Regulation of neutrophil trafficking from the bone marrow

Cellular and Molecular Life Sciences

Volumn 69, Issue 9, 2012, Pages 1415-1423

  Day, Ryan B ^a   Link, Daniel C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CXCL1; CXCL12 (stromal derived factor 1; SDF 1); CXCL2; CXCR2; CXCR4; Granulocyte colony stimulating factor (G CSF); Leukocyte trafficking; Neutrophils; WHIM syndrome

Indexed keywords

ALPHA4 INTEGRIN; BETA2 INTEGRIN; CATHEPSIN G; CD11B ANTIGEN; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CHEMOKINE RECEPTOR CXCR7; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; DIPEPTIDYL PEPTIDASE I; GELATINASE B; GRANULOCYTE COLONY STIMULATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17; L SELECTIN; LEUKOCYTE ELASTASE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PLERIXAFOR; STEM CELL FACTOR RECEPTOR; STROMAL CELL DERIVED FACTOR 1; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4; CELL ADHESION MOLECULE; CXCR4 PROTEIN, HUMAN; CXCR4 PROTEIN, MOUSE; PEPTIDE HYDROLASE;

BONE MARROW; DRUG EFFECT; DRUG TARGETING; GENE MUTATION; GENETIC DISORDER; GRANULOPOIESIS; HUMAN; NEUTROPHIL CHEMOTAXIS; NEUTROPHILIA; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; WHIM SYNDROME; ANIMAL; BIOLOGICAL MODEL; CELL MOTION; HOMEOSTASIS; MOUSE; NEUTROPHIL; PHYSIOLOGY;

ANIMALS; BONE MARROW; CELL ADHESION MOLECULES; CELL MOVEMENT; HOMEOSTASIS; HUMANS; MICE; MODELS, BIOLOGICAL; NEUTROPHILS; PEPTIDE HYDROLASES; RECEPTORS, CXCR4; RECEPTORS, INTERLEUKIN-8B; SIGNAL TRANSDUCTION;

EID: 84862307996     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0870-8     Document Type: Review

References (96)

