Successful islet autotransplantation in humans: Functional insulin secretory reserve as an estimate of surviving islet cell mass

Diabetes

Volumn 47, Issue 3, 1998, Pages 324-330

  Teuscher, Adrian U ^a   Kendau, David M ^a   Smets, Yves F C ^a   Leone, John P ^a   Sutherland, David E R ^a   Paul Robertson, R ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUCOSE; INSULIN;

ADULT; ARTICLE; AUTOTRANSPLANTATION; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HUMAN; INSULIN RELEASE; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADULT; ARGININE; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHRONIC DISEASE; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; GLUCOSE TOLERANCE TEST; GRAFT SURVIVAL; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; PANCREATITIS; PROSPECTIVE STUDIES; TIME FACTORS; TRANSPLANTATION, AUTOLOGOUS;

EID: 2642648673     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.3.324     Document Type: Article

References (18)

1. Hering BJ, Browatzki CC, Schultz AO, Bretzel RG, Federlin K: Islet transplant registry report on adult and fetal islet allografts. Transplant Proc 26:565-568, 1994
2. Pyzdrowski KL, Kendall DM, Halter JB, Nakhleh RF, Sutherland DER, Robertson RP: Preserved insulin secretion and insulin independence in recipients of islet autografts, N Engl J Med 327:220-226, 1992
3. Farney AC, Najarian JS, Nakhleh RE, Lioveras G, Field MJ, Gores PF, Sutherland DE: Autotransplantation of dispersed pancreatic islet tissue combined with total or near-total pancreatectomy for treatment of chronic pancreatitis. Surgery 110:427-439, 1991
4. Wahoff DG, Paplois BE, Kendall DM, Najarian JS, Farney AC, Leone JP, Jessenin J, Dunn DL, Robertson RP, Sutherland DER: Autologous islet transplantation to prevent diabetes after pancreatic resection. Am J Surg 222:562-579, 1995
5. Seaquist ER, Robertson RP: Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors. J Clin Invest 89:1761-1766, 1992
6. Teuscher A, Seaquist ER, Robertson RP: Diminished insulin secretory reserve in diabetic pancreas transplant and nondiabetic kidney transplant recipients. Diabetes 43:593-598, 1994
7. McCulloch DK, Koerker DJ, Kahn SE, Bonner-Weir S, Palmer JP: Correlations of in vivo β-cell function tests with β-cell mass and pancreatic insulin content in streptozocin-administered baboons. Diabetes 40:673-679, 1991
8. Morgan CR, Lazarow A: Immunoassay of insulin: two antibody system: plasma insulin levels of normal, subdiabetic and diabetic rats. Diabetes 12:115-126, 1963
9. Tobin BW, Lewis JT, Chen DZX, Finegood DT. Insulin secretory function in relation to transplanted islet mass in STZ-induced diabetic rats. Diabetes 42:98-105, 1093
10. Ward WK, Wallum BJ, Beard JC, Taborsky GJ Jr, Porte D Jr: Reduction of glycemie potentiation sensitive indicator of β-cell loss in partially pancreatectomized dogs. Diabetes 37:723-729, 1988
11. Seaquist ER, Kahn SE, Clark PM, Hales N, Porte D Jr, Robertson RP: Hyperproinsulinemia is associated with increased β cell demand after hemipancreatectomy in humans. J Clin Invest 97:455-460, 1996
12. Kaufman DB, Morel P, Field MJ, Munn SR, Sutherland DER: Purified canine islet autografts. Transplantation 50:385-391, 1990
13. Montana E, Bonner-Weir S, Weir GC: Transplanted beta cell response to increased metabolic demand. J Clin Invest 93:1577-1582, 1994
14. Weir GC, Bonner-Weir S, Leahy JL: Islet mass and function in diabetes and transplantation. Diabetes 39:401-405, 1990
15. Robertson RP: Cyclosporin-induced inhibition of insulin secretion in isolated rat islets and HIT cells. Diabetes 35:1016-1019, 1986
16. Robertson RP, Franklin G, Nelson L: Intravenous glucose tolerance and pancreatic islet β-cell function in patients with multiple sclerosis during two-year treatment with cyclosporin. Diabetes 38:58-64, 1989
17. Redmon JB, Olson LK, Armstrong MB, Greene MJ, Robertson RP: Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. J Clin Invest 98:2786-2793, 1996
18. Pirsch JD, Miller J, Deierhoi MH, Vincenti F, Filo RS for the FK606 Kidney Transplant Study Group: A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. Transplantation 63:977-983, 1997