-
1
-
-
4143151942
-
Pathogenesis of type 2 diabetes mellitus
-
PMID:15308380
-
DeFronzo RA. Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 2004; 88:787-835; PMID:15308380; http://dx.doi.org/10.1016/j.mcna.2004.04.013.
-
(2004)
Med Clin North Am
, vol.88
, pp. 787-835
-
-
DeFronzo, R.A.1
-
2
-
-
0037283601
-
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
-
PMID:12637977
-
Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 2003; 46:3-19; PMID:12637977.
-
(2003)
Diabetologia
, vol.46
, pp. 3-19
-
-
Kahn, S.E.1
-
3
-
-
0035122304
-
Regulation of beta-cell mass by hormones and growth factors
-
PMID:11272193
-
Nielsen JH, Galsgaard ED, Møldrup A, Friedrichsen BN, Billestrup N, Hansen JA, et al. Regulation of beta-cell mass by hormones and growth factors. Diabetes 2001; 50:25-9; PMID:11272193; http://dx.doi.org/10.2337/ diabetes.50.2007.S25.
-
(2001)
Diabetes
, vol.50
, pp. 25-29
-
-
Nielsen, J.H.1
Galsgaard, E.D.2
Møldrup, A.3
Friedrichsen, B.N.4
Billestrup, N.5
Hansen, J.A.6
-
4
-
-
0032742992
-
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
-
PMID:10491414
-
Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999; 104:787-94; PMID:10491414; http://dx.doi.org/10.1172/JCI7231.
-
(1999)
J Clin Invest
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
Pratley, R.E.4
-
5
-
-
0015324576
-
The metabolism of proinsulin and insulin by the liver
-
PMID:5014618
-
Rubenstein AH, Pottenger LA, Mako M, Getz GS, Steiner DF. The metabolism of proinsulin and insulin by the liver. J Clin Invest 1972; 51:912-21; PMID:5014618; http://dx.doi.org/10.1172/JCI106886.
-
(1972)
J Clin Invest
, vol.51
, pp. 912-921
-
-
Rubenstein, A.H.1
Pottenger, L.A.2
Mako, M.3
Getz, G.S.4
Steiner, D.F.5
-
6
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
PMID:3899825
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-9; PMID:3899825; http://dx.doi.org/10.1007/BF00280883.
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
Turner, R.C.6
-
7
-
-
0033556082
-
Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
-
PMID:9914469
-
Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem 1999; 259:3-17; PMID:9914469; http://dx.doi.org/10.1046/j.1432-327.1999.00043.x.
-
(1999)
Eur J Biochem
, vol.259
, pp. 3-17
-
-
Lang, J.1
-
8
-
-
77957235524
-
The insulin secretory granule as a signaling hub
-
PMID:20609596
-
Suckale J, Solimena M. The insulin secretory granule as a signaling hub. Trends Endocrinol Metab 2010; 21:599-609; PMID:20609596; http://dx.doi.org/10. 1016/j.tem.2010.06.003.
-
(2010)
Trends Endocrinol Metab
, vol.21
, pp. 599-609
-
-
Suckale, J.1
Solimena, M.2
-
9
-
-
66849115296
-
Mechanisms of biphasic insulin-granule exocytosis-roles of the cytoskeleton, small GTPases and SNARE proteins
-
PMID:19295123
-
Wang Z, Thurmond DC. Mechanisms of biphasic insulin-granule exocytosis-roles of the cytoskeleton, small GTPases and SNARE proteins. J Cell Sci 2009; 122:893-903; PMID:19295123; http://dx.doi.org/10.1242/jcs.034355.
-
(2009)
J Cell Sci
, vol.122
, pp. 893-903
-
-
Wang, Z.1
Thurmond, D.C.2
-
10
-
-
2642648673
-
Successful islet auto-transplantation in humans: Functional insulin secretory reserve as an estimate of surviving islet cell mass
-
PMID:9519735
-
Teuscher AU, Kendall DM, Smets YF, Leone JP, Sutherland DE, Robertson RP. Successful islet auto-transplantation in humans: functional insulin secretory reserve as an estimate of surviving islet cell mass. Diabetes 1998; 47:324-30; PMID:9519735; http://dx.doi.org/10.2337/diabetes.47.3.324.
