메뉴 건너뛰기




Volumn 2012, Issue , 2012, Pages

The molecular biology of soft-tissue sarcomas and current trends in therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; AXITINIB; BRIVANIB; CANCER VACCINE; CEDIRANIB; CIXUTUMUMAB; CYTOKINE; EVEROLIMUS; FIGITUMUMAB; IMATINIB; INTERFERON; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; METFORMIN; MICRORNA; MONOCLONAL ANTIBODY; N ACETYLSARCOSYLGLYCYLVALYL DEXTRO ALLOISOLEUCYLTHREONYLNORVALYLISOLEUCYLARGINYLPROLINE ETHYLAMIDE; PAZOPANIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAPAMYCIN; RIDAFOROLIMUS; SOMATOMEDIN; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TIVANTINIB; UNINDEXED DRUG; VASCULOTROPIN; VIRUS DNA;

EID: 84862275926     PISSN: 1357714X     EISSN: 13691643     Source Type: Journal    
DOI: 10.1155/2012/849456     Document Type: Review
Times cited : (43)

References (106)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D., Weinberg R. A., Hallmarks of cancer: the next generation Cell 2011 144 5 646 674
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84979948588 scopus 로고
    • A sarcoma of the fowl transmissible by an agent separable from the tumor cells
    • Rous P., A sarcoma of the fowl transmissible by an agent separable from the tumor cells The Journal of Experimental Medicine 1911 13 397 411
    • (1911) The Journal of Experimental Medicine , vol.13 , pp. 397-411
    • Rous, P.1
  • 4
    • 0034060617 scopus 로고    scopus 로고
    • Viral carcinogenesis: Revelation of molecular mechanisms and etiology of human disease
    • Butel J. S., Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease Carcinogenesis 2000 21 3 405 426 (Pubitemid 30137926)
    • (2000) Carcinogenesis , vol.21 , Issue.3 , pp. 405-426
    • Butel, J.S.1
  • 6
    • 0017250977 scopus 로고
    • DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
    • Stehelin D., Varmus H. E., Bishop J. M., Vogt P. K., DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA Nature 1976 260 5547 170 173
    • (1976) Nature , vol.260 , Issue.5547 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3    Vogt, P.K.4
  • 7
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E. R., Vogelstein B., A genetic model for colorectal tumorigenesis Cell 1990 61 5 759 767
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 8
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: The first 30 years
    • DOI 10.1038/nrc1097
    • Malumbres M., Barbacid M., RAS oncogenes: the first 30 years Nature Reviews Cancer 2003 3 6 459 465 (Pubitemid 37328850)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 9
    • 0033056764 scopus 로고    scopus 로고
    • The molecular perspective: The ras oncogene
    • Goodsell D. S., The molecular perspective: the RAS oncogene Oncologist 1999 4 3 263 264 (Pubitemid 29297488)
    • (1999) Oncologist , vol.4 , Issue.3 , pp. 263-264
    • Goodsell, D.S.1
  • 10
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • DOI 10.1038/nrc969
    • Downward J., Targeting ras signalling pathways in cancer therapy Nature Reviews Cancer 2003 3 1 11 22 (Pubitemid 37328883)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.1 , pp. 11-22
    • Downward, J.1
  • 12
    • 0015489522 scopus 로고
    • Antitumor effects of interferon
    • Gresser I., Antitumor effects of interferon Advances in Cancer Research 1973 16 97 140
    • (1973) Advances in Cancer Research , vol.16 , pp. 97-140
    • Gresser, I.1
  • 13
    • 34548142987 scopus 로고    scopus 로고
    • Interferons and osteosarcoma
    • DOI 10.1016/j.cytogfr.2007.06.014, PII S1359610107000834
    • Strander H., Interferons and osteosarcoma Cytokine and Growth Factor Reviews 2007 18 5-6 373 380 (Pubitemid 47302835)
    • (2007) Cytokine and Growth Factor Reviews , vol.18 , Issue.5-6 , pp. 373-380
    • Strander, H.1
  • 14
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I- and type-II-interferon-mediated signalling
    • DOI 10.1038/nri1604
    • Platanias L. C., Mechanisms of type-I- and type-II-interferon-mediated signalling Nature Reviews Immunology 2005 5 5 375 386 (Pubitemid 40685987)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.5 , pp. 375-386
    • Platanias, L.C.1
  • 15
    • 38749146809 scopus 로고    scopus 로고
    • 2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin
    • DOI 10.1091/mbc.E07-04-0358
    • Panaretakis T., Hjortsberg L., Tamm K. P., Bjrklund A. C., Joseph B., Grander D., Interferon induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin Molecular Biology of the Cell 2008 19 1 41 50 (Pubitemid 351186131)
    • (2008) Molecular Biology of the Cell , vol.19 , Issue.1 , pp. 41-50
    • Panaretakis, T.1    Hjortsberg, L.2    Tamm, K.P.3    Bjorklund, A.-C.4    Joseph, B.5    Grander, D.6
  • 16
    • 0019741613 scopus 로고
    • Historical introduction, burkitt's lymphoma, nasopharyngeal carcinoma and Kaposi's sarcoma
    • Hutt M. S. R., Historical introduction, burkitt's lymphoma, nasopharyngeal carcinoma and Kaposi's sarcoma Transactions of the Royal Society of Tropical Medicine and Hygiene 1981 75 6 761 765
    • (1981) Transactions of the Royal Society of Tropical Medicine and Hygiene , vol.75 , Issue.6 , pp. 761-765
    • Hutt, M.S.R.1
  • 17
    • 0025096694 scopus 로고
    • Kaposi's sarcoma among persons with AIDS: A sexually transmitted infection?
