Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6

EMBO Journal

Volumn 16, Issue 17, 1997, Pages 5345-5352

  Ihara, Sayoko ^a   Nakajima, Koichi ^b   Fukada, Toshiyuki ^b   Hibi, Masahiko ^b   Nagata, Satoshi ^a   Hirano, Toshio ^b   Fukui, Yasuhisa ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Differentiation; Interleukin 6; NGF; PC12 cells; STAT3

Indexed keywords

CHIMERIC PROTEIN; CYTOKINE RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; NERVE GROWTH FACTOR; PROTEIN SUBUNIT; RECEPTOR PROTEIN; STAT3 PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NERVE GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; INTERLEUKIN-6; MODELS, BIOLOGICAL; NERVE GROWTH FACTORS; NEURITES; NEURONS; PC12 CELLS; RATS; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

ANIMALIA;

EID: 0030817615     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.17.5345     Document Type: Article

References (31)

1. Aoki, N., Yamaguchi-Aoki, Y. and Ullrich, A. (1996) The novel protein-tyrosine phosphatase PTP20 is a positive regulator of PC12 cell neuronal differentiation. J. Biol. Chem., 271, 29422-29426.
2. Bennett, A.M., Tang, T.U Sugimoto, S., Walsh, C.T. and Neel, B.G. (1994) Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc. Natl Acad. Sci. USA, 91, 7335-7339.
3. Cowley, S., Patterson, H., Kemp, P. and Marshall, C.J. (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cell. Cell, 77, 841-852.
4. Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K. and Hirano, T. (1996) Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity, 5, 449-460.
5. Greene, L.A. and Tischler, A.S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor Proc. Natl Acad. Sci. USA, 73, 2424-2428.
6. Hama, T., Miyamoto, M., Tsukui, H., Nishio, C. and Hatanaka, H. (1980) Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci. Lett., 104, 340-344.
7. Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T. and Kishimoto, T. (1990) Molecular cloning and expression of an IL-6 signal transducer. gp130. Cell, 63, 1149-1157.
8. Hirano, T. (1992) The biology of interleukin 6. Chem. Immunol., 51, 153-180.
9. Hirano, T. (1994) Interleukin-6. In Thomson, A. (ed.), The Cytokine Handbook, 2nd edn. Academic Press, London, pp. 145-168.
10. Hirano, T., Matsuda, T. and Nakajima, K. (1994) Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily. Stem Cells, 12, 262-277.
11. Ihara, S., Iwamatsu, A., Fujiyoshi, T., Komi, A., Yamori, T. and Fukui, Y. (1996) Identification of Interleukin-6 as a factor that induces neunte outgrowth by PC12 cells primed with NGF. J. Biochem., 120, 865-868.
12. Kim, U.-H., Donald Fink, J., Kim, H.S., Park, D.J., Contreras, M.L., Guroff, G. and Rhee, S.G. (1991) Nerve growth factor stimulates phosphorylation of phospholipase C-γ in PC12 cells. J. Biol. Chem., 266, 1359-1362.
13. Kojima, H., Nakajima, K. and Hirano, T. (1996) IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s). Oncogene, 12, 547-554.
14. Lutticken, C. et al. (1994) Association of transcription factor APRF and protein kinase Jakl with the interleukin-6 signal transducer gp130. Science, 263, 89-92.
15. Murphy, M., Reid, K., Hilton, D.J. and Bartlett, P.F. (1991) Generation of sensory neurons is stimulated by leukemia inhibitory factor. Proc. Natl Acad. Sci. USA, 88, 3498-3501.
16. Nakajima, K., Matsuda, T., Fujitani, Y., Kojima, H., Yamakawa, Y., Nakae, K., Takeda, T. and Hirano, T. (1995) Signal transduction through IL-6 receptor: involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway. Ann. NY Acad. Sci., 762, 55-70.
17. Nakajima, K., Yamanaka, Y. Nakae, K., Kojima, H., Ichiba, M., Kiuchi, N., Kitaoka, T., Fukada, T., Hibi, M. and Hirano, T. (1996) A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J., 15, 3651-3658.
18. Noda, M., Ko, M., Ogura, A., Liu, D.G., Amano, T., Takano, T. and Ikawa, Y. (1985) Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature, 318, 73-75.
19. Pang, L., Sawada, T., Decker, S.J. and Saltiel, A.R. (1995) Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem., 270, 13585-13588.
20. Patterson, P.H. and Nawa,H. (1993) Neuronal differentiation factors/ cytokines and synaptic plasticity. Cell (Suppl.), 72, 123-137.
21. Sadowski, H.B., Shuai, K., Darnell, J.E., Jr and Gilman, M.Z. (1993) A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science, 261, 1739-1744.
22. Satoh, T., Nakamura, S., Taga, T., Matsuda, T., Hirano, T., Kishimoto, T. and Kajiro, Y. (1988) Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6. Mol. Cell. Biol., 8, 3546-3549.
23. Sendtner, M., Kreutzberg, G.W. and Thoenen, H. (1990) Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature, 345, 440-441.
24. Stahl, N., Farruggella, T.J., Boulton, T.G., Zhong, Z., Darnell, J.E.,Jr and Yancopoulos, G.D. (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors Science, 267, 1349-1353.
25. Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T. and Kishimoto, T. (1989) Interleukin 6 (IL-6) triggers the association of its receptor (IL-6-R) with a possible signal transducer, gp130. Cell, 58, 573-581.
26. Vambutas, V., Kaplan, D.R., Sells, M.A. and Chernoff, J. (1995) Nerve growth factor stimulates tyrosine phosphorylation and activation of src homology-containing protein-tyrosine phosphatase 1 in PC12 cells. J. Biol. Chem., 270, 25629-25633.
27. Wegenka, U.M., Buschmann, J., Lutticken, C., Heinrich, P.C. and Horn, F. (1993) Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the post-translational level. Mol. Cell. Biol., 13, 276-288.
28. Wu, Y.Y. and Bradshaw, R.A. (1996a) Induction of neurite outgrowth by interleukin-6 is accompanied by activation of stat3 signalling pathway in a variant PC12 cell (E2) line. J. Biol. Chem., 271, 13023-13032.
29. Wu, Y.Y. and Bradshaw, R.A. (1996b) Synergestic induction of neurite outgrowth by nerve growth factor or epidermal growth factor and interleukin-6 in PC12 cells. J. Biol. Chem., 271, 13033-13039.
30. Yamanaka, Y., Nakajima, K., Fukada, T., Hibi, M. and Hirano, T. (1996) Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO J., 15, 1557-1565.
31. Yasukawa, K., Hirano, T., Watanabe, Y., Muratani, K., Matsuda, T. and Kishimoto, T. (1987) Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J., 6, 2939-2945.