The curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress

Investigational New Drugs

Volumn 30, Issue 2, 2012, Pages 558-567

  Sahoo, Kaustuv ^a   Dozmorov, Mikhail G ^b   Anant, Shrikant ^c   Awasthi, Vibhudutta ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; CLEFMA; Curcumin; Oxidative stress; Reactive oxygen species

Indexed keywords

4 [3,5 BIS(2 CHLOROBENZYLIDENE 4 OXO PIPERIDINE 1 YL) 4 OXO 2 BUTENOIC ACID]; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CATALASE; CURCUMIN; DOXORUBICIN; GEMCITABINE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; PACLITAXEL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 4 (3,5 BIS(2 CHLOROBENZYLIDENE) 4 OXOPIPERIDINE 1 YL) 4 OXO 2 BUTENOIC ACID; 4-(3,5-BIS(2-CHLOROBENZYLIDENE)-4-OXOPIPERIDINE-1-YL)-4-OXO-2-BUTENOIC ACID; ANTIOXIDANT; BENZYLIDENE DERIVATIVE; NFE2L2 PROTEIN, HUMAN; PIPERIDONE DERIVATIVE;

AMINO ACID METABOLISM; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LUNG FIBROBLAST; MICROARRAY ANALYSIS; MITOCHONDRION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION; ACTIVE TRANSPORT; ADENOCARCINOMA; CELL DEATH; CELL PROLIFERATION; DNA MICROARRAY; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; METHODOLOGY; PATHOLOGY; PHOSPHORYLATION; TIME; TUMOR CELL LINE; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; BENZYLIDENE COMPOUNDS; BLOTTING, WESTERN; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE; HUMANS; LUNG NEOPLASMS; NF-E2-RELATED FACTOR 2; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; PIPERIDONES; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 84862273568     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9610-4     Document Type: Article

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