    • DOI 10.1016/0140-6736(90)90001-L
    • Beral V., Peterman T. A., Berkelman R. L., Jaffe H. W., Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? The Lancet 1990 335 8682 123 128 (Pubitemid 20032724)
    • (1990) Lancet , vol.335 , Issue.8682 , pp. 123-128
    • Beral, V.1    Peterman, T.A.2    Berkelman, R.L.3    Jaffe, H.W.4
  • 18
    • 0029005449 scopus 로고
    • Detection of herpesvirus-like dna sequences in Kaposi's sarcoma in patients with and those without HIV infection
    • Moore P. S., Chang Y., Detection of herpesvirus-like dna sequences in Kaposi's sarcoma in patients with and those without HIV infection New England Journal of Medicine 1995 332 18 1181 1185
    • (1995) New England Journal of Medicine , vol.332 , Issue.18 , pp. 1181-1185
    • Moore, P.S.1    Chang, Y.2
  • 19
    • 0042467672 scopus 로고    scopus 로고
    • The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression
    • DOI 10.1038/sj.onc.1206555
    • West J. T., Wood C., The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression Oncogene 2003 22 33 5150 5163 (Pubitemid 37059596)
    • (2003) Oncogene , vol.22 , Issue.33 REV. ISS. 2 , pp. 5150-5163
    • West, J.T.1    Wood, C.2
  • 22
    • 0020538943 scopus 로고
    • Preliminary observations on the effect of recombinant leukocyte A interferon in homosexual men with Kaposi's sarcoma
    • Krown S. E., Real F. X., Cunningham Rundles S., Preliminary observations on the effect of recombinant leukocyte a interferon in homosexual men with Kaposi's sarcoma New England Journal of Medicine 1983 308 18 1071 1076 (Pubitemid 13124896)
    • (1983) New England Journal of Medicine , vol.308 , Issue.18 , pp. 1071-1076
    • Krown, S.E.1    Real, F.X.2    Cunningham Rundles, S.3
  • 23
    • 0021924090 scopus 로고
    • Treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma with lymphoblastoid interferon
    • Rios A., Mansell P. W. A., Newell G. R., Treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma with lymphoblastoid interferon Journal of Clinical Oncology 1985 3 4 506 512 (Pubitemid 15116928)
    • (1985) Journal of Clinical Oncology , vol.3 , Issue.4 , pp. 506-512
    • Rios, A.1    Mansell, P.W.A.2    Newell, G.R.3
  • 24
    • 0020559541 scopus 로고
    • The Hardy-Zuckerman 2-FeSV, a new feline retrovirus with oncogene homology to Abelson-MuLV
    • Besmer P., Hardy W. D. Jr., Zuckerman E. E., The hardy-zuckerman 2-FeSV, a new feline retrovirus with oncogene homology to abelson-MuLV Nature 1983 303 5920 825 828 (Pubitemid 13054500)
    • (1983) Nature , vol.303 , Issue.5920 , pp. 825-828
    • Besmer, P.1    Hardy Jr., W.D.2    Zuckerman, E.E.3
  • 28
    • 0036303804 scopus 로고    scopus 로고
    • Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    • DOI 10.1053/hupa.2002.124124
    • Heinrich M. C., Rubin B. P., Longley B. J., Fletcher J. A., Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations Human Pathology 2002 33 5 484 495 (Pubitemid 34747867)
    • (2002) Human Pathology , vol.33 , Issue.5 , pp. 484-495
    • Heinrich, M.C.1    Rubin, B.P.2    Longley B.Jack3    Fletcher, J.A.4
  • 29
    • 77950604218 scopus 로고    scopus 로고
    • Optimal use of targeted agents for advanced gastrointestinal stromal tumours
    • Reichardt P., Optimal use of targeted agents for advanced gastrointestinal stromal tumours Oncology 2010 78 2 130 140
    • (2010) Oncology , vol.78 , Issue.2 , pp. 130-140
    • Reichardt, P.1
  • 30
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI 571 a selective tyrosine kinase inhibitor
    • Heinrich M. C., Griffith D. J., Druker B. J., Wait C. L., Ott K. A., Zigler A. J., Inhibition of c-KIT receptor tyrosine kinase activity by STI 571 a selective tyrosine kinase inhibitor Blood 2000 96 3 925 932 (Pubitemid 30618049)
    • (2000) Blood , vol.96 , Issue.3 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Zigler, A.J.6
  • 31
    • 0035899418 scopus 로고    scopus 로고
    • STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
    • DOI 10.1038/sj.onc.1204704
