메뉴 건너뛰기




Volumn 93, Issue 11, 2012, Pages 1075-1085

Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients

(11)  Nashan, Björn a   Gaston, Robert b   Emery, Vincent c   Säemann, Marcus D d   Mueller, Nicolas J e   Couzi, Lionel f   Dantal, Jacques g   Shihab, Fuad h   Mulgaonkar, Shamkant i   Seun Kim, Yu j   Brennan, Daniel C k  


Author keywords

Anti CMV mechanism of action; Cytomegalovirus (CMV); Everolimus; Mammalian target of rapamycin (mTOR) inhibitors; Sirolimus

Indexed keywords

ACICLOVIR; ALEMTUZUMAB; AZATHIOPRINE; BASILIXIMAB; CYCLOSPORIN; DACLIZUMAB; EVEROLIMUS; GANCICLOVIR; HYPERIMMUNE GLOBULIN; IMMUNOSUPPRESSIVE AGENT; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; RAPAMYCIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY; VALACICLOVIR; VALGANCICLOVIR;

EID: 84862290097     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31824810e6     Document Type: Review
Times cited : (120)

References (79)
  • 1
    • 70350129075 scopus 로고    scopus 로고
    • The 'indirect' effects of cytomegalovirus infection
    • Freeman RB Jr. The 'indirect' effects of cytomegalovirus infection. Am J Transplant 2009; 9: 2453.
    • (2009) Am J Transplant , vol.9 , pp. 2453
    • Freeman Jr., R.B.1
  • 2
    • 42049088686 scopus 로고    scopus 로고
    • Severe cytomegalovirus infection in apparently immunocompetent patients: A systematic review
    • Rafailidis PI, Mourtzoukou EG, Varbobitis IC, et al. Severe cytomegalovirus infection in apparently immunocompetent patients: A systematic review. Virol J 2008; 5: 47.
    • (2008) Virol J , vol.5 , pp. 47
    • Rafailidis, P.I.1    Mourtzoukou, E.G.2    Varbobitis, I.C.3
  • 3
    • 37349073878 scopus 로고    scopus 로고
    • Infection in solid-organ transplant recipients
    • Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med 2007; 357: 2601.
    • (2007) N Engl J Med , vol.357 , pp. 2601
    • Fishman, J.A.1
  • 4
    • 3042808460 scopus 로고    scopus 로고
    • Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival
    • Sagedal S, Hartmann A, Nordal KP, et al. Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival. Kidney Int 2004; 66: 329.
    • (2004) Kidney Int , vol.66 , pp. 329
    • Sagedal, S.1    Hartmann, A.2    Nordal, K.P.3
  • 5
    • 33644825977 scopus 로고    scopus 로고
    • Meta-analysis: The efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients
    • Kalil AC, Levitsky J, Lyden E, et al. Meta-analysis: The efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients. Ann Intern Med 2005; 143: 870.
    • (2005) Ann Intern Med , vol.143 , pp. 870
    • Kalil, A.C.1    Levitsky, J.2    Lyden, E.3
  • 6
    • 20444453778 scopus 로고    scopus 로고
    • Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solidorgan transplants: A systematic review of randomised controlled trials
    • Hodson EM, Jones CA, Webster AC, et al. Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solidorgan transplants: A systematic review of randomised controlled trials. Lancet 2005; 365: 2105.
    • (2005) Lancet , vol.365 , pp. 2105
    • Hodson, E.M.1    Jones, C.A.2    Webster, A.C.3
  • 7
    • 17144396219 scopus 로고    scopus 로고
    • Effect of CMV infection on chronic rejection of kidney transplants
    • Prösch S, Cinatl J, Scholz M, eds Monograph virology. Basel, Karger
    • Lautenschlager I, Helanterä I, Inkinen K, et al. Effect of CMV infection on chronic rejection of kidney transplants. In: Prösch S, Cinatl J, Scholz M, eds. New aspects of CMV-related immunopathology. Monograph virology. Basel, Karger 2003, p 10.
    • (2003) New Aspects of CMV-related Immunopathology , pp. 10
    • Lautenschlager, I.1    Helanterä, I.2    Inkinen, K.3
  • 8
    • 13144268553 scopus 로고    scopus 로고
    • Canadian Society of Transplantation Consensus Workshop on cytomegalovirus management in solid organ transplantation final report
    • Preiksaitis JK, Brennan DC, Fishman J, et al. Canadian Society of Transplantation Consensus Workshop on cytomegalovirus management in solid organ transplantation final report. Am J Transplant 2005; 5: 218.