1. Grau AJ, Boddy AW, Dukovic DA, Buggle F, Lichy C, Brandt T, Hacke W (2004) Leukocyte count as an independent predictor of recurrent ischemic events. Stroke 35(5):1147-1152 (Pubitemid 38543534)
2. Madjid M, Awan I, Willerson JT, Casscells SW (2004) Leuko-cyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol 44(10):1945-1956 (Pubitemid 39473277)
3. Demetri GD, Griffin JD (1991) Granulocyte colony-stimulating factor and its receptor. Blood 78(11):2791-2808
4. Semerad CL, Liu F, Gregory AD, Stumpf K, Link DC (2002) G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity 17(4):413-423 (Pubitemid 35223531)
5. Lieschke GJ, Grail D, Hodgson G, Metcalf D, Stanley E, Cheers C, Fowler KJ, Basu S, Zhan YF, Dunn AR (1994) Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 84(6):1737-1746 (Pubitemid 24286121)
6. Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC (1996) Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity 5(5):491-501 (Pubitemid 26423476)
7. Molineux G, Migdalska A, Szmitkowski M, Zsebo K, Dexter TM (1991) The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor. Blood 78(4):961-966
8. Seymour JF, Lieschke GJ, Grail D, Quilici C, Hodgson G, Dunn AR (1997) Mice lacking both granulocyte colony-stimulating factor (CSF) and granulocyte-macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival. Blood 90(8):3037-3049 (Pubitemid 27444197)
9. Liu F, Poursine-Laurent J, Wu HY, Link DC (1997) Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood 90(7):2583-2590 (Pubitemid 27413467)
10. Rosmarin AG, Yang Z, Resendes KK (2005) Transcriptional regulation in myelopoiesis: hematopoietic fate choice, myeloid differentiation, and leukemogenesis. Exp Hematol 33(2):131-143 (Pubitemid 40164893)
11. Cartwright GE, Athens JW, Wintrobe MM (1964) The kinetics of granulopoiesis in normal man. Blood 24:780-803
12. Dancey JT, Deubelbeiss KA, Harker LA, Finch CA (1976) Neutrophil kinetics in man. J Clin Invest 58(3):705-715
13. 2O reveals a human neutrophil lifespan of 5.4 days. Blood 116 (4):625-627
14. Rankin SM (2010) The bone marrow: a site of neutrophil clear-ance. J Leukoc Biol 88(2):241-251
15. Thakur ML, Lavender JP, Arnot RN, Silvester DJ, Segal AW (1977) Indium-111-labeled autologous leukocytes in man. J Nucl Med 18(10):1014-1021
16. Suratt BT, Young SK, Lieber J, Nick JA, Henson PM, Worthen GS (2001) Neutrophil maturation and activation determine ana-tomic site of clearance from circulation. Am J Physiol Lung Cell Mol Physiol 281(4):L913-L921
17. Furze RC, Rankin SM (2008) Neutrophil mobilization and clearance in the bone marrow. Immunology 125(3):281-288
18. Nagase H, Miyamasu M, Yamaguchi M, Imanishi M, Tsuno NH, Matsushima K, Yamamoto K, Morita Y, Hirai K (2002) Cyto-kine-mediated regulation of CXCR4 expression in human neutrophils. J Leukoc Biol 71(4):711-717
19. Martin C, Burdon PCE, Bridger G, Gutierrez-Ramos JC, Wil-liams TJ, Rankin SM (2003) Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity 19(4):583-593 (Pubitemid 37311439)
20. Suratt BT, Petty JM, Young SK, Malcolm KC, Lieber JG, Nick JA, Gonzalo J-A, Henson PM, Worthen GS (2004) Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Blood 104(2):565-571 (Pubitemid 38900043)
21. Eash KJ, Means JM, White DW, Link DC (2009) CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood 113(19):4711-4719
22. Campbell FR (1972) Ultrastructural studies of transmural migration of blood cells in the bone marrow of rats, mice and guinea pigs. Am J Anat 135(4):521-535
23. Inoue S, Osmond DG (2001) Basement membrane of mouse bone marrow sinusoids shows distinctive structure and proteoglycan composition: a high resolution ultrastructural study. Anat Rec 264(3):294-304 (Pubitemid 33035470)
24. Burdon PCE, Martin C, Rankin SM (2008) Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines. Br J Haematol 142(1):100-108 (Pubitemid 351783141)
25. Lévesque JP, Hendy J, Takamatsu Y, Williams B, Winkler IG, Simmons PJ (2002) Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone mar-row into a highly proteolytic environment. Exp Hematol 30(5):440-449 (Pubitemid 34556735)
26. Opdenakker G, Fibbe WE, Van Damme J (1998) The molecular basis ofleukocytosis. Immunol Today 19(4):182-189
27. Etzioni A (2009) Genetic etiologies of leukocyte adhesion defects. Curr Opin Immunol 21(5):481-486
28. Simmons PJ, Masinovsky B, Longenecker BM, Berenson R, Torok-Storb B, Gallatin WM (1992) Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding ofhematopoietic progenitor cells. Blood 80(2):388-395
29. Schweitzer KM, Dräger AM, van der Valk P, Thijsen SF, Zevenbergen A, Theijsmeijer AP, van der Schoot CE, Lange-nhuijsen MM (1996) Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hema-topoietic tissues. Am J Pathol 148(1):165-175