    • Tuveson D. A., Willis N. A., Jacks T., Griffin J. D., Singer S., Fletcher C. D. M., Fletcher J. A., Demetri G. D., STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications Oncogene 2001 20 36 5054 5058 (Pubitemid 32769795)
    • (2001) Oncogene , vol.20 , Issue.36 , pp. 5054-5058
    • Tuveson, D.A.1    Willis, N.A.2    Jacks, T.3    Griffin, J.D.4    Singer, S.5    Fletcher, C.D.M.6    Fletcher, J.A.7    Demetri, G.D.8
  • 35
    • 36749030022 scopus 로고    scopus 로고
    • KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway
    • DOI 10.1038/sj.onc.1210558, PII 1210558
    • Bauer S., Duensing A., Demetri G. D., Fletcher J. A., KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway Oncogene 2007 26 54 7560 7568 (Pubitemid 350207707)
    • (2007) Oncogene , vol.26 , Issue.54 , pp. 7560-7568
    • Bauer, S.1    Duensing, A.2    Demetri, G.D.3    Fletcher, J.A.4
  • 36
    • 34249946843 scopus 로고    scopus 로고
    • Molecular pathology in sarcomas
    • lava E., Molecular pathology in sarcomas Clinical and Translational Oncology 2007 9 3 130 144
    • (2007) Clinical and Translational Oncology , vol.9 , Issue.3 , pp. 130-144
    • Lava, E.1
  • 37
    • 77950358906 scopus 로고    scopus 로고
    • Molecular pathology of sarcomas: Concepts and clinical implications
    • Bovée J. V. M. G., Hogendoorn P. C. W., Molecular pathology of sarcomas: concepts and clinical implications Virchows Archiv 2010 456 2 193 199
    • (2010) Virchows Archiv , vol.456 , Issue.2 , pp. 193-199
    • Bovée, J.V.M.G.1    Hogendoorn, P.C.W.2
  • 38
    • 58549090731 scopus 로고    scopus 로고
    • Recent advances in the molecular pathology of soft tissue sarcoma: Implications for diagnosis, patient prognosis, and molecular target therapy in the future
    • Oda Y., Tsuneyoshi M., Recent advances in the molecular pathology of soft tissue sarcoma: implications for diagnosis, patient prognosis, and molecular target therapy in the future Cancer Science 2009 100 2 200 208
    • (2009) Cancer Science , vol.100 , Issue.2 , pp. 200-208
    • Oda, Y.1    Tsuneyoshi, M.2
  • 39
    • 0141799898 scopus 로고    scopus 로고
    • Mechanisms of sarcoma development
    • Helman L. J., Meltzer P., Mechanisms of sarcoma development Nature Reviews Cancer 2003 3 9 685 694 (Pubitemid 37328823)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.9 , pp. 685-694
    • Helman, L.J.1    Meltzer, P.2
  • 40
    • 77950344833 scopus 로고    scopus 로고
    • Genomic characteristics of soft tissue sarcomas
    • Mertens F., Panagopoulos I., Mandahl N., Genomic characteristics of soft tissue sarcomas Virchows Archiv 2010 456 2 129 139
    • (2010) Virchows Archiv , vol.456 , Issue.2 , pp. 129-139
    • Mertens, F.1    Panagopoulos, I.2    Mandahl, N.3
  • 44
    • 0031838697 scopus 로고    scopus 로고
    • Translocations, cancer and the puzzle of specificity
    • DOI 10.1038/475
    • Barr F. G., Translocations, cancer and the puzzle of specificity Nature Genetics 1998 19 2 121 124 (Pubitemid 28248791)
    • (1998) Nature Genetics , vol.19 , Issue.2 , pp. 121-124
    • Barr, F.G.1
  • 45
    • 0031953233 scopus 로고    scopus 로고
    • A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma
    • DOI 10.1038/ng0298-184
    • Knezevich S. R., McFadden D. E., Tao W., Lim J. F., Sorensen P. H. B., A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma Nature Genetics 1998 18 2 184 187 (Pubitemid 28082471)
    • (1998) Nature Genetics , vol.18 , Issue.2 , pp. 184-187
    • Knezevich, S.R.1    McFadden, D.E.2    Tao, W.3    Lim, J.F.4    Sorensen, P.H.B.5
  • 46
    • 1342325439 scopus 로고    scopus 로고
    • A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: An essential interaction for transformation
    • DOI 10.1074/jbc.M307388200
    • Lannon C. L., Martin M. J., Tognon C. E., Jin W., Kim S. J., Sorensen P. H. B., A highly conserved NTRK3 c-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation Journal of Biological Chemistry 2004 279 8 6225 6234 (Pubitemid 38248755)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.8 , pp. 6225-6234