    • (2005) Am J Transplant , vol.5 , pp. 218
    • Preiksaitis, J.K.1    Brennan, D.C.2    Fishman, J.3
  • 9
    • 0036819751 scopus 로고    scopus 로고
    • The impact of cytomegalovirus infection and disease on rejection episodes in renal allograft recipients
    • Sagedal S, Nordal KP, Hartmann A, et al. The impact of cytomegalovirus infection and disease on rejection episodes in renal allograft recipients. Am J Transplant 2002; 2: 850.
    • (2002) Am J Transplant , vol.2 , pp. 850
    • Sagedal, S.1    Nordal, K.P.2    Hartmann, A.3
  • 10
    • 33746895463 scopus 로고    scopus 로고
    • Prophylactic versus preemptive oral valganciclovir for the management of cytomegalovirus infection in adult renal transplant recipients
    • Khoury JA, Storch GA, Bohl DL, et al. Prophylactic versus preemptive oral valganciclovir for the management of cytomegalovirus infection in adult renal transplant recipients. Am J Transplant 2006; 6: 2134.
    • (2006) Am J Transplant , vol.6 , pp. 2134
    • Khoury, J.A.1    Storch, G.A.2    Bohl, D.L.3
  • 11
    • 16244378141 scopus 로고    scopus 로고
    • Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: A 3-year randomized multicenter phase III study
    • Lorber MI, Mulgaonkar S, Butt KMH, et al. Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: A 3-year randomized, multicenter, phase III study. Transplantation 2005; 80: 244.
    • (2005) Transplantation , vol.80 , pp. 244
    • Lorber, M.I.1    Mulgaonkar, S.2    Butt, K.M.H.3
  • 12
    • 33845672656 scopus 로고    scopus 로고
    • 12-month safety and efficacy of everolimus with reduced exposure cyclosporine in de novo renal transplant recipients
    • Tedesco Silva H Jr, Vitko S, Pascual J, et al. 12-month safety and efficacy of everolimus with reduced exposure cyclosporine in de novo renal transplant recipients. Transpl Int 2007; 20: 27.
    • (2007) Transpl Int , vol.20 , pp. 27
    • Tedesco Silva Jr., H.1    Vitko, S.2    Pascual, J.3
  • 13
    • 11144357432 scopus 로고    scopus 로고
    • Everolimus with optimized cyclosporine dosing in renal transplant recipients: 6-month safety and efficacy results of two randomized studies
    • Vitko S, Tedesco H, Eris J, et al. Everolimus with optimized cyclosporine dosing in renal transplant recipients: 6-month safety and efficacy results of two randomized studies. Am J Transplant 2004; 4: 626.
    • (2004) Am J Transplant , vol.4 , pp. 626
    • Vitko, S.1    Tedesco, H.2    Eris, J.3
  • 14
    • 0345161813 scopus 로고    scopus 로고
    • Sirolimus (rapamycin)-based therapy in human renal transplantation: Similar efficacy and different toxicity compared with cyclosporine
    • Sirolimus European Renal Transplant Study Group
    • Groth CG, Bäckman L, Morales JM, et al. Sirolimus (rapamycin)-based therapy in human renal transplantation: Similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group. Transplantation 1999; 67: 1036.
    • (1999) Transplantation , vol.67 , pp. 1036
    • Groth, C.G.1    Bäckman, L.2    Morales, J.M.3
  • 15
    • 18244427344 scopus 로고    scopus 로고
    • Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients
    • Kreis H, Cisterne J-M, Land W, et al. Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients. Transplantation 2000; 69: 1252.
    • (2000) Transplantation , vol.69 , pp. 1252
    • Kreis, H.1    Cisterne, J.-M.2    Land, W.3
  • 16
    • 77952945224 scopus 로고    scopus 로고
    • Everolimus plus reducedexposure CsA versus mycophenolic acid plus standard-exposure CsA in renal-transplant recipients
    • Tedesco SilvaHJr, Cibrik D, Johnston T, et al. Everolimus plus reducedexposure CsA versus mycophenolic acid plus standard-exposure CsA in renal-transplant recipients. Am J Transplant 2010; 10: 1401.
    • (2010) Am J Transplant , vol.10 , pp. 1401
    • Tedesco Silva Jr., H.1    Cibrik, D.2    Johnston, T.3
  • 17
    • 33644696712 scopus 로고    scopus 로고
    • Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients
    • Vítko Š, Margreiter R, Weimar W, et al. Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients. Am J Transplant 2005; 5: 2521.
    • (2005) Am J Transplant , vol.5 , pp. 2521
    • Vítko, Š.1    Margreiter, R.2    Weimar, W.3
  • 18
    • 77951480815 scopus 로고    scopus 로고
    • Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication
    • Moorman NJ, Shenk T. Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication. J Virol 2010; 84: 5260.
