Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases

Immunology Letters

Volumn 145, Issue 1-2, 2012, Pages 62-67

  Corsiero, Elisa ^a   Bombardieri, Michele ^a   Manzo, Antonio ^b   Bugatti, Serena ^b   Uguccioni, Mariagrazia ^c   Pitzalis, Costantino ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF PAVIA   (Italy)

^c INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

Activation induced cytidine deaminase; Autoantibodies; Ectopic lymphoid structures; Lymphoid chemokines; Rheumatoid arthritis; Sj gren's syndrome

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CHEMOKINE; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; LYMPHOID CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE DIFFERENTIATION; CELL INFILTRATION; CELL MATURATION; CELL SELECTION; CYTOKINE PRODUCTION; ECTOPIC LYMPHOID STRUCTURE; ENDOTHELIUM CELL; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMORAL IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; LYMPHOID ORGAN; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS; SALIVARY GLAND; SJOEGREN SYNDROME; SOMATIC HYPERMUTATION; STROMA CELL; SYNOVIUM; UPREGULATION;

EID: 84862186837     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2012.04.013     Document Type: Review

References (60)

1. Kobayashi Y., Watanabe T. Synthesis of artificial lymphoid tissue with immunological function. Trends Immunol 2010, 31:422-428.
2. van de Pavert S.A., Mebius R.E. New insights into the development of lymphoid tissues. Nat Rev Immunol 2010, 10:664-674.
3. Aloisi F., Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006, 6:205-217.
4. Manzo A., Bombardieri M., Humby F., Pitzalis C. Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling. Immunol Rev 2010, 233:267-285.
5. Mazzucchelli L., Blaser A., Kappeler A., Scharli P., Laissue J.A., Baggiolini M., et al. BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. J Clin Invest 1999, 104:R49-R54.
6. Irvine D.J., Stachowiak A.N., Hori Y. Lymphoid tissue engineering: invoking lymphoid tissue neogenesis in immunotherapy and models of immunity. Semin Immunol 2008, 20:137-146.
7. Hjelmstrom P. Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines. J Leukoc Biol 2001, 69:331-339.
8. Hjelmstrom P., Fjell J., Nakagawa T., Sacca R., Cuff C.A., Ruddle N.H. Lymphoid tissue homing chemokines are expressed in chronic inflammation. Am J Pathol 2000, 156:1133-1138.
9. Katakai T., Hara T., Sugai M., Gonda H., Shimizu A. Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis. J Immunol 2003, 171:4359-4368.
10. + -ATPase-reactive TCR transgenic mouse. J Immunol 2006, 177:7858-7867.
11. Thaunat O., Field A.C., Dai J., Louedec L., Patey N., Bloch M.F., et al. Lymphoid neogenesis in chronic rejection: evidence for a local humoral alloimmune response. Proc Natl Acad Sci U S A 2005, 102:14723-14728.
12. Baddoura F.K., Nasr I.W., Wrobel B., Li Q., Ruddle N.H., Lakkis F.G. Lymphoid neogenesis in murine cardiac allografts undergoing chronic rejection. Am J Transplant 2005, 5:510-516.
13. Link A., Vogt T.K., Favre S., Britschgi M.R., Acha-Orbea H., Hinz B., et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol 2007, 8:1255-1265.
14. Pereira J.P., Kelly L.M., Cyster J.G. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int Immunol 2010, 22:413-419.
15. Cupedo T., Mebius R.E. Role of chemokines in the development of secondary and tertiary lymphoid tissues. Semin Immunol 2003, 15:243-248.
16. Luther S.A., Lopez T., Bai W., Hanahan D., Cyster J.G. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 2000, 12:471-481.
17. Luther S.A., Bidgol A., Hargreaves D.C., Schmidt A., Xu Y., Paniyadi J., et al. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol 2002, 169:424-433.
