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Volumn 34, Issue 1, 2012, Pages 9-16

Inhibition of TGFβ signaling and its implications in anticancer treatments

Author keywords

Cancer; Inhibition of TGF signaling; TGF ; Therapeutic strategy

Indexed keywords

1D11; 2 (5 CHLORO 2 FLUOROPHENYL) 4 (4 PYRIDINYLAMINO)PTERIDINE; 2G7; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; A 83 01; ANTINEOPLASTIC AGENT; ANTP SM2A; AP 11014; AP 15012; BELAGENPUMATUCEL L; BEVACIZUMAB; DISITERTIDE; FRESOLIMUMAB; GW6604; IN 1130; KI26894; LERDELIMUMAB; LY2109761; LY2157299; LY364947; LY550410; LY580276; METELIMUMAB; NPC 30345; P17; RANAGENGLIOTUCEL T; SB 505124; SD 093; SIS3; SM305; SML6; SR 2F; SRIII; SX 007; TASISULAM; TRABEDERSEN; TRANILAST; TRANSFORMING GROWTH FACTOR BETA; TRX CBP; TRX FOXHLB; TRX LEFL; TRX SARA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84862488155     PISSN: 18129269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (52)

References (95)
  • 1
    • 0015406707 scopus 로고
    • A unifying hypothesis concerning the nature of malignant growth
    • Holley RW. A unifying hypothesis concerning the nature of malignant growth. Proc Natl Acad Sci USA 1972; 69: 2840-1.
    • (1972) Proc Natl Acad Sci USA , vol.69 , pp. 2840-2841
    • Holley, R.W.1
  • 2
    • 77349121470 scopus 로고    scopus 로고
    • The discovery of TGF-β: A historical perspective
    • Derynck R, Miyazono K, eds. New York: Cold Spring Harbor Laboratory Press
    • Moses HL, Roberts AB. The discovery of TGF-β: a historical perspective. In: The TGF-β Family. Derynck R, Miyazono K, eds. New York: Cold Spring Harbor Laboratory Press, 2008: 1-28.
    • (2008) The TGF-β Family , pp. 1-28
    • Moses, H.L.1    Roberts, A.B.2
  • 4
    • 39149136533 scopus 로고    scopus 로고
    • Yin-Yang activities and vicious cycles in the tumor microenvironment
    • DOI 10.1158/0008-5472.CAN-07-2917
    • Witz IP. Yin-Yang activities and vicious cycles in the tumor microenvironment. Cancer Res 2008; 68: 9-13. (Pubitemid 351380098)
    • (2008) Cancer Research , vol.68 , Issue.1 , pp. 9-13
    • Witz, I.P.1
  • 5
    • 47549090432 scopus 로고    scopus 로고
    • TGFβ in cancer
    • Massagué J. TGFβ in cancer. Cell 2008; 134: 215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 6
    • 67349091089 scopus 로고    scopus 로고
    • Transforming growth factor-β signaling emerging stem cell target in metastatic breast cancer
    • Tan AR, Alexe G, Reiss M. Transforming growth factor-β signaling emerging stem cell target in metastatic breast cancer. Breast Cancer Res Treat 2009; 115: 1-63.
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 1-63
    • Tan, A.R.1    Alexe, G.2    Reiss, M.3
  • 7
    • 0034468039 scopus 로고    scopus 로고
    • Transforming growth factor-β and breast cancer: Tumor promoting effects of transforming growth factor-β
    • DOI 10.1186/bcr44
    • Dumont N, Arteaga CL. Transforming growth factor-β and breast cancer: tumor promoting effects of transforming growth factor-β. Breast Cancer Res 2000; 2: 125-32. (Pubitemid 32223575)
    • (2000) Breast Cancer Research , vol.2 , Issue.2 , pp. 125-132
    • Dumont, N.1    Arteaga, C.L.2
  • 8
    • 77952896646 scopus 로고    scopus 로고
    • TGFβ signalling: A complex web in cancer progression
    • Ikushima H, Miyazono K. TGFβ signalling: a complex web in cancer progression. Nat Rev Cancer 2010; 10: 415-24.