    • (2010) J Virol , vol.84 , pp. 5260
    • Moorman, N.J.1    Shenk, T.2
  • 19
    • 33744473322 scopus 로고    scopus 로고
    • Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: A systematic review and metaanalysis of randomized trials
    • Webster AC, Lee VWS, Chapman JR, et al. Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: A systematic review and metaanalysis of randomized trials. Transplantation 2006; 81: 1234.
    • (2006) Transplantation , vol.81 , pp. 1234
    • Webster, A.C.1    Vws, L.2    Chapman, J.R.3
  • 20
    • 79953242027 scopus 로고    scopus 로고
    • Paradoxical aspects of rapamycin immunobiology in transplantation
    • Ferrer IR, Araki K, Ford ML. Paradoxical aspects of rapamycin immunobiology in transplantation. Am J Transplant 2011; 11: 654.
    • (2011) Am J Transplant , vol.11 , pp. 654
    • Ferrer, I.R.1    Araki, K.2    Ford, M.L.3
  • 21
    • 0036912410 scopus 로고    scopus 로고
    • Review of the proliferation inhibitor everolimus
    • Nashan B. Review of the proliferation inhibitor everolimus. Expert Opin Investig Drugs 2002; 11: 1845.
    • (2002) Expert Opin Investig Drugs , vol.11 , pp. 1845
    • Nashan, B.1
  • 22
    • 77954813558 scopus 로고
    • Strategies for managing cytomegalovirus in transplant recipients
    • Razonable RR. Strategies for managing cytomegalovirus in transplant recipients. Expert Opin Pharmacother 2010; 11: 1983.
    • (1983) Expert Opin Pharmacother , vol.11
    • Razonable, R.R.1
  • 23
    • 37349034394 scopus 로고    scopus 로고
    • Reduced exposure to calcineurin inhibitors in renal transplantation
    • Ekberg H, Tedesco-Silva H, Demirbas A, et al. Reduced exposure to calcineurin inhibitors in renal transplantation.NEngl J Med 2007; 357: 2562.
    • (2007) NEngl J Med , vol.357 , pp. 2562
    • Ekberg, H.1    Tedesco-Silva, H.2    Demirbas, A.3
  • 24
    • 52449085831 scopus 로고    scopus 로고
    • Impact of current transplantation management on the development of cytomegalovirus disease after renal transplantation
    • San Juan R, Aguado JM, Lumbreras C, et al. Impact of current transplantation management on the development of cytomegalovirus disease after renal transplantation. Clin Infect Dis 2008; 47: 875.
    • (2008) Clin Infect Dis , vol.47 , pp. 875
    • San Juan, R.1    Aguado, J.M.2    Lumbreras, C.3
  • 25
    • 17844404571 scopus 로고    scopus 로고
    • Does mycophenolate mofetil increase the incidence of cytomegalovirus disease compared with azathioprine after cadaveric kidney transplantation?
    • Basic-Jukic N, Kes P, Bubic-Filipi LJ, et al. Does mycophenolate mofetil increase the incidence of cytomegalovirus disease compared with azathioprine after cadaveric kidney transplantation? Transplant Proc 2005; 37: 850.
    • (2005) Transplant Proc , vol.37 , pp. 850
    • Basic-Jukic, N.1    Kes, P.2    Bubic-Filipi, L.J.3
  • 26
    • 0006986048 scopus 로고    scopus 로고
    • A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation
    • The Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group
    • The Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group. A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation. Transplantation 1996; 61: 1029.
    • (1996) Transplantation , vol.61 , pp. 1029
  • 27
    • 0029115531 scopus 로고
    • Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients
    • for the US Renal Transplant Mycophenolate Mofetil Study Group
    • Sollinger HW, for the US Renal Transplant Mycophenolate Mofetil Study Group. Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. Transplantation 1995; 60: 225.
    • (1995) Transplantation , vol.60 , pp. 225
    • Sollinger, H.W.1
  • 28
    • 0029006409 scopus 로고
    • Placebocontrolled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection
    • European Mycophenolate Mofetil Cooperative Study Group
    • European Mycophenolate Mofetil Cooperative Study Group. Placebocontrolled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 1995; 345: 1321.
    • (1995) Lancet , vol.345 , pp. 1321
  • 29
    • 34748853697 scopus 로고    scopus 로고
    • Randomized controlled study comparing reduced calcineurin inhibitors exposure versus standard cyclosporine-based immunosuppression
    • Hernández D, Miquel R, Porrini E, et al. Randomized controlled study comparing reduced calcineurin inhibitors exposure versus standard cyclosporine-based immunosuppression. Transplantation 2007; 84: 706.
    • (2007) Transplantation , vol.84 , pp. 706
    • Hernández, D.1    Miquel, R.2    Porrini, E.3
  • 30
    • 77950926374 scopus 로고    scopus 로고
    • International consensus guidelines on the management of cytomegalovirus in solid organ transplantation
    • Kotton CN, Kumar D, Caliendo AM, et al. International consensus guidelines on the management of cytomegalovirus in solid organ transplantation. Transplantation 2010; 89: 779.
