Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction

Neurobiology of Disease

Volumn 28, Issue 1, 2007, Pages 52-64

  Ahtiainen, Laura ^a   Kolikova, Julia ^b   Mutka, Aino Liisa ^b   Luiro, Kaisu ^a   Gentile, Massimiliano ^a   Ikonen, Elina ^b   Khiroug, Leonard ^b   Jalanko, Anu ^a   Kopra, Outi ^a,b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Calcium homeostasis; Cholesterol; Infantile neuronal ceroid lipofuscinosis; Microarray; Neuron culture; Neuron maturation; Palmitoyl protein thioesterase 1; Synapse

Indexed keywords

CHOLESTEROL; GLUTAMIC ACID; PALMITOYL PROTEIN THIOESTERASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CALCIUM HOMEOSTASIS; CELL MATURATION; CELL PROLIFERATION; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DNA MICROARRAY; ENZYME DEFICIENCY; KNOCKOUT MOUSE; MOUSE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NEURONAL CEROID LIPOFUSCINOSIS; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STEROL SYNTHESIS; SYNAPTOGENESIS; UNINDEXED SEQUENCE;

ANIMALS; CALCIUM; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHOLESTEROL; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; HIPPOCAMPUS; HOMEOSTASIS; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONAL CEROID-LIPOFUSCINOSES; NEURONS; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; STEM CELLS; SYNAPSES; THIOLESTER HYDROLASES;

EID: 34548843340     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2007.06.012     Document Type: Article

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