18. + T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid. J Clin Invest 2006, 116:2622-2632.
19. Chisholm D.M., Mason D.K. Labial salivary gland biopsy in Sjogren's disease. J Clin Pathol 1968, 21:656-660.
20. Voulgarelis M., Moutsopoulos H.M. Lymphoproliferation in autoimmunity and Sjogren's syndrome. Curr Rheumatol Rep 2003, 5:317-323.
21. Stott D.I., Hiepe F., Hummel M., Steinhauser G., Berek C. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome. J Clin Invest 1998, 102:938-946.
22. Routsias J.G., Tzioufas A.G., Moutsopoulos H.M. The clinical value of intracellular autoantigens B-cell epitopes in systemic rheumatic diseases. Clin Chim Acta 2004, 340:1-25.
23. Dawson L.J., Stanbury J., Venn N., Hasdimir B., Rogers S.N., Smith P.M. Antimuscarinic antibodies in primary Sjogren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum 2006, 54:1165-1173.
24. Humphreys-Beher M.G., Peck A.B. New concepts for the development of autoimmune exocrinopathy derived from studies with the NOD mouse model. Arch Oral Biol 1999, 44(Suppl. 1):S21-S25.
25. Barone F., Bombardieri M., Manzo A., Blades M.C., Morgan P.R., Challacombe S.J., et al. Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjogren's syndrome. Arthritis Rheum 2005, 52:1773-1784.
26. Bombardieri M., Barone F., Pittoni V., Alessandri C., Conigliaro P., Blades M.C., et al. Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjogren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate. Arthritis Res Ther 2004, 6:R447-R456.
27. Szekanecz Z., Vegvari A., Szabo Z., Koch A.E. Chemokines and chemokine receptors in arthritis. Front Biosci (Schol Ed) 2010, 2:153-167.
28. Takemura S., Braun A., Crowson C., Kurtin P.J., Cofield R.H., O'Fallon W.M., et al. Lymphoid neogenesis in rheumatoid synovitis. J Immunol 2001, 167:1072-1080.
29. Humby F., Bombardieri M., Manzo A., Kelly S., Blades M.C., Kirkham B., et al. Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med 2009, 6:e1.
30. Adhikari N., Basi D.L., Townsend D., Rusch M., Mariash A., Mullegama S., et al. Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling. J Mol Cell Cardiol 2010, 49:287-293.
31. Carlsen H.S., Baekkevold E.S., Morton H.C., Haraldsen G., Brandtzaeg P. Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. Blood 2004, 104:3021-3027.
32. Manzo A., Vitolo B., Humby F., Caporali R., Jarrossay D., Dell'accio F., et al. Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint. Arthritis Rheum 2008, 58:3377-3387.
33. Marston B., Palanichamy A., Anolik J.H. B cells in the pathogenesis and treatment of rheumatoid arthritis. Curr Opin Rheumatol 2010, 22:307-315.
34. Xanthou G., Polihronis M., Tzioufas A.G., Paikos S., Sideras P., Moutsopoulos H.M. Lymphoid chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sjogren's syndrome patients: possible participation in lymphoid structure formation. Arthritis Rheum 2001, 44:408-418.
35. Salomonsson S., Jonsson M.V., Skarstein K., Brokstad K.A., Hjelmstrom P., Wahren-Herlenius M., et al. Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome. Arthritis Rheum 2003, 48:3187-3201.
36. Amft N., Curnow S.J., Scheel-Toellner D., Devadas A., Oates J., Crocker J., et al. Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjogren's syndrome. Arthritis Rheum 2001, 44:2633-2641.
37. Barone F., Bombardieri M., Rosado M.M., Morgan P.R., Challacombe S.J., De Vita S., et al. CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization. J Immunol 2008, 180:5130-5140.
38. Smith J.R., Braziel R.M., Paoletti S., Lipp M., Uguccioni M., Rosenbaum J.T. Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. Blood 2003, 101:815-821.