    • (2010) Transplantation , vol.89 , pp. 779
    • Kotton, C.N.1    Kumar, D.2    Caliendo, A.M.3
  • 31
    • 0029927762 scopus 로고    scopus 로고
    • Impact of high-dose oral acyclovir prophylaxis on cytomegalovirus (CMV) disease in CMV high-risk renal transplant recipients
    • Kletzmayr J, Kotzmann H, Popow-Kraupp T, et al. Impact of high-dose oral acyclovir prophylaxis on cytomegalovirus (CMV) disease in CMV high-risk renal transplant recipients. J Am Soc Nephrol 1996; 7: 325.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 325
    • Kletzmayr, J.1    Kotzmann, H.2    Popow-Kraupp, T.3
  • 32
    • 21244444619 scopus 로고    scopus 로고
    • The impact of early cytomegalovirus infection and disease in renal transplant recipients
    • Sagedal S, Hartmann A, Rollag H. The impact of early cytomegalovirus infection and disease in renal transplant recipients. Clin Microbiol Infect 2005; 11: 518.
    • (2005) Clin Microbiol Infect , vol.11 , pp. 518
    • Sagedal, S.1    Hartmann, A.2    Rollag, H.3
  • 33
    • 41349087090 scopus 로고    scopus 로고
    • Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy
    • O'Brien S, Ravandi F, Riehl T, et al. Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy. Blood 2008; 111: 1816.
    • (2008) Blood , vol.111 , pp. 1816
    • O'Brien, S.1    Ravandi, F.2    Riehl, T.3
  • 34
    • 44849085080 scopus 로고    scopus 로고
    • Reduced exposure to calcineurin inhibitors in renal transplantation [10]
    • van den Hoogen M, Hilbrands L. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2008; 358: 2519. (Pubitemid 351793043)
    • (2008) New England Journal of Medicine , vol.358 , Issue.23 , pp. 2519
    • Van Den Hoogen, M.1    Hilbrands, L.2
  • 35
    • 33644889043 scopus 로고    scopus 로고
    • Complete avoidance of calcineurin inhibitors in renal transplantation: A randomized trial comparing sirolimus and tacrolimus
    • Larson TS, Dean PG, Stegall MD, et al. Complete avoidance of calcineurin inhibitors in renal transplantation: A randomized trial comparing sirolimus and tacrolimus. Am J Transplant 2006; 6: 514.
    • (2006) Am J Transplant , vol.6 , pp. 514
    • Larson, T.S.1    Dean, P.G.2    Stegall, M.D.3
  • 36
    • 77954088420 scopus 로고    scopus 로고
    • Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids
    • Glotz D, Charpentier B, Abramovicz D, et al. Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids. Transplantation 2010; 89: 1511.
    • (2010) Transplantation , vol.89 , pp. 1511
    • Glotz, D.1    Charpentier, B.2    Abramovicz, D.3
  • 37
    • 77956693664 scopus 로고    scopus 로고
    • Immunosuppressive therapy and infection after kidney transplantation
    • Fortun J, Martin-Davila P, Pascual J, et al. Immunosuppressive therapy and infection after kidney transplantation. Transpl Infect Dis 2010; 12: 397.
    • (2010) Transpl Infect Dis , vol.12 , pp. 397
    • Fortun, J.1    Martin-Davila, P.2    Pascual, J.3
  • 38
    • 84862289910 scopus 로고    scopus 로고
    • Everolimus-treated renal transplant patients have a lower incidence of CMV and BKV: Results from a multicenter, prospective study
    • 1659 (abstract)
    • Tedesco-Silva H, Johnston T, Kim YS, et al. Everolimus-treated renal transplant patients have a lower incidence of CMV and BKV: Results from a multicenter, prospective study. Am J Transplant 2010; 10(suppl 4): 509, 1659 (abstract).
    • Am J Transplant 2010 , vol.10 , Issue.SUPPL. 4 , pp. 509
    • Tedesco-Silva, H.1    Johnston, T.2    Kim, Y.S.3
  • 39
    • 84857194014 scopus 로고    scopus 로고
    • Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: Pooled analysis of three clinical trials
    • Brennan DC, Legendre C, Patel D, et al. Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: Pooled analysis of three clinical trials. Am J Transplant 2011; 11: 2453.
    • (2011) Am J Transplant , vol.11 , pp. 2453
    • Brennan, D.C.1    Legendre, C.2    Patel, D.3
  • 40
    • 9244246780 scopus 로고    scopus 로고
    • Everolimus (Certican) 12-month safety and efficacy versus mycophenolate mofetil in de novo renal transplant recipients
    • Vítko Š, Margreiter R,WeimarW, et al. Everolimus (Certican) 12-month safety and efficacy versus mycophenolate mofetil in de novo renal transplant recipients. Transplantation 2004; 78: 1532.
