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Volumn 318, Issue 13, 2012, Pages 1586-1596

Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway

Author keywords

Angiogenesis; Endothelial cell; ERK; IL 6; Polyphenol; STAT 3

Indexed keywords

ANGIOGENESIS INHIBITOR; APIGENIN; DELPHINIDIN; ELLAGIC ACID; GELATINASE A; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYPHENOL; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

EID: 84862010246     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.04.004     Document Type: Article
Times cited : (65)

References (55)
  • 2
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    • Colotta F., Allavena P., Sica A., Garlanda C., Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009, 30:1073-1081.
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 6
    • 77957592789 scopus 로고    scopus 로고
    • Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals
    • Gupta S.C., Kim J.H., Prasad S., Aggarwal B.B. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010, 29:405-434.
    • (2010) Cancer Metastasis Rev. , vol.29 , pp. 405-434
    • Gupta, S.C.1    Kim, J.H.2    Prasad, S.3    Aggarwal, B.B.4
  • 7
  • 8
    • 0035254648 scopus 로고    scopus 로고
    • Angiogenesis: regulators and clinical applications
    • Liekens S., De Clercq E., Neyts J. Angiogenesis: regulators and clinical applications. Biochem. Pharmacol. 2001, 61:253-270.
    • (2001) Biochem. Pharmacol. , vol.61 , pp. 253-270
    • Liekens, S.1    De Clercq, E.2    Neyts, J.3
  • 9
    • 65549144056 scopus 로고    scopus 로고
    • Angiogenesis links chronic inflammation with cancer
    • Kobayashi H., Lin P.C. Angiogenesis links chronic inflammation with cancer. Methods Mol. Biol. 2009, 511:185-191.
    • (2009) Methods Mol. Biol. , vol.511 , pp. 185-191
    • Kobayashi, H.1    Lin, P.C.2
  • 10
    • 28244456279 scopus 로고    scopus 로고
    • Tumor inflammatory angiogenesis and its chemoprevention
    • Albini A., Tosetti F., Benelli R., Noonan D.M. Tumor inflammatory angiogenesis and its chemoprevention. Cancer Res. 2005, 65:10637-10641.
    • (2005) Cancer Res. , vol.65 , pp. 10637-10641
    • Albini, A.1    Tosetti, F.2    Benelli, R.3    Noonan, D.M.4
  • 11
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 9744236585 scopus 로고    scopus 로고
    • Interleukin-6 induced basic fibroblast growth factor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and PI3-kinase/Akt pathways
    • Jee S.H., Chu C.Y., Chiu H.C., Huang Y.L., Tsai W.L., Liao Y.H., Kuo M.L. Interleukin-6 induced basic fibroblast growth factor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and PI3-kinase/Akt pathways. J. Invest. Dermatol. 2004, 123:1169-1175.
    • (2004) J. Invest. Dermatol. , vol.123 , pp. 1169-1175
    • Jee, S.H.1    Chu, C.Y.2    Chiu, H.C.3    Huang, Y.L.4    Tsai, W.L.5    Liao, Y.H.6    Kuo, M.L.7
  • 14
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    • Heinrich P.C., Behrmann I., Muller-Newen G., Schaper F., Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J. 1998, 334(Pt 2):297-314.
    • (1998) Biochem. J. , vol.334 , Issue.PART 2 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 15
    • 39549102220 scopus 로고    scopus 로고
    • STAT3: a critical transcription activator in angiogenesis
    • Chen Z., Han Z.C. STAT3: a critical transcription activator in angiogenesis. Med. Res. Rev. 2008, 28:185-200.
    • (2008) Med. Res. Rev. , vol.28 , pp. 185-200
    • Chen, Z.1    Han, Z.C.2
  • 17
    • 49549097364 scopus 로고    scopus 로고
    • The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective
    • Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc. Nutr. Soc. 2008, 67:253-256.
    • (2008) Proc. Nutr. Soc. , vol.67 , pp. 253-256
