Chiral ruthenium(II) anthraquinone complexes as dual inhibitors of topoisomerases i and II

Journal of Biological Inorganic Chemistry

Volumn 17, Issue 1, 2012, Pages 81-96

  Kou, Jun Feng ^a   Qian, Chen ^a   Wang, Jin Quan ^a,b   Chen, Xiang ^a   Wang, Li Li ^a   Chao, Hui ^a,c   Ji, Liang Nian ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Cytotoxicity Apoptosis; DNA binding; Ruthenium(II) complexes; Topoisomerase inhibition

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CISPLATIN; DELTA [(2,2' BIPYRIDINE)[2 (ANTHRACENE 9,10 DION 2 YL)IMIDAZO[4,5 F][1,10]PHENANTHROLINE]]RUTHENIUM COMPLEX; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); FLUOROURACIL; LAMBDA [(2,2' BIPYRIDINE)[2 (ANTHRACENE 9,10 DION 2 YL)IMIDAZO[4,5 F][1,10]PHENANTHROLINE]]RUTHENIUM COMPLEX; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BASE PAIRING; BINDING AFFINITY; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CHROMATIN; COMET ASSAY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA DAMAGE; DNA STRAND; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DETERMINATION; DRUG DNA BINDING; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; STAINING; TUMOR CELL LINE;

ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; CATTLE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ESCHERICHIA COLI; HUMANS; ORGANOMETALLIC COMPOUNDS; RUTHENIUM; STRUCTURE-ACTIVITY RELATIONSHIP; THYMUS GLAND; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 84862513802     PISSN: 09498257     EISSN: 14321327     Source Type: Journal    
DOI: 10.1007/s00775-011-0831-6     Document Type: Article

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