    • (2004) Transplantation , vol.78 , pp. 1532
    • Vítko, Š.1    Margreiter, R.2    Weimar, W.3
  • 41
    • 34548632281 scopus 로고    scopus 로고
    • The use of sirolimus in ganciclovir-resistant cytomegalovirus infections in renal transplant recipients
    • Ozaki KS, Câmara NOS, Nogueira E, et al. The use of sirolimus in ganciclovir-resistant cytomegalovirus infections in renal transplant recipients. Clin Transplant 2007; 21: 675.
    • (2007) Clin Transplant , vol.21 , pp. 675
    • Ozaki, K.S.1    Nos, C.2    Nogueira, E.3
  • 42
    • 79952361568 scopus 로고    scopus 로고
    • Everolimus-based calcineurininhibitor-free regimen in recipients of de-novo kidney transplants: An open-label randomised controlled trial
    • Budde K, Becker T, Arns W, et al. Everolimus-based, calcineurininhibitor- free regimen in recipients of de-novo kidney transplants: An open-label, randomised, controlled trial. Lancet 2011; 377: 837.
    • (2011) Lancet , vol.377 , pp. 837
    • Budde, K.1    Becker, T.2    Arns, W.3
  • 43
    • 65249134974 scopus 로고    scopus 로고
    • Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: Concept study
    • Lebranchu Y, Thierry A, Toupance O, et al. Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: Concept study. Am J Transplant 2009; 9: 1115.
    • (2009) Am J Transplant , vol.9 , pp. 1115
    • Lebranchu, Y.1    Thierry, A.2    Toupance, O.3
  • 44
    • 77957583305 scopus 로고    scopus 로고
    • Efficacy and safety of de novo or early everolimus with low cyclosporine in deceased-donor kidney transplant recipients at specified risk of delayed graft function: 12-month results of a randomized multicenter trial
    • Dantal J, Berthoux F, Moal MC, et al. Efficacy and safety of de novo or early everolimus with low cyclosporine in deceased-donor kidney transplant recipients at specified risk of delayed graft function: 12-month results of a randomized, multicenter trial. Transpl Int 2010; 23: 1084.
    • (2010) Transpl Int , vol.23 , pp. 1084
    • Dantal, J.1    Berthoux, F.2    Moal, M.C.3
  • 45
    • 79958010182 scopus 로고    scopus 로고
    • Risk factors for late-onset cytomegalovirus disease in donor seropositive/recipient seronegative kidney transplant recipients who receive antiviral prophylaxis
    • Boudreault AA, Xie H, Rakita RM, et al. Risk factors for late-onset cytomegalovirus disease in donor seropositive/recipient seronegative kidney transplant recipients who receive antiviral prophylaxis. Transpl Infect Dis 2011; 13: 244.
    • (2011) Transpl Infect Dis , vol.13 , pp. 244
    • Boudreault, A.A.1    Xie, H.2    Rakita, R.M.3
  • 46
    • 77954952597 scopus 로고    scopus 로고
    • Renal function efficacy and safety of sirolimus and mycophenolate mofetil after short-term calcineurin inhibitor-based quadruple therapy in de novo renal transplant patients: One-year analysis of a randomized multicenter trial
    • Guba M, Pratschke J, Hugo C, et al. Renal function, efficacy, and safety of sirolimus and mycophenolate mofetil after short-term calcineurin inhibitor-based quadruple therapy in de novo renal transplant patients: One-year analysis of a randomized multicenter trial. Transplantation 2010; 90: 175.
    • (2010) Transplantation , pp. 175
    • Guba, M.1    Pratschke, J.2    Hugo, C.3
  • 47
    • 4644252994 scopus 로고    scopus 로고
    • Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase
    • Kudchodkar SB, Yu Y, Maguire TG, et al. Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase. J Virol 2004; 78: 11030.
    • (2004) J Virol , vol.78 , pp. 11030
    • Kudchodkar, S.B.1    Yu, Y.2    Maguire, T.G.3
  • 48
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen CC, Kang SA, Chang JW, et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009; 284: 8023.
    • (2009) J Biol Chem , vol.284 , pp. 8023
    • Thoreen, C.C.1    Kang, S.A.2    Chang, J.W.3
  • 49
    • 79952844950 scopus 로고    scopus 로고
    • The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection
    • Clippinger AJ, Maguire TG, Alwine JC. The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. J Virol 2011; 85: 3930.