    • (2010) Nat Rev Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 10
    • 12144258900 scopus 로고    scopus 로고
    • Dual role of transforming growth factor B in mammary tumorigenesis and metastatic progression
    • Muraoka-Cook RS, Dumont N, Arteaga CL. Dual role of transforming growth factor B in mammary tumorigenesis and metastatic progression. Clin Cancer Res 2005; 11: 937-43.
    • (2005) Clin Cancer Res , vol.11 , pp. 937-943
    • Muraoka-Cook, R.S.1    Dumont, N.2    Arteaga, C.L.3
  • 11
    • 84862495002 scopus 로고    scopus 로고
    • Acta Universitatis Upsaliensis. Digital comprehensive summaries of Uppsala dissertations from the Faculty of Medicine 57. ISBN 91-554-6303-7
    • Kowanetz M. Novel regulators of the TGF-β signaling pathway. Acta Universitatis Upsaliensis. Digital comprehensive summaries of Uppsala dissertations from the Faculty of Medicine 57. 2005; 69pp. ISBN 91-554-6303-7.
    • (2005) Novel Regulators of the TGF-β Signaling Pathway , pp. 69
    • Kowanetz, M.1
  • 12
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi Y, Massagué J. Mechanism of TGF-β signaling from cell membrane to the nucleus. Cell 2003; 113: 685-700. (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 13
    • 0028170226 scopus 로고
    • Mechanism of activation of the TGF-β receptor
    • Wrana JL, Attisano L, Wieser R, et al. Mechanism of activation of the TGF-β receptor. Nature 1994; 370: 341-7.
    • (1994) Nature , vol.370 , pp. 341-347
    • Wrana, J.L.1    Attisano, L.2    Wieser, R.3
  • 14
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-β superfamily
    • Attisano L, Wrana JL. Signal transduction by the TGF-β superfamily. Science 2002; 296: 1646-7.
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 15
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massagué J. TGF-β signal transduction. Annu Rev Biochem 1998; 67: 753-91.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massagué, J.1
  • 16
    • 70450187617 scopus 로고    scopus 로고
    • The regulation of TGFßsignal transduction
    • Moustakas A, Heldin CH. The regulation of TGFßsignal transduction. Development 2009; 136: 3699-714.
    • (2009) Development , vol.136 , pp. 3699-3714
    • Moustakas, A.1    Heldin, C.H.2
  • 17
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-β signaling through smads
    • DOI 10.1146/annurev.cellbio.21.022404.142018
    • Feng XH, Derynck R. Specificity and versatility in TGF-β signaling through Smads. Annu Rev Cell Dev Biol 2005; 21: 659-93. (Pubitemid 41740650)
    • (2005) Annual Review of Cell and Developmental Biology , vol.21 , pp. 659-693
    • Feng, X.-H.1    Derynck, R.2
  • 18
    • 15744372725 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human cancer
    • DOI 10.1200/JCO.2005.02.047
    • Elliott RL, Blobe GC. Role of transforming growth factor beta in human cancer. J Clin Oncol 2005; 23: 2078-93. (Pubitemid 46211385)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.9 , pp. 2078-2093
    • Elliott, R.L.1    Blobe, G.C.2
  • 19
    • 80755187843 scopus 로고    scopus 로고
    • Smad phosphoisoform signaling specificity: The right place at the right time
    • Matsuzaki K. Smad phosphoisoform signaling specificity: the right place at the right time. Carcinogenesis 2011; 32: 1578-88.
    • (2011) Carcinogenesis , vol.32 , pp. 1578-1588
    • Matsuzaki, K.1
  • 20
    • 84859439644 scopus 로고    scopus 로고
    • TGF-β signal transduction spreading to a wider field: A broad variety of mechanisms for context-dependent effects of TGF-β
    • Ikushima H, Miyazono K. TGF-β signal transduction spreading to a wider field: a broad variety of mechanisms for context-dependent effects of TGF-β. Cell Tissue Res 2012; 347: 37-49.