    • Lannon, C.L.1    Martin, M.J.2    Tognon, C.E.3    Jin, W.4    Kim, S.-J.5    Sorensen, P.H.B.6
  • 47
    • 0030061771 scopus 로고    scopus 로고
    • The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator
    • Fujimura Y., Ohno T., Siddique H., Lee L., Rao V. N., Reddy E. S. P., The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator Oncogene 1996 12 1 159 167 (Pubitemid 26041252)
    • (1996) Oncogene , vol.12 , Issue.1 , pp. 159-167
    • Fujimura, Y.1    Ohno, T.2    Siddique, H.3    Lee, L.4    Rao, V.N.5    Reddy, E.S.P.6
  • 51
    • 77951709259 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy
    • Zha J., Lackner M. R., Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy Clinical Cancer Research 2010 16 9 2512 2517
    • (2010) Clinical Cancer Research , vol.16 , Issue.9 , pp. 2512-2517
    • Zha, J.1    Lackner, M.R.2
  • 55
    • 72449133456 scopus 로고    scopus 로고
    • Sorafenib induces growth inhibition and apoptosis in human synovial sarcoma cells via inhibiting the RAF/MEK/ERK signaling pathway
    • Peng C. L., Guo W., Ji T., Ren T., Yang Y., Li D. S., Qu H. Y., Li X., Tang S., Yan T. Q., Tang X. D., Sorafenib induces growth inhibition and apoptosis in human synovial sarcoma cells via inhibiting the RAF/MEK/ERK signaling pathway Cancer Biology and Therapy 2009 8 18 1729 1736
    • (2009) Cancer Biology and Therapy , vol.8 , Issue.18 , pp. 1729-1736
    • Peng, C.L.1    Guo, W.2    Ji, T.3    Ren, T.4    Yang, Y.5    Li, D.S.6    Qu, H.Y.7    Li, X.8    Tang, S.9    Yan, T.Q.10    Tang, X.D.11
  • 57
    • 79957509564 scopus 로고    scopus 로고
    • The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas
    • Vemulapalli S., Mita A., Alvarado Y., Sankhala K., Mita M., The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas Targeted Oncology 2011 6 1 29 39
    • (2011) Targeted Oncology , vol.6 , Issue.1 , pp. 29-39
    • Vemulapalli, S.1    Mita, A.2    Alvarado, Y.3    Sankhala, K.4    Mita, M.5
  • 58
    • 34548427415 scopus 로고    scopus 로고
    • The biology behind mTOR inhibition in sarcoma
    • DOI 10.1634/theoncologist.12-8-1007
    • Wan X., Helman L. J., The biology behind mtor inhibition in sarcoma Oncologist 2007 12 8 1007 1018 (Pubitemid 47359144)
    • (2007) Oncologist , vol.12 , Issue.8 , pp. 1007-1018
    • Wan, X.1    Helman, L.J.2
  • 59
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • DOI 10.1038/cr.2007.64, PII CR200764
    • Yang Q., Guan K. L., Expanding mTOR signaling Cell Research 2007 17 8 666 681 (Pubitemid 47255937)
    • (2007) Cell Research , vol.17 , Issue.8 , pp. 666-681
    • Yang, Q.1    Guan, K.-L.2
  • 60
    • 3142647035 scopus 로고    scopus 로고
    • Changing concepts in the pathological basis of soft tissue and bone sarcoma treatment
    • DOI 10.1016/j.ejca.2004.04.004, PII S0959804904003132
    • Hogendoorn P. C. W., Collin F., Daugaard S., Dei Tos A. P., Fisher C., Schneider U., Sciot R., Changing concepts in the pathological basis of soft tissue and bone sarcoma treatment European Journal of Cancer 2004 40 11 1644 1654 (Pubitemid 38902898)
    • (2004) European Journal of Cancer , vol.40 , Issue.11 , pp. 1644-1654
    • Hogendoorn, P.C.W.1    Collin, F.2    Daugaard, S.3    Dei Tos, A.P.4    Fisher, C.5    Schneider, U.6    Sciot, R.7
  • 61
    • 0035074474 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and soft tissue sarcomas: Tumor expression correlates with grade
    • DOI 10.1245/aso.2001.8.3.260
    • Chao C., Al-Saleem T., Brooks J. J., Rogatko A., Kraybill W. G., Eisenberg B., Vascular endothelial growth factor and soft tissue sarcomas: tumor expression correlates with grade Annals of Surgical Oncology 2001 8 3 260 267 (Pubitemid 32294808)
    • (2001) Annals of Surgical Oncology , vol.8 , Issue.3 , pp. 260-267
    • Chao, C.1    Al-Saleem, T.2    Brooks, J.J.3    Rogatko, A.4    Kraybill, W.G.5    Eisenberg, B.6
  • 62
    • 0036276451 scopus 로고    scopus 로고
    • Molecular approaches to sarcoma therapy
    • DOI 10.1080/13577140220127530
