Runx1 deficiency in CD4 + T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells

Journal of Immunology

Volumn 188, Issue 11, 2012, Pages 5408-5420

  Wong, Won Fen ^a   Kohu, Kazuyoshi ^a   Nakamura, Akira ^a,b   Ebina, Masahito ^c   Kikuchi, Toshiaki ^c   Tazawa, Ryushi ^d   Tanaka, Keisuke ^a   Kon, Shunsuke ^a   Funaki, Tomo ^a   Sugahara Tobinai, Akiko ^a   Looi, Chung Yeng ^a   Endo, Shota ^a   Funayama, Ryo ^c   Kurokawa, Mineo ^e   Habu, Sonoko ^f   Ishii, Naoto ^c   Fukumoto, Manabu ^a   Nakata, Koh ^d   Takai, Toshiyuki ^a   Satake, Masanobu ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Department of Immunology   (Japan)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 21; TRANSCRIPTION FACTOR RUNX1;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BINDING SITE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FATAL AUTOIMMUNE INFLAMMATORY LUNG DISEASE; FLOW CYTOMETRY; HISTOLOGY; HUMORAL IMMUNITY; IMMUNOBLOTTING; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; INTRON; LUNG ALVEOLUS PROTEINOSIS; LUNG LAVAGE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PLASMA CELL; PLASMID; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; RESPIRATORY FAILURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CYTOKINES; HUMANS; INFLAMMATION; JURKAT CELLS; LUNG DISEASES; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; PULMONARY ALVEOLI;

EID: 84862086432     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102991     Document Type: Article

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