    • (2012) Cell Tissue Res , vol.347 , pp. 37-49
    • Ikushima, H.1    Miyazono, K.2
  • 21
    • 68549123472 scopus 로고    scopus 로고
    • New regulatory mechanisms of TGF-β receptor function
    • Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-β receptor function. Trends Cell Biol 2009; 19: 385-94.
    • (2009) Trends Cell Biol , vol.19 , pp. 385-394
    • Kang, J.S.1    Liu, C.2    Derynck, R.3
  • 23
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • DOI 10.1093/emboj/17.11.3091
    • Dennler S, Itoh S, Vivien D, et al. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 1998; 17: 3091-100. (Pubitemid 28254381)
    • (1998) EMBO Journal , vol.17 , Issue.11 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    Dijke, P.T.4    Huet, S.5    Gauthier, J.-M.6
  • 24
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-b family signalling
    • DOI 10.1038/nature02006
    • Derynck R, Zhang YE. Smad-dependent and Smadindependent pathways in TGF-b family signalling. Nature 2003; 425: 577-84. (Pubitemid 37280136)
    • (2003) Nature , vol.425 , Issue.6958 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 25
    • 58149213801 scopus 로고    scopus 로고
    • Non-Smad pathways in TGF-beta signaling
    • Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res 2009; 19: 128-39.
    • (2009) Cell Res , vol.19 , pp. 128-139
    • Zhang, Y.E.1
  • 28
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-β signals
    • Moustakas A, Heldin CH. Non-Smad TGF-β signals. J Cell Sci 2005; 118: 3573-84.
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 29
    • 72049091524 scopus 로고    scopus 로고
    • Targeting the transforming growth factor-β signaling pathway in human cancer
    • Nagaraj NS, Datta PK. Targeting the transforming growth factor-β signaling pathway in human cancer. Expert Opin Investig Drugs 2010; 19: 77-91.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 77-91
    • Nagaraj, N.S.1    Datta, P.K.2
  • 30
    • 33751580492 scopus 로고    scopus 로고
    • Silence, on désactive les genes
    • Harel-Bellan A. Silence, clean up genes! Med Sci (Paris) 2006; 22: 993-4. (Pubitemid 44845313)
    • (2006) Medecine/Sciences , vol.22 , Issue.11 , pp. 993-994
    • Harel-Bellan, A.1
  • 31
    • 1242293004 scopus 로고    scopus 로고
    • Inhibition de l'expression génique par l'ARN interférence: Applications dans le domaine du cancer
    • Ait-Si-Ali S, Guasconi V, Harel-Bellan A. RNA interference and its possible use in cancer therapy. Bull Cancer 2004; 91:15-8. (Pubitemid 38230456)
    • (2004) Bulletin du Cancer , vol.91 , Issue.1 , pp. 15-18
    • Ait-Si-Ali, S.1    Guasconi, V.2    Harel-Bellan, A.3
  • 32
    • 33745211255 scopus 로고    scopus 로고
    • Antisense oligonucleotides: From design to therapeutic application
    • Chan, JHP, Lim S, Wong WSF. Antisense oligonucleotides: from design to therapeutic application. Clin Exp Pharmacol Physiol 2006; 33: 533-40.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 533-540
    • Chan, J.H.P.1    Lim, S.2    Wong, W.S.F.3
  • 33
    • 25444491540 scopus 로고    scopus 로고
    • Specific therapy for high-grade glioma by convection enhanced delivery of the TGF-β2 specific antisense oligonucleotide AP12009
    • Bogdahn U, Hau P, Brawanski A, et al. Specific therapy for high-grade glioma by convection enhanced delivery of the TGF-β2 specific antisense oligonucleotide AP12009. Proc Am Soc Clin Oncol 2004; 23: 110.
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 110
    • Bogdahn, U.1    Hau, P.2    Brawanski, A.3
  • 34
    • 79951602633 scopus 로고    scopus 로고
    • Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
    • Bogdahn U, Hau P, Stockhammer G, et al. Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro Oncol 2011; 13: 132-42.