    • Wiseman, M.1
  • 18
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh Y.J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 2003, 3:768-780.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 19
    • 79955572744 scopus 로고    scopus 로고
    • Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis
    • Kang N.J., Shin S.H., Lee H.J., Lee K.W. Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis. Pharmacol. Ther. 2011, 130:310-324.
    • (2011) Pharmacol. Ther. , vol.130 , pp. 310-324
    • Kang, N.J.1    Shin, S.H.2    Lee, H.J.3    Lee, K.W.4
  • 20
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C., Williamson G., Morand C., Scalbert A., Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 2005, 81:230S-242S.
    • (2005) Am. J. Clin. Nutr. , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 21
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: bioavailability, metabolic effects, and safety
    • Ross J.A., Kasum C.M. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu. Rev. Nutr. 2002, 22:19-34.
    • (2002) Annu. Rev. Nutr. , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 22
    • 48649095089 scopus 로고    scopus 로고
    • Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways
    • Ramos S. Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol. Nutr. Food Res. 2008, 52:507-526.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 507-526
    • Ramos, S.1
  • 24
    • 0025288244 scopus 로고
    • Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation
    • Araki S., Shimada Y., Kaji K., Hayashi H. Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation. Biochem. Biophys. Res. Commun. 1990, 168:1194-1200.
    • (1990) Biochem. Biophys. Res. Commun. , vol.168 , pp. 1194-1200
    • Araki, S.1    Shimada, Y.2    Kaji, K.3    Hayashi, H.4
  • 28
    • 2442685645 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
    • Xie T.X., Wei D., Liu M., Gao A.C., Ali-Osman F., Sawaya R., Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004, 23:3550-3560.
    • (2004) Oncogene , vol.23 , pp. 3550-3560
    • Xie, T.X.1    Wei, D.2    Liu, M.3    Gao, A.C.4    Ali-Osman, F.5    Sawaya, R.6    Huang, S.7
  • 29
    • 0034724677 scopus 로고    scopus 로고
    • SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
    • Schmitz J., Weissenbach M., Haan S., Heinrich P.C., Schaper F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 2000, 275:12848-12856.
    • (2000) J. Biol. Chem. , vol.275 , pp. 12848-12856
    • Schmitz, J.1    Weissenbach, M.2    Haan, S.3    Heinrich, P.C.4    Schaper, F.5
  • 30
    • 34249825478 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its relationship to inflammatory mediators
    • Angelo L.S., Kurzrock R. Vascular endothelial growth factor and its relationship to inflammatory mediators. Clin. Cancer Res. 2007, 13:2825-2830.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2825-2830
    • Angelo, L.S.1    Kurzrock, R.2
  • 31
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • Cohen T., Nahari D., Cerem L.W., Neufeld G., Levi B.Z. Interleukin 6 induces the expression of vascular endothelial growth factor. J. Biol. Chem. 1996, 271:736-741.
    • (1996) J. Biol. Chem. , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.W.3    Neufeld, G.4    Levi, B.Z.5
  • 33
    • 0037591513 scopus 로고    scopus 로고
    • Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients
    • Bachelot T., Ray-Coquard I., Menetrier-Caux C., Rastkha M., Duc A., Blay J.Y. Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients. Br. J. Cancer 2003, 88:1721-1726.
    • (2003) Br. J. Cancer , vol.88 , pp. 1721-1726
    • Bachelot, T.1    Ray-Coquard, I.2    Menetrier-Caux, C.3    Rastkha, M.4    Duc, A.5    Blay, J.Y.6
