Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors

Journal of Biological Chemistry

Volumn 287, Issue 24, 2012, Pages 20727-20736

  Platt, Randall J ^a   Han, Tiffany S ^a   Green, Brad R ^a   Smith, Misty D ^a   Skalicky, Jack ^b   Gruszczyński, Paweł ^c,d   White, H Steve ^a   Olivera, Baldomero ^a   Bulaj, Grzegorz ^a   Gajewiak, Joanna ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF GDA SK   (Poland)

^d Biolab Innovative Research Technologies   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACID RECEPTORS; CARBOXYGLUTAMIC ACID; CONE SNAILS; DIVALENT CATION; EXTRACELLULAR; GLUTAMATE RECEPTOR; HELICAL CONFORMATION; HELICAL PEPTIDE; HELICITIES; IN-VITRO; N-METHYL-D-ASPARTATE; NMDA RECEPTOR; NMR STUDIES; NON-COVALENT INTERACTION; OLEFINIC BOND; PHARMACOLOGICAL PROPERTIES; RING-CLOSING METATHESIS REACTIONS; SINGLE PRODUCT; TO EFFECT;

AMINO ACIDS; ENZYME ACTIVITY;

PEPTIDES;

4 CARBOXYGLUTAMIC ACID; CONANTOKIN G; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; RING CLOSING METATHESIS; STRUCTURE ACTIVITY RELATION;

1-CARBOXYGLUTAMIC ACID; ANIMALS; CONOTOXINS; EPILEPSY; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, N-METHYL-D-ASPARTATE;

GASTROPODA; MUS;

EID: 84862001925     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.350462     Document Type: Article

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