-
(1998)
Diabetes
, vol.47
, pp. 324-330
-
-
Teuscher, A.U.1
Kendall, D.M.2
Smets, Y.F.3
Leone, J.P.4
Sutherland, D.E.5
Robertson, R.P.6
-
11
-
-
31544436629
-
Minimal model: Perspective from 2005
-
PMID:16439839
-
Bergman RN. Minimal model: perspective from 2005. Horm Res 2005; 64:8-15; PMID:16439839; http://dx.doi.org/10.1159/000089312.
-
(2005)
Horm Res
, vol.64
, pp. 8-15
-
-
Bergman, R.N.1
-
12
-
-
0019406016
-
The regulation of glucose-induced insulin secretion by pre-stimulus glucose level and tolbutamide in normal man
-
PMID:7028551
-
Pfeifer MA, Graf RJ, Halter JB, Porte D Jr. The regulation of glucose-induced insulin secretion by pre-stimulus glucose level and tolbutamide in normal man. Diabetologia 1981; 21:198-205; PMID:7028551; http://dx.doi.org/ 10.1007/BF00252654.
-
(1981)
Diabetologia
, vol.21
, pp. 198-205
-
-
Pfeifer, M.A.1
Graf, R.J.2
Halter, J.B.3
Porte Jr., D.4
-
13
-
-
0019760459
-
Differential effects of tolbutamide on first and second phase insulin secretion in noninsulin-dependent diabetes mellitus
-
PMID:7028776
-
Pfeifer MA, Halter JB, Beard JC, Porte D Jr. Differential effects of tolbutamide on first and second phase insulin secretion in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1981; 53:1256-62; PMID:7028776; http://dx.doi.org/10.1210/jcem-53-6-1256.
-
(1981)
J Clin Endocrinol Metab
, vol.53
, pp. 1256-1262
-
-
Pfeifer, M.A.1
Halter, J.B.2
Beard, J.C.3
Porte Jr., D.4
-
14
-
-
0019301475
-
Quantitative estimation of beta cell sensitivity to glucose in the intact organism: A minimal model of insulin kinetics in the dog
-
PMID:7002673
-
Toffolo G, Bergman RN, Finegood DT, Bowden CR, Cobelli C. Quantitative estimation of beta cell sensitivity to glucose in the intact organism: a minimal model of insulin kinetics in the dog. Diabetes 1980; 29:979-90; PMID:7002673; http://dx.doi.org/10.2337/diabetes.29.12.979.
-
(1980)
Diabetes
, vol.29
, pp. 979-990
-
-
Toffolo, G.1
Bergman, R.N.2
Finegood, D.T.3
Bowden, C.R.4
Cobelli, C.5
-
15
-
-
34547109615
-
Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests
-
PMID:17341552
-
Cobelli C, Toffolo GM, Dalla Man C, Campioni M, Denti P, Caumo A, et al. Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. Am J Physiol Endocrinol Metab 2007; 293:1-15; PMID:17341552; http://dx.doi.org/10. 1152/ajpendo.00421.2006.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
, pp. 1-15
-
-
Cobelli, C.1
Toffolo, G.M.2
Dalla Man, C.3
Campioni, M.4
Denti, P.5
Caumo, A.6
-
16
-
-
0032870338
-
Beta-cell function during insulin-modified intravenous glucose tolerance test successfully assessed by the C-peptide minimal model
-
PMID:10484058
-
Toffolo G, Cefalu WT, Cobelli C. Beta-cell function during insulin-modified intravenous glucose tolerance test successfully assessed by the C-peptide minimal model. Metabolism 1999; 48:1162-6; PMID:10484058; http://dx.doi.org/10.1016/S0026-0495(99)90132-4.
-
(1999)
Metabolism
, vol.48
, pp. 1162-1166
-
-
Toffolo, G.1
Cefalu, W.T.2
Cobelli, C.3
-
17
-
-
0036306096
-
Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the US
-
American Diabetes Association GENNID Study Group PMID:12086947
-
Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE; American Diabetes Association GENNID Study Group. Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the US. Diabetes 2002; 51:2170-8; PMID:12086947; http://dx.doi.org/10.2337/diabetes. 51.7.2170.