    • Olsen R. J., Tarantolo S. R., Hinrichs S. H., Molecular approaches to sarcoma therapy Sarcoma 2002 6 1 27 42 (Pubitemid 34620886)
    • (2002) Sarcoma , vol.6 , Issue.1 , pp. 27-42
    • Olsen, R.J.1    Tarantolo, S.R.2    Hinrichs, S.H.3
  • 63
    • 33748764143 scopus 로고    scopus 로고
    • Angiogenic Profile of Soft Tissue Sarcomas Based on Analysis of Circulating Factors and Microarray Gene Expression
    • DOI 10.1016/j.jss.2006.01.023, PII S0022480406000187
    • Yoon S. S., Segal N. H., Park P. J., Detwiller K. Y., Fernando N. T., Ryeom S. W., Brennan M. F., Singer S., Angiogenic profile of soft tissue sarcomas based on analysis of circulating factors and microarray gene expression Journal of Surgical Research 2006 135 2 282 290 (Pubitemid 44414877)
    • (2006) Journal of Surgical Research , vol.135 , Issue.2 , pp. 282-290
    • Yoon, S.S.1    Segal, N.H.2    Park, P.J.3    Detwiller, K.Y.4    Fernando, N.T.5    Ryeom, S.W.6    Brennan, M.F.7    Singer, S.8
  • 65
    • 35148815673 scopus 로고    scopus 로고
    • Whole-genome profiling in liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms
    • DOI 10.1158/0008-5472.CAN-07-1133
    • Johnson J. E., Gettings E. J., Schwalm J., Pei J., Testa J. R., Litwin S., Von Mehren M., Broccoli D., Whole-genome profiling in liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms Cancer Research 2007 67 19 9221 9228 (Pubitemid 47535909)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 9221-9228
    • Johnson, J.E.1    Gettings, E.J.2    Schwalm, J.3    Pei, J.4    Testa, J.R.5    Litwin, S.6    Von Mehren, M.7    Broccoli, D.8
  • 66
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • Takebe N., Harris P. J., Warren R. Q., Ivy S. P., Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways Nature Reviews Clinical Oncology 2011 8 2 97 106
    • (2011) Nature Reviews Clinical Oncology , vol.8 , Issue.2 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 67
    • 7744236303 scopus 로고    scopus 로고
    • Cancer stem cell biology: From leukemia to solid tumors
    • DOI 10.1016/j.ceb.2004.09.002, PII S0955067404001310
    • Jordan C. T., Cancer stem cell biology: from leukemia to solid tumors Current Opinion in Cell Biology 2004 16 6 708 712 (Pubitemid 39463123)
    • (2004) Current Opinion in Cell Biology , vol.16 , Issue.6 , pp. 708-712
    • Jordan, C.T.1
  • 69
    • 33746924453 scopus 로고    scopus 로고
    • Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma
    • DOI 10.1158/0008-5472.CAN-05-3979
    • Riggi N., Cironi L., Provero P., Suv M. L., Stehle J. C., Baumer K., Guillou L., Stamenkovic I., Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma Cancer Research 2006 66 14 7016 7023 (Pubitemid 44197677)
    • (2006) Cancer Research , vol.66 , Issue.14 , pp. 7016-7023
    • Riggi, N.1    Cironi, L.2    Provero, P.3    Suva, M.-L.4    Stehle, J.-C.5    Baumer, K.6    Guillou, L.7    Stamenkovic, I.8
  • 70
    • 34250749646 scopus 로고    scopus 로고
    • Mesenchymal to epithelial transition in development and disease
    • DOI 10.1159/000101298
    • Chaffer C. L., Thompson E. W., Williams E. D., Mesenchymal to epithelial transition in development and disease Cells Tissues Organs 2007 185 13 7 19 (Pubitemid 46956838)
    • (2007) Cells Tissues Organs , vol.185 , Issue.1-3 , pp. 7-19
    • Chaffer, C.L.1    Thompson, E.W.2    Williams, E.D.3
  • 71
    • 0036214828 scopus 로고    scopus 로고
    • Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues
    • Laskin W. B., Miettinen M., Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues Archives of Pathology and Laboratory Medicine 2002 126 4 425 431 (Pubitemid 34286806)
    • (2002) Archives of Pathology and Laboratory Medicine , vol.126 , Issue.4 , pp. 425-431
    • Laskin, W.B.1    Miettinen, M.2
  • 72
    • 33746906998 scopus 로고    scopus 로고
    • SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: A potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma
    • DOI 10.1158/0008-5472.CAN-05-3697