  • 35
    • 47249157693 scopus 로고    scopus 로고
    • Delphinidin, a dietary anthocyanidin, inhibits platelet-derived growth factor ligand/receptor (PDGF/PDGFR) signaling
    • Lamy S., Beaulieu E., Labbe D., Bedard V., Moghrabi A., Barrette S., Gingras D., Beliveau R. Delphinidin, a dietary anthocyanidin, inhibits platelet-derived growth factor ligand/receptor (PDGF/PDGFR) signaling. Carcinogenesis 2008, 29:1033-1041.
    • (2008) Carcinogenesis , vol.29 , pp. 1033-1041
    • Lamy, S.1    Beaulieu, E.2    Labbe, D.3    Bedard, V.4    Moghrabi, A.5    Barrette, S.6    Gingras, D.7    Beliveau, R.8
  • 36
    • 0037081274 scopus 로고    scopus 로고
    • Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation
    • Lamy S., Gingras D., Beliveau R. Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res. 2002, 62:381-385.
    • (2002) Cancer Res. , vol.62 , pp. 381-385
    • Lamy, S.1    Gingras, D.2    Beliveau, R.3
  • 37
    • 0035284754 scopus 로고    scopus 로고
    • Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway
    • Li W.Q., Dehnade F., Zafarullah M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J. Immunol. 2001, 166:3491-3498.
    • (2001) J. Immunol. , vol.166 , pp. 3491-3498
    • Li, W.Q.1    Dehnade, F.2    Zafarullah, M.3
  • 38
    • 33747470228 scopus 로고    scopus 로고
    • Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane)
    • Chakravarti N., Myers J.N., Aggarwal B.B. Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane). Int. J. Cancer 2006, 119:1268-1275.
    • (2006) Int. J. Cancer , vol.119 , pp. 1268-1275
    • Chakravarti, N.1    Myers, J.N.2    Aggarwal, B.B.3
  • 39
    • 33947197883 scopus 로고    scopus 로고
    • Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
    • Bhardwaj A., Sethi G., Vadhan-Raj S., Bueso-Ramos C., Takada Y., Gaur U., Nair A.S., Shishodia S., Aggarwal B.B. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 2007, 109:2293-2302.
    • (2007) Blood , vol.109 , pp. 2293-2302
    • Bhardwaj, A.1    Sethi, G.2    Vadhan-Raj, S.3    Bueso-Ramos, C.4    Takada, Y.5    Gaur, U.6    Nair, A.S.7    Shishodia, S.8    Aggarwal, B.B.9
  • 40
    • 27744438212 scopus 로고    scopus 로고
    • Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation
    • Wung B.S., Hsu M.C., Wu C.C., Hsieh C.W. Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation. Life Sci. 2005, 78:389-397.
    • (2005) Life Sci. , vol.78 , pp. 389-397
    • Wung, B.S.1    Hsu, M.C.2    Wu, C.C.3    Hsieh, C.W.4
  • 41
    • 33646411225 scopus 로고    scopus 로고
    • Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids
    • Selvendiran K., Koga H., Ueno T., Yoshida T., Maeyama M., Torimura T., Yano H., Kojiro M., Sata M. Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Cancer Res. 2006, 66:4826-4834.
    • (2006) Cancer Res. , vol.66 , pp. 4826-4834
    • Selvendiran, K.1    Koga, H.2    Ueno, T.3    Yoshida, T.4    Maeyama, M.5    Torimura, T.6    Yano, H.7    Kojiro, M.8    Sata, M.9
  • 42
    • 77950089188 scopus 로고    scopus 로고
    • Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism
    • Anso E., Zuazo A., Irigoyen M., Urdaci M.C., Rouzaut A., Martinez-Irujo J.J. Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. Biochem. Pharmacol. 2010, 79:1600-1609.
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 1600-1609
    • Anso, E.1    Zuazo, A.2    Irigoyen, M.3    Urdaci, M.C.4    Rouzaut, A.5    Martinez-Irujo, J.J.6
  • 44
    • 0035671397 scopus 로고    scopus 로고
    • Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines
    • Masuda M., Suzui M., Weinstein I.B. Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin. Cancer Res. 2001, 7:4220-4229.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 4220-4229