    • (2011) J Virol , vol.85 , pp. 3930
    • Clippinger, A.J.1    Maguire, T.G.2    Alwine, J.C.3
  • 50
    • 67650074206 scopus 로고    scopus 로고
    • MTOR regulates memory CD8 T cell differentiation
    • Araki K, Turner AP, Shaffer VO, et al. mTOR regulates memory CD8 T cell differentiation. Nature 2009; 460: 108.
    • (2009) Nature , vol.460 , pp. 108
    • Araki, K.1    Turner, A.P.2    Shaffer, V.O.3
  • 51
    • 77956893188 scopus 로고    scopus 로고
    • Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses
    • Ferrer IR, Wagener ME, Robertson JM, et al. Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. J Immunol 2010; 185: 2004.
    • (2004) J Immunol , pp. 185
    • Ferrer, I.R.1    Wagener, M.E.2    Robertson, J.M.3
  • 52
    • 0032588983 scopus 로고    scopus 로고
    • Implication of FC T cells in the human immune response to cytomegalovirus
    • Déchanet J, Merville P, Lim A, et al. Implication of FC T cells in the human immune response to cytomegalovirus. J Clin Invest 1999; 103: 1437.
    • (1999) J Clin Invest , vol.103 , pp. 1437
    • Déchanet, J.1    Merville, P.2    Lim, A.3
  • 53
    • 21144437846 scopus 로고    scopus 로고
    • Shared reactivity of VC2neg FC T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells
    • Halary F, Pitard V, Dlubek D, et al. Shared reactivity of VC2neg FC T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells. J Exp Med 2005; 201: 1567.
    • (2005) J Exp Med , vol.201 , pp. 1567
    • Halary, F.1    Pitard, V.2    Dlubek, D.3
  • 54
    • 79953814668 scopus 로고    scopus 로고
    • Rapamycin increases the yield and effector function of human FC T cells stimulated in vitro
    • Li H, Pauza CD. Rapamycin increases the yield and effector function of human FC T cells stimulated in vitro. Cancer Immunol Immunother 2011; 60: 361.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 361
    • Li, H.1    Pauza, C.D.2
  • 55
    • 72449147738 scopus 로고    scopus 로고
    • The multifunctional role of mTOR in innate immunity: Implications for transplant immunity
    • Säemann MD, Haidinger M, Hecking M, et al. The multifunctional role of mTOR in innate immunity: Implications for transplant immunity. Am J Transplant 2009; 9: 2655.
    • (2009) Am J Transplant , vol.9 , pp. 2655
    • Säemann, M.D.1    Haidinger, M.2    Hecking, M.3
  • 56
    • 54949109311 scopus 로고    scopus 로고
    • The TSC-mTOR signaling pathway regulates the innate inflammatory response
    • Weichhart T, Costantino G, Poglitsch M, et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008; 29: 565.
    • (2008) Immunity , vol.29 , pp. 565
    • Weichhart, T.1    Costantino, G.2    Poglitsch, M.3
  • 57
    • 40049106893 scopus 로고    scopus 로고
    • Latent membrane protein 1 of EBV activates phosphatidylinositol 3-kinase to induce production of IL-10
    • Lambert SL, Martinez OM. Latent membrane protein 1 of EBV activates phosphatidylinositol 3-kinase to induce production of IL-10. J Immunol 2007; 179: 8225.
    • (2007) J Immunol , vol.179 , pp. 8225
    • Lambert, S.L.1    Martinez, O.M.2
  • 58
    • 60849100558 scopus 로고    scopus 로고
    • Epstein-Barr virus, rapamycin, and host immune responses
    • Krams SM, Martinez OM. Epstein-Barr virus, rapamycin, and host immune responses. Curr Opin Organ Transplant 2008; 13: 563.
    • (2008) Curr Opin Organ Transplant , vol.13 , pp. 563
    • Krams, S.M.1    Martinez, O.M.2
  • 59
    • 70350536363 scopus 로고    scopus 로고
    • IL-12 and type i IFN response of neonatal myeloid DC to human CMV infection
    • Renneson J, Dutta B, Goriely S, et al. IL-12 and type I IFN response of neonatal myeloid DC to human CMV infection. Eur J Immunol 2009; 39: 2789.
    • (2009) Eur J Immunol , vol.39 , pp. 2789
    • Renneson, J.1    Dutta, B.2    Goriely, S.3
  • 60
    • 0037128167 scopus 로고    scopus 로고
    • Interferon A and interleukin 12 responses to viral infections: Pathways regulating dendritic cell cytokine expression in vivo
    • Dalod M, Salazar-Mather TP, Malmgaard L, et al. Interferon A and interleukin 12 responses to viral infections: Pathways regulating dendritic cell cytokine expression in vivo. J Exp Med 2002; 195: 517.
