Implication of γδ T cells in the human immune response to cytomegalovirus

Journal of Clinical Investigation

Volumn 103, Issue 10, 1999, Pages 1437-1449

  Déchanet, Julie ^a,f   Merville, Pierre ^a,c   Lim, Annick ^b   Retière, Christelle ^d   Pitard, Vincent ^a   Lafarge, Xavier ^a   Michelson, Susan ^b   Méric, Claude ^e   Hallet, Marie Martine ^d   Kourilsky, Philippe ^b   Potaux, Luc ^c   Bonneville, Marc ^d   Moreau, Jean François ^a  

^a CNRS   (France)

^b INSTITUT PASTEUR   (France)

^c BORDEAUX UNIVERSITY HOSPITAL   (France)

^d INSTITUT DE BIOLOGIE   (France)

^e Pasteur Merieux Connaught   (France)

^f CNRS Bordeaux Segalen University   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; PRIMER DNA;

AMINO ACID SEQUENCE; ARTICLE; CELL FATE; CLINICAL ARTICLE; CYTOMEGALOVIRUS INFECTION; GENETIC VARIABILITY; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; ADOLESCENT; ADULT; CHILD; CYTOMEGALIC INCLUSION BODY DISEASE; CYTOMEGALOVIRUS; FEMALE; GENETICS; IMMUNOLOGY; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; TIME;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; CHILD; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA PRIMERS; FEMALE; HUMANS; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; TIME FACTORS;

EID: 0032588983     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5409     Document Type: Article

References (70)

