Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation

American Journal of Respiratory and Critical Care Medicine

Volumn 181, Issue 7, 2010, Pages 688-698

  Damayanti, Triya ^a   Kikuchi, Toshiaki ^b   Zaini, Jamal ^a   Daito, Hisayoshi ^a   Kanehira, Masahiko ^a   Kohu, Kazuyoshi ^c   Ishii, Naoto ^a   Satake, Masanobu ^c   Sugamura, Kazuo ^a   Nukiwa, Toshihiro ^a,b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Environmental illness; Inhalation therapy; Neutralizing antibodies

Indexed keywords

OX40 LIGAND; TRANSCRIPTION FACTOR RUNX3; ALLERGEN; CD134 ANTIGEN;

ADAPTIVE IMMUNITY; ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; HELPER CELL; HOUSE DUST ALLERGY; INFLAMMATION; LUNG LAVAGE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BRONCHUS HYPERREACTIVITY; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DISEASE MODEL; IMMUNOLOGY; LUNG; PYROGLYPHIDAE;

ALLERGENS; ANIMALS; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; LUNG; MICE; MICE, INBRED C57BL; NATURAL KILLER T-CELLS; OX40 LIGAND; PYROGLYPHIDAE; RECEPTORS, OX40;

EID: 77951936959     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200910-1598OC     Document Type: Article

References (53)

1. Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Enander I, Venge P, Ahlstedt S, Simony-Lafontaine J, Godard P, et al. Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033-1039.
2. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 2001;344:350-362.
3. Hamid Q, Tulic M. Immunobiology of asthma. Annu Rev Physiol 2009; 71:489-507.
4. H2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
5. Arestides RS, He H, Westlake RM, Chen AI, Sharpe AH, Perkins DL, Finn PW. Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation. Eur J Immunol 2002;32:2874-2880. (Pubitemid 35238180)
6. Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 2009;9:271-285.
7. Fang L, Adkins B, Deyev V, Podack ER. Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J Exp Med 2008;205:1037-1048. (Pubitemid 351679680)
8. Hoshino A, Tanaka Y, Akiba H, Asakura Y, Mita Y, Sakurai T, Takaoka A, Nakaike S, Ishii N, Sugamura K, et al. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur J Immunol 2003;33:861-869. (Pubitemid 36546673)
9. Jember AG, Zuberi R, Liu FT, Croft M. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J Exp Med 2001;193:387-392. (Pubitemid 32524521)
10. Meylan F, Davidson TS, Kahle E, Kinder M, Acharya K, Jankovic D, Bundoc V, Hodges M, Shevach EM, Keane-Myers A, et al. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 2008;29:79-89.
11. Polte T, Foell J, Werner C, Hoymann HG, Braun A, Burdach S, Mittler RS, Hansen G. CD137-mediated immunotherapy for allergic asthma. J Clin Invest 2006;116:1025-1036.
12. Salek-Ardakani S, Song J, Halteman BS, Jember AG, Akiba H, Yagita H, Croft M. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med 2003;198:315-324. (Pubitemid 36987856)
13. Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, et al. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J Clin Invest 2007;117:3868-3878.
14. Croft M, So T, Duan W, Soroosh P. The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev 2009;229: 173-191.
15. Sugamura K, Ishii N, Weinberg AD. Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol 2004;4:420-431. (Pubitemid 38745554)
16. Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005;23:23-68. (Pubitemid 40563164)
17. Diana J, Griseri T, Lagaye S, Beaudoin L, Autrusseau E, Gautron AS, Tomkiewicz C, Herbelin A, Barouki R, von Herrath M, et al. NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner. Immunity 2009;30:289-299.
18. Marschner A, Rothenfusser S, Hornung V, Prell D, Krug A, Kerkmann M, Wellisch D, Poeck H, Greinacher A, Giese T, et al. CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells. Eur J Immunol 2005;35:2347-2357. (Pubitemid 41179755)
19. + Th cell antitumor immunity in mice. J Clin Invest 2007;117:3330-3338.
20. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol 2007;25:297-336.
21. Kronenberg M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 2005;23:877-900. (Pubitemid 40563188)
22. Matsuda JL, Mallevaey T, Scott-Browne J, Gapin L. CD1d-restricted iNKT cells, the "Swiss-Army knife" of the immune system. Curr Opin Immunol 2008;20:358-368.
23. Meyer EH, DeKruyff RH, Umetsu DT. T cells and NKT cells in the pathogenesis of asthma. Annu Rev Med 2008;59:281-292.
24. Van Kaer L. NKT cells: T lymphocytes with innate effector functions. Curr Opin Immunol 2007;19:354-364. (Pubitemid 46687006)
25. + natural killer T cells in bronchial asthma. N Engl J Med 2006;354:1117-1129.
26. Ho LP. Natural killer T cells in asthma: toward increased understanding. N Engl J Med 2007;356:1466-1468. (Pubitemid 46556333)
27. Vijayanand P, Seumois G, Pickard C, Powell RM, Angco G, Sammut D, Gadola SD, Friedmann PS, Djukanovic R. Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease. N Engl J Med 2007;356:1410-1422. (Pubitemid 46556326)
28. Zaini J, Andarini S, Kikuchi T, Nukiwa T. OX40L-OX40 interactions contribute to NKT activation in a mouse model of allergic airway disease [abstract]. Am J Respir Crit Care Med 2008;177:A981.
29. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature 1991;353:180-184.
30. Cui J, Watanabe N, Kawano T, Yamashita M, Kamata T, Shimizu C, Kimura M, Shimizu E, Koike J, Koseki H, et al. Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Va14 natural killer T cells. J Exp Med 1999;190:783-792. (Pubitemid 29451624)
31. Kohu K, Sato T, Ohno S, Hayashi K, Uchino R, Abe N, Nakazato M, Yoshida N, Kikuchi T, Iwakura Y, et al. Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage. J Immunol 2005;174:2627-2636. (Pubitemid 40279676)
32. Pippig SD, Pena-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol 1999;163:6520-6529.
33. + T cell differentiation. Immunity 2003;18:475-487.
34. Kikuchi T, Crystal RG. Antigen-pulsed dendritic cells expressing macrophage-derived chemokine elicit Th2 responses and promote specific humoral immunity. J Clin Invest 2001;108:917-927. (Pubitemid 32880300)
35. + T cells. Nat Med 2000;6:1154-1159.
36. Murata K, Ishii N, Takano H, Miura S, Ndhlovu LC, Nose M, Noda T, Sugamura K. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med 2000;191:365-374. (Pubitemid 30060925)
37. Collins A, Littman DR, Taniuchi I. RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol 2009;9:106-115.
38. Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 2007;8:145-153.
39. Naoe Y, Setoguchi R, Akiyama K, Muroi S, Kuroda M, Hatam F, Littman DR, Taniuchi I. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf β binding to the Il4 silencer. J Exp Med 2007;204: 1749-1755. (Pubitemid 47236313)
40. Walker LS, Gulbranson-Judge A, Flynn S, Brocker T, Lane PJ. Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol Today 2000;21:333-337. (Pubitemid 30428304)
41. Kotani A, Hori T, Matsumura Y, Uchiyama T. Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC chemokine RANTES/CCL5. Immunol Lett 2002;84:1-7. (Pubitemid 34879913)
42. Ito T, Wang YH, Duramad O, Hori T, Delespesse GJ, Watanabe N, Qin FX, Yao Z, Cao W, Liu YJ. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 2005;202:1213-1223. (Pubitemid 41586952)
43. So T, Song J, Sugie K, Altman A, Croft M. Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci USA 2006;103:3740-3745. (Pubitemid 43376625)
44. Glimcher LH, Townsend MJ, Sullivan BM, Lord GM. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat Rev Immunol 2004;4:900-911.
45. Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC. GATA-3 regulates the development and function of invariant NKT cells. J Immunol 2006;177:6650-6659. (Pubitemid 44715028)
46. Townsend MJ, Weinmann AS, Matsuda JL, Salomon R, Farnham PJ, Biron CA, Gapin L, Glimcher LH. T-bet regulates the terminal maturation and homeostasis of NK and Vα14i NKT cells. Immunity 2004;20:477-494. (Pubitemid 38482125)
47. Cerundolo V, Silk JD, Masri SH, Salio M. Harnessing invariant NKT cells in vaccination strategies. Nat Rev Immunol 2009;9:28-38.
48. Goff RD, Gao Y, Mattner J, Zhou D, Yin N, Cantu C III, Teyton L, Bendelac A, Savage PB. Effects of lipid chain lengths in α-galactosylceramides on cytokine release by natural killer T cells. J Am Chem Soc 2004;126:13602-13603. (Pubitemid 39407224)
49. H2 bias of natural killer T cells. Nature 2001;413:531-534.
50. Yu KO, Im JS, Molano A, Dutronc Y, Illarionov PA, Forestier C, Fujiwara N, Arias I, Miyake S, Yamamura T, et al. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of α-galactosylceramides. Proc Natl Acad Sci USA 2005;102:3383-3388. (Pubitemid 40328054)
51. Andarini S, Kikuchi T, Nukiwa M, Pradono P, Suzuki T, Ohkouchi S, Inoue A, Maemondo M, Ishii N, Saijo Y, et al. Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts. Cancer Res 2004;64:3281-3287. (Pubitemid 38581434)
52. Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 2003;9:582-588. (Pubitemid 36597105)
53. α14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J Immunol 2003;171:1637-1641.