    • (2002) J Exp Med , vol.195 , pp. 517
    • Dalod, M.1    Salazar-Mather, T.P.2    Malmgaard, L.3
  • 62
    • 0034652261 scopus 로고    scopus 로고
    • Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
    • Kotenko SV, Saccani S, Izotova LS, et al. Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10). Proc Natl Acad Sci USA 2000; 97: 1695.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1695
    • Kotenko, S.V.1    Saccani, S.2    Izotova, L.S.3
  • 63
    • 0037089402 scopus 로고    scopus 로고
    • Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells
    • Moutaftsi M, Mehl AM, Borysiewicz LK, et al. Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells. Blood 2002; 99: 2913.
    • (2002) Blood , vol.99 , pp. 2913
    • Moutaftsi, M.1    Mehl, A.M.2    Borysiewicz, L.K.3
  • 64
    • 46249086111 scopus 로고    scopus 로고
    • Association between a polymorphism in the IL-12p40 gene and cytomegalovirus reactivation after kidney transplantation
    • Hoffmann TW, Halimi JM, Büchler M, et al. Association between a polymorphism in the IL-12p40 gene and cytomegalovirus reactivation after kidney transplantation. Transplantation 2008; 85: 1406.
    • (2008) Transplantation , vol.85 , pp. 1406
    • Hoffmann, T.W.1    Halimi, J.M.2    Büchler, M.3
  • 65
    • 40749108069 scopus 로고    scopus 로고
    • Delayed-onset primary cytomegalovirus disease and the risk of allograft failure and mortality after kidney transplantation
    • Arthurs SK, Eid AJ, Pedersen RA, et al. Delayed-onset primary cytomegalovirus disease and the risk of allograft failure and mortality after kidney transplantation. Clin Infect Dis 2008; 46: 840.
    • (2008) Clin Infect Dis , vol.46 , pp. 840
    • Arthurs, S.K.1    Eid, A.J.2    Pedersen, R.A.3
  • 66
    • 79953743926 scopus 로고    scopus 로고
    • Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: A phase 2 randomised placebo-controlled trial
    • Griffiths PD, Stanton A, McCarrell E, et al. Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: A phase 2 randomised placebo-controlled trial. Lancet 2011; 377: 1256.
    • (2011) Lancet , vol.377 , pp. 1256
    • Griffiths, P.D.1    Stanton, A.2    McCarrell, E.3
  • 67
    • 35248844442 scopus 로고    scopus 로고
    • Sirolimus versus cyclosporine in kidney recipients receiving thymoglobulin, mycophenolate mofetil and a 6-month course of steroids
    • Büchler M, Caillard S, Barbier S, et al. Sirolimus versus cyclosporine in kidney recipients receiving thymoglobulin, mycophenolate mofetil and a 6-month course of steroids. Am J Transplant 2007; 7: 2522.
    • (2007) Am J Transplant , vol.7 , pp. 2522
    • Büchler, M.1    Caillard, S.2    Barbier, S.3
  • 68
    • 77149153725 scopus 로고    scopus 로고
    • Lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil in de novo cardiac transplant recipients: A randomized multicenter study
    • Viganò M, Dengler T, Mattei MF, et al. Lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil in de novo cardiac transplant recipients: A randomized, multicenter study. Transpl Infect Dis 2010; 12: 23.
    • (2010) Transpl Infect Dis , vol.12 , pp. 23
    • Viganò, M.1    Dengler, T.2    Mattei, M.F.3
  • 69
    • 2342533013 scopus 로고    scopus 로고
    • Low incidence of cytomegalovirus disease in liver transplant recipients receiving sirolimus primary immunosuppression with 3-day corticosteroid taper
    • Trotter JF, Wallack A, Steinberg T. Low incidence of cytomegalovirus disease in liver transplant recipients receiving sirolimus primary immunosuppression with 3-day corticosteroid taper. Transpl Infect Dis 2003; 5: 174.
    • (2003) Transpl Infect Dis , vol.5 , pp. 174
    • Trotter, J.F.1    Wallack, A.2    Steinberg, T.3
  • 70
    • 47249142845 scopus 로고    scopus 로고
    • Alemtuzumab (Campath-1H) and tacrolimus monotherapy after renal transplantation: Results of a prospective randomized trial
    • Margreiter R,Klempnauer J, Neuhaus P, et al. Alemtuzumab (Campath-1H) and tacrolimus monotherapy after renal transplantation: Results of a prospective randomized trial. Am J Transplant 2008; 8: 1480.
    • (2008) Am J Transplant , vol.8 , pp. 1480
    • Margreiter Rklempnauer, J.1    Neuhaus, P.2
  • 71
    • 68949218373 scopus 로고    scopus 로고
    • Cytomegalovirus infection renal transplant recipients: Risk factors and outcome
    • Kanter J, Pallardó L, Gavela E, et al. Cytomegalovirus infection renal transplant recipients: Risk factors and outcome. Transplant Proc 2009; 41: 2156.