    • (2011) Neuro Oncol , vol.13 , pp. 132-142
    • Bogdahn, U.1    Hau, P.2    Stockhammer, G.3
  • 35
    • 84862503807 scopus 로고    scopus 로고
    • Antisense Pharma. 1st June 2011; Press release
    • Antisense Pharma. 1st June 2011; Press release.
  • 38
    • 84862503141 scopus 로고    scopus 로고
    • Antisense Pharma. 7th June 2011; Press release
    • Antisense Pharma. 7th June 2011; Press release.
  • 39
    • 70350256851 scopus 로고    scopus 로고
    • 4th November Press release
    • PR Newswire. 4th November 2009; Press release.
    • (2009) PR Newswire
  • 41
    • 67651091694 scopus 로고    scopus 로고
    • Phase II trial of Belagenpumatucel-L, a TGF-beta2 antisense gene modified allogeneic tumor vaccine in advanced non-small cell lung cancer (NSCLC) patients
    • Nemunaitis J, Nemunaitis M, Senzer N, et al. Phase II trial of Belagenpumatucel-L, a TGF-beta2 antisense gene modified allogeneic tumor vaccine in advanced non-small cell lung cancer (NSCLC) patients. Cancer Gene Ther 2009; 16: 620-4.
    • (2009) Cancer Gene Ther , vol.16 , pp. 620-624
    • Nemunaitis, J.1    Nemunaitis, M.2    Senzer, N.3
  • 42
    • 0037350545 scopus 로고    scopus 로고
    • Immunotherapy: Past, present and future
    • DOI 10.1038/nm0303-269
    • Waldmann TA. Immunotherapy: past, present and future. Nature Med 2003; 9: 269-77. (Pubitemid 36362781)
    • (2003) Nature Medicine , vol.9 , Issue.3 , pp. 269-277
    • Waldmann, T.A.1
  • 43
    • 77951523463 scopus 로고    scopus 로고
    • Bispecific antibodies for cancer therapy: The light at the end of the tunnel?
    • Chames P, Baty D. Bispecific antibodies for cancer therapy: the light at the end of the tunnel? MAbs 2009; 1: 539-47.
    • (2009) MAbs , vol.1 , pp. 539-547
    • Chames, P.1    Baty, D.2
  • 44
    • 79952281795 scopus 로고    scopus 로고
    • Improving cancer immunotherapy by targeting tumor-induced immune suppression
    • Stewart TJ, Smyth MJ. Improving cancer immunotherapy by targeting tumor-induced immune suppression. Cancer Metastasis Rev 2011; 30: 125-40.
    • (2011) Cancer Metastasis Rev , vol.30 , pp. 125-140
    • Stewart, T.J.1    Smyth, M.J.2
  • 45
    • 56849115306 scopus 로고    scopus 로고
    • Phase I/II study of GC1008: A human anti-transforming growth factor-beta (TGFβ) monoclonal antibody (MAb) in patients with advanced malignant melanoma (MM) or renal cell carcinoma (RCC)
    • Morris JC, Shapiro GI, Tan AR, et al. Phase I/II study of GC1008: A human anti-transforming growth factor-beta (TGFβ) monoclonal antibody (MAb) in patients with advanced malignant melanoma (MM) or renal cell carcinoma (RCC). J Clin Oncol 2008; 26: 9028.
    • (2008) J Clin Oncol , vol.26 , pp. 9028
    • Morris, J.C.1    Shapiro, G.I.2    Tan, A.R.3
  • 46
    • 34748861947 scopus 로고    scopus 로고
    • A phase III study of sub-conjunctival human anti-transforming growth factor beta (2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy
    • Khaw P, Grehn F, Holló GP, et al. A phase III study of sub-conjunctival human anti-transforming growth factor beta (2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology 2007; 114: 1822-30.
