Association between a polymorphism in the il-12p40 gene and cytomegalovirus reactivation after kidney transplantation

Transplantation

Volumn 85, Issue 10, 2008, Pages 1406-1411

  Hoffmann, Thomas W ^a   Halimi, Jean Michel ^a,b   Büchler, Mathias ^a,b   Velge Roussel, Florence ^a   Goudeau, Alain ^a,b   Al Najjar, Azmi ^b   Boulanger, Marie Denise ^c   Houssaini, Tarik Sqalli ^d   Marliere, Jean Frédéric ^b   Lebranchu, Yvon ^a,b   Baron, Christophe ^a,b,e  

^a UNIVERSITÉ DE TOURS   (France)

^b CHU BRETONNEAU   (France)

^c ETABLISSEMENT FRANÇAIS DU SANG   (France)

^d HASSAN II UNIVERSITY HOSPITAL   (Morocco)

^e UNIVERSITY HOSPITAL OF TOURS   (France)

Author keywords

Cytomegalovirus infection; Genetic polymorphism; IL 12p40; Kidney transplantation

Indexed keywords

ACICLOVIR; AZATHIOPRINE; CALCINEURIN INHIBITOR; GAMMA INTERFERON; GANCICLOVIR; INTERLEUKIN 12P40; INTERLEUKIN 2 RECEPTOR ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; SYNAPTOTAGMIN I; THYMOCYTE ANTIBODY; VALACICLOVIR; VALGANCICLOVIR; INTERLEUKIN 12; PRIMER DNA;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HEREDITY; HETEROZYGOTE; HUMAN; IMMUNE RESPONSE; INFECTION RISK; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SERODIAGNOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS REACTIVATION; CLASSIFICATION; CYTOMEGALOVIRUS; GENETICS; KIDNEY DISEASE; MIDDLE AGED; PHYSIOLOGY; VIRUS ACTIVATION;

3' UNTRANSLATED REGIONS; ADULT; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA PRIMERS; FEMALE; GENOTYPE; HUMANS; INTERLEUKIN-12; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; VIRUS ACTIVATION;

EID: 46249086111     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31816c7dc7     Document Type: Article

References (39)