    • Saito T., Nagai M., Ladanyi M., SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma Cancer Research 2006 66 14 6919 6927 (Pubitemid 44197666)
    • (2006) Cancer Research , vol.66 , Issue.14 , pp. 6919-6927
    • Saito, T.1    Nagai, M.2    Ladanyi, M.3
  • 73
    • 79955125547 scopus 로고    scopus 로고
    • Human chondrosarcoma cells acquire an epithelial-like gene expression pattern via an epigenetic switch: Evidence for mesenchymal-epithelial transition during sarcomagenesis
    • Fitzgerald M. P., Gourronc F., Teoh M. L. T., Provenzano M. J., Case A. J., Martin J. A., Domann F. E., Human chondrosarcoma cells acquire an epithelial-like gene expression pattern via an epigenetic switch: evidence for mesenchymal-epithelial transition during sarcomagenesis Sarcoma 2011 2011 11
    • (2011) Sarcoma , vol.2011 , pp. 11
    • Fitzgerald, M.P.1    Gourronc, F.2    Teoh, M.L.T.3    Provenzano, M.J.4    Case, A.J.5    Martin, J.A.6    Domann, F.E.7
  • 74
    • 34250644946 scopus 로고    scopus 로고
    • MicroRNAs: Recently discovered key regulators of proliferation and apoptosis in animal cells: Identification of miRNAs regulating growth and survival
    • DOI 10.1007/s10616-007-9049-4, Global mRNA and Protein Expression Analysis - Research applications in Cancer and other Diseases and in Biopharmaceutical Production
    • Gammell P., Micrornas: recently discovered key regulators of proliferation and apoptosis in animal cells: identification of mirnas regulating growth and survival Cytotechnology 2007 53 13 55 63 (Pubitemid 46944869)
    • (2007) Cytotechnology , vol.53 , Issue.1-3 , pp. 55-63
    • Gammell, P.1
  • 83
    • 78649438066 scopus 로고    scopus 로고
    • Activity of R1507, a monoclonal antibody to the insulinlike growth factor-1 receptor (IGF1R), in patients with recurrent or refractory Ewing's sarcoma family of tumors (ESFT): Results of a phase II SARC study
    • abstract 10000
    • Pappo A. S., Patel S., Crowley J., Activity of R1507, a monoclonal antibody to the insulinlike growth factor-1 receptor (IGF1R), in patients with recurrent or refractory Ewing's sarcoma family of tumors (ESFT): results of a phase II SARC study Journal of Clinical Oncology 2010 28, supplement 15, abstract 10000
    • (2010) Journal of Clinical Oncology
    • Pappo, A.S.1    Patel, S.2    Crowley, J.3
  • 84
    • 33745212417 scopus 로고    scopus 로고
    • Insulin-like growth factor i receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in ewing tumor
    • Martins A. S., Mackintosh C., Herrero Martn D., Campos M., Hernndez T., Ordez J. L., De Alava E., Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in ewing tumor Clinical Cancer Research 2006 12 11 3532 3540
    • (2006) Clinical Cancer Research , vol.12 , Issue.11 , pp. 3532-3540
    • Martins, A.S.1    MacKintosh, C.2    Herrero Martn, D.3    Campos, M.4    Hernndez, T.5    Ordez, J.L.6    De Alava, E.7
  • 85
    • 84858772025 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 receptor (IGF-1R): A potential therapeutic target for gastrointestinal stromal tumors (GIST)
    • abstract 10507
    • Godwin A. K., Rink L., Chi T., Insulin-like growth factor 1 receptor (IGF-1R): a potential therapeutic target for gastrointestinal stromal tumors (GIST) Journal of Clinical Oncology 2008 26, supplement, abstract 10507
    • (2008) Journal of Clinical Oncology
    • Godwin, A.K.1    Rink, L.2    Chi, T.3
  • 87
    • 77956014125 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors in treating soft tissue sarcomas: Sunitinib in non-GIST sarcomas
    • Homet Moreno B., Garralda Cabanas E., Hitt R., Tyrosine kinase inhibitors in treating soft tissue sarcomas: sunitinib in non-GIST sarcomas Clinical and Translational Oncology 2010 12 7 468 472
    • (2010) Clinical and Translational Oncology , vol.12 , Issue.7 , pp. 468-472
    • Homet Moreno, B.1    Garralda Cabanas, E.2    Hitt, R.3
  • 89
    • 67650337802 scopus 로고    scopus 로고
    • Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the european organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043)