    • (2007) Ophthalmology , vol.114 , pp. 1822-1830
    • Khaw, P.1    Grehn, F.2    Holló, G.P.3
  • 48
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF-β signalling inhibitors for cancer therapy
    • DOI 10.1038/nrd1580
    • Yingling JM, Blanchard KL, Sawyer JS. Development of TGF-β signalling inhibitors for cancer therapy. Nat Rev Drug Discov 2004; 3: 1011-22. (Pubitemid 39642364)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.12 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 50
    • 9444260479 scopus 로고    scopus 로고
    • Biological impediments to monoclonal antibody-based cancer immunotherapy
    • Christiansen J, Rajasekaran AK. Biological impediments to monoclonal antibody-based cancer immunotherapy. Mol Cancer Ther 2004; 3: 1493-501. (Pubitemid 39562594)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.11 , pp. 1493-1501
    • Christiansen, J.1    Rajasekaran, A.K.2
  • 51
    • 20344385003 scopus 로고    scopus 로고
    • A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers
    • DOI 10.1593/neo.04640
    • Halder SK, Beauchamp RD, Datta PK. A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 2005; 7: 509-21. (Pubitemid 40791869)
    • (2005) Neoplasia , vol.7 , Issue.5 , pp. 509-521
    • Halder, S.K.1    Beauchamp, R.D.2    Datta, P.K.3
  • 53
    • 1342265719 scopus 로고    scopus 로고
    • SB-505124 Is a Selective Inhibitor of Transforming Growth Factor-β Type I Receptors ALK4, ALK5, and ALK7
    • DOI 10.1124/mol.65.3.744
    • DaCosta Byfield S, Major C, Laping NJ, et al. SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5 and ALK7. Mol Pharmacol 2004; 65: 744-52. (Pubitemid 38264042)
    • (2004) Molecular Pharmacology , vol.65 , Issue.3 , pp. 744-752
    • DaCosta, B.S.1    Major, C.2    Laping, N.J.3    Roberts, A.B.4
  • 55
    • 1642323740 scopus 로고    scopus 로고
    • Protein Kinase Inhibitors: Insights into Drug Design from Structure
    • DOI 10.1126/science.1095920
    • Noble MEM, Endicott JA, Johnson LN. Protein kinase inhibitors: insights into drug design from structure. Science 2004; 303: 1800-5. (Pubitemid 38374863)
    • (2004) Science , vol.303 , Issue.5665 , pp. 1800-1805
    • Noble, M.E.M.1    Endicott, J.A.2    Johnson, L.N.3
  • 56
    • 70350072838 scopus 로고    scopus 로고
    • Cardiotoxicity induced by tyrosine kinase inhibitors
    • Orphanos GS, Ioannidis GN, Ardavanis AG. Cardiotoxicity induced by tyrosine kinase inhibitors. Acta Oncol 2009; 48:964-70.
    • (2009) Acta Oncol , vol.48 , pp. 964-970
    • Orphanos, G.S.1    Ioannidis, G.N.2    Ardavanis, A.G.3
  • 57
    • 0036714017 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGFbeta type I receptor kinase
    • DOI 10.1021/bi025936u
    • Yakymovych I, Engström U, Grimsby S, et al. Inhibition of transforming growth factor beta signaling by low molecular weight compounds interfering with ATP- or biding sites of the TGF beta type I receptor kinase. Biochemistry 2002; 41: 11000-7. (Pubitemid 35001214)
    • (2002) Biochemistry , vol.41 , Issue.36 , pp. 11000-11007
    • Yakymovych, I.1    Engstrom, U.2    Grimsby, S.3    Heldin, C.-H.4    Souchelnytskyi, S.5
  • 58
    • 25444497522 scopus 로고    scopus 로고
    • The TGF-β1 antisense oligonucleotide AP 11014 for the treatment of non-small-cell lung, colorectal and prostate cancer: Preclinical studies
    • Schlingensiepen KH, Bischof A, Egger T, et al. The TGF-β1 antisense oligonucleotide AP 11014 for the treatment of non-small-cell lung, colorectal and prostate cancer: preclinical studies. Proc Am Soc Clin Oncol 2004; 23: 227.
