Imbalanced production of cytokines by T cells associates with the activation/exhaustion status of memory T cells in chronic HIV type 1 infection

AIDS Research and Human Retroviruses

Volumn 28, Issue 7, 2012, Pages 702-714

  Nakayama, Kaori ^a   Nakamura, Hitomi ^a   Koga, Michiko ^a   Koibuchi, Tomohiko ^a   Fujii, Takeshi ^a   Miura, Toshiyuki ^a   Iwamoto, Aikichi ^a   Kawana Tachikawa, Ai ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD38 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 17; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PROTEIN MIG; RANTES; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MEMORY T LYMPHOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH2 CELL;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CYTOKINES; FEMALE; HIV SEROPOSITIVITY; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MACROPHAGE INFLAMMATORY PROTEINS; MALE; MIDDLE AGED; T-LYMPHOCYTES; VIRAL LOAD; YOUNG ADULT;

EID: 84862126026     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2011.0073     Document Type: Article

References (51)

1. Mellors JW, Munoz A, Giorgi JV, et al.: Plasma viral load and CD4 + lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997;126:946-954. (Pubitemid 27255797)
2. Grossman Z, Meier-Schellersheim M, Paul WE, and Picker LJ: Pathogenesis of HIV infection: What the virus spares is as important as what it destroys. Nat Med 2006;12:289-295. (Pubitemid 43355074)
3. Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, and Giorgi JV: Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 1997;16:83-92.
4. Silvestri G, Sodora DL, Koup RA, et al.: Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 2003;18:441-452. (Pubitemid 36351522)
5. Hirsch VM: What can natural infection of African monkeys with simian immunodeficiency virus tell us about the pathogenesis of AIDS? AIDS Rev 2004;6:40-53. (Pubitemid 38607540)
6. Betts MR, Nason MC, West SM, et al.: HIV nonprogressors preferentially maintain highly functional HIV-specific CD8 + T cells. Blood 2006;107:4781-4789. (Pubitemid 43882629)
7. Freel SA, Lamoreaux L, Chattopadhyay PK, et al.: Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination. J Virol 2010;84:4998-5006.
8. Nemes E, Bertoncelli L, Lugli E, et al.: Cytotoxic granule release dominates gag-specific CD4 + T-cell response in different phases of HIV infection. AIDS 2010;24:947-957.
9. Brenchley JM, Karandikar NJ, Betts MR, et al.: Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8 + T cells. Blood 2003;101:2711-2720. (Pubitemid 36857634)
10. Palmer BE, Blyveis N, Fontenot AP, and Wilson CC: Functional and phenotypic characterization of CD57 + CD4 + T cells and their association with HIV-1-induced T cell dysfunction. J Immunol 2005;175:8415-8423. (Pubitemid 41798409)
11. Day CL, Kaufmann DE, Kiepiela P, et al.: PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006;443:350-354. (Pubitemid 44435155)
12. Kaufmann DE, Kavanagh DG, Pereyra F, et al.: Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol 2007;8:1246-1254. (Pubitemid 350011764)
13. DSouza M, Fontenot AP, Mack DG, et al.: Programmed death 1 expression on HIV-specific CD4 + T cells is driven by viral replication and associated with T cell dysfunction. J Immunol 2007;179:1979-1987.
14. Mosmann TR and Coffman RL: TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173. (Pubitemid 19138011)
15. Barrat FJ, Cua DJ, Boonstra A, et al.: In vitro generation of interleukin 10-producing regulatory CD4( + ) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002;195:603-616. (Pubitemid 34461505)
16. Harrington LE, Hatton RD, Mangan PR, et al.: Interleukin 17-producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123-1132. (Pubitemid 41541790)
17. Charlton B and Lafferty KJ: The Th1/Th2 balance in autoimmunity. Curr Opin Immunol 1995;7:793-798. (Pubitemid 26038519)
18. Clerici M and Shearer GM: A TH1/TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993;14:107-111. (Pubitemid 23068292)
19. Thobakgale CF, Streeck H, Mkhwanazi N, et al.: CD8( +) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection. AIDS Res Hum Retroviruses 2011;27:1005-1012.
20. Hammarstrom S, Hammarstrom ML, Sundblad G, Arnarp J, and Lonngren J: Mitogenic leukoagglutinin from Phaseolus vulgaris binds to a pentasaccharide unit in N-acetyllactosamine- type glycoprotein glycans. Proc Natl Acad Sci USA 1982;79:1611-1615. (Pubitemid 12113318)
21. Janossy G, Greaves MF, Doenhoff MJ, and Snajdr J: Lymphocyte activation. V. Quantitation of the proliferative responses to mitogens using defined T and B cell populations. Clin Exp Immunol 1973;14:581-596.
22. Scott MG and Nahm MH: Mitogen-induced human IgG subclass expression. J Immunol 1984;133:2454-2460. (Pubitemid 15204768)
