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANTRODIA CINNAMOMEA; BASIDIOMYCOTA;

EID: 67349185576     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.03.034     Document Type: Article

References (30)

1. Borchers A.T., Keen C.L., and Gershwin M.E. Mushrooms, tumors, and immunity: an update. Experimental Biology and Medicine (Maywood, N.J.) 229 (2004) 393-406
2. Chen H.S., Tsai Y.F., Lin S., Lin C.C., Khoo K.H., Lin C.H., and Wong C.H. Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorganic & Medicinal Chemistry 12 (2004) 5595-5601
3. Chen C.H., Yang S.W., and Shen Y.C. New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum. Journal of Natural Products 58 (1995) 1655-1661
4. Cheng J.J., Huang N.K., Chang T.T., Wang D.L., and Lu M.K. Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells. Life Sciences 76 (2005) 3029-3042
5. Del Vecchio M., Bajetta E., Canova S., Lotze M.T., Wesa A., Parmiani G., and Anichini A. Interleukin-12: biological properties and clinical application. Clinical Cancer Research 13 (2007) 4677-4685
6. Dias S., Boyd R., and Balkwill F. IL-12 regulates VEGF and MMPs in a murine breast cancer model. International Journal of Cancer 78 (1998) 361-365
7. Dubois M., Gilles K.A., Hamilton J.K., Rebers P.A., and Smith F. Colorimetric method for determination of sugars and related substances. Analytical Chemistry 28 (1956) 350-356
8. Ferrara N. VEGF: an update on biological and therapeutic aspects. Current Opinion in Biotechnology 11 (2000) 617-624
9. Ferrara N., and Kerbel R.S. Angiogenesis as a therapeutic target. Nature 438 (2005) 967-974
10. Folkman J. What is the evidence that tumors are angiogenesis dependent?. Journal of the National Cancer Institute 82 (1990) 4-6
11. Fukushima M. The overdose of drugs in Japan. Nature 342 (1989) 850-851
12. Hardy M.R., Townsend R.R., and Lee Y.C. Monosaccharide analysis of glycoconjugates by anion exchange chromatography with plused amperometric detection. Analytical Biochemistry 170 (1988) 54-62
13. Hsu H.Y., Hua K.F., Lin C.C., Lin C.H., Hsu J., and Wong C.H. Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways. The Journal of Immunology 173 (2004) 5989-5999
14. Ikekawa T. Beneficial effects of edible and medicinal mushrooms on health care. International Journal of Medicinal Mushrooms 4 (2001) 291-298
15. Kim G.Y., Choi G.S., Lee S.H., and Park Y.M. Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-alpha from peritoneal macrophages. Journal of Ethnopharmacology 95 (2004) 69-76
16. Ko Y.T., and Lin Y.L. 1, 3-Beta-glucan quantification by a fluorescence microassay and analysis of its distribution in foods. Journal of Agricultural and Food Chemistry 52 (2004) 3313-3318
17. Lee I.H., Huang R.L., Chen C.T., Chen H.C., Hsu W.C., and Lu M.K. Antrodia campharata polysaccharides exhibit anti-hepatitis B virus effects. FEMS Microbiology Letters 209 (2002) 63-67
18. Li M.H., Miao Z.H., Tan W.F., Yue J.M., Zhang C., Lin L.P., Zhang X.W., and Ding J. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1 by promoting proteasome-mediated degradation. Clinical Cancer Research 10 (2004) 8266-8274
19. Liu J.J., Huang T.S., Hsu M.L., Chen C.C., Lin W.S., Lu F.J., and Chang W.H. Antitumor effects of the partially purified polysaccharides from Antrodia camphorate and the mechanism of its action. Toxicology and Applied Pharmacology 201 (2004) 186-193
20. Lu M.K., Cheng J.J., Lai L., Lin Y.J., and Huang N.K. Fermented Antrodia cinnamomea extract protects rat PC12 cells from serum deprivation-induced apoptosis: the role of the MAPK family. Journal of Agricultural and Food Chemistry 56 (2008) 865-874
21. Nakamura N., Hirakawa A., Gao J.J., Kakuda H., Shiro M., Komatsu Y., Sheu C.C., and Hattori M. Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorate and their cytotoxic effects on LLC tumor cell line. Journal of Natural Products 67 (2004) 46-48
22. Oppenheim J., and Fujiwara H. The role of cytokines in cancer. Cytokine & Growth Factor Review 7 (1996) 279-288
23. Ou H.T., Shieh C.J., Chen J.Y., and Chang H.M. The antiproliferative and differentiating effects of human leukemic U937 cells are mediated by cytokines from activated mononuclear cells by dietary mushrooms. Journal of Agricultural and Food Chemistry 53 (2005) 300-305
24. Rodolfo M., and Colombo M.P. Interleukin-12 as an adjuvant for cancer immunotherapy. Methods 19 (1999) 114-120
25. Shibata M.A., Ito Y., Morimoto J., Kusakabe K., Yoshinaka R., and Otsuki Y. In vivo electrogene transfer of interleukin-12 inhibits tumor growth and lymph node and lung metastases in mouse mammary carcinomas. Journal of Gene Medicine 8 (2006) 335-352
26. Strasly M., Cavallo F., Geuna M., Mitola S., Colombo M.P., Forni G., and Bussolino F. IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk. The Journal of Immunology 166 (2001) 3890-3899
27. Wasser S.P. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Applied Microbiology and Biotechnology 60 (2002) 258-274
28. Wasser S.P., and Weis A.L. Medicinal properties of substances occurring in higher basidiomycetes mushrooms: current perspectives (review). International Journal of Medicinal Mushrooms 1 (1999) 31-62
29. Zaidman B.Z., Yassin M., Mahajna J., and Wasser S.P. Medicinal mushroom modulators of molecular targets as cancer therapeutics. Applied Microbiology and Biotechnology 67 (2005) 453-468
30. Zang M., and Su C.H. Ganoderma camphoratum, a new taxon in genus Ganoderma from Taiwan, China. Acta Botanica Gallica 12 (1990) 395-396