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 227
    • Schlingensiepen, K.H.1    Bischof, A.2    Egger, T.3
  • 59
    • 67650609666 scopus 로고    scopus 로고
    • Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor β1-associated osteoblastic changes
    • Izumi K, Mizokami A, Li YQ, et al. Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor β1-associated osteoblastic changes. The prostate 2009; 69: 1222-34.
    • (2009) The Prostate , vol.69 , pp. 1222-1234
    • Izumi, K.1    Mizokami, A.2    Li, Y.Q.3
  • 60
    • 67650305810 scopus 로고    scopus 로고
    • Tranilast inhibits the growth and metastasis of mammary carcinoma
    • Chakrabarti R, Subramaniam V, Abdalla S, et al. Tranilast inhibits the growth and metastasis of mammary carcinoma. Anticancer Drugs 2009; 20: 334-45.
    • (2009) Anticancer Drugs , vol.20 , pp. 334-345
    • Chakrabarti, R.1    Subramaniam, V.2    Abdalla, S.3
  • 61
    • 77949372619 scopus 로고    scopus 로고
    • Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer
    • Subramaniam V, Chakrabarti R, Prud'homme GJ, et al. Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer. Anticancer Drugs 2010; 21: 351-61.
    • (2010) Anticancer Drugs , vol.21 , pp. 351-361
    • Subramaniam, V.1    Chakrabarti, R.2    Prud'Homme, G.J.3
  • 62
    • 78650681544 scopus 로고    scopus 로고
    • Tranilast treatment decreases cell growth, migration and inhibits colony formation of human breast cancer cells
    • Subramaniam V, Ace O, Prud'homme GJ, et al. Tranilast treatment decreases cell growth, migration and inhibits colony formation of human breast cancer cells. Exp Mol Pathol 2011; 90: 116-22.
    • (2011) Exp Mol Pathol , vol.90 , pp. 116-122
    • Subramaniam, V.1    Ace, O.2    Prud'Homme, G.J.3
  • 63
    • 77949527093 scopus 로고    scopus 로고
    • Bevacizumab accelerates corneal wound healing by inhibiting TGF-β2 expression in alkali-burned mouse cornea
    • Lee SH, Leem HS, Jeong SM, et al. Bevacizumab accelerates corneal wound healing by inhibiting TGF-β2 expression in alkali-burned mouse cornea. BMB Rep 2009; 42: 800-5.
    • (2009) BMB Rep , vol.42 , pp. 800-805
    • Lee, S.H.1    Leem, H.S.2    Jeong, S.M.3
  • 64
    • 33751047033 scopus 로고    scopus 로고
    • Phase I clinical trial of a TGF-b antisense-modified tumor cell vaccine in patients with advanced glioma
    • Ge L, Hoa N, Bota D A, et al. Phase I clinical trial of a TGF-b antisense-modified tumor cell vaccine in patients with advanced glioma. Cancer Gene Ther 2006; 13: 1052-60.
    • (2006) Cancer Gene Ther , vol.13 , pp. 1052-1060
    • Ge, L.1    Hoa, N.2    Bota, D.A.3
  • 65
    • 79955080612 scopus 로고    scopus 로고
    • Immunotherapy of brain cancers: The past, the present, and future directions
    • Ge L, Hoa N, Bota D A, et al. Immunotherapy of brain cancers: the past, the present, and future directions. Clin Dev Immunol 2010; 2010: 296453.
    • (2010) Clin Dev Immunol , vol.2010 , pp. 296453
    • Ge, L.1    Hoa, N.2    Bota, D.A.3
  • 66
    • 34748886279 scopus 로고    scopus 로고
    • Factors affecting the outcome of trabeculectomy: An analysis based on combined data from two phase III studies of an antibody to transforming growth factor beta2, CAT-152. F
    • Grehn F, Holló GP, Khaw P, et al. Factors affecting the outcome of trabeculectomy: an analysis based on combined data from two phase III studies of an antibody to transforming growth factor beta2, CAT-152. F. Ophthalmology 2007; 114: 1831-8.
