Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solid-organ transplants: A systematic review of randomised controlled trials

Lancet

Volumn 365, Issue 9477, 2005, Pages 2105-2115

  Hodson, Elisabeth M ^a,d   Jones, Cheryl A ^b,e   Webster, Angela C ^a,d   Strippoli, Giovanni F M ^a,f   Barclay, Peter G ^c   Kable, Kathy ^c   Vimalachandra, Dushyanthi ^a   Craig, Jonathan C ^a,d  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^c WESTMEAD HOSPITAL   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

^f UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; FOSCARNET; GANCICLOVIR; PLACEBO; VALACICLOVIR; VALGANCICLOVIR;

ACUTE GRAFT REJECTION; ANTIBIOTIC PROPHYLAXIS; BACTERIAL INFECTION; CELL COUNT; CLINICAL TRIAL; CONFIDENCE INTERVAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DATA ANALYSIS; DEATH; DRUG EFFICACY; GRAFT FAILURE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HUMAN; INFECTION PREVENTION; LEUKOPENIA; META ANALYSIS; MORTALITY; MYCOSIS; NEUTROPHIL; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PROPHYLAXIS; PROTOZOAL INFECTION; RECIPIENT; REGRESSION ANALYSIS; REVIEW; RISK ASSESSMENT; RISK REDUCTION; SIDE EFFECT; STATISTICAL SIGNIFICANCE; SYSTEMATIC REVIEW; VARICELLA ZOSTER VIRUS;

EID: 20444453778     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)66553-1     Document Type: Article

References (55)