    • Sleijfer S., Ray-Coquard I., Papai Z., Le Cesne A., Scurr M., Schffski P., Collin F., Pandite L., Marreaud S., De Brauwer A., Van Glabbeke M., Verweij J., Blay J. Y., Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the european organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043) Journal of Clinical Oncology 2009 27 19 3126 3132
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.19 , pp. 3126-3132
    • Sleijfer, S.1    Ray-Coquard, I.2    Papai, Z.3    Le Cesne, A.4    Scurr, M.5    Schffski, P.6    Collin, F.7    Pandite, L.8    Marreaud, S.9    De Brauwer, A.10    Van Glabbeke, M.11    Verweij, J.12    Blay, J.Y.13
  • 90
    • 80355141438 scopus 로고    scopus 로고
    • PALETTE: A randomized, double-blind, phase III trial of pazopanib versus placebo in patients (pts) with soft-tissue sarcoma (STS) whose disease has progressed during or following prior chemotherapy
    • abstract LBA10002
    • Van Der Graaf W. T., Blay J., Chawla S. P., PALETTE: a randomized, double-blind, phase III trial of pazopanib versus placebo in patients (pts) with soft-tissue sarcoma (STS) whose disease has progressed during or following prior chemotherapy Journal of Clinical Oncology 2011 29, supplement, abstract LBA10002
    • (2011) Journal of Clinical Oncology
    • Van Der Graaf, W.T.1    Blay, J.2    Chawla, S.P.3
  • 91
    • 84855541297 scopus 로고    scopus 로고
    • Brivanib (BMS-582664) in advanced soft-tissue sarcoma (STS): Biomarker and subset results of a phase II randomized discontinuation trial
    • abstract 10000
    • Schwartz G. S., Maki R. G., Ratain M. J., Brivanib (BMS-582664) in advanced soft-tissue sarcoma (STS): biomarker and subset results of a phase II randomized discontinuation trial Journal of Clinical Oncology 2011 29, supplement, abstract 10000
    • (2011) Journal of Clinical Oncology
    • Schwartz, G.S.1    Maki, R.G.2    Ratain, M.J.3
  • 92
    • 80054083352 scopus 로고    scopus 로고
    • An evaluation of cediranib as a new agent for alveolar soft part sarcoma
    • abstract 10001
    • Kummar S., Strassberger A., Monks A., An evaluation of cediranib as a new agent for alveolar soft part sarcoma Journal of Clinical Oncology 2011 29, supplement, abstract 10001
    • (2011) Journal of Clinical Oncology
    • Kummar, S.1    Strassberger, A.2    Monks, A.3
  • 93
    • 76749121298 scopus 로고    scopus 로고
    • Preliminary results from a phase II study of ARQ 197 in patients with microphthalmia transcription factor family (MiT)-associated tumors
    • abstract 10502
    • Goldberg J., Demetri G. D., Choy E., Preliminary results from a phase II study of ARQ 197 in patients with microphthalmia transcription factor family (MiT)-associated tumors Journal of Clinical Oncology 2009 27, supplement 15, abstract 10502
    • (2009) Journal of Clinical Oncology
    • Goldberg, J.1    Demetri, G.D.2    Choy, E.3
  • 94
    • 84858002307 scopus 로고    scopus 로고
    • Systemic therapy for advanced soft tissue sarcomas: Highlighting novel therapies and treatment approaches
    • Riedel R. F., Systemic therapy for advanced soft tissue sarcomas: highlighting novel therapies and treatment approaches Cancer 2012 118 6 1474 1485
    • (2012) Cancer , vol.118 , Issue.6 , pp. 1474-1485
    • Riedel, R.F.1
  • 95
    • 33845342538 scopus 로고    scopus 로고
    • Targeted anti-cancer therapies for renal cancer
    • DOI 10.2165/00003495-200666170-00002
    • Amato R. J., Jac J., Targeted anti-cancer therapies for renal cancer Drugs 2006 66 17 2161 2171 (Pubitemid 44878527)
    • (2006) Drugs , vol.66 , Issue.17 , pp. 2161-2171
    • Amato, R.J.1    Jac, J.2
  • 97
    • 84055206678 scopus 로고    scopus 로고
    • New developments in mammalian target of rapamycin inhibitors for the treatment of sarcoma
    • Agulnik M., New developments in mammalian target of rapamycin inhibitors for the treatment of sarcoma Cancer 2012 118 6 1486 1497
    • (2012) Cancer , vol.118 , Issue.6 , pp. 1486-1497
    • Agulnik, M.1
  • 98
    • 80054055727 scopus 로고    scopus 로고