    • (2007) Ophthalmology , vol.114 , pp. 1831-1838
    • Grehn, F.1    Holló, G.P.2    Khaw, P.3
  • 68
    • 77952609184 scopus 로고    scopus 로고
    • Targeting the transforming growth factor-β pathway inhibits human basallike breast cancer metastasis
    • Ganapathy V, Ge R, Grazioli AV, et al. Targeting the transforming growth factor-β pathway inhibits human basallike breast cancer metastasis. Mol Cancer 2010; 9:122.
    • (2010) Mol Cancer , vol.9 , pp. 122
    • Ganapathy, V.1    Ge, R.2    Grazioli, A.V.3
  • 69
    • 0027137485 scopus 로고
    • Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression
    • Arteaga CL, Hurd SD, Winnier AR, et al. Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression. J Clin Invest 1993; 92: 2569-76. (Pubitemid 24006519)
    • (1993) Journal of Clinical Investigation , vol.92 , Issue.6 , pp. 2569-2576
    • Arteaga, C.L.1    Hurd, S.D.2    Winnier, A.R.3    Johnson, M.D.4    Fendly, B.M.5    Forbes, J.T.6
  • 71
    • 29644443725 scopus 로고    scopus 로고
    • The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta
    • DOI 10.1111/j.1349-7006.2005.00103.x
    • Tojo M, Hamashima Y, Hanyu A, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-tomesenchymal transition by transforming growth factor-beta. Cancer Sci 2005; 96: 791-800. (Pubitemid 43019830)
    • (2005) Cancer Science , vol.96 , Issue.11 , pp. 791-800
    • Tojo, M.1    Hamashima, Y.2    Hanyu, A.3    Kajimoto, T.4    Saitoh, M.5    Miyazono, K.6    Node, M.7    Imamura, T.8
  • 74
    • 33748939751 scopus 로고    scopus 로고
    • IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy
    • Moon JA, Kim HT, Cho IS, et al. IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. Kidney Int 2006; 70: 1234-43.
    • (2006) Kidney Int , vol.70 , pp. 1234-1243
    • Moon, J.A.1    Kim, H.T.2    Cho, I.S.3
  • 76
    • 37149042061 scopus 로고    scopus 로고
    • Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-b kinase antagonist, in mice
    • DOI 10.1016/j.ejca.2007.10.008, PII S0959804907008003
    • Bueno L, de Alwis DP, Pitou C. Semi-mechanistic modeling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-b kinase antagonist, in mice. Eur J Cancer 2008; 44: 142-50. (Pubitemid 350256941)
    • (2008) European Journal of Cancer , vol.44 , Issue.1 , pp. 142-150
    • Bueno, L.1    De Alwis, D.P.2    Pitou, C.3    Yingling, J.4    Lahn, M.5    Glatt, S.6    Troconiz, I.F.7
  • 78
    • 58149350373 scopus 로고    scopus 로고
    • Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells
    • Haritunians T, Gueller S, O'Kelly J, et al. Novel acyl sulfonamide LY573636-sodium: effect on hematopoietic malignant cells. Oncol Rep 2008; 20: 1237-42.
    • (2008) Oncol Rep , vol.20 , pp. 1237-1242
    • Haritunians, T.1    Gueller, S.2    O'Kelly, J.3
  • 79
    • 84862494012 scopus 로고    scopus 로고
    • Lilly Suspends Study of Tasisulam for Metastatic Melanoma
    • Roxanne Nelson. Lilly Suspends Study of Tasisulam for Metastatic Melanoma. Medscape Medical News Oncology.
    • Medscape Medical News Oncology
    • Nelson, R.1
  • 82
    • 33751320565 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-β type I receptor kinase in vivo
    • Ge R, Rajeev V, Ray P, et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-β type I receptor kinase in vivo. Clin Cancer Res 2006; 12: 4315-30.