1. RH Rubin, SA Kemmerly, D Conti Prevention of primary cytomegalovirus disease in organ transplant recipients with oral ganciclovir or oral acyclovir prophylaxis Transpl Infect Dis 2 2000 112 17
2. J Waiser, K Budde, M Schreiber Effectiveness of deferred therapy with ganciclovir in renal allograft recipients with cytomegalovirus disease Transplant Proc 30 1998 2083 85
3. SR Duncan, WF Grgurich, AT Iacono A comparison of ganciclovir and acyclovir to prevent cytomegalovirus after lung transplantation Am J Respir Crit Care Med 150 1994 146 52
4. MA Schnitzler, JA Lowell, KL Hardinger, SB Boxerman, TC Bailey, DC Brennan The association of cytomegalovirus sero-pairing with outcomes and costs following cadaveric renal transplantation prior to the introduction of oral ganciclovir CMV prophylaxis Am J Transplant 3 2003 445 51
5. MJ George, DR Snydman, BG Werner The independent role of cytomegalovirus as a risk factor for invasive fungal disease in orthotopic liver transplant recipients Am J Med 103 1997 106 13
6. M Ho Advances in understanding cytomegalovirus infection after transplantation Transplant Proc 26 1994 7 11
7. SR Smith, DW Butterly, PJ Conlon, RC Harland, OE Emovon Incidence of cytomegalovirus disease in renal transplantation without antilymphocyte induction: is prophylaxis necessary? Transplant Proc 30 1998 2097 99
8. PL Hibberd, NE Tolkoff-Rubin, AB Cosimi Symptomatic cytomegalovirus disease in the cytomegalovirus antibody seropositive renal transplant recipient treated with OKT3 Transplantation 53 1992 68 72
9. K Dickersin, R Scherer, C Lefebvre Identifying relevant studies for systematic reviews BMJ 309 1994 1286 91
10. Lefebvre C, McDonald S. Development of a sensitive search strategy for reports of randomized controlled trials in EMBASE. Proceedings of the 4th International Cochrane Colloquium, Oct 20-24, 1996, Adelaide, Australia.
11. JP Higgins, SG Thompson, JJ Deeks, DG Altman Measuring inconsistency in meta-analyses BMJ 327 2003 557 60
12. HH Balfour Jr, BA Chace, JT Stapleton, RL Simmons, DS Fryd A randomized, placebo-controlled trial of oral acyclovir for the prevention of cytomegalovirus disease in recipients of renal allografts N Engl J Med 320 1989 1381 87
13. J Kletzmayr, H Kotzmann, T Popow-Kraupp, J Kovarik, R Klauser Impact of high-dose oral acyclovir prophylaxis on cytomegalovirus (CMV) disease in CMV high-risk renal transplant recipients J Am Soc Nephrol 7 1996 325 30
14. L Rostaing, A Crespin, J Icart Cytomegalovirus (CMV) prophylaxis by acyclovir in pre-transplant CMV-positive renal transplant recipients Transplant Int 7 suppl 1 1994 S331 35
15. L Barkholt, I Lewensohn-Fuchs, BG Ericzon, G Tyden, J Andersson High-dose acyclovir prophylaxis reduces cytomegalovirus disease in liver transplant patients Transpl Infect Dis 1 1999 89 97
16. J Gavalda, J De Otero, E Murio Two grams daily of oral acyclovir reduces the incidence of cytomegalovirus disease in CMV seropositive liver transplant recipients Transplant Int 10 1997 462 65
17. F Saliba, D Eyraud, D Samuel Randomized controlled trial of acyclovir for the prevention of cytomegalovirus infection and disease in liver transplant recipients Transplant Proc 25 1993 1444 45
18. N Ahsan, MJ Holman, HC Yang Efficacy of oral ganciclovir in prevention of cytomegalovirus infection in post-kidney transplant patients Clin Transplant 11 1997 633 39
19. DC Brennan, KA Garlock, GG Singer Prophylactic oral ganciclovir compared with deferred therapy for control of cytomegalovirus in renal transplant recipients Transplantation 64 1997 1843 46
20. DJ Conti, BM Freed, TP Singh Preemptive ganciclovir therapy in cytomegalovirus-seropositive renal transplants recipients Arch Surg 130 1995 1217 22
21. PL Hibberd, NE Tolkoff-Rubin, D Conti Preemptive ganciclovir therapy to prevent cytomegalovirus disease, in cytomegalovirus antibody-positive renal transplant recipients: a randomized controlled trial Ann Intern Med 123 1995 18 26
22. H Leray, G Mourad, G Chong, M Segondy, C Mion Prophylactic treatment of cytomegalovirus primary infection with ganciclovir in renal transplant recipients Transplant Proc 27 1995 2448
23. C Pouteil-Noble, F Megas, F Chapuis Cytomegalovirus prophylaxis by ganciclovir followed by high-dose acyclovir in renal transplantation: a randomized, controlled trial Transplant Proc 28 1996 2811
24. E Rondeau, B Bourgeon, MN Peraldi Effect of prophylactic ganciclovir on cytomegalovirus infection in renal transplant recipients Nephrol Dial Transplant 8 1993 858 62
25. AT Cohen, JG O'Grady, S Sutherland, R Sallie, K-C Tan, R Williams Controlled trial of prophylactic versus therapeutic use of ganciclovir after liver transplantation in adults J Med Virol 40 1993 5 9
26. E Gane, F Saliba, GJ Valdecasas Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients Lancet 350 1997 1729 33
27. PS Macdonald, AM Keogh, D Marshman A double-blind placebo-controlled trial of low-dose ganciclovir to prevent cytomegalovirus disease after heart transplantation J Heart Lung Transplant 14 1995 32 38
28. TC Merigan, DG Renlund, S Keay A controlled trial of ganciclovir to prevent cytomegalovirus disease after heart transplantation N Engl J Med 326 1992 1182 86
29. D Lowance, HH Neumayer, CM Legendre Valacyclovir for the prevention of cytomegalovirus disease after renal transplantation N Engl J Med 340 1999 1462 70