    • (2009) Transplant Proc , vol.41 , pp. 2156
    • Kanter, J.1    Pallardó, L.2    Gavela, E.3
  • 72
    • 78650119705 scopus 로고    scopus 로고
    • Cytomegalovirus risk factors in renal transplantation with modern immunosuppression
    • Bataille S, Moal V, Gaudart J, et al. Cytomegalovirus risk factors in renal transplantation with modern immunosuppression. Transpl Infect Dis 2010; 12: 480.
    • (2010) Transpl Infect Dis , vol.12 , pp. 480
    • Bataille, S.1    Moal, V.2    Gaudart, J.3
  • 73
    • 25844486486 scopus 로고    scopus 로고
    • Documento de consenso GESITRA-SEIMC sobre prevención y tratamiento de la infección por citomegalovirus en pacientes transplantados EConsensus document from GESITRA-SEIMC on the prevention and treatment of cytomegalovirus infection in transplanted patients
    • Torre-Cisneros J, Fortun J, Aguado JM, et al. Documento de consenso GESITRA-SEIMC sobre prevención y tratamiento de la infección por citomegalovirus en pacientes transplantados EConsensus document from GESITRA-SEIMC on the prevention and treatment of cytomegalovirus infection in transplanted patients. Enferm Infecc Microbiol Clin 2005; 23: 424.
    • (2005) Enferm Infecc Microbiol Clin , vol.23 , pp. 424
    • Torre-Cisneros, J.1    Fortun, J.2    Aguado, J.M.3
  • 74
    • 10744228977 scopus 로고    scopus 로고
    • Bicêtre hospital experience with sirolimus-based therapy in human renal transplantation: The Sirolimus European Renal Transplant Study
    • Charpentier B, Groth CG, Bäckman L, et al. Bicêtre hospital experience with sirolimus-based therapy in human renal transplantation: The Sirolimus European Renal Transplant Study. Transplant Proc 2003; 35(suppl 3A): 58S.
    • (2003) Transplant Proc , vol.35 , Issue.SUPPL. 3A
    • Charpentier, B.1    Groth, C.G.2    Bäckman, L.3
  • 75
    • 34247582790 scopus 로고    scopus 로고
    • Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs
    • Flechner SM, Goldfarb D, Solez K, et al. Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs. Transplantation 2007; 83: 883.
    • (2007) Transplantation , vol.83 , pp. 883
    • Flechner, S.M.1    Goldfarb, D.2    Solez, K.3
  • 76
    • 33645649901 scopus 로고    scopus 로고
    • A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate versus cyclosporine/sirolimus in renal transplantation: Three-year analysis
    • Ciancio G, Burke GW, Gaynor JJ, et al. A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate versus cyclosporine/ sirolimus in renal transplantation: Three-year analysis. Transplantation 2006; 81: 845.
    • (2006) Transplantation , vol.81 , pp. 845
    • Ciancio, G.1    Burke, G.W.2    Gaynor, J.J.3
  • 77
    • 3943072739 scopus 로고    scopus 로고
    • Everolimus and reduced-exposure cyclosporine in de novo renal-transplant recipients: A three-year phase II randomized multicenter open-label study
    • Nashan B, Curtis J, Ponticelli C, et al. Everolimus and reduced-exposure cyclosporine in de novo renal-transplant recipients: A three-year phase II, randomized, multicenter, open-label study. Transplantation 2004; 78: 1332.
    • (2004) Transplantation , vol.78 , pp. 1332
    • Nashan, B.1    Curtis, J.2    Ponticelli, C.3
  • 78
    • 73849119625 scopus 로고    scopus 로고
    • Everolimus with very lowexposure cyclosporine a in de novo kidney transplantation: A multicenter randomized controlled trial
    • Salvadori M, Scolari MP, Bertoni E, et al. Everolimus with very lowexposure cyclosporine a in de novo kidney transplantation: A multicenter, randomized, controlled trial. Transplantation 2009; 88: 1194.
    • (2009) Transplantation , vol.88 , pp. 1194
    • Salvadori, M.1    Scolari, M.P.2    Bertoni, E.3
  • 79
    • 84862273677 scopus 로고    scopus 로고
    • Cyclosporine (CYA) very low dose with everolimus (E) high dose is associated with better outcomes in renal transplant patients with respect to standard treatment with EC-MPS (M)
    • SA-FC449 (abstract)
    • Bertoni E, Salvadori M. Cyclosporine (CYA) very low dose with everolimus (E) high dose is associated with better outcomes in renal transplant patients with respect to standard treatment with EC-MPS (M). J Am Soc Nephrol 2010; 21: 102A, SA-FC449 (abstract).
    • (2010) J Am Soc Nephrol , vol.21
    • Bertoni, E.1    Salvadori, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.