30. Scott LM, Priestley GV, Papayannopoulou T (2003) Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol Cell Biol 23(24):9349-9360 (Pubitemid 37499821)
31. Burdon PCE, Martin C, Rankin SM (2005) The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner. Blood 105(6):2543-2548 (Pubitemid 40387057)
32. Ley K, Laudanna C, Cybulsky MI, Nourshargh S (2007) Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 7(9):678-689 (Pubitemid 47327397)
33. Larangeira AP, Silva AR, Gomes RN, Penido C, Henriques MG, Castro-Faria-Neto HC, Bozza PT (2001) Mechanisms of allergen-and LPS-induced bone marrow eosinophil mobilization and eosinophil accumulation into the pleural cavity: a role for CD11b/ CD18 complex. Inflamm Res 50(6):309-316 (Pubitemid 32607778)
34. Scharffetter-Kochanek K, Lu H, Norman K, van Nood N, Munoz F, Grabbe S, Mc Arthur M, Lorenzo I, Kaplan S, Ley K, Smith CW, Montgomery CA, Rich S, Beaude AL (1998) Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med 188(1):119-131 (Pubitemid 28328611)
35. Forlow SB, Schurr JR, Kolls JK, Bagby GJ, Schwarzenberger PO, Ley K (2001) Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice. Blood 98(12):3309-3314
36. Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K (2005) Phagocytosis of apoptotic neutrophils regulates granulo-poiesis via IL-23 and IL-17. Immunity 22(3):285-294 (Pubitemid 40387471)
37. Rogowski O, Sasson Y, Kassirer M, Zeltser D, Maharshak N, Arber N, Halperin P, Serrov J, Sorkin P, Eldor A, Berliner S (1998) Down-regulation of the CD62L antigen as a possible mechanism for neutrophilia during inflammation. Br J Haematol 101(4):666-669 (Pubitemid 28308515)
38. Kassirer M, Zeltser D, Gluzman B, Leibovitz E, Goldberg Y, Roth A, Keren G, Rotstein R, Shapira I, Arber N, Berliner AS (1999) The appearance of L-selectin (low) polymorphonuclear leukocytes in the circulating pool of peripheral blood during myocardial infarction correlates with neutrophilia and with the size of the infarct. Clin Cardiol 22(11):721-726 (Pubitemid 29511002)
39. Robinson SD, Frenette PS, Rayburn H, Cummiskey M, Ullman-Culleré M, Wagner DD, Hynes RO (1999) Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Proc Natl Acad Sci USA 96(20): 11452-11457 (Pubitemid 29487401)
40. Arbonés ML, Ord DC, Ley K, Ratech H, Maynard-Curry C, Otten G, Capon DJ, Tedder TF (1994) Lymphocyte homing and leu-kocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1(4):247-260
41. Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MAS, Werb Z, Rafii S (2002) Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109(5):625-637 (Pubitemid 34628725)
42. Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L, Ponomaryov T, Taichman RS, Arenzana-Seisdedos F, Fujii N, Sandbank J, Zipori D, Lapidot T (2002) G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulat-ing CXCR4. Nat Immunol 3(7):687-694 (Pubitemid 34752479)
43. Lévesque J-P, Hendy J, Winkler IG, Takamatsu Y, Simmons PJ (2003) Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface ofhematopoietic progenitor cells. Exp Hematol 31(2):109-117 (Pubitemid 36184635)
44. Lévesque J-P, Hendy J, Takamatsu Y, Simmons PJ, Bendall LJ (2003) Disruption of the CXCR4/CXCL12 chemotactic interac-tion during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 111(2):187-196 (Pubitemid 36105917)
45. Levesque J, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC (2004) Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood 104(1):65-72 (Pubitemid 38879839)
46. Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC (1997) The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 185(1):111-120 (Pubitemid 27039446)
47. Kawabata K, Ujikawa M, Egawa T, Kawamoto H, Tachibana K, Iizasa H, Katsura Y, Kishimoto T, Nagasawa T (1999) A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution. Proc Natl Acad Sci USA 96(10):5663-5667 (Pubitemid 29234675)
48. Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara T, Honjo T (1995) Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics 28(3):495-500
49. Semerad CL, Christopher MJ, Liu F, Short B, Simmons PJ, Winkler I, Levesque J, Chappel J, Ross FP, Link DC (2005) G-CSF potently inhibits osteoblast activity and CXCL12 m RNA expression in the bone marrow. Blood 106(9):3020-3027 (Pubitemid 41565894)
50. Ara T, Nakamura Y, Egawa T, Sugiyama T, Abe K, Kishimoto T, Matsui Y, Nagasawa T (2003) Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proc Natl Acad Sci USA 100(9):5319-5323 (Pubitemid 36542703)
51. Sugiyama T, Kohara H, Noda M, Nagasawa T (2006) Mainte-nance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 25(6):977-988 (Pubitemid 44894948)