1. Sagedal S, Nordal KP, Hartmann A, et al. A prospective study of the natural course of cytomegalovirus infection and disease in renal allograft recipients. Transplantation 2000; 70: 1166.
2. Brennan DC. Cytomegalovirus in renal transplantation. J Am Soc Nephrol 2001; 12: 848.
3. Humar A, Gillingham KJ, Payne WD, et al. Association between cytomegalovirus disease and chronic rejection in kidney transplant recipients. Transplantation 1999; 68: 1879.
4. Sagedal S, Hartmann A, Nordal KP, et al. Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival. Kidney Int 2004; 66: 329.
5. Sagedal S, Nordal KP, Hartmann A, et al. The impact of cytomegalovirus infection and disease on rejection episodes in renal allograft recipients. Am J Transplant 2002; 2: 850.
6. Hussain T, Burch M, Fenton MJ, et al. Positive pretransplantation cytomegalovirus serology is a risk factor for cardiac allograft vasculopathy in children. Circulation 2007; 115: 1798.
7. Potena L, Holweg CT, Chin C, et al. Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection. Transplantation 2006; 82: 398.
8. Lautenschlager I, Soots A, Krogerus L, et al. Effect of cytomegalovirus on an experimental model of chronic renal allograft rejection under triple-drug treatment in the rat. Transplantation 1997; 64: 391.
9. Lee SH, Webb JR, Vidal SM. Innate immunity to cytomegalovirus: The Cmv1 locus and its role in natural killer cell function. Microbes Infect 2002; 4: 1491.
10. Presti RM, Pollock JL, Dal Canto AJ, et al. Interferon gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vessels. J Exp Med 1998; 188: 577.
11. Lucin P, Pavic I, Polic B, et al. Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands. J Virol 1992; 66: 1977.
12. Reddehase MJ, Mutter W, Munch K, et al. CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. J Virol 1987; 61: 3102.
13. Halary F, Pitard V, Dlubek D, et al. Shared reactivity of V{delta}2(neg) {gamma}{delta} T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells. J Exp Med 2005; 201: 1567.
14. Lafarge X, Merville P, Cazin MC, et al. Cytomegalovirus infection in transplant recipients resolves when circulating gammadelta T lymphocytes expand, suggesting a protective antiviral role. J Infect Dis 2001; 184: 533.
15. Ninomiya T, Takimoto H, Matsuzaki G, et al. Vgamma1-gammadelta T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon-gamma. Immunology 2000; 99: 187.
16. Carr JA, Rogerson JA, Mulqueen MJ, et al. The role of endogenous interleukin-12 in resistance to murine cytomegalovirus (MCMV) infection and a novel action for endogenous IL-12 p40. J Interferon Cytokine Res 1999; 19: 1145.
17. Orange JS, Biron CA. Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J Immunol 1996; 156: 4746.
18. Sieburth D, Jabs EW, Warrington JA, et al. Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 1992; 14: 59.
19. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3: 133.
20. Magram J, Connaughton SE, Warrier RR, et al. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 1996; 4: 471.
21. Cooper AM, Khader SA. IL-12p40: An inherently agonistic cytokine. Trends Immunol 2007; 28: 33.
22. Piccotti JR, Chan SY, Li K, et al. Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4- and CD8- IFN-gamma-producing cells. J Immunol 1997; 158: 643.
23. Ha SJ, Lee CH, Lee SB, et al. A novel function of IL-12p40 as a chemotactic molecule for macrophages. J Immunol 1999; 163: 2902.
24. Khader SA, Partida-Sanchez S, Bell G, et al. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J Exp Med 2006; 203: 1805.
25. Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 2005; 5: 521.
26. Hall MA, McGlinn E, Coakley G, et al. Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. Genes Immun 2000; 1: 219.
27. Huang D, Cancilla MR, Morahan G. Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit. Genes Immun 2000; 1: 515.
28. Morahan G, Huang D, Ymer SI, et al. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. Nat Genet 2001; 27: 218.
29. Stanilova S, Miteva L. Taq-I polymorphism in 3-UTR of the IL-12B and association with IL-12p40 production from human PBMC. Genes Immun 2005; 6: 364.
30. van Veen T, Crusius JB, Schrijver HM, et al. Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis. Ann Neurol 2001; 50: 275.
31. Windsor L, Morahan G, Huang D, et al. Alleles of the IL12B 3-UTR associate with late onset of type 1 diabetes. Hum Immunol 2004; 65: 1432.
32. Cargill M, Schrodi SJ, Chang M, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasisrisk genes. Am J Hum Genet 2007; 80: 273.
33. Alakulppi NS, Kyllonen LE, Salo HM, et al. The impact of donor cytokine gene polymorphisms on the incidence of cytomegalovirus infection after kidney transplantation. Transpl Immunol 2006; 16: 258.
34. Kijpittayarit S, Eid AJ, Brown RA, et al. Relationship between Toll-like receptor 2 polymorphism and cytomegalovirus disease after liver transplantation. Clin Infect Dis 2007; 44: 1315.
35. Mueller T, Mas-Marques A, Sarrazin C, et al. Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. J Hepatol 2004; 41: 652.
36. Yakushiji K, Gondo H, Kamezaki K, et al. Monitoring of cytomegalovirus reactivation after allogeneic stem cell transplantation: Comparison of an antigenemia assay and quantitative real-time polymerase chain reaction. Bone Marrow Transplant 2002; 29: 599.
37. Heinzel FP, Hujer AM, Ahmed FN, et al. In vivo production and function of IL-12 p40 homodimers. J Immunol 1997; 158: 4381.
38. Ruzek MC, Miller AH, Opal SM, et al. Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection. J Exp Med 1997; 185: 1185.
39. Sun W, He X, Guo Z, et al. IL-12p40-overexpressing immature dendritic cells induce T cell hyporesponsiveness in vitro but accelerate allograft rejection in vivo: Role of NK cell activation and interferongamma production. Immunol Lett 2004; 94: 191.