-
(2002)
Diabetes
, vol.51
, pp. 2170-2178
-
-
Jensen, C.C.1
Cnop, M.2
Hull, R.L.3
Fujimoto, W.Y.4
Kahn, S.E.5
-
18
-
-
61849106040
-
Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels
-
PMID:18957530
-
Utzschneider KM, Prigeon RL, Faulenbach MV, Tong J, Carr DB, Boyko EJ, et al. Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care 2009; 32:335-41; PMID:18957530; http://dx.doi.org/10.2337/dc08-1478.
-
(2009)
Diabetes Care
, vol.32
, pp. 335-341
-
-
Utzschneider, K.M.1
Prigeon, R.L.2
Faulenbach, M.V.3
Tong, J.4
Carr, D.B.5
Boyko, E.J.6
-
19
-
-
44649144546
-
Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes
-
PMID:18544104
-
Mari A, Tura A, Pacini G, Kautzky-Willer A, Ferrannini E. Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes. Diabet Med 2008; 25:671-7; PMID:18544104; http://dx.doi.org/10.1111/j.1464-5491.2008. 02441.x.
-
(2008)
Diabet Med
, vol.25
, pp. 671-677
-
-
Mari, A.1
Tura, A.2
Pacini, G.3
Kautzky-Willer, A.4
Ferrannini, E.5
-
20
-
-
12244299450
-
Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: A new analysis
-
PMID:15483086
-
Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA. Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 2005; 90:493-500; PMID:15483086; http://dx.doi.org/10.1210/jc.2004-1133.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 493-500
-
-
Ferrannini, E.1
Gastaldelli, A.2
Miyazaki, Y.3
Matsuda, M.4
Mari, A.5
DeFronzo, R.A.6
-
21
-
-
63249105863
-
Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice
-
PMID:19171749
-
Han MS, Chung KW, Cheon HG, Rhee SD, Yoon CH, Lee MK, et al. Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice. Diabetes 2009; 58:329-36; PMID:19171749; http://dx.doi.org/10. 2337/db08-0080.
-
(2009)
Diabetes
, vol.58
, pp. 329-336
-
-
Han, M.S.1
Chung, K.W.2
Cheon, H.G.3
Rhee, S.D.4
Yoon, C.H.5
Lee, M.K.6
-
22
-
-
0033555490
-
Gastrectomy induces impaired insulin and glucagon secretion: Evidence for a gastro-insular axis in mice
-
PMID:9852337
-
Salehi A, Chen D, Håkanson R, Nordin G, Lundquist I. Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice. J Physiol 1999; 514:579-91; PMID:9852337; http://dx.doi.org/10. 1111/j.1469-7793.1999.579ae.x.
-
(1999)
J Physiol
, vol.514
, pp. 579-591
-
-
Salehi, A.1
Chen, D.2
Håkanson, R.3
Nordin, G.4
Lundquist, I.5
-
23
-
-
0037304628
-
Insulinogenic index at 15 min as a marker of nutritional rehabilitation in anorexia nervosa
-
PMID:12540385
-
Yasuhara D, Naruo T, Nagai N, Tanaka M, Muranaga T, Nozoe S. Insulinogenic index at 15 min as a marker of nutritional rehabilitation in anorexia nervosa. Am J Clin Nutr 2003; 77:292-9; PMID:12540385.
-
(2003)
Am J Clin Nutr
, vol.77
, pp. 292-299
-
-
Yasuhara, D.1
Naruo, T.2
Nagai, N.3
Tanaka, M.4
Muranaga, T.5
Nozoe, S.6
-
24
-
-
0027964618
-
How to measure insulin secretion
-
PMID:7956679
-
Hovorka R, Jones RH. How to measure insulin secretion. Diabetes Metab Rev 1994; 10:91-117; PMID:7956679; http://dx.doi.org/10.1002/dmr.5610100204.
-
(1994)
Diabetes Metab Rev
, vol.10
, pp. 91-117
-
-
Hovorka, R.1
Jones, R.H.2
-
25
-
-
84857503964
-
Estimation of prehepatic insulin secretion: Comparison between standardized C-peptide and insulin kinetic models
-
PMID:21944265
-
Tura A, Pacini G, Kautzky-Willer A, Gastaldelli A, Defronzo RA, Ferrannini E, et al. Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models. Metabolism 2012; 61:434-43; PMID:21944265; http://dx.doi.org/10.1016/j.metabol.2011.08.001.