    • Results of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus as maintenance therapy in advanced sarcoma patients following clinical benefit from prior standard cytotoxic chemotherapy
    • abstract 10005
    • Chawla S. P., Blay J., Ray-Coquard I. L., Results of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus as maintenance therapy in advanced sarcoma patients following clinical benefit from prior standard cytotoxic chemotherapy Journal of Clinical Oncology 2011 29, supplement, abstract 10005
    • (2011) Journal of Clinical Oncology
    • Chawla, S.P.1    Blay, J.2    Ray-Coquard, I.L.3
  • 99
    • 79957509564 scopus 로고    scopus 로고
    • The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas
    • Vemulapalli S., Mita A., Alvarado Y., Sankhala K., Mita M., The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas Targeted Oncology 2011 6 1 29 39
    • (2011) Targeted Oncology , vol.6 , Issue.1 , pp. 29-39
    • Vemulapalli, S.1    Mita, A.2    Alvarado, Y.3    Sankhala, K.4    Mita, M.5
  • 100
    • 0037093071 scopus 로고    scopus 로고
    • Melatonin: From basic research to cancer treatment clinics
    • DOI 10.1200/JCO.2002.11.004
    • Vijayalaxmi C. R., Thomas R., Reiter R., Herman T. S., Melatonin: from basic research to cancer treatment clinics Journal of Clinical Oncology 2002 20 10 2575 2601 (Pubitemid 34525746)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.10 , pp. 2575-2601
    • Vijayalaxmi1    Thomas Jr., C.R.2    Reiter, R.J.3    Herman, T.S.4
  • 101
    • 71549153554 scopus 로고    scopus 로고
    • Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human ewing sarcoma cancer cells: Potentiation of the extrinsic apoptotic pathway
    • Casado-Zapico S., Rodriguez-Blanco J., Garca-Santos G., Martn V., Snchez-Snchez A. M., Antoln I., Rodriguez C., Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway Journal of Pineal Research 2010 48 1 72 80
    • (2010) Journal of Pineal Research , vol.48 , Issue.1 , pp. 72-80
    • Casado-Zapico, S.1    Rodriguez-Blanco, J.2    Garca-Santos, G.3    Martn, V.4    Snchez-Snchez, A.M.5    Antoln, I.6    Rodriguez, C.7
  • 103
    • 78751647387 scopus 로고    scopus 로고
    • Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST
    • abstract 10038
    • Richter S., Pink D., Hohenberger P., Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST Journal of Clinical Oncology 2010 28, 15s, supplement, abstract 10038
    • (2010) Journal of Clinical Oncology
    • Richter, S.1    Pink, D.2    Hohenberger, P.3
  • 104
    • 47749120694 scopus 로고    scopus 로고
    • Response assessment in clinical trials: Implications for sarcoma clinical trial design
    • supplement 2
    • Jaffe C. C., Response assessment in clinical trials: implications for sarcoma clinical trial design Oncologist 2008 13 supplement 2 14 18
    • (2008) Oncologist , vol.13 , pp. 14-18
    • Jaffe, C.C.1
  • 105
    • 1842451619 scopus 로고    scopus 로고
    • 18F-FDG PET in staging and early prediction of response to therapy of recurrent gastrointestinal stromal tumors
    • Gayed I., Vu T., Iyer R., Johnson M., Macapinlac H., Swanston N., Podoloff D., The role of 18F-FDG PET in staging and early prediction of response to therapy of recurrent gastrointestinal stromal tumors Journal of Nuclear Medicine 2004 45 1 17 21 (Pubitemid 47611603)
    • (2004) Journal of Nuclear Medicine , vol.45 , Issue.1 , pp. 17-21
    • Gayed, I.1    Vu, T.2    Iyer, R.3    Johnson, M.4    Macapinlac, H.5    Swanston, N.6    Podoloff, D.7
  • 106
    • 66149139452 scopus 로고    scopus 로고
    • From recist to percist: Evolving considerations for pet response criteria in solid tumors
    • supplement 5
    • Wahl R. L., Jacene H., Kasamon Y., Lodge M. A., From recist to percist: evolving considerations for pet response criteria in solid tumors Journal of Nuclear Medicine 2009 50 supplement 5 122 150
    • (2009) Journal of Nuclear Medicine , vol.50 , pp. 122-150
    • Wahl, R.L.1    Jacene, H.2    Kasamon, Y.3    Lodge, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.