30. JJ Egan, KB Carroll, N Yonan, A Woodcock, A Crisp Valacyclovir prevention of cytomegalovirus reactivation after heart transplantation: a randomized trial J Heart Lung Transplant 21 2002 460 66
31. SM Flechner, RK Avery, R Fisher A randomized prospective controlled trial of oral acyclovir versus oral ganciclovir for cytomegalovirus prophylaxis in high-risk kidney transplant recipients Transplantation 66 1998 1682 88
32. AD Badley, EC Seaberg, MK Porayko Prophylaxis of cytomegalovirus infection in liver transplantation: a randomized trial comparing a combination of ganciclovir and acyclovir to acyclovir Transplantation 64 1997 66 73
33. M Green, M Kaufmann, J Wilson, J Reyes Comparison of intravenous ganciclovir followed by oral acyclovir with intravenous ganciclovir alone for prevention of cytomegalovirus and Epstein- Barr virus disease after liver transplantation in children Clin Infect Dis 25 1997 1344 49
34. M Martin, R Manez, P Linden A prospective randomized trial comparing sequential ganciclovir-high dose acyclovir to high dose acyclovir for prevention of cytomegalovirus disease in adult liver transplant recipients Transplantation 58 1994 779 85
35. PZ Nakazato, W Burns, P Moore, R Garcia-Kennedy, K Cox, C Esquivel Viral prophylaxis in hepatic transplantation: Preliminary report of a randomized trial of acyclovir and gancyclovir Transplant Proc 25 1993 1935 37
36. DJ Winston, D Wirin, A Shaked, RW Busuttil Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients Lancet 346 1995 69 74
37. DJ Winston, RW Busuttil Randomized controlled trial of oral ganciclovir versus oral acyclovir after induction with intravenous ganciclovir for long-term prophylaxis of cytomegalovirus disease in cytomegalovirus-seropositive liver transplant recipients Transplantation 75 2003 229 33
38. C Paya, A Humar, E Dominguez Efficacy and safety of valganciclovir vs oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients Am J Transplant 4 2004 611 20
39. T Reischig, K Opatrny Jr, M Bouda, V Treska, P Jindra, MT Svecova Trial of oral ganciclovir versus oral valacyclovir for prophylaxis of cytomegalovirus disease after renal transplantation: a randomized prospective controlled trial Transpl Int 15 2002 615 22
40. T Reischig, P Jindra, J Mares Valacyclovir for cytomegalovirus prophylaxis reduces the risk of acute renal allograft rejection: a randomized comparison of oral ganciclovir and valacyclovir Am J Transplant 4 2004 493
41. DJ Winston, RW Busuttil Randomized controlled trial of sequential intravenous and oral ganciclovir versus prolonged intravenous ganciclovir for long-term prophylaxis of cytomegalovirus disease in high-risk cytomegalovirus-seronegative liver transplant recipients with cytomegalovirus-seropositive donors Transplantation 77 2004 305 08
42. MI Hertz, C Jordan, SK Savik Randomized trial of daily versus three-times-weekly prophylactic ganciclovir after lung and heart-lung transplantation J Heart Lung Transplant 17 1998 913 20
43. RS Baliga, PV Kadambi, B Javaid A nationwide survey of cytomegalovirus prophylaxis and treatment in the transplant community Am J Transplant 4 2004 495
44. C Couchoud Cytomegalovirus prophylaxis with antiviral agents for solid organ transplantation Cochrane Database Syst Rev 2000 CD001320
45. P Fiddian, CA Sabin, PD Griffiths Valacyclovir provides optimum acyclovir exposure for prevention of cytomegalovirus and related outcomes after organ transplantation J Infect Dis 186 suppl 1 2002 S110 15
46. S Gourishankar, W Wong, M Dorval Meta-analysis of prophylaxis of CMV disease in solid organ transplantation: is ganciclovir a superior agent to acyclovir? Transplant Proc 33 2001 1870 72
47. HA Valantine Role of CMV in transplant coronary artery disease and survival after heart transplantation Transpl Infect Dis 1 suppl 1 1999 25 30
48. SV Jassal, JM Roscoe, JS Zaltzman Clinical practice guidelines: prevention of cytomegalovirus disease after renal transplantation J Am Soc Nephrol 9 1998 1697 708
49. BW Van der, R Speich Management of cytomegalovirus infection and disease after solid-organ transplantation Clin Infect Dis 33 suppl 1 2001 S32 37
50. ME Falagas, DR Snydman, J Griffith, R Ruthazer, BG Werner Effect of cytomegalovirus infection status on first-year mortality rates among orthotopic liver transplant recipients Ann Intern Med 126 1997 275 79
51. ME Falagas, C Paya, R Ruthazer Significance of cytomegalovirus for long-term survival after orthotopic liver transplantation: a prospective derivation and validation cohort analysis Transplantation 66 1998 1020 28
52. N Singh, T Gayowski, ME Falagas, DR Snydman Cytomegalovirus and death in liver transplantation Ann Intern Med 127 1997 412 13
53. R Shapiro, ML Jordan, VP Scantlebury A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients Transplantation 67 1999 411 15
54. LA Bonet Predictors of mortality following heart transplantation: Spanish Registry of Heart Transplantation 1984-2001 Transplant Proc 35 2003 1946 50
55. EP Trulock, LB Edwards, DO Taylor The registry of the international society for heart and lung transplantation: twentieth official adult lung and heart-lung transplant report 2003 J Heart Lung Transplant 22 2003 625 35