    • Masuda, M.1    Suzui, M.2    Weinstein, I.B.3
  • 46
    • 0033567964 scopus 로고    scopus 로고
    • Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas
    • Kossakowska A.E., Edwards D.R., Prusinkiewicz C., Zhang M.C., Guo D., Urbanski S.J., Grogan T., Marquez L.A., Janowska-Wieczorek A. Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas. Blood 1999, 94:2080-2089.
    • (1999) Blood , vol.94 , pp. 2080-2089
    • Kossakowska, A.E.1    Edwards, D.R.2    Prusinkiewicz, C.3    Zhang, M.C.4    Guo, D.5    Urbanski, S.J.6    Grogan, T.7    Marquez, L.A.8    Janowska-Wieczorek, A.9
  • 48
    • 1642502300 scopus 로고    scopus 로고
    • Structure, conformation, and electronic properties of apigenin, luteolin, and taxifolin antioxidants. A first principle theoretical study
    • Leopoldini M., Pitarch I.P., Russo N., Toscano M. Structure, conformation, and electronic properties of apigenin, luteolin, and taxifolin antioxidants. A first principle theoretical study. J. Phys. Chem. A 2004, 108:92-96.
    • (2004) J. Phys. Chem. A , vol.108 , pp. 92-96
    • Leopoldini, M.1    Pitarch, I.P.2    Russo, N.3    Toscano, M.4
  • 49
    • 0037116579 scopus 로고    scopus 로고
    • Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation
    • Llorens F., Garcia L., Itarte E., Gomez N. Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation. FEBS Lett. 2002, 510:149-153.
    • (2002) FEBS Lett. , vol.510 , pp. 149-153
    • Llorens, F.1    Garcia, L.2    Itarte, E.3    Gomez, N.4
  • 50
    • 0035469062 scopus 로고    scopus 로고
    • Association and contribution of ERK to IL-6-induced activation of signal transducer and activator of transcription in a human myeloma cell line
    • Song L., Shen B., Li Y. Association and contribution of ERK to IL-6-induced activation of signal transducer and activator of transcription in a human myeloma cell line. Chin. Med. J. (Engl) 2001, 114:954-957.
    • (2001) Chin. Med. J. (Engl) , vol.114 , pp. 954-957
    • Song, L.1    Shen, B.2    Li, Y.3
  • 51
    • 0032530159 scopus 로고    scopus 로고
    • Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases
    • Sengupta T.K., Talbot E.S., Scherle P.A., Ivashkiv L.B. Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:11107-11112.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 11107-11112
    • Sengupta, T.K.1    Talbot, E.S.2    Scherle, P.A.3    Ivashkiv, L.B.4
  • 52
    • 0030817615 scopus 로고    scopus 로고
    • Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6
    • Ihara S., Nakajima K., Fukada T., Hibi M., Nagata S., Hirano T., Fukui Y. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. EMBO J. 1997, 16:5345-5352.
    • (1997) EMBO J. , vol.16 , pp. 5345-5352
    • Ihara, S.1    Nakajima, K.2    Fukada, T.3    Hibi, M.4    Nagata, S.5    Hirano, T.6    Fukui, Y.7
  • 53
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z., Zhong Z., Darnell J.E. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995, 82:241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell, J.E.3
  • 54
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STAT-promoter complexes
    • Zhang X., Blenis J., Li H.C., Schindler C., Chen-Kiang S. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 1995, 267:1990-1994.
    • (1995) Science , vol.267 , pp. 1990-1994
    • Zhang, X.1    Blenis, J.2    Li, H.C.3    Schindler, C.4    Chen-Kiang, S.5
  • 55
    • 0030046753 scopus 로고    scopus 로고
    • STATs: signal transducers and activators of transcription
    • Ihle J.N. STATs: signal transducers and activators of transcription. Cell 1996, 84:331-334.
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.N.1


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