-
(2012)
Metabolism
, vol.61
, pp. 434-443
-
-
Tura, A.1
Pacini, G.2
Kautzky-Willer, A.3
Gastaldelli, A.4
Defronzo, R.A.5
Ferrannini, E.6
-
26
-
-
0026504160
-
Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance
-
PMID:1551497
-
Van Cauter E, Mestrez F, Sturis J, Polonsky KS. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 1992; 41:368-77; PMID:1551497; http://dx.doi.org/10.2337/diabetes.41.3.368.
-
(1992)
Diabetes
, vol.41
, pp. 368-377
-
-
Van Cauter, E.1
Mestrez, F.2
Sturis, J.3
Polonsky, K.S.4
-
27
-
-
0030152634
-
A stochastic deconvolution method to reconstruct insulin secretion rate after a glucose stimulus
-
PMID:8849464
-
Sparacino G, Cobelli C. A stochastic deconvolution method to reconstruct insulin secretion rate after a glucose stimulus. IEEE Trans Biomed Eng 1996; 43:512-29; PMID:8849464; http://dx.doi.org/10.1109/10.488799.
-
(1996)
IEEE Trans Biomed Eng
, vol.43
, pp. 512-529
-
-
Sparacino, G.1
Cobelli, C.2
-
28
-
-
0034741650
-
Insulin secretion rate during glucose stimuli: Alternative analyses of C-peptide data
-
PMID:11556725
-
Breda E, Cobelli C. Insulin secretion rate during glucose stimuli: alternative analyses of C-peptide data. Ann Biomed Eng 2001; 29:692-700; PMID:11556725; http://dx.doi.org/10.1114/1.1385804.
-
(2001)
Ann Biomed Eng
, vol.29
, pp. 692-700
-
-
Breda, E.1
Cobelli, C.2
-
29
-
-
0018520840
-
Glucose clamp technique: A method for quantifying insulin secretion and resistance
-
PMID:382871
-
DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237:214-23; PMID:382871.
-
(1979)
Am J Physiol
, vol.237
, pp. 214-223
-
-
DeFronzo, R.A.1
Tobin, J.D.2
Andres, R.3
-
30
-
-
0034011891
-
Association between birth weight and insulin sensitivity in healthy young men in Korea: Role of visceral adiposity
-
PMID:10808063
-
Choi CS, Kim C, Lee WJ, Park JY, Hong SK, Lee MG, et al. Association between birth weight and insulin sensitivity in healthy young men in Korea: role of visceral adiposity. Diabetes Res Clin Pract 2000; 49:53-9; PMID:10808063; http://dx.doi.org/10.1016/S0168-8227(00)00131-5.
-
(2000)
Diabetes Res Clin Pract
, vol.49
, pp. 53-59
-
-
Choi, C.S.1
Kim, C.2
Lee, W.J.3
Park, J.Y.4
Hong, S.K.5
Lee, M.G.6
-
31
-
-
0028240330
-
Loss of the first phase insulin response to intravenous glucose in subjects with persistent impaired glucose tolerance
-
PMID:8088119
-
Davies MJ, Rayman G, Grenfell A, Gray IP, Day JL, Hales CN. Loss of the first phase insulin response to intravenous glucose in subjects with persistent impaired glucose tolerance. Diabet Med 1994; 11:432-6; PMID:8088119; http://dx.doi.org/10.1111/j.1464-5491.1994.tb00302.x.
-
(1994)
Diabet Med
, vol.11
, pp. 432-436
-
-
Davies, M.J.1
Rayman, G.2
Grenfell, A.3
Gray, I.P.4
Day, J.L.5
Hales, C.N.6
-
32
-
-
0036314864
-
Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?
-
PMID:11815469
-
Gerich JE. Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes? Diabetes 2002; 51:117-21; PMID:11815469; http://dx.doi.org/10.2337/diabetes.51.2007.S117.