    • (2006) Clin Cancer Res , vol.12 , pp. 4315-4330
    • Ge, R.1    Rajeev, V.2    Ray, P.3
  • 84
    • 33947246042 scopus 로고    scopus 로고
    • A novel small-molecule inhibitor of transforming growth factor β type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection
    • DOI 10.1158/0008-5472.CAN-06-2389
    • Suzuki E, Kim S, Cheung HK, et al. A novel smallmolecule inhibitor of transforming growth factor β type I kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res 2007; 67: 2351-9. (Pubitemid 46424257)
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 2351-2359
    • Suzuki, E.1    Kim, S.2    Cheung, H.-K.3    Corbley, M.J.4    Zhang, X.5    Sun, L.6    Shan, F.7    Singh, J.8    Lee, W.-C.9    Albelda, S.M.10    Ling, L.E.11
  • 87
    • 42249099019 scopus 로고    scopus 로고
    • LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
    • DOI 10.1158/1535-7163.MCT-07-0337
    • Melisi D, Ishiyama S, Sclabas GM, et al. LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther 2008; 7: 829-40. (Pubitemid 351551036)
    • (2008) Molecular Cancer Therapeutics , vol.7 , Issue.4 , pp. 829-840
    • Melisi, D.1    Ishiyama, S.2    Sclabas, G.M.3    Fleming, J.B.4    Xia, Q.5    Tortora, G.6    Abbruzzese, J.L.7    Chiao, P.J.8
  • 89
    • 84862501562 scopus 로고    scopus 로고
    • th March 2010; Press release
    • th March 2010; Press release.
  • 90
    • 47949104587 scopus 로고    scopus 로고
    • In vitro and in vivo down-regulation of regulatory T cell activity with a peptide inhibitor of TGF-beta1
    • Gil-Guerrero L, Dotor J, Huibregtse IL, et al. In vitro and in vivo down-regulation of regulatory T cell activity with a peptide inhibitor of TGF-beta1. J Immunol 2008; 81: 126-35.
    • (2008) J Immunol , vol.81 , pp. 126-135
    • Gil-Guerrero, L.1    Dotor, J.2    Huibregtse, I.L.3
  • 91
    • 0033215194 scopus 로고    scopus 로고
    • A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells
    • Bandyopadhyay A, Zhu Y, Cibull ML, et al. A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDAMB-231 cells. Cancer Res 1999; 59: 5041-6. (Pubitemid 29472913)
    • (1999) Cancer Research , vol.59 , Issue.19 , pp. 5041-5046
    • Bandyopadhyay, A.1    Zhu, Y.2    Cibull, M.L.3    Bao, L.4    Chen, C.5    Sun, S.6
  • 93
    • 20544444943 scopus 로고    scopus 로고
    • Selective inhibition of TGF-responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP
    • DOI 10.1038/sj.onc.1208556
    • Cui Q, Lim SK, Zhao B, et al. Selective inhibition of TGF-responsive genes by Smad-interacting peptide apta mers from FoxH1, Lef1 and CBP. Oncogene 2005; 24: 3864-74. (Pubitemid 40896398)
    • (2005) Oncogene , vol.24 , Issue.24 , pp. 3864-3874
    • Cui, Q.1    Lim, S.K.2    Zhao, B.3    Hoffmann, F.M.4
  • 94
    • 33748305561 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA
    • DOI 10.1091/mbc.E05-10-0990
    • Zhao BM, M.F Hoffman MF. Inhibition of transforming growth factor-beta1-induced signaling and epithelial-tomesenchymal transition by the Smad-binding peptide aptamer Trx-SARA. Mol Biol Cell 2006; 17: 3819-31. (Pubitemid 44330868)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.9 , pp. 3819-3831
    • Zhao, B.M.1    Hoffmann, F.M.2
  • 95
    • 31044448265 scopus 로고    scopus 로고
    • Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression
    • DOI 10.1124/mol.105.017483
    • Jinnin M, Ihn H, Tamaki K. Characterization of SIS3, a novel specific inhibitor of smad3, and its effect on transforming growth factor-beta-1-induced extracellular matrix expression. Mol Pharmacol 2006; 69: 597-607. (Pubitemid 43121957)
    • (2006) Molecular Pharmacology , vol.69 , Issue.2 , pp. 597-607
    • Jinnin, M.1    Ihn, H.2    Tamaki, K.3


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