52. Christopher MJ, Liu F, Hilton MJ, Long F, Link DC (2009) Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobili-zation. Blood 114(7):1331-1339
53. Sierro F, Biben C, Martínez-Muñoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, Harvey RP, Martínez-A C, Mackay CR, Mackay F (2007) Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci USA 104(37):14759-14764 (Pubitemid 350003216)
54. Berahovich RD, Zabel BA, Penfold MET, Lewén S, Wany Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, Mc Grath KE, Jaen JC, Schall TJ (2010) CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol 185(9):5130-5139
55. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T (1996) Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382(6592): 635-638 (Pubitemid 26268957)
56. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR (1998) Function of the chemokine receptor CXCR4 in haemat-opoiesis and in cerebellar development. Nature 393(6685): 595-599 (Pubitemid 28319251)
57. Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kat-aoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, Kishimoto T, Nagasawa T (1998) The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393(6685):591-594 (Pubitemid 28319250)
58. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Ki-shimoto T, Bronson RT, Springer TA (1998) Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 95(16):9448-9453 (Pubitemid 28506251)
59. Ma Q, Jones D, Springer TA (1999) The chemokine receptor CXCR4 is required for the retention of B lineage and granulo-cytic precursors within the bone marrow microenvironment. Immunity 10(4):463-471 (Pubitemid 29205482)
60. Tzeng Y, Li H, Kang Y, Chen W, Cheng W, Lai D (2011) Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood 117(2):429-439
61. Liles WC, Broxmeyer HE, Rodger E, Wood B, Hübel K, Cooper S, Hangoc G, Bridger GJ, Henson GW, Calandra G, Dale DC (2003) Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood 102(8):2728-2730 (Pubitemid 37248839)
62. Broxmeyer HE, Orschell CM, Clapp DW, Hangoc G, Cooper S, Plett PA, Liles WC, Li X, Graham-Evans B, Campbell TB, Calandra G, Bridger G, Dale DC, Srour EF (2005) Rapid mobi-lization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 201(8):1307-1318 (Pubitemid 40629073)
63. Hernandez PA, Gorlin RJ, Lukens JN, Taniuchi S, Bohinjec J, Francois F, Klotman ME, Diaz GA (2003) Mutations in the che-mokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. Nat Genet 34(1):70-74 (Pubitemid 36548793)
64. Kawai T, Malech HL (2009) WHIM syndrome: congenital immune deficiency disease. Curr Opin Hematol 16(1):20-26
65. Kawai T, Choi U, Cardwell L, De Ravin SS, Naumann N, Whiting-Theobald NL, Linton GF, Moon J, Murphy PM, Malech HL (2007) WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4. Blood 109(1):78-84 (Pubitemid 46070121)
66. Walters KB, Green JM, Surfus JC, Yoo SK, Huttenlocher A (2010) Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome. Blood 116(15):2803-2811
67. Gulino AV, Moratto D, Sozzani S, Cavadini P, Otero K, Tassone L, Imberti L, Pirovano S, Notarangelo LD, Soresina R, Mazzolari E, Nelson DL, Notarangelo LD, Badolato R (2004) Altered leu-kocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome. Blood 104(2):444-452 (Pubitemid 38900027)
68. Balabanian K, Lagane B, Pablos JL, Laurent L, Planchenault T, Verola O, Lebbe C, Kerob D, Dupuy A, Hermine O, Nicolas J, Latger-Cannard V, Bensoussan D, Bordigoni P, Baleux F, Le Deist F, Virelizier J, Arenzana-Seisdedos F, Bachelerie F (2005) WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12. Blood 105(6):2449-2457 (Pubitemid 40387045)
69. Kawai T, Choi U, Whiting-Theobald NL, Linton GF, Brenner S, Sechler JMG, Murphy PM, Malech HL (2005) Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome. Exp Hematol 33(4):460-468 (Pubitemid 40387629)
70. Lagane B, Chow KYC, Balabanian K, Levoye A, Harriague J, Planchenault T, Baleux F, Gunera-Saad N, Arenzana-Seisdedos F, Bachelerie F (2008) CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome. Blood 112(1):34-44
71. Mc Cormick PJ, Segarra M, Gasperini P, Gulino AV, Tosato G (2009) Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syn-drome-associated CXCR4 mutant receptor. PLo S ONE 4(12):e8102
72. Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Be-novic JL (2010) Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differen-tial modulation of CXCR4 signaling. J Biol Chem 285(10):7805-7817
73. Laterveer L, Lindley IJ, Hamilton MS, Willemze R, Fibbe WE (1995) Interleukin-8 induces rapid mobilization ofhematopoietic stem cells with radioprotective capacity and long-term myel-olymphoid repopulating ability. Blood 85(8):2269-2275