-
(2002)
Diabetes
, vol.51
, pp. 117-121
-
-
Gerich, J.E.1
-
33
-
-
0013953978
-
Stimulation of insulin secretion by amino acids
-
PMID:5919350
-
Floyd JC Jr, Fajans SS, Conn JW, Knopf RF, Rull J. Stimulation of insulin secretion by amino acids. J Clin Invest 1966; 45:1487-502; PMID:5919350; http://dx.doi.org/10.1172/JCI105456.
-
(1966)
J Clin Invest
, vol.45
, pp. 1487-1502
-
-
Floyd Jr., J.C.1
Fajans, S.S.2
Conn, J.W.3
Knopf, R.F.4
Rull, J.5
-
34
-
-
0031421192
-
The stimulation of insulin secretion in non-insulin-dependent diabetic patients by amino acids and gliclazide in the basal and hyperglycemic state
-
PMID:9439551
-
Matthews DR, Boland O. The stimulation of insulin secretion in non-insulin-dependent diabetic patients by amino acids and gliclazide in the basal and hyperglycemic state. Metabolism 1997; 46:5-9; PMID:9439551; http://dx.doi.org/10.1016/S0026-0495(97)90309-7.
-
(1997)
Metabolism
, vol.46
, pp. 5-9
-
-
Matthews, D.R.1
Boland, O.2
-
35
-
-
0030695028
-
Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene
-
PMID:9356021
-
Herman WH, Fajans SS, Smith MJ, Polonsky KS, Bell GI, Halter JB. Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene. Diabetes 1997; 46:1749-54; PMID:9356021; http://dx.doi.org/10.2337/diabetes.46. 11.1749.
-
(1997)
Diabetes
, vol.46
, pp. 1749-1754
-
-
Herman, W.H.1
Fajans, S.S.2
Smith, M.J.3
Polonsky, K.S.4
Bell, G.I.5
Halter, J.B.6
-
36
-
-
0033949496
-
Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate
-
PMID:10871567
-
van Loon LJ, Saris WH, Verhagen H, Wagenmakers AJ. Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate. Am J Clin Nutr 2000; 72:96-105; PMID:10871567.
-
(2000)
Am J Clin Nutr
, vol.72
, pp. 96-105
-
-
Van Loon, L.J.1
Saris, W.H.2
Verhagen, H.3
Wagenmakers, A.J.4
-
37
-
-
70450267509
-
Evaluation of beta cell dysfunction by mixed meal tolerance test and oral L-arginine in patients with newly diagnosed type 2 diabetes mellitus
-
PMID:19924604
-
Ozbek M, Erdogan M, Karadeniz M, Cetinkalp S, Ozgen AG, Saygili F, et al. Evaluation of beta cell dysfunction by mixed meal tolerance test and oral L-arginine in patients with newly diagnosed type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 2009; 117:573-6; PMID:19924604; http://dx.doi.org/10.1055/s- 0029-1234087.
-
(2009)
Exp Clin Endocrinol Diabetes
, vol.117
, pp. 573-576
-
-
Ozbek, M.1
Erdogan, M.2
Karadeniz, M.3
Cetinkalp, S.4
Ozgen, A.G.5
Saygili, F.6
-
38
-
-
77949595748
-
Effects of meal size and composition on incretin, alpha-cell and beta-cell responses
-
PMID:19846181
-
Rijkelijkhuizen JM, McQuarrie K, Girman CJ, Stein PP, Mari A, Holst JJ, et al. Effects of meal size and composition on incretin, alpha-cell and beta-cell responses. Metabolism 2010; 59:502-11; PMID:19846181; http://dx.doi.org/10.1016/j.metabol.2009.07.039.
-
(2010)
Metabolism
, vol.59
, pp. 502-511
-
-
Rijkelijkhuizen, J.M.1
McQuarrie, K.2
Girman, C.J.3
Stein, P.P.4
Mari, A.5
Holst, J.J.6
-
39
-
-
0036311151
-
Assessing insulin secretion by modeling in multiple-meal tests: Role of potentiation
-
PMID:11815483
-
Mari A, Tura A, Gastaldelli A, Ferrannini E. Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation. Diabetes 2002; 51:221-6; PMID:11815483; http://dx.doi.org/10.2337/diabetes.51.2007.S221.
-
(2002)
Diabetes
, vol.51
, pp. 221-226
-
-
Mari, A.1
Tura, A.2
Gastaldelli, A.3
Ferrannini, E.4
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