1. Haas, W., Pereira, P., and Tonegawa, S. 1993. Gamma/delta cells. Annu. Rev. Immunol. 11:637-685.
2. Kaufmann, S.H.E. 1996. γδ and other unconventional T lymphocytes: what do they see and what do they do? Proc. Natl. Acad Sci. USA. 93:2272-2279.
3. Rauler, D.H. 1989. The structure, function, and molecular genetics of the γδ T cell receptor. Annu. Rev. Immunol. 7:175-207.
4. Deusch, K., et al. 1991. A major fraction of human intraepithelial lymphocytes simultaneously expresses the γδ T-cell receptor, the CD8 accessory molecule and preferentially uses the Vδ1 gene segment. Eur. J. Immunol. 21:1053-1059.
5. Parker, C.M., et al. 1990. Evidence for extrathymic changes in the T cell receptor γδ repertoire. J. Exp. Med. 171:1597-1612.
6. De Libero, G. 1997. Sentinel function of broadly reactive human γδ T cells. Immunol. Today. 18:22-26.
7. Falini, B., et al. 1989. Distribution of T cells bearing different forms of the T cell receptor γδ in normal and pathological human tissues. J. Immunol. 143:2480-2488.
8. Modlin, R.L., et al. 1989. Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions. Nature. 339:544-548.
9. Ho, M., Webster, H.K., Tongtawe, P., Pattanpanyasat, K., and Weidanz, W.P. 1990. Increased γδ T cells in acute Plasmodium falciparum malaria. Immunol. Lett. 140:2171-2175.
10. Scalise, F., et al. 1992. Lymphocytes bearing the γδ T-cell receptor in acute toxoplasmosis. Immunology. 76:668-670.
11. De Paoli, P., et al. 1990. γδ T cell receptor-bearing lymphocytes during Epstein-Barr virus infection. J. Infect. Dis. 161:1013-1016.
12. Autran, M., et al. 1989. T cell receptor γδ lymphocyte subsets during HIV infection. Clin. Exp. Immunol. 75:206-210.
13. Munk, M.E., et al. 1993. Onchocerca volvulus provides ligands for the stimulation o fhuman γδ T lymphocytes expressing Vδ1 chains. J. Infect. Dis. 168:1241-1247.
14. Giacomelli, R., et al. 1994. Increase of circulating γδ T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease. Clin. Exp. Immunol. 98:83-88.
15. Tanaka, Y., Morita, C.T., Nieves, E., Brenner, M.B., and Bloom, B.R. 1995. Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature. 375:155-158.
16. Constant, P., et al. 1994. Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands. Science. 264:267-270.
17. Groh, V., Steinle, A., Bauer, S., and Spies, T. 1998. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science. 279:1737-1740.
18. Hiromatsu, K., et al. 1992. Aprocective role of γδ T cells in primary infection with Listeria monocytogenes in mice. J. Exp. Med. 175:49-56.
19. Monbaerts, P., Arnoldi, J., Russ, F., Tonegawa, S., and Kaufmann, S.H. 1993. Different roles of αβ and γδ T cells in immunity against intracellular bacterial pathogen. Nature. 365:53-56.
20. Sciammas, R., Kodukula, P., Tang, Q., Hendricks, R.L., and Bluestone, J.A. 1997. T cell receptor-γ/δ cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J. Exp. Med. 185:1969-1975.
21. Mukasa, A., et al. 1995. Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of αβ and γδ T cells. J. Immunol. 155:2047-2056.
22. Roberts, S.J., et al. 1996. T-cell αβ and γδ deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc. Natl. Acad. Sci. USA. 93:11774-11779.
23. + cells. Proc. Natl. Acad. Sci. USA. 91:11948-11952.
24. Snydman, D.R., Rubin, R.H., and Werner, B.G. 1993. New developments in cytomegalovirus prevention and management. Am. J. Kidney Dis. 21:217-228.
25. Waldman, W.J., Adams, P.W., Knight, D.A., and Sedmak, D.D. 1997. CMV as an exacerbating agent in transplant vascular sclerosis: potential immune-mediated mechanisms modelled in vitro. Transplant. Proc. 29:1545-1546.
26. Yilmaz, S., et al. 1996. Cytomegalovirus infection-enhanced chronic kidney allograft rejection is linked with intercellular adhesion molecule-1 expression. Kidney Int. 50:526-537.
27. Richardson, W.P., Colvin, R.B., and Cheeseman, S.H. 1981. Glomerulopathy associated with cytomegalovirus viremia in renal allografts. N. Engl. J. Med. 305:57-63.
28. Li, C.R., Greenberg, P.D., Gilbert, M.J., Goodrich, J.M., and Riddell, S.R. 1994. Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: correlation with CMV disease and effect of ganciclovir prophylaxis. Blood. 83:1971-1979.
29. + T cells. Clin. Exp. Immunol. 95:465-473.
30. Déchanet, J., et al. 1999. Major expansion of γδ T lymphocytes following cytomegalovirus infection in kidney allograft recipients. J. Infect. Dis. 179:1-8.
31. Hinz, T., et al. 1997. Identification of the complete expressed human TCR Vγ repertoire by flow cytometry. Int. Immunol. 9:1065-1072.
32. Kabelitz, D., et al. 1994. New monoclonal antibody (23D12) recognizing three different Vγ elements of the human γδ T cell receptor. 23D12+ cells comprise a major subpopularion of γδ T cells in postnatal thymus. J. Immunol. 152:3128-3136.
33. Peyrat, M.A., et al. 1995. Repertoire analysis of human peripheral blood lymphocytes using a human Vδ3 region-specific monoclonal antibody. Characterization of dual T cell receptor (TCR) δ-chain expressors and αβ T cells expressing Vδ3JαCα-encoded TCR chains. J. Immunol. 155:3060-3067.
