One-pot synthesis of chiral azetidines from chloroaldehyde and chiral amines

Tetrahedron Letters

Volumn 52, Issue 28, 2011, Pages 3618-3620

  Orr, Suvi T M ^a   Cabral, Shawn ^a   Fernando, Dilinie P ^a   Makowski, Teresa ^a  

^a PFIZER INC   (United States)

Author keywords

Azetidines; Chiral amines; Reductive amination

Indexed keywords

ALDEHYDE DERIVATIVE; AMINE; AZETIDINE DERIVATIVE; CHLOROALDEHYDE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOMER; ONE POT SYNTHESIS; PROTON TRANSPORT; STEREOCHEMISTRY;

EID: 79958266771     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.05.027     Document Type: Article

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18. 4) and concentrated under reduced pressure to give a clear oil or a white solid. The crude material was purified by Biotage system on a 10 g silica gel cartridge by eluting with ethyl acetate in heptanes or by recrystallization from warm isopropyl alcohol.
19. 4 + H 396.3.