74. King AG, Horowitz D, Dillon SB, Levin R, Farese AM, Mac-Vittie TJ, Pelus LM (2001) Rapid mobilization of murine hematopoietic stem cells with enhanced engraftment properties and evaluation of hematopoietic progenitor cell mobilization in rhesus monkeys by a single injection of SB-251353, a specific truncated form of the human CXC chemokine GRObeta. Blood 97(6):1534-1542 (Pubitemid 32217211)
75. Eash KJ, Greenbaum AM, Gopalan PK, Link DC (2010) CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest 120(7):2423-2431
76. Köhler A, De Filippo K, Hasenberg M, van den Brandt C, Nye E, Hosking MP, Lane TE, Männ L, Ransohoff RM, Hauser AE, Winter O, Schraven B, Geiger H, Hogg N, Gunzer M (2011) G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood 117(16):4349-4357
77. Wengner AM, Pitchford SC, Furze RC, Rankin SM (2008) The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood 111(1):42-49
78. Cacalano G, Lee J, Kikly K, Ryan AM, Pitts-Meek S, Hultgren B, Wood WI, Moore MW (1994) Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 265(5172):682-684 (Pubitemid 24268283)
79. Shuster DE, Kehrli ME, Ackermann MR (1995) Neutrophilia in mice that lack the murine IL-8 receptor homolog. Science 269(5230):1590-1591
80. Broxmeyer HE, Cooper S, Cacalano G, Hague NL, Bailish E, Moore MW (1996) Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue. J Exp Med 184(5):1825-1832 (Pubitemid 26404473)
81. Kawakami M, Tsutsumi H, Kumakawa T, Abe H, Hirai M, Ku-rosawa S, Mori M, Fukushima M (1990) Levels of serum granulocyte colony-stimulating factor in patients with infections. Blood 76(10):1962-1964
82. Delano MJ, Kelly-Scumpia KM, Thayer TC, Winfield RD, Scumpia PO, Cuenca AG, Harrington PB, O'Malley KA, Warner E, Gabrilovich S, Mathews CE, Laface D, Heyworth PG, Ram-phal R, Strieter RM, Moldawer LL, Efron PA (2011) Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol 187(2):911-918
83. Richardson RM, Tokunaga K, Marjoram R, Sata T, Snyderman R (2003) Interleukin-8-mediated heterologous receptor internaliza-tion provides resistance to HIV-1 infectivity: Role of signal strength and receptor desensitization. J Biol Chem 278(18):15867-15873 (Pubitemid 36799702)
84. Christopher MJ, Rao M, Liu F, Woloszynek JR, Link DC (2011) Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J Exp Med 208(2):251-260
85. Balabanian K, Levoye A, Klemm L, Lagane B, Hermine O, Harriague J, Baleux F, Arenzana-Seisdedos F, Bachelerie F (2008) Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling. J Clin Invest 118(3):1074-1084 (Pubitemid 351364615)
86. Bradley ME, Bond ME, Manini J, Brown Z, Charlton SJ (2009) SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor. Br J Pharmacol 158(1):328-338
87. Holz O, Khalilieh S, Ludwig-Sengpiel A, Watz H, Stryszak P, Soni P, Tsai M, Sadeh J, Magnussen H (2010) SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects. Eur Respir J 35(3):564-570
88. Lazaar AL, Sweeney LE, Macdonald AJ, Alexis NE, Chen C, Tal-Singer R (2011) SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol 72(2):282-293
89. Burger JA, Peled A (2009) CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers. Leukemia 23(1):43-52
90. Lazennec G, Richmond A (2010) Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol Med 16(3):133-144
91. Hendrix CW, Flexner C, Mac Farland RT, Giandomenico C, Fuchs EJ, Redpath E, Bridger G, Henson GW (2000) Pharma-cokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers. Antimicrob Agents Chemother 44(6):1667-1673 (Pubitemid 30340812)
92. Hendrix CW, Collier AC, Lederman MM, Schols D, Pollard RB, Brown S, Jackson JB, Coombs RW, Glesby MJ, Flexner CW, Bridger GJ, Badel K, Mac Farland RT, Henson GW, Calandra G (2004) Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection. J Acquir Immune Defic Syndr 37(2):1253-1262 (Pubitemid 39281506)
93. Mc Candless EE, Wang Q, Woerner BM, Harper JM, Klein RS (2006) CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoim-mune encephalomyelitis. J Immunol 177(11):8053-8064 (Pubitemid 44846323)
94. Matthys P, Hatse S, Vermeire K, Wuyts A, Bridger G, Henson GW, De Clercq E, Billiau A, Schols D (2001) AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflam-mation in IFN-gamma receptor-deficient mice. J Immunol 167(8):4686-4692 (Pubitemid 32954350)
95. Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ (2002) AMD3100, a Cx CR4 antagonist, attenuates allergic lung inflam-mationandairwayhyperreactivity. Am JPathol160(4):1353-1360 (Pubitemid 34411639)
96. Xia X-M, Wang F-Y, Xu W-A, Wang Z-K, Liu J, Lu Y-K, Jin X-X, Lu H, Shen Y-Z (2010) CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis. World J Gastroenterol 16(23):2873-2880