34. Romagné, F., et al. 1996. Structural analysis of γδ TCR using a novel set of TCR γ and δ chain-specific monoclonal antibodies generated against soluble γδ TCR. Evidence for a specific conformation adopted by the Jδ2 region and for a V1 polymorphism. J. Immunol. Methods. 189:25-36.
35. - T lymphocytes in AIDS patients with disseminated Mycobacterium avium-intracellulare complex infection. J. Inject. Dis. 174:969-976.
36. Chomczynski, P., and Saachi, N. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
37. Even, J., et al. 1995. Tcell repertoires in healthy and diseased human tissues analyzed by T cell receptor β chain CDR3 size determination. Evidence for oligoclonal expansions in tumors and inflammatory diseases. Res. Immunol. 146:65-80.
38. Pannetier, C., et al. 1993. The sizes of CDR3 hypervariable regions of the murine Tcell receptor β chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA. 90:4319-4323.
39. Davodeau, F., et al. 1993. Peripheral selection of antigen receptor junctional features in a major human γδ subset. Eur. J. Immunol. 23:804-808.
40. Pitard, V., et al. 1997. Production and characterization of monoclonal antibodies against the human leukemia inhibitory factor low affinity receptor, gp190. J. Immunol. Methods. 205:177-190.
41. + cells with restricted T cell receptor δ gene junctional repertoire in the peripheral blood of healthy donors. J. Exp. Med. 178:121-127.
42. Tsuji, M., et al. 1994. γδ T cells contribute to immunity against the liver stages of malaria in αβ T-cell-deficient mice. Proc. Natl. Acad. Sci. USA. 91:345-349.
43. D'Souza, C.D., et al. 1997. An anti-inflammatory role for γδ T lymphocytes in acquired immunity to Mycobacterium tuberculosis. J. Immunol. 158:1217-1221.
44. Azuma, M., Phillips, J.H., and Lanier, L.L. 1993. CD28-Tlymphocytes. Antigenic and functional properties. J. Immunol. 150:1147-1159.
45. + T lymphocyte subsets that express HLA class 1-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations. Proc. Natl. Acad. Sci. USA. 93:12433-12438.
46. - T cells in rheumatoid arthritis. Mol. Med. 2:608-618.
47. + T cell expansion in the peripheral blood of HIV-infected persons. J. Immunol. 154:1418-1431.
48. Poccia, P., et al. 1996. Peripheral Vγ9/Vδ2 T cell deletion and anergy to non-peptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J. Immunol. 157:449-461.
49. Wucherpfennig, K. W., et al. 1992. γδ T cell-receptor repertoire in acute multiple sclerosis lesions. Proc. Natl. Acad. Sci. USA. 89:4588-4592.
50. Sioud, M., Forre, O., and Natvig, J.B. 1991. T cell receptor δ diversity of freshly isolated T lymphocytes in rheumatoid synovitis. Eur. J. Immunol. 21:239-241.
51. + phenotypes are increased in coeliac disease. Scand. J. Immunol. 30:665-672.
52. high γδ T cells in Lyme arthritis. J. Exp. Med. 184:2109-2117.
53. Uyemura, K., et al. 1991. Evidence for clonal selection of γδ T cells in response to a human pathogen. J. Exp. Med. 174:683-692.
54. Soderström, K., et al. 1994. High expression of Vγ8 is a shared feature of human γδ T cells in the epithelium of the gut and in the inflamed synovial tissue. J. Immunol. 152:6017-6027.
55. Labalette, M., et al. 1995. Implication of cyclosporine in up-regulation of Bcl-2 expression and maintenance of CD8 lymphocytosis in cytomegalovirus-infected allograft recipients. Transplantation. 59:1714-1722.
56. Hill, A., et al. 1995. Herpes simplex virus turns off the TAP to evade host immunity. Nature. 375:411-415.
57. Fruh, K., et al. 1995. A viral inhibitor of peptide transporters for antigen presentation. Nature. 375:415-418.
58. Ahn, K., et al. 1996. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proc. Natl. Acad. Sci. USA. 93:10990-10995.
59. Jones, T.R., et al, 1996. Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proc. Natl. Acad. Sci. USA. 93:11327-11333.
60. Wiertz, E.J.H.J., et al. 1996. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature. 384:432-438.
61. Lehner, P.J., Karttunen, J.T., Wilkinson, G.W.G, and Cresswell, P. 1997. The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translation. Proc. Natl. Acad. Sci. USA. 94:6904-6909.
62. Gilbert, M.J., Riddell, S., Plachter, B., and Greenberg, P.D. 1996. Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product. Nature. 383:720-722.
63. Beck, S., and Barrell, B.G. 1988. Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature. 331:269-272.
64. Cosman, D., et al. 1997. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 7:273-282.
65. Farrell, H.E., et al. 1997. Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo. Nature. 386:510-514.
66. Reyburn, H.T., et al. 1997. The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells. Nature. 386:514-517.
67. Leong, C.C., et al. 1998. Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: the role of endogenous class I major histocompatibility complex and a viral class I homolog. J. Exp. Med. 187:1681-1687.
68. Schild, H., et al. 1994. The nature of MHC recognition by γδ T cells. Cell. 76:29-37.
69. Morita, C.T., et al. 1995. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity. 3:495-507.
70. + αα i-IEL is resistant to cyclosporin A. J. Immunol. 155:4224-4230.