39. Smith J.R., Falkenhagen K.M., Coupland S.E., Chipps T.J., Rosenbaum J.T., Braziel R.M. Malignant B cells from patients with primary central nervous system lymphoma express stromal cell-derived factor-1. Am J Clin Pathol 2007, 127:633-641.
40. Dorner T., Radbruch A. Selecting B cells and plasma cells to memory. J Exp Med 2005, 201:497-499.
41. Manser T. Textbook germinal centers. J Immunol 2004, 172:3369-3375.
42. Honjo T., Muramatsu M., Fagarasan S. AID: how does it aid antibody diversity. Immunity 2004, 20:659-668.
43. Pham P., Bransteitter R., Petruska J., Goodman M.F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 2003, 424:103-107.
44. Honjo T., Kinoshita K., Muramatsu M. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu Rev Immunol 2002, 20:165-196.
45. Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000, 102:553-563.
46. Bombardieri M., Barone F., Humby F., Kelly S., McGurk M., Morgan P., et al. Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjogren's syndrome. J Immunol 2007, 179:4929-4938.
47. Barreto V., Reina-San-Martin B., Ramiro A.R., McBride K.M., Nussenzweig M.C. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell 2003, 12:501-508.
48. Gause A., Gundlach K., Zdichavsky M., Jacobs G., Koch B., Hopf T., et al. The B lymphocyte in rheumatoid arthritis: analysis of rearranged V kappa genes from B cells infiltrating the synovial membrane. Eur J Immunol 1995, 25:2775-2782.
49. Schroder A.E., Greiner A., Seyfert C., Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 1996, 93:221-225.
50. Serafini B., Rosicarelli B., Franciotta D., Magliozzi R., Reynolds R., Cinque P., et al. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med 2007, 204:2899-2912.
51. Thaunat O., Patey N., Gautreau C., Lechaton S., Fremeaux-Bacchi V., Dieu-Nosjean M.C., et al. B cell survival in intragraft tertiary lymphoid organs after rituximab therapy. Transplantation 2008, 85:1648-1653.
52. Schellekens G.A., de Jong B.A., van den Hoogen F.H., van de Putte L.B., van Venrooij W.J. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 1998, 101:273-281.
53. Gregorio A., Gambini C., Gerloni V., Parafioriti A., Sormani M.P., Gregorio S., et al. Lymphoid neogenesis in juvenile idiopathic arthritis correlates with ANA positivity and plasma cells infiltration. Rheumatology (Oxford) 2007, 46:308-313.
54. Kim H.J., Krenn V., Steinhauser G., Berek C. Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis. J Immunol 1999, 162:3053-3062.
55. Thurlings R.M., Vos K., Wijbrandts C.A., Zwinderman A.H., Gerlag D.M., Tak P.P. Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response. Ann Rheum Dis 2008, 67:917-925.
56. Scheel T., Gursche A., Zacher J., Haupl T., Berek C. V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis. Arthritis Rheum 2011, 63:63-72.
57. Gellrich S., Rutz S., Borkowski A., Golembowski S., Gromnica-Ihle E., Sterry W., et al. Analysis of V(H)-D-J(H) gene transcripts in B cells infiltrating the salivary glands and lymph node tissues of patients with Sjogren's syndrome. Arthritis Rheum 1999, 42:240-247.
58. Jacobi A.M., Hansen A., Kaufmann O., Pruss A., Burmester G.R., Lipsky P.E., et al. Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjogren's syndrome. Arthritis Res 2002, 4:R4.
59. Le Pottier L., Devauchelle V., Fautrel A., Daridon C., Saraux A., Youinou P., et al. Ectopic germinal centers are rare in Sjogren's syndrome salivary glands and do not exclude autoreactive B cells. J Immunol 2009, 182:3540-3547.
60. Ekland E.H., Forster R., Lipp M., Cyster J.G. Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells. J Immunol 2004, 172:4700-4708.