23. Ceuppens JL, Baroja ML, Lorre K, Van Damme J, and Billiau A: Human T cell activation with phytohemagglutinin. The function of IL-6 as an accessory signal. J Immunol 1988; 141:3868-3874.
24. Unanue ER and Allen PM: The basis for the immunoregulatory role of macrophages and other accessory cells. Science 1987;236:551-557. (Pubitemid 17069919)
25. Sallusto F, Lenig D, Forster R, Lipp M, and Lanzavecchia A: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401:708-712.
26. Agarwal S, Viola JP, and Rao A: Chromatin-based regulatory mechanisms governing cytokine gene transcription. J Allergy Clin Immunol 1999;103:990-999. (Pubitemid 29343059)
27. Wherry EJ and Ahmed R: Memory CD8 T-cell differentiation during viral infection. J Virol 2004;78:5535-5545. (Pubitemid 38661640)
28. Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, and Ahmed R: Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 2003;77:4911-4927. (Pubitemid 36402840)
29. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, and Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8 + T cells. Science 1995;270:1811-1815.
30. Bonecchi R, Bianchi G, Bordignon PP, et al.: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998;187:129-134. (Pubitemid 28044828)
31. Ferbas J, Giorgi JV, Amini S, et al.: Antigen-specific production of RANTES, macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta in vitro is a correlate of reduced human immunodeficiency virus burden in vivo. J Infect Dis 2000;182:1247-1250.
32. Siveke JT and Hamann A: T helper 1 and T helper 2 cells respond differentially to chemokines. J Immunol 1998;160: 550-554. (Pubitemid 28049291)
33. Taub DD, Conlon K, Lloyd AR, Oppenheim JJ, and Kelvin DJ: Preferential migration of activated CD4 + and CD8 + T cells in response to MIP-1 alpha and MIP-1 beta. Science 1993;260:355-358. (Pubitemid 23160144)
34. Dolan MJ, Kulkarni H, Camargo JF, et al.: CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nat Immunol 2007;8:1324-1336. (Pubitemid 350131170)
35. Gonzalez E, Kulkarni H, Bolivar H, et al.: The influence of CCL3L1 gene-containing segmental duplications on HIV-1/ AIDS susceptibility. Science 2005;307:1434-1440. (Pubitemid 40321934)
36. Gosselin A, Monteiro P, Chomont N, et al.: Peripheral blood CCR4 + CCR6 + and CXCR3 + CCR6 + CD4 + T cells are highly permissive to HIV-1 infection. J Immunol 2010;184: 1604-1616.
37. Lim HW, Lee J, Hillsamer P, and Kim CH: Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3 + regulatory T cells. J Immunol 2008; 180:122-129.
38. Fernandez N, Renedo M, Garcia-Rodriguez C, and Sanchez Crespo M: Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES. J Immunol 2002;169:3321-3328. (Pubitemid 35013181)
39. Dodon MD, Li Z, Hamaia S, and Gazzolo L: Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells. J Gen Virol 2004;85:1921-1932. (Pubitemid 39023271)
40. Penix L, Weaver WM, Pang Y, Young HA, and Wilson CB: Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells. J Exp Med 1993;178:1483-1496. (Pubitemid 23318427)
41. Acosta-Rodriguez EV, Rivino L, Geginat J, et al.: Surface phenotype and antigenic specificity of human interleukin 17- producing T helper memory cells. Nat Immunol 2007;8:639-646. (Pubitemid 46785128)
42. Ouyang W, Kolls JK, and Zheng Y: The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008;28:454-467. (Pubitemid 351471762)
43. Lin Y, Ritchea S, Logar A, et al.: Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 2009;31: 799-810.
44. Brenchley JM, Price DA, Schacker TW, et al.: Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006;12:1365-1371. (Pubitemid 44924494)
45. Raffatellu M, Santos RL, Verhoeven DE, et al.: Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat Med 2008;14:421-428. (Pubitemid 351499394)
46. Brenchley JM, Paiardini M, Knox KS, et al.: Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood 2008;112:2826-2835.
47. Brenchley JM and Douek DC: HIV infection and the gastrointestinal immune system. Mucosal Immunol 2008;1:23-30.
48. Cecchinato V, Trindade CJ, Laurence A, et al.: Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virusinfected macaques. Mucosal Immunol 2008;1:279-288. (Pubitemid 351850534)
49. Appay V, van Lier RA, Sallusto F, and Roederer M: Phenotype and function of human T lymphocyte subsets: Consensus and issues. Cytometry A 2008;73(11):975-983.
50. Sauce D, Almeida JR, Larsen M, et al.: PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status. AIDS 2007;21:2005-2013. (Pubitemid 47462149)
51. Trautmann L, Janbazian L, Chomont N, et al.: Upregulation of PD-1 expression on HIV-specific CD8 + T cells leads to reversible immune dysfunction. Nat Med 2006;12: 